m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01464)

Target Name	E3 ubiquitin-protein ligase pellino homolog 2 (PELI2)
Synonyms	Pellino-2; EC 2.3.2.27; RING-type E3 ubiquitin transferase pellino homolog 2 Click to Show/Hide
Gene Name	PELI2
Chromosomal Location	14q22.3
Family	Pellino family
Function	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Click to Show/Hide
Gene ID	57161
Uniprot ID	PELI2_HUMAN
HGNC ID	HGNC:8828
KEGG ID	hsa:57161

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01464)

E3 ubiquitin-protein ligase pellino homolog 2 (PELI2)

Adenosine-to-Inosine editing (A-to-I)

In total 9 m6A sequence/site(s) in this target gene
mod ID: A2ISITE006360		Click to Show/Hide the Full List
mod site	chr14:56293422-56293423:+		[2]
Sequence	ACTTAGTTCTGTGGTATTGAATTGACGACGTAACCTCTCTG
Transcript ID List	rmsk_4182010; ENST00000267460.9
External Link	RMBase: RNA-editing_site_38624
mod ID: A2ISITE006361		Click to Show/Hide the Full List
mod site	chr14:56293433-56293434:+		[2]
Sequence	TGGTATTGAATTGACGACGTAACCTCTCTGTGCCTGGCTTC
Transcript ID List	ENST00000267460.9; rmsk_4182010
External Link	RMBase: RNA-editing_site_38625
mod ID: A2ISITE006362		Click to Show/Hide the Full List
mod site	chr14:56293434-56293435:+		[2]
Sequence	GGTATTGAATTGACGACGTAACCTCTCTGTGCCTGGCTTCC
Transcript ID List	rmsk_4182010; ENST00000267460.9
External Link	RMBase: RNA-editing_site_38626
mod ID: A2ISITE006363		Click to Show/Hide the Full List
mod site	chr14:56293492-56293493:+		[2]
Sequence	ATAATATTAATACATGTCTAATAGGACTGTTGTGAGAACTA
Transcript ID List	ENST00000267460.9
External Link	RMBase: RNA-editing_site_38627
mod ID: A2ISITE006364		Click to Show/Hide the Full List
mod site	chr14:56293885-56293886:+		[2]
Sequence	TTGTTCCACAGCCAGAGGCTAGGCCACCACCATACCTCAGC
Transcript ID List	rmsk_4182011; ENST00000267460.9
External Link	RMBase: RNA-editing_site_38628
mod ID: A2ISITE006365		Click to Show/Hide the Full List
mod site	chr14:56294855-56294856:+		[2]
Sequence	CTTATTTAGTTCTCACAACAATCCTATAAGACATGTATTGG
Transcript ID List	ENST00000267460.9
External Link	RMBase: RNA-editing_site_38629
mod ID: A2ISITE006366		Click to Show/Hide the Full List
mod site	chr14:56294863-56294864:+		[2]
Sequence	GTTCTCACAACAATCCTATAAGACATGTATTGGCATTATTC
Transcript ID List	ENST00000267460.9
External Link	RMBase: RNA-editing_site_38630
mod ID: A2ISITE006367		Click to Show/Hide the Full List
mod site	chr14:56294921-56294922:+		[2]
Sequence	AAGCCAGGCCCAGAGAGGTTAAGTCGTTGACTCAAGACCAC
Transcript ID List	ENST00000267460.9
External Link	RMBase: RNA-editing_site_38631
mod ID: A2ISITE006368		Click to Show/Hide the Full List
mod site	chr14:56294922-56294923:+		[2]
Sequence	AGCCAGGCCCAGAGAGGTTAAGTCGTTGACTCAAGACCACA
Transcript ID List	ENST00000267460.9
External Link	RMBase: RNA-editing_site_38632

N6-methyladenosine (m6A)

