m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01444)
Target Name Alpha-synuclein (SNCA)
Synonyms
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
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Gene Name SNCA
Chromosomal Location 4q22.1
Family synuclein family
Function
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:28288128, PubMed:30404828, PubMed:20798282, PubMed:26442590). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).
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Gene ID 6622
Uniprot ID
SYUA_HUMAN
HGNC ID
HGNC:11138
KEGG ID
hsa:6622
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01444)
Alpha-synuclein (SNCA)
Adenosine-to-Inosine editing (A-to-I)
In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000484 Click to Show/Hide the Full List
mod site chr4:89767725-89767726:- [2]
Sequence CAGGCAGTTGAGAAAGGAGAATCACTTGAACTCAGGAGGCA
Transcript ID List ENST00000394991.7; ENST00000336904.7; rmsk_1374558; ENST00000394989.6; ENST00000508895.5; ENST00000394986.5; ENST00000420646.6; ENST00000618500.4; ENST00000506244.5; ENST00000505199.5; ENST00000611107.1; ENST00000345009.8
External Link RMBase: RNA-editing_site_105899
N6-methyladenosine (m6A)
In total 26 m6A sequence/site(s) in this target gene
mod ID: M6ASITE066656 Click to Show/Hide the Full List
mod site chr4:89725013-89725014:- [3]
Sequence GTAGAAAGTATAATTTCAAGACAGAATATTCTAGACATGCT
Motif Score 2.897386905
Cell/Tissue List brain
Seq Type List m6A-REF-seq
Transcript ID List ENST00000394989.6; ENST00000618500.4; ENST00000420646.6; ENST00000336904.7
External Link RMBase: m6A_site_644484
mod ID: M6ASITE066657 Click to Show/Hide the Full List
mod site chr4:89725491-89725492:- [4]
Sequence TGTAGAAGATGATTTTGACTACACCCTCCTTAGAGAGCCAT
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000420646.6; ENST00000394989.6; ENST00000336904.7; ENST00000618500.4
External Link RMBase: m6A_site_644485
mod ID: M6ASITE066658 Click to Show/Hide the Full List
mod site chr4:89725845-89725846:- [5]
Sequence AGAAGTGTGTTTTGGTATGCACTGGTTCCTTAAGTGGCTGT
Motif Score 3.252583333
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000394989.6; ENST00000336904.7; ENST00000618500.4; ENST00000420646.6
External Link RMBase: m6A_site_644486
mod ID: M6ASITE066659 Click to Show/Hide the Full List
mod site chr4:89725974-89725975:-
Sequence ATTAAGAACTGACACAAAGGACAAAAATATAAAGTTATTAA
Motif Score 3.643047619
Cell/Tissue List HEK293T
Seq Type List MeRIP-seq
Transcript ID List ENST00000618500.4; ENST00000345009.8; ENST00000336904.7; ENST00000394989.6; ENST00000420646.6
External Link RMBase: m6A_site_644487
mod ID: M6ASITE066660 Click to Show/Hide the Full List
mod site chr4:89725987-89725988:-
Sequence ATAAGCAACATGAATTAAGAACTGACACAAAGGACAAAAAT
Motif Score 3.373380952
Cell/Tissue List HEK293T
Seq Type List MeRIP-seq
Transcript ID List ENST00000394989.6; ENST00000345009.8; ENST00000618500.4; ENST00000336904.7; ENST00000420646.6
External Link RMBase: m6A_site_644488
mod ID: M6ASITE066661 Click to Show/Hide the Full List
mod site chr4:89726240-89726241:- [5]
Sequence TTTAGGTGTCTTTTAATGATACTGTCTAAGAATAATGACGT
Motif Score 2.53247619
