m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01417)

Target Name	CD70 antigen (CD70)
Synonyms	CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD antigen CD70 Click to Show/Hide
Gene Name	CD70
Chromosomal Location	19p13.3
Family	Tumor necrosis factor family
Function	Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Click to Show/Hide
Gene ID	970
Uniprot ID	CD70_HUMAN
HGNC ID	HGNC:11937
KEGG ID	hsa:970

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01417)

CD70 antigen (CD70)

Adenosine-to-Inosine editing (A-to-I)

In total 29 m6A sequence/site(s) in this target gene
mod ID: A2ISITE008792		Click to Show/Hide the Full List
mod site	chr19:6583722-6583723:-		[2]
Sequence	CTACTAAACATTTAAAAATTAGCTGGGTGTGGTGATGGGCA
Transcript ID List	rmsk_4925577; ENST00000423145.7
External Link	RMBase: RNA-editing_site_65141
mod ID: A2ISITE008793		Click to Show/Hide the Full List
mod site	chr19:6583889-6583890:-		[2]
Sequence	TGAGGCAGGAGGGTCACTTAAACCCCGGAGGTGGAGGTTGC
Transcript ID List	rmsk_4925578; ENST00000423145.7
External Link	RMBase: RNA-editing_site_65142
mod ID: A2ISITE008794		Click to Show/Hide the Full List
mod site	chr19:6583890-6583891:-		[2]
Sequence	GTGAGGCAGGAGGGTCACTTAAACCCCGGAGGTGGAGGTTG
Transcript ID List	ENST00000423145.7; rmsk_4925578
External Link	RMBase: RNA-editing_site_65143
mod ID: A2ISITE008795		Click to Show/Hide the Full List
mod site	chr19:6583894-6583895:-		[2]
Sequence	GAGGGTGAGGCAGGAGGGTCACTTAAACCCCGGAGGTGGAG
Transcript ID List	rmsk_4925578; ENST00000423145.7
External Link	RMBase: RNA-editing_site_65144
mod ID: A2ISITE008796		Click to Show/Hide the Full List
mod site	chr19:6583929-6583930:-		[2]
Sequence	CATGGTGGCCGGCACCTGTAAACCCAGCTACTCAGGAGGGT
Transcript ID List	ENST00000423145.7; rmsk_4925578
External Link	RMBase: RNA-editing_site_65145
mod ID: A2ISITE008797		Click to Show/Hide the Full List
mod site	chr19:6583930-6583931:-		[2]
Sequence	GCATGGTGGCCGGCACCTGTAAACCCAGCTACTCAGGAGGG
Transcript ID List	rmsk_4925578; ENST00000423145.7
External Link	RMBase: RNA-editing_site_65146
mod ID: A2ISITE008798		Click to Show/Hide the Full List
mod site	chr19:6584283-6584284:-		[3]
Sequence	ATCTCTTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAAG
Transcript ID List	ENST00000423145.7
External Link	RMBase: RNA-editing_site_65147
mod ID: A2ISITE008799		Click to Show/Hide the Full List
mod site	chr19:6584349-6584350:-		[2]
Sequence	CACGTCCGGCTAATTTTTCTATTATTAGTAGAGACGGGCTT
Transcript ID List	ENST00000423145.7
External Link	RMBase: RNA-editing_site_65148
mod ID: A2ISITE008800		Click to Show/Hide the Full List
mod site	chr19:6584384-6584385:-		[2]
Sequence	AGCCTCCCAAGTCTGGGACTACAGAAATCCGCCACCACGTC
Transcript ID List	ENST00000423145.7
External Link	RMBase: RNA-editing_site_65149
mod ID: A2ISITE008801		Click to Show/Hide the Full List
mod site	chr19:6584418-6584419:-		[2]
Sequence	CCACCCTCCCAGGTTCAAGCAATTCTTCTGCCTCAGCCTCC
Transcript ID List	ENST00000423145.7
External Link	RMBase: RNA-editing_site_65150
mod ID: A2ISITE008802		Click to Show/Hide the Full List
mod site	chr19:6584422-6584423:-		[2]
Sequence	ACCTCCACCCTCCCAGGTTCAAGCAATTCTTCTGCCTCAGC
Transcript ID List	ENST00000423145.7
External Link	RMBase: RNA-editing_site_65151
mod ID: A2ISITE008803		Click to Show/Hide the Full List
mod site	chr19:6584459-6584460:-		[2]
Sequence	AGGCTGGAGTGCAGTGGCATAATCTCAGCTCACTGCAACCT
Transcript ID List	ENST00000423145.7
External Link	RMBase: RNA-editing_site_65152
mod ID: A2ISITE008804		Click to Show/Hide the Full List
mod site	chr19:6584614-6584615:-		[2]
Sequence	TTCCCGCCTCGGTCTCCCCAAGTGCTGGGATTACAGGCATG
Transcript ID List	ENST00000423145.7
External Link	RMBase: RNA-editing_site_65153
mod ID: A2ISITE008805		Click to Show/Hide the Full List
mod site	chr19:6584679-6584680:-		[2]
