m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01430)

Target Name	Catalase (CAT)
Synonyms	EC 1.11.1.6 Click to Show/Hide
Gene Name	CAT
Chromosomal Location	11p13
Family	Catalase family
Function	Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). Click to Show/Hide
Gene ID	847
Uniprot ID	CATA_HUMAN
HGNC ID	HGNC:1516
KEGG ID	hsa:847

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01430)

Catalase (CAT)

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005135		Click to Show/Hide the Full List
mod site	chr11:34471633-34471634:+
Sequence	GAAGGTTAGGATTTAACAGTCATTTAAAAAAAAAATTTGTT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000241052.5; ENST00000648322.1
External Link	RMBase: m5C_site_7241

N6-methyladenosine (m6A)

In total 34 m6A sequence/site(s) in this target gene
mod ID: M6ASITE004889		Click to Show/Hide the Full List
mod site	chr11:34438963-34438964:+		[2]
Sequence	TTTGCCTGCTGAGGGTGGAGACCCACGAGCCGAGGCCTCCT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; fibroblasts; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000648322.1; ENST00000241052.5
External Link	RMBase: m6A_site_137030
mod ID: M6ASITE004890		Click to Show/Hide the Full List
mod site	chr11:34439003-34439004:+		[2]
Sequence	TGCAGTGTTCTGCACAGCAAACCGCACGCTATGGCTGACAG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; A549; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000241052.5; ENST00000648322.1
External Link	RMBase: m6A_site_137031
mod ID: M6ASITE004891		Click to Show/Hide the Full List
mod site	chr11:34439020-34439021:+		[3]
Sequence	CAAACCGCACGCTATGGCTGACAGCCGGGATCCCGCCAGCG
Motif Score	2.859755952
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000648322.1; ENST00000241052.5
External Link	RMBase: m6A_site_137032
mod ID: M6ASITE004892		Click to Show/Hide the Full List
mod site	chr11:34449234-34449235:+		[4]
Sequence	AGCTGGTAACCCAGTAGGAGACAAACTTAATGTTATTACAG
Motif Score	2.897386905
Cell/Tissue List	HepG2; A549; hESC-HEK293T; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000241052.5; ENST00000648322.1
External Link	RMBase: m6A_site_137033
mod ID: M6ASITE004893		Click to Show/Hide the Full List
mod site	chr11:34451010-34451011:+		[5]
Sequence	CCTTTGGCTACTTTGAGGTCACACATGACATTACCAAATAC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000241052.5; ENST00000648322.1; ENST00000650153.1
External Link	RMBase: m6A_site_137034
mod ID: M6ASITE004894		Click to Show/Hide the Full List
mod site	chr11:34451017-34451018:+		[5]
Sequence	CTACTTTGAGGTCACACATGACATTACCAAATACTCCAAGG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000648322.1; ENST00000650153.1; ENST00000241052.5
External Link	RMBase: m6A_site_137035
mod ID: M6ASITE004895		Click to Show/Hide the Full List
mod site	chr11:34452097-34452098:+		[5]
Sequence	TGGAGAATCGGGTTCAGCTGACACAGTTCGGGACCCTCGTG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000241052.5; ENST00000648322.1; ENST00000650153.1
External Link	RMBase: m6A_site_137036
mod ID: M6ASITE004896		Click to Show/Hide the Full List
mod site	chr11:34452172-34452173:+		[5]
Sequence	CTGGGATCTCGTTGGAAATAACACCCCCATTTTCTTCATCA
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000650153.1; ENST00000648322.1; ENST00000241052.5
External Link	RMBase: m6A_site_137037
mod ID: M6ASITE004897		Click to Show/Hide the Full List
mod site	chr11:34453147-34453148:+		[5]
Sequence	GACACATCTGAAGGATCCGGACATGGTCTGGGACTTCTGGA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000648322.1; ENST00000650153.1; ENST00000241052.5
External Link	RMBase: m6A_site_137038
mod ID: M6ASITE004898		Click to Show/Hide the Full List
mod site	chr11:34453838-34453839:+		[5]
Sequence	GATCGGGGGATTCCAGATGGACATCGCCACATGAATGGATA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000648322.1; ENST00000241052.5; ENST00000650153.1
External Link	RMBase: m6A_site_137039
mod ID: M6ASITE004899		Click to Show/Hide the Full List
mod site	chr11:34453846-34453847:+		[3]