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000394991.7; ENST00000618500.4; ENST00000394986.5; ENST00000394989.6; ENST00000345009.8; ENST00000336904.7; ENST00000420646.6
External Link RMBase: m6A_site_644489
mod ID: M6ASITE066662 Click to Show/Hide the Full List
mod site chr4:89726369-89726370:- [5]
Sequence CTTCAATCTACGATGTTAAAACAAATTAAAAACACCTAAGT
Motif Score 2.20572619
Cell/Tissue List HEK293T; hESC-HEK293T
Seq Type List DART-seq; MAZTER-seq
Transcript ID List ENST00000345009.8; ENST00000336904.7; ENST00000394986.5; ENST00000420646.6; ENST00000394989.6; ENST00000618500.4; ENST00000394991.7; ENST00000508895.5
External Link RMBase: m6A_site_644490
mod ID: M6ASITE066663 Click to Show/Hide the Full List
mod site chr4:89726380-89726381:- [5]
Sequence GGATTTTGTGGCTTCAATCTACGATGTTAAAACAAATTAAA
Motif Score 2.05260119
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000420646.6; ENST00000336904.7; ENST00000394986.5; ENST00000394989.6; ENST00000508895.5; ENST00000394991.7; ENST00000345009.8; ENST00000618500.4
External Link RMBase: m6A_site_644491
mod ID: M6ASITE066664 Click to Show/Hide the Full List
mod site chr4:89726428-89726429:- [4]
Sequence TCCCTTTCACTGAAGTGAATACATGGTAGCAGGGTCTTTGT
Motif Score 2.110482143
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000336904.7; ENST00000420646.6; ENST00000345009.8; ENST00000394986.5; ENST00000618500.4; ENST00000508895.5; ENST00000394989.6; ENST00000394991.7
External Link RMBase: m6A_site_644492
mod ID: M6ASITE066665 Click to Show/Hide the Full List
mod site chr4:89726572-89726573:- [3]
Sequence TGACAGATGTTCCATCCTGTACAAGTGCTCAGTTCCAATGT
Motif Score 2.856142857
Cell/Tissue List brain
Seq Type List m6A-REF-seq
Transcript ID List ENST00000394989.6; ENST00000394991.7; ENST00000618500.4; ENST00000394986.5; ENST00000508895.5; ENST00000420646.6; ENST00000345009.8; ENST00000336904.7
External Link RMBase: m6A_site_644493
mod ID: M6ASITE066666 Click to Show/Hide the Full List
mod site chr4:89729221-89729222:- [4]
Sequence AGATATGCCTGTGGATCCTGACAATGAGGCTTATGAAATGC
Motif Score 2.859755952
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000506244.5; ENST00000394989.6; ENST00000394986.5; ENST00000345009.8; ENST00000508895.5; ENST00000505199.5; ENST00000336904.7; ENST00000618500.4; ENST00000394991.7; ENST00000420646.6; ENST00000611107.1
External Link RMBase: m6A_site_644494
mod ID: M6ASITE066667 Click to Show/Hide the Full List
mod site chr4:89822258-89822259:- [6]
Sequence CACTGGCTTTGTCAAAAAGGACCAGTTGGGCAAGGTATGGC
Motif Score 3.622404762
Cell/Tissue List U2OS; MM6
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000618500.4; ENST00000394989.6; ENST00000505199.5; ENST00000394986.5; ENST00000502987.5; ENST00000336904.7; ENST00000345009.8; ENST00000508895.5; ENST00000394991.7; ENST00000506244.5; ENST00000611107.1; ENST00000420646.6
External Link RMBase: m6A_site_644495
mod ID: M6ASITE066668 Click to Show/Hide the Full List
mod site chr4:89822310-89822311:- [6]
Sequence TGACAGCAGTAGCCCAGAAGACAGTGGAGGGAGCAGGGAGC
Motif Score 2.897386905
Cell/Tissue List U2OS; MM6