Sequence	TTGAGATGAGGTCTCATTACATTGCCCCAGCTGGTCTCAAA
Transcript ID List	ENST00000423145.7
External Link	RMBase: RNA-editing_site_65154
mod ID: A2ISITE008806		Click to Show/Hide the Full List
mod site	chr19:6584770-6584771:-		[4]
Sequence	TGGGCTCAAGCGATCCTCCCACCTCAGCCTCCCAAATAGCT
Transcript ID List	ENST00000423145.7
External Link	RMBase: RNA-editing_site_65155
mod ID: A2ISITE008807		Click to Show/Hide the Full List
mod site	chr19:6585053-6585054:-		[2]
Sequence	GCGGAAGTTTCAGGGAGCCAAGATCGCGTCATTGCACTGCA
Transcript ID List	ENST00000423145.7; rmsk_4925585
External Link	RMBase: RNA-editing_site_65156
mod ID: A2ISITE008808		Click to Show/Hide the Full List
mod site	chr19:6585542-6585543:-		[4]
Sequence	TCAAGACCAGCCTGGGCAACATAGTGAGACCCCCATCTCTA
Transcript ID List	rmsk_4925587; ENST00000423145.7
External Link	RMBase: RNA-editing_site_65157
mod ID: A2ISITE008809		Click to Show/Hide the Full List
mod site	chr19:6585560-6585561:-		[4]
Sequence	TCGCTTGAGCCTAGGAGTTCAAGACCAGCCTGGGCAACATA
Transcript ID List	rmsk_4925587; ENST00000423145.7
External Link	RMBase: RNA-editing_site_65158
mod ID: A2ISITE008810		Click to Show/Hide the Full List
mod site	chr19:6585811-6585812:-		[2]
Sequence	CTTCGTGGCGTGCATCTGTAATCCCAGCTACTCGGCCGACT
Transcript ID List	ENST00000423145.7; rmsk_4925588
External Link	RMBase: RNA-editing_site_65159
mod ID: A2ISITE008812		Click to Show/Hide the Full List
mod site	chr19:6586716-6586717:-		[3]
Sequence	GTCTCAGCCTCCCAGGCTCAAGCGATCCTCCAGCCTCAGCC
Transcript ID List	ENST00000423145.7; ENST00000245903.4
External Link	RMBase: RNA-editing_site_65160
mod ID: A2ISITE008813		Click to Show/Hide the Full List
mod site	chr19:6586723-6586724:-		[3]
Sequence	CACTGCAGTCTCAGCCTCCCAGGCTCAAGCGATCCTCCAGC
Transcript ID List	ENST00000245903.4; ENST00000423145.7
External Link	RMBase: RNA-editing_site_65161
mod ID: A2ISITE008814		Click to Show/Hide the Full List
mod site	chr19:6586747-6586748:-		[3]
Sequence	GAGTGCAGTGGTGTGATCATAGCTCACTGCAGTCTCAGCCT
Transcript ID List	ENST00000245903.4; ENST00000423145.7
External Link	RMBase: RNA-editing_site_65162
mod ID: A2ISITE008815		Click to Show/Hide the Full List
mod site	chr19:6587800-6587801:-		[3]
Sequence	TGGGAGATAGCTTGAGCCCCAGAGGCTGAGGCTGCAGTGAG
Transcript ID List	rmsk_4925599; ENST00000423145.7; ENST00000245903.4
External Link	RMBase: RNA-editing_site_65163
mod ID: A2ISITE008816		Click to Show/Hide the Full List
mod site	chr19:6587873-6587874:-		[3]
Sequence	TCTAGAACAAAATTTTGAAAATTAGCTGGTCATGGTGGCGC
Transcript ID List	ENST00000423145.7; ENST00000245903.4; rmsk_4925599
External Link	RMBase: RNA-editing_site_65164
mod ID: A2ISITE008817		Click to Show/Hide the Full List
mod site	chr19:6587874-6587875:-		[3]
Sequence	CTCTAGAACAAAATTTTGAAAATTAGCTGGTCATGGTGGCG
Transcript ID List	ENST00000423145.7; rmsk_4925599; ENST00000245903.4
External Link	RMBase: RNA-editing_site_65165
mod ID: A2ISITE008818		Click to Show/Hide the Full List
mod site	chr19:6594737-6594738:-		[4]
Sequence	CCTCCCAAAGTGCTGAGATTACATGTATGAGCCACCCCACC
Transcript ID List	ENST00000597430.2
External Link	RMBase: RNA-editing_site_65166
mod ID: A2ISITE008819		Click to Show/Hide the Full List
mod site	chr19:6596417-6596418:-		[3]
Sequence	TCCCAGAACTTTGGGAGGCCAAAGTTGGCGAATCACTTGAG
Transcript ID List	rmsk_4925621; ENST00000597430.2
External Link	RMBase: RNA-editing_site_65167
mod ID: A2ISITE008820		Click to Show/Hide the Full List
mod site	chr19:6597013-6597014:-		[3]
Sequence	TTGTTGGTCAGGCTGCTCTCAGACTCTCGACCTCAGGTGAT
Transcript ID List	ENST00000597430.2
External Link	RMBase: RNA-editing_site_65168
mod ID: A2ISITE008821		Click to Show/Hide the Full List
mod site	chr19:6597047-6597048:-		[4]
Sequence	GAGGGGTGGTCTCCTCCCTTAACAGGGTTTCTCCTTGTTGG
Transcript ID List	ENST00000597430.2
External Link	RMBase: RNA-editing_site_65169