Sequence	GATTCCAGATGGACATCGCCACATGAATGGATATGGATCAC
Motif Score	2.053113095
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000650153.1; ENST00000241052.5; ENST00000528104.2; ENST00000648322.1
External Link	RMBase: m6A_site_137040
mod ID: M6ASITE004900		Click to Show/Hide the Full List
mod site	chr11:34453865-34453866:+		[5]
Sequence	CACATGAATGGATATGGATCACATACTTTCAAGCTGGTTAA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000528104.2; ENST00000650153.1; ENST00000241052.5; ENST00000648322.1
External Link	RMBase: m6A_site_137041
mod ID: M6ASITE004901		Click to Show/Hide the Full List
mod site	chr11:34456109-34456110:+		[3]
Sequence	ATCTTTTTAACGCCATTGCCACAGGAAAGTACCCCTCCTGG
Motif Score	2.053113095
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000650153.1; ENST00000648322.1; ENST00000241052.5; ENST00000528104.2
External Link	RMBase: m6A_site_137042
mod ID: M6ASITE004902		Click to Show/Hide the Full List
mod site	chr11:34456674-34456675:+		[5]
Sequence	TCATTTTCAGGTTTGGCCTCACAAGGACTACCCTCTCATCC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000241052.5; ENST00000650153.1; ENST00000528104.2; ENST00000648322.1
External Link	RMBase: m6A_site_137043
mod ID: M6ASITE004903		Click to Show/Hide the Full List
mod site	chr11:34456680-34456681:+		[6]
Sequence	TCAGGTTTGGCCTCACAAGGACTACCCTCTCATCCCAGTTG
Motif Score	4.065041667
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000648322.1; ENST00000241052.5; ENST00000528104.2; ENST00000650153.1
External Link	RMBase: m6A_site_137044
mod ID: M6ASITE004904		Click to Show/Hide the Full List
mod site	chr11:34456750-34456751:+		[7]
Sequence	AATTACTTTGCTGAGGTTGAACAGATAGCCTTCGACCCAAG
Motif Score	2.951386905
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000650153.1; ENST00000648322.1; ENST00000241052.5; ENST00000528104.2
External Link	RMBase: m6A_site_137045
mod ID: M6ASITE004905		Click to Show/Hide the Full List
mod site	chr11:34456803-34456804:+		[3]
Sequence	TGGCATTGAGGCCAGTCCTGACAAAATGCTTCAGGTGAGCC
Motif Score	2.859755952
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000241052.5; ENST00000650153.1; ENST00000648322.1; ENST00000528104.2
External Link	RMBase: m6A_site_137046
mod ID: M6ASITE004906		Click to Show/Hide the Full List
mod site	chr11:34456919-34456920:+		[7]
Sequence	TATGTGAGGAATTAACAAGAACATTACTTAAACTTTAATCT
Motif Score	2.951386905
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000650153.1; ENST00000648322.1; ENST00000241052.5; ENST00000528104.2
External Link	RMBase: m6A_site_137047
mod ID: M6ASITE004907		Click to Show/Hide the Full List
mod site	chr11:34461272-34461273:+		[5]
Sequence	CCGCCTTTTTGCCTATCCTGACACTCACCGCCATCGCCTGG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000648322.1; ENST00000530343.1; ENST00000650153.1; ENST00000241052.5
External Link	RMBase: m6A_site_137048
mod ID: M6ASITE004908		Click to Show/Hide the Full List
mod site	chr11:34461320-34461321:+		[8]
Sequence	TTATCTTCATATACCTGTGAACTGTCCCTACCGTGCTCGAG
Motif Score	3.373380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000650153.1; ENST00000648322.1; ENST00000530343.1; ENST00000241052.5
External Link	RMBase: m6A_site_137049
mod ID: M6ASITE004909		Click to Show/Hide the Full List
mod site	chr11:34461380-34461381:+		[5]
Sequence	CGGCCCGATGTGCATGCAGGACAATCAGGGTAGGCCTAAAG
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000241052.5; ENST00000650153.1; ENST00000648322.1; ENST00000530343.1
External Link	RMBase: m6A_site_137050
mod ID: M6ASITE004910		Click to Show/Hide the Full List
mod site	chr11:34464206-34464207:+		[5]
Sequence	TGGAGAAGTGCGGAGATTCAACACTGCCAATGATGATAACG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000241052.5; ENST00000525707.2; ENST00000648322.1
External Link	RMBase: m6A_site_137051
mod ID: M6ASITE004911		Click to Show/Hide the Full List
mod site	chr11:34464208-34464209:+		[8]
Sequence	GAGAAGTGCGGAGATTCAACACTGCCAATGATGATAACGTT