In total 35 m6A sequence/site(s) in this target gene
mod ID: M6ASITE019733		Click to Show/Hide the Full List
mod site	chr14:56118508-56118509:+		[3]
Sequence	CACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCT
Motif Score	4.065041667
Cell/Tissue List	GSC-11; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000267460.9; ENST00000559044.5
External Link	RMBase: m6A_site_248652
mod ID: M6ASITE019734		Click to Show/Hide the Full List
mod site	chr14:56118595-56118596:+		[4]
Sequence	GGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGG
Motif Score	4.065041667
Cell/Tissue List	CD34; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000559044.5; ENST00000267460.9; rmsk_4181780
External Link	RMBase: m6A_site_248653
mod ID: M6ASITE019735		Click to Show/Hide the Full List
mod site	chr14:56118683-56118684:+		[4]
Sequence	TTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGA
Motif Score	2.951386905
Cell/Tissue List	CD34; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000559044.5; ENST00000267460.9
External Link	RMBase: m6A_site_248654
mod ID: M6ASITE019736		Click to Show/Hide the Full List
mod site	chr14:56178421-56178422:+		[5]
Sequence	CCCAAGGCAAATGGTGTCAAACCCAGCACCGTCCATGTGAT
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000561019.1; ENST00000267460.9; ENST00000559044.5
External Link	RMBase: m6A_site_248655
mod ID: M6ASITE019737		Click to Show/Hide the Full List
mod site	chr14:56279729-56279730:+		[5]
Sequence	ACACTTTGTCAAGGAATCAGACTGTGGTGGTGGAGTACACA
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000561019.1; ENST00000267460.9; ENST00000559044.5
External Link	RMBase: m6A_site_248656
mod ID: M6ASITE019738		Click to Show/Hide the Full List
mod site	chr14:56288479-56288480:+		[5]
Sequence	TATCGACTTCGTTGTCACAGACACGATTTCTGGCAGCCAGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000561019.1; ENST00000559044.5; ENST00000267460.9
External Link	RMBase: m6A_site_248657
mod ID: M6ASITE019739		Click to Show/Hide the Full List
mod site	chr14:56288500-56288501:+		[5]
Sequence	CACGATTTCTGGCAGCCAGAACACGGACGAAGCCCAGATCA
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000267460.9; ENST00000559044.5; ENST00000561019.1
External Link	RMBase: m6A_site_248658
mod ID: M6ASITE019740		Click to Show/Hide the Full List
mod site	chr14:56288573-56288574:+		[5]
Sequence	ATCGTGTGCGACAGGAATGAACCTTACACAGCACGGATATT
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000559044.5; ENST00000267460.9; ENST00000561019.1
External Link	RMBase: m6A_site_248659
mod ID: M6ASITE019741		Click to Show/Hide the Full List
mod site	chr14:56288620-56288621:+		[5]
Sequence	CGGATTTGACTCTTCCAAAAACATATTTCTTGGAGTAAGTA
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000561019.1; ENST00000267460.9; ENST00000559044.5
External Link	RMBase: m6A_site_248660
mod ID: M6ASITE019742		Click to Show/Hide the Full List
mod site	chr14:56290289-56290290:+		[5]
Sequence	AAAGGCAGCAAAGTGGAAAAACCCCGACGGCCACATGGATG
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000561019.1; ENST00000267460.9; ENST00000559044.5
External Link	RMBase: m6A_site_248661
mod ID: M6ASITE019743		Click to Show/Hide the Full List
mod site	chr14:56290426-56290427:+		[5]
Sequence	ATGTGTACACCTTGCGAGAAACCAGGTCGGCCCAGCAACGA
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248662
mod ID: M6ASITE019744		Click to Show/Hide the Full List
mod site	chr14:56296611-56296612:+		[4]
Sequence	TGTTGTAGGTGGAAAGTGAGACCAACGTCCTGCAGGACGGC
Motif Score	2.876744048
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248663
mod ID: M6ASITE019745		Click to Show/Hide the Full List
mod site	chr14:56296671-56296672:+		[4]
Sequence	GGGCCACTCTCCTCTGGAGAACAGCAGATGGGCTTTTTCAT
Motif Score	2.951386905
Cell/Tissue List	CD34; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248664
mod ID: M6ASITE019746		Click to Show/Hide the Full List
mod site	chr14:56296920-56296921:+		[5]
Sequence	GGGAGTGTCCCATGTGCAGGACTGTGGGCCCCTATGTGCCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; H1A; H1B; hNPCs; hESCs; fibroblasts; CD8T; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; endometrial; HEC-1-A; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248665
mod ID: M6ASITE019747		Click to Show/Hide the Full List
mod site	chr14:56296982-56296983:+		[5]
Sequence	GGATTTTATGTAGACGCAGGACCGCCAACTCATGCTTTCAC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; hESCs; fibroblasts; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; endometrial; HEC-1-A; GSCs; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248666
mod ID: M6ASITE019748		Click to Show/Hide the Full List
mod site	chr14:56297012-56297013:+		[5]
Sequence	CATGCTTTCACTCCCTGTGGACACGTGTGCTCGGAGAAGTC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; kidney; A549; HepG2; H1A; H1B; hESCs; fibroblasts; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248667
mod ID: M6ASITE019749		Click to Show/Hide the Full List
mod site	chr14:56297070-56297071:+		[5]
Sequence	AGATCCCGTTGCCTCATGGAACTCATGCATTTCACGCTGCT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; H1A; H1B; hESCs; fibroblasts; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248668