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001691		Click to Show/Hide the Full List
mod site	chr19:6586335-6586336:-		[5]
Sequence	CCGCTCCTTCCTGCATGGACCAGAGCTGGACAAGGGGCAGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000245903.4; ENST00000423145.7
External Link	RMBase: m5C_site_22308

N6-methyladenosine (m6A)

In total 25 m6A sequence/site(s) in this target gene
mod ID: M6ASITE038882		Click to Show/Hide the Full List
mod site	chr19:6583221-6583222:-		[6]
Sequence	GAGGAAAATAGTGGCAGAAAACCTGAGTCACAAGCCCGAGG
Motif Score	2.185083333
Cell/Tissue List	iSLK; TREX
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000423145.7
External Link	RMBase: m6A_site_414497
mod ID: M6ASITE038883		Click to Show/Hide the Full List
mod site	chr19:6583260-6583261:-		[7]
Sequence	CTGGTTTTGTAACAGCTGGAACCTCAGTATTTAACAGTTGA
Motif Score	2.930744048
Cell/Tissue List	GM12878; iSLK; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000423145.7
External Link	RMBase: m6A_site_414498
mod ID: M6ASITE038884		Click to Show/Hide the Full List
mod site	chr19:6583306-6583307:-		[8]
Sequence	TGAGGAAAACAGAGGCGTAAACCGTTGAGTCATCTGTCCAA
Motif Score	2.185083333
Cell/Tissue List	HepG2; GM12878; LCLs; iSLK; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000423145.7
External Link	RMBase: m6A_site_414499
mod ID: M6ASITE038886		Click to Show/Hide the Full List
mod site	chr19:6583318-6583319:-		[8]
Sequence	CCATTTCACAGATGAGGAAAACAGAGGCGTAAACCGTTGAG
Motif Score	2.20572619
Cell/Tissue List	HepG2; GM12878; LCLs; iSLK; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000423145.7
External Link	RMBase: m6A_site_414500
mod ID: M6ASITE038887		Click to Show/Hide the Full List
mod site	chr19:6583391-6583392:-		[9]
Sequence	CACACTGTTTTATCCCATTAACTCAGCTCGTGTTCATGCAA
Motif Score	2.590089286
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000423145.7
External Link	RMBase: m6A_site_414501
mod ID: M6ASITE038888		Click to Show/Hide the Full List
mod site	chr19:6583415-6583416:-		[10]
Sequence	TCTTACGGCATTTAATATGGACTGCACACTGTTTTATCCCA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; fibroblasts; A549; GM12878; LCLs; peripheral-blood; iSLK; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000423145.7
External Link	RMBase: m6A_site_414502
mod ID: M6ASITE038889		Click to Show/Hide the Full List
mod site	chr19:6583452-6583453:-		[10]
Sequence	TTTGGATTTTGGAACTGGGGACTCAAAGTCAAGTGCTTCTT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; fibroblasts; A549; GM12878; LCLs; peripheral-blood; iSLK; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000423145.7
External Link	RMBase: m6A_site_414503
mod ID: M6ASITE038890		Click to Show/Hide the Full List
mod site	chr19:6583459-6583460:-		[10]
Sequence	AGGGCTTTTTGGATTTTGGAACTGGGGACTCAAAGTCAAGT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; fibroblasts; A549; GM12878; LCLs; peripheral-blood; iSLK; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000423145.7
External Link	RMBase: m6A_site_414504
mod ID: M6ASITE038891		Click to Show/Hide the Full List
mod site	chr19:6585894-6585895:-		[8]
Sequence	TGGGGGGTAGTGGTGGCAGGACAAGAGAAGGCATTGAGCTT
Motif Score	3.643047619
Cell/Tissue List	HepG2; A549; GM12878; LCLs; iSLK; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000245903.4; ENST00000423145.7
External Link	RMBase: m6A_site_414505
mod ID: M6ASITE038892		Click to Show/Hide the Full List
mod site	chr19:6586051-6586052:-		[10]
Sequence	CTTCCCGAAACACTGATGAGACCTTCTTTGGAGTGCAGTGG
Motif Score	2.876744048