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000241052.5; ENST00000525707.2; ENST00000648322.1
External Link	RMBase: m6A_site_137052
mod ID: M6ASITE004912		Click to Show/Hide the Full List
mod site	chr11:34468370-34468371:+		[5]
Sequence	GCCGGCCACCTGAAGGATGCACAAATTTTCATCCAGAAGAA
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000648322.1; ENST00000241052.5; ENST00000525707.2
External Link	RMBase: m6A_site_137053
mod ID: M6ASITE004913		Click to Show/Hide the Full List
mod site	chr11:34470985-34470986:+		[8]
Sequence	CTTCACTGAGGTCCACCCTGACTACGGGAGCCACATCCAGG
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000241052.5; ENST00000534710.2; ENST00000648322.1
External Link	RMBase: m6A_site_137054
mod ID: M6ASITE004914		Click to Show/Hide the Full List
mod site	chr11:34470997-34470998:+		[5]
Sequence	CCACCCTGACTACGGGAGCCACATCCAGGCTCTTCTGGACA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000241052.5; ENST00000648322.1; ENST00000534710.2
External Link	RMBase: m6A_site_137055
mod ID: M6ASITE004915		Click to Show/Hide the Full List
mod site	chr11:34471581-34471582:+		[3]
Sequence	TTTCTATAGCAGATTGTGTAACAATTTTAATGCTATTTCCC
Motif Score	2.168095238
Cell/Tissue List	kidney; HEK293T
Seq Type List	m6A-REF-seq; DART-seq
Transcript ID List	ENST00000648322.1; ENST00000241052.5
External Link	RMBase: m6A_site_137056
mod ID: M6ASITE004916		Click to Show/Hide the Full List
mod site	chr11:34471628-34471629:+		[3]
Sequence	AAAATGAAGGTTAGGATTTAACAGTCATTTAAAAAAAAAAT
Motif Score	2.168095238
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000648322.1; ENST00000241052.5
External Link	RMBase: m6A_site_137057
mod ID: M6ASITE004917		Click to Show/Hide the Full List
mod site	chr11:34471657-34471658:+		[8]
Sequence	TAAAAAAAAAATTTGTTTTGACGGATGATTGGATTATTCAT
Motif Score	2.833690476
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000241052.5; ENST00000648322.1
External Link	RMBase: m6A_site_137058
mod ID: M6ASITE004918		Click to Show/Hide the Full List
mod site	chr11:34471727-34471728:+		[8]
Sequence	TAGAAATATGATTTTATTTGACAAAATTTGTTGAAATTATG
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000648322.1; ENST00000241052.5
External Link	RMBase: m6A_site_137059
mod ID: M6ASITE004919		Click to Show/Hide the Full List
mod site	chr11:34471755-34471756:+		[5]
Sequence	TGTTGAAATTATGTATGTTTACATATCACCTCATGGCCTAT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000648322.1; ENST00000241052.5
External Link	RMBase: m6A_site_137060
mod ID: M6ASITE004920		Click to Show/Hide the Full List
mod site	chr11:34471827-34471828:+		[8]
Sequence	AGAAAAGATAAAGATGATCTACTCAGAAATTTTTATTTTTC
Motif Score	2.500660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000241052.5; ENST00000648322.1
External Link	RMBase: m6A_site_137061
mod ID: M6ASITE004921		Click to Show/Hide the Full List
mod site	chr11:34471869-34471870:+		[5]
Sequence	AAGGTTCTCATAGGAAAAGTACATTTAATACAGCAGTGTCA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000648322.1; ENST00000241052.5
External Link	RMBase: m6A_site_137062
mod ID: M6ASITE004922		Click to Show/Hide the Full List
mod site	chr11:34471972-34471973:+		[5]
Sequence	TCATTTTTTTCACTGGAGTTACATTAATGTTAATTCAGCAC
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000241052.5; ENST00000648322.1
External Link	RMBase: m6A_site_137063

Ref 1	GEMSTONE-301: a phase III clinical trial of CS1001 as consolidation therapy in patients with locally advanced/unresectable (stage III) non-small cell lung cancer (NSCLC) who did not have disease progression after prior concurrent/sequential chemoradiotherapy. Transl Lung Cancer Res. 2020 Oct;9(5):2008-2015. doi: 10.21037/tlcr-20-608.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 4	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
Ref 7	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 8	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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