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000420646.6; ENST00000345009.8; ENST00000611107.1; ENST00000508895.5; ENST00000394991.7; ENST00000505199.5; ENST00000336904.7; ENST00000394989.6; ENST00000506244.5; ENST00000618500.4; ENST00000394986.5; ENST00000502987.5
External Link RMBase: m6A_site_644496
mod ID: M6ASITE066669 Click to Show/Hide the Full List
mod site chr4:89822376-89822377:- [7]
Sequence TTGTACCAGTGGCTGAGAAGACCAAAGAGCAAGTGACAAAT
Motif Score 2.876744048
Cell/Tissue List CD34; U2OS; MM6; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000508895.5; ENST00000506691.1; ENST00000611107.1; ENST00000336904.7; ENST00000505199.5; ENST00000394986.5; ENST00000618500.4; ENST00000420646.6; ENST00000506244.5; ENST00000502987.5; ENST00000345009.8; ENST00000394989.6; ENST00000394991.7
External Link RMBase: m6A_site_644497
mod ID: M6ASITE066670 Click to Show/Hide the Full List
mod site chr4:89828175-89828176:- [7]
Sequence TTGTTTTTGTAGGCTCCAAAACCAAGGAGGGAGTGGTGCAT
Motif Score 2.185083333
Cell/Tissue List CD34; U2OS; MM6; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000420646.6; ENST00000506691.1; ENST00000506244.5; ENST00000394986.5; ENST00000611107.1; ENST00000394991.7; ENST00000505199.5; ENST00000502987.5; ENST00000345009.8; ENST00000336904.7; ENST00000618500.4; ENST00000508895.5; ENST00000394989.6
External Link RMBase: m6A_site_644498
mod ID: M6ASITE066671 Click to Show/Hide the Full List
mod site chr4:89835570-89835571:- [7]
Sequence TGGCAGAAGCAGCAGGAAAGACAAAAGAGGGTGTTCTCTAT
Motif Score 2.897386905
Cell/Tissue List CD34; hESC-HEK293T; U2OS; MM6; endometrial
Seq Type List m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List ENST00000345009.8; ENST00000508895.5; ENST00000336904.7; ENST00000502987.5; ENST00000394989.6; ENST00000420646.6; ENST00000394991.7; ENST00000394986.5; ENST00000505199.5; ENST00000506244.5; ENST00000618500.4; ENST00000506691.1; ENST00000611107.1
External Link RMBase: m6A_site_644499
mod ID: M6ASITE066672 Click to Show/Hide the Full List
mod site chr4:89835598-89835599:- [7]
Sequence GCTGCTGCTGAGAAAACCAAACAGGGTGTGGCAGAAGCAGC
Motif Score 2.20572619
Cell/Tissue List CD34; MM6; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000506691.1; ENST00000508895.5; ENST00000394991.7; ENST00000394986.5; ENST00000420646.6; ENST00000336904.7; ENST00000611107.1; ENST00000345009.8; ENST00000618500.4; ENST00000505199.5; ENST00000506244.5; ENST00000502987.5; ENST00000394989.6
External Link RMBase: m6A_site_644500
mod ID: M6ASITE066673 Click to Show/Hide the Full List
mod site chr4:89835603-89835604:- [7]
Sequence TTGTGGCTGCTGCTGAGAAAACCAAACAGGGTGTGGCAGAA
Motif Score 2.185083333
Cell/Tissue List CD34; MM6; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000336904.7; ENST00000618500.4; ENST00000394989.6; ENST00000394986.5; ENST00000611107.1; ENST00000506244.5; ENST00000420646.6; ENST00000502987.5; ENST00000394991.7; ENST00000505199.5; ENST00000345009.8; ENST00000506691.1; ENST00000508895.5
External Link RMBase: m6A_site_644501
mod ID: M6ASITE066674 Click to Show/Hide the Full List
mod site chr4:89835646-89835647:- [7]
Sequence ATGGATGTATTCATGAAAGGACTTTCAAAGGCCAAGGAGGG
Motif Score 4.065041667