mod ID: M6ASITE019750		Click to Show/Hide the Full List
mod site	chr14:56297128-56297129:+		[5]
Sequence	ACAGCTGGTTGGGGAGCAAAACTGCATCAAATTAATTTTCC
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34; HEK293T; A549; HepG2; H1A; H1B; hESCs; fibroblasts; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248669
mod ID: M6ASITE019751		Click to Show/Hide the Full List
mod site	chr14:56297161-56297162:+		[6]
Sequence	AATTTTCCAAGGTCCAATTGACTGACGCCCTTGACAGCCAT
Motif Score	3.28175
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248670
mod ID: M6ASITE019752		Click to Show/Hide the Full List
mod site	chr14:56297296-56297297:+		[7]
Sequence	GCTGGAAATAAAGAGAGGGGACATGGTGATGAAACATGGCA
Motif Score	3.643047619
Cell/Tissue List	HEK293T; Huh7; Jurkat; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248671
mod ID: M6ASITE019753		Click to Show/Hide the Full List
mod site	chr14:56297309-56297310:+		[7]
Sequence	AGAGGGGACATGGTGATGAAACATGGCAGGAGTGTAACAGA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; Huh7; Jurkat; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248672
mod ID: M6ASITE019754		Click to Show/Hide the Full List
mod site	chr14:56297356-56297357:+		[7]
Sequence	TGGTGTGTTGCATGCTCAAAACAGCAGCGTCGTCATTGAAG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; Huh7; Jurkat
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248673
mod ID: M6ASITE019755		Click to Show/Hide the Full List
mod site	chr14:56297593-56297594:+		[8]
Sequence	AGGTGTTACGCGAAGGGCGCACAGTGTCTAGAAATACTTGA
Motif Score	2.830589286
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248674
mod ID: M6ASITE019756		Click to Show/Hide the Full List
mod site	chr14:56297625-56297626:+		[4]
Sequence	AATACTTGATCGTGGCTCAAACCTGACCAGACAGCAGAGGG
Motif Score	2.185083333
Cell/Tissue List	CD34; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248675
mod ID: M6ASITE019757		Click to Show/Hide the Full List
mod site	chr14:56297635-56297636:+		[4]
Sequence	CGTGGCTCAAACCTGACCAGACAGCAGAGGGGCGGCTCTGT
Motif Score	2.897386905
Cell/Tissue List	CD34; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248676
mod ID: M6ASITE019758		Click to Show/Hide the Full List
mod site	chr14:56297672-56297673:+		[4]
Sequence	CTGTACAGTGTGACTGGTGGACAGATGGCCTTAGGCACAGG
Motif Score	3.643047619
Cell/Tissue List	CD34; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248677
mod ID: M6ASITE019759		Click to Show/Hide the Full List
mod site	chr14:56298470-56298471:+		[9]
Sequence	GAAGGTAAAGATCCTTTAGGACATGAGACTGGTAGAAGCTG
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248678
mod ID: M6ASITE019760		Click to Show/Hide the Full List
mod site	chr14:56298576-56298577:+		[9]
Sequence	GACTTTTTTTTAACCTTTGTACATATACGTAATTTATATGA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248679
mod ID: M6ASITE019761		Click to Show/Hide the Full List
mod site	chr14:56298713-56298714:+		[10]
Sequence	ACGCTTTTCCTTAAAGTGATACGATAATATTACTCTTGATT
Motif Score	2.084416667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248680
mod ID: M6ASITE019762		Click to Show/Hide the Full List
mod site	chr14:56300330-56300331:+		[9]
Sequence	TATGTCAGAAACTGGCATAAACATGATTGTAGTAGAATTTA
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248681
mod ID: M6ASITE019763		Click to Show/Hide the Full List
mod site	chr14:56300388-56300389:+		[9]
Sequence	GGAAATTATTTTAAGTTATTACATTTACTGTATTGGGAAAC
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248682
mod ID: M6ASITE019764		Click to Show/Hide the Full List
mod site	chr14:56300835-56300836:+		[10]
Sequence	GATGCGCCTCCTTCTGTGCGACCAATGAGACGACTTCAGCA
Motif Score	2.844928571
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248683
mod ID: M6ASITE019765		Click to Show/Hide the Full List
mod site	chr14:56300929-56300930:+		[10]
Sequence	AGTATTTTCTTTTTAGTATAACTTACATCCTTTCAAATAAG
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248684
mod ID: M6ASITE019766		Click to Show/Hide the Full List
mod site	chr14:56301079-56301080:+		[10]
Sequence	GTTTCTTTTTAGCTGAGATGACAGATTGCTTCTCTGTATTA
Motif Score	2.859755952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248685
mod ID: M6ASITE019767		Click to Show/Hide the Full List
mod site	chr14:56301127-56301128:+		[10]
Sequence	TAGAAGTTAAGGGGATGGTCACATTTACCATGTATTGTGTT
Motif Score	2.047297619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000267460.9
External Link	RMBase: m6A_site_248686

Ref 1	US patent application no. 6,238,921, Antisense oligonucleotide modulation of human mdm2 expression.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell. 2017 Apr 10;31(4):591-606.e6. doi: 10.1016/j.ccell.2017.02.013. Epub 2017 Mar 23.
Ref 4	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
Ref 7	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 8	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 9	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 10	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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