m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01422)

Target Name	DNA-binding protein inhibitor ID-3 (ID3)
Synonyms	Class B basic helix-loop-helix protein 25; bHLHb25; Helix-loop-helix protein HEIR-1; ID-like protein inhibitor HLH 1R21; Inhibitor of DNA binding 3; Inhibitor of differentiation 3 Click to Show/Hide
Gene Name	ID3
Chromosomal Location	1p36.12
Function	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Click to Show/Hide
Gene ID	3399
Uniprot ID	ID3_HUMAN
HGNC ID	HGNC:5362
KEGG ID	hsa:3399

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01422)

DNA-binding protein inhibitor ID-3 (ID3)

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000588		Click to Show/Hide the Full List
mod site	chr1:23559481-23559482:-		[2]
Sequence	CGCGTTGCAGGTCACTGTAGCGGGACTTCTTTTGGTTTTCT
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000374561.6
External Link	RMBase: Nm_site_88

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000536		Click to Show/Hide the Full List
mod site	chr1:23559344-23559345:-		[3]
Sequence	GTCTGGCCATCGCCCGGGGCCGAGGGAAGGGCCCGGCAGCT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000374561.6; ENST00000486541.1
External Link	RMBase: m5C_site_1472
mod ID: M5CSITE000537		Click to Show/Hide the Full List
mod site	chr1:23559345-23559346:-		[3]
Sequence	AGTCTGGCCATCGCCCGGGGCCGAGGGAAGGGCCCGGCAGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000486541.1; ENST00000374561.6
External Link	RMBase: m5C_site_1473

N6-methyladenosine (m6A)

In total 16 m6A sequence/site(s) in this target gene
mod ID: M6ASITE005328		Click to Show/Hide the Full List
mod site	chr1:23557962-23557963:-		[4]
Sequence	TAAACTTTTTATAAAAGTTAACATTTTGCATAATAAACGAT
Motif Score	2.168095238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000463312.1; ENST00000374561.6
External Link	RMBase: m6A_site_13867
mod ID: M6ASITE005336		Click to Show/Hide the Full List
mod site	chr1:23558008-23558009:-		[4]
Sequence	ACCTTTTTTACAGGAAGGTGACTTTCTGTAACAATGCGATG
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000374561.6; ENST00000463312.1
External Link	RMBase: m6A_site_13868
mod ID: M6ASITE005337		Click to Show/Hide the Full List
mod site	chr1:23558028-23558029:-		[4]
Sequence	ATAGAGTATATAGGTTTTGTACCTTTTTTACAGGAAGGTGA
Motif Score	2.8355
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000463312.1; ENST00000374561.6
External Link	RMBase: m6A_site_13869
mod ID: M6ASITE005338		Click to Show/Hide the Full List
mod site	chr1:23558056-23558057:-		[5]
Sequence	TCTGTTGCCCTGATTTATGAACTCTATAATAGAGTATATAG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; A549
Seq Type List	m6A-seq; DART-seq; m6A-CLIP/IP
Transcript ID List	ENST00000374561.6; ENST00000463312.1
External Link	RMBase: m6A_site_13870
mod ID: M6ASITE005339		Click to Show/Hide the Full List
mod site	chr1:23558128-23558129:-		[5]
Sequence	AAGGAGTGGCTGCTCTCCAAACTATGCCAAGGCGGCGGCAG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000374561.6; ENST00000463312.1
External Link	RMBase: m6A_site_13871
mod ID: M6ASITE005340		Click to Show/Hide the Full List
mod site	chr1:23558257-23558258:-		[5]
Sequence	TCAGGAGCGAAGGACTGTGAACTTGTGGCCTGAAGAGCCAG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; A549
Seq Type List	m6A-seq; DART-seq; m6A-CLIP/IP
Transcript ID List	ENST00000463312.1; ENST00000374561.6
External Link	RMBase: m6A_site_13872
mod ID: M6ASITE005341		Click to Show/Hide the Full List
mod site	chr1:23558264-23558265:-		[5]
Sequence	CTGGTGCTCAGGAGCGAAGGACTGTGAACTTGTGGCCTGAA
Motif Score	4.065041667
Cell/Tissue List	HeLa; A549
Seq Type List	m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000374561.6; ENST00000463312.1
External Link	RMBase: m6A_site_13873
mod ID: M6ASITE005342		Click to Show/Hide the Full List
mod site	chr1:23558286-23558287:-		[5]
Sequence	AATCCCTTCCTGGAGACTAAACCTGGTGCTCAGGAGCGAAG
Motif Score	2.185083333
Cell/Tissue List	HeLa; A549
Seq Type List	m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000374561.6; ENST00000463312.1
External Link	RMBase: m6A_site_13874
mod ID: M6ASITE005343		Click to Show/Hide the Full List
mod site	chr1:23558291-23558292:-		[5]
Sequence	CACCAAATCCCTTCCTGGAGACTAAACCTGGTGCTCAGGAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; A549
Seq Type List	m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000374561.6; ENST00000463312.1
External Link	RMBase: m6A_site_13875
mod ID: M6ASITE005344		Click to Show/Hide the Full List
mod site	chr1:23558315-23558316:-		[4]
Sequence	AACTTCGCCCTGCCCACTTGACTTCACCAAATCCCTTCCTG
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000374561.6; ENST00000463312.1
External Link	RMBase: m6A_site_13876
mod ID: M6ASITE005345		Click to Show/Hide the Full List
mod site	chr1:23558374-23558375:-		[5]
Sequence	TTCTGCCTGGGACCCCGGGAACCTCTCCTGCCGGAAGCCGG
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000463312.1; ENST00000374561.6
External Link	RMBase: m6A_site_13877
mod ID: M6ASITE005346		Click to Show/Hide the Full List
mod site	chr1:23558383-23558384:-		[5]
Sequence	TGGCGCCCGTTCTGCCTGGGACCCCGGGAACCTCTCCTGCC
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000463312.1; ENST00000374561.6
External Link	RMBase: m6A_site_13878
mod ID: M6ASITE005347		Click to Show/Hide the Full List
mod site	chr1:23558452-23558453:-		[5]
Sequence	CCTCGGCACGCTCGGCGGAAACTGACTGCTCCTTGGTCTTC
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000463312.1; ENST00000486541.1; ENST00000374561.6
External Link	RMBase: m6A_site_13879
mod ID: M6ASITE005348		Click to Show/Hide the Full List
mod site	chr1:23558943-23558944:-		[6]
Sequence	ACTGACTCGGCCGTGTCCTGACACCTCCAGGTGAGTATCTC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000463312.1; ENST00000374561.6; ENST00000486541.1
External Link	RMBase: m6A_site_13880
mod ID: M6ASITE005349		Click to Show/Hide the Full List
mod site	chr1:23559199-23559200:-		[7]
Sequence	CCTACAGCGCGTCATCGACTACATTCTCGACCTGCAGGTAG
Motif Score	2.078666667
Cell/Tissue List	brain; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000486541.1; ENST00000374561.6
External Link	RMBase: m6A_site_13881
mod ID: M6ASITE005350		Click to Show/Hide the Full List
mod site	chr1:23559298-23559299:-		[6]
Sequence	GCCGCTGAGCTTGCTGGACGACATGAACCACTGCTACTCCC
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000486541.1; ENST00000374561.6
External Link	RMBase: m6A_site_13882

Ref 1	Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. doi: 10.1038/s41573-020-00108-x. Epub 2021 Jan 19.
Ref 2	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.
Ref 3	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 4	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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