Cell/Tissue List CD34; MM6; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000394989.6; ENST00000345009.8; ENST00000618500.4; ENST00000336904.7; ENST00000506244.5; ENST00000611107.1; ENST00000505199.5; ENST00000506691.1; ENST00000394986.5; ENST00000508895.5; ENST00000394991.7; ENST00000420646.6; ENST00000502987.5
External Link RMBase: m6A_site_644502
mod ID: M6ASITE066675 Click to Show/Hide the Full List
mod site chr4:89836137-89836138:- [7]
Sequence TGCTGTTTGCCTGAGTTTGAACCACACCCCGAGTGAGCAGT
Motif Score 2.930744048
Cell/Tissue List CD34; MM6
Seq Type List m6A-seq
Transcript ID List ENST00000508895.5; ENST00000420646.6; ENST00000618500.4; ENST00000394991.7; ENST00000394989.6; ENST00000506244.5; ENST00000336904.7; ENST00000394986.5; ENST00000506691.1
External Link RMBase: m6A_site_644503
mod ID: M6ASITE066676 Click to Show/Hide the Full List
mod site chr4:89836174-89836175:- [7]
Sequence TGGATGTTGGATGGATTAGAACCATCACACTTGGGCCTGCT
Motif Score 2.930744048
Cell/Tissue List CD34
Seq Type List m6A-seq
Transcript ID List ENST00000394991.7; ENST00000506244.5; ENST00000394989.6; ENST00000336904.7; ENST00000394986.5; ENST00000506691.1; ENST00000618500.4; ENST00000420646.6; ENST00000508895.5
External Link RMBase: m6A_site_644504
mod ID: M6ASITE066677 Click to Show/Hide the Full List
mod site chr4:89836747-89836748:- [7]
Sequence AGTTGTGGAGAAGCAGAGGGACTCAGGTAAGTACCTGTGGA
Motif Score 4.065041667
Cell/Tissue List CD34
Seq Type List m6A-seq
Transcript ID List ENST00000506244.5; ENST00000394986.5; ENST00000394991.7; ENST00000336904.7; ENST00000506691.1; ENST00000420646.6; ENST00000394989.6
External Link RMBase: m6A_site_644505
mod ID: M6ASITE066678 Click to Show/Hide the Full List
mod site chr4:89836985-89836986:- [8]
Sequence TCCACCCTCGTGAGCGGAGAACTGGGAGTGGCCATTCGACG
Motif Score 3.373380952
Cell/Tissue List HEK293T; HEK293A-TOA; iSLK; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000336904.7; ENST00000394991.7; ENST00000394986.5; ENST00000506244.5; ENST00000394989.6; ENST00000506691.1
External Link RMBase: m6A_site_644506
mod ID: M6ASITE066679 Click to Show/Hide the Full List
mod site chr4:89837074-89837075:- [7]
Sequence GCGTGCGGGCTGCAGCGCAGACCCCGGCCCGGCCCCTCCGA
Motif Score 2.876744048
Cell/Tissue List CD34; H1A; fibroblasts; HEK293T; HEK293A-TOA; TIME; iSLK; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000506244.5; ENST00000394986.5; ENST00000394989.6; ENST00000394991.7; ENST00000506691.1; ENST00000336904.7
External Link RMBase: m6A_site_644507
mod ID: M6ASITE066680 Click to Show/Hide the Full List
mod site chr4:89837177-89837178:- [9]
Sequence GGAGAAGGAGAAGGAGGAGGACTAGGAGGAGGAGGACGGCG
Motif Score 4.065041667
Cell/Tissue List H1A; H1B; hESCs; fibroblasts; HEK293A-TOA; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000394989.6; ENST00000394991.7; ENST00000336904.7
External Link RMBase: m6A_site_644508
mod ID: M6ASITE066681 Click to Show/Hide the Full List
mod site chr4:89838276-89838277:- [9]
Sequence CATTCTGGTGTGATCCAGGAACAGCTGTCTTCCAGCTCTGA
Motif Score 2.951386905
Cell/Tissue List H1B
Seq Type List m6A-seq
Transcript ID List ENST00000336904.7
External Link RMBase: m6A_site_644509