Cell/Tissue List	HEK293T; A549; HepG2; U2OS; fibroblasts; GM12878; LCLs; MM6; peripheral-blood; iSLK; TREX; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000245903.4; ENST00000423145.7
External Link	RMBase: m6A_site_414506
mod ID: M6ASITE038893		Click to Show/Hide the Full List
mod site	chr19:6586062-6586063:-		[10]
Sequence	GACACTTTTGCCTTCCCGAAACACTGATGAGACCTTCTTTG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; A549; HepG2; U2OS; fibroblasts; GM12878; LCLs; MM6; peripheral-blood; iSLK; TREX; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000423145.7; ENST00000245903.4
External Link	RMBase: m6A_site_414507
mod ID: M6ASITE038894		Click to Show/Hide the Full List
mod site	chr19:6586081-6586082:-		[10]
Sequence	TCTGCACCAACCTCACTGGGACACTTTTGCCTTCCCGAAAC
Motif Score	3.643047619
Cell/Tissue List	HEK293T; A549; HepG2; U2OS; fibroblasts; GM12878; LCLs; MM6; peripheral-blood; iSLK; TREX; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000245903.4; ENST00000423145.7
External Link	RMBase: m6A_site_414508
mod ID: M6ASITE038895		Click to Show/Hide the Full List
mod site	chr19:6586107-6586108:-		[11]
Sequence	GACGCCCCTGGCCCGAGGGGACACACTCTGCACCAACCTCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; fibroblasts; GM12878; LCLs; MM6; peripheral-blood; iSLK; TREX; TIME; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000245903.4; ENST00000423145.7
External Link	RMBase: m6A_site_414509
mod ID: M6ASITE038896		Click to Show/Hide the Full List
mod site	chr19:6586126-6586127:-		[12]
Sequence	CCATTGCCTCCCAGCGCCTGACGCCCCTGGCCCGAGGGGAC
Motif Score	2.833690476
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000423145.7; ENST00000245903.4
External Link	RMBase: m6A_site_414510
mod ID: M6ASITE038897		Click to Show/Hide the Full List
mod site	chr19:6586326-6586327:-		[13]
Sequence	CCTGCATGGACCAGAGCTGGACAAGGGGCAGCTACGTATCC
Motif Score	3.643047619
Cell/Tissue List	MM6; peripheral-blood; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000423145.7; ENST00000245903.4
External Link	RMBase: m6A_site_414511
mod ID: M6ASITE038898		Click to Show/Hide the Full List
mod site	chr19:6586337-6586338:-		[13]
Sequence	GGCCGCTCCTTCCTGCATGGACCAGAGCTGGACAAGGGGCA
Motif Score	3.622404762
Cell/Tissue List	MM6; peripheral-blood; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000245903.4; ENST00000423145.7
External Link	RMBase: m6A_site_414512
mod ID: M6ASITE038899		Click to Show/Hide the Full List
mod site	chr19:6586392-6586393:-		[13]
Sequence	GCCCCCAGGACCTCAGCAGGACCCCAGGCTATACTGGCAGG
Motif Score	3.622404762
Cell/Tissue List	MM6; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000245903.4; ENST00000423145.7
External Link	RMBase: m6A_site_414513
mod ID: M6ASITE038900		Click to Show/Hide the Full List
mod site	chr19:6592423-6592424:-		[14]
Sequence	CTTGAGCCCAGATGTTTGAGACCAGCCTGGTAACATAGTAA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; HepG2; fibroblasts; A549; MM6; iSLK; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_4925609; ENST00000597430.2
External Link	RMBase: m6A_site_414514
mod ID: M6ASITE038901		Click to Show/Hide the Full List
mod site	chr19:6592461-6592462:-		[10]
Sequence	TCATCCCGGCACTTTGGGGGACCTACGCAGCAGGATCGCTT
Motif Score	3.622404762
Cell/Tissue List	HEK293T; HeLa; HepG2; A549; MM6; iSLK; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000597430.2; rmsk_4925609
External Link	RMBase: m6A_site_414515
mod ID: M6ASITE038902		Click to Show/Hide the Full List
mod site	chr19:6592518-6592519:-		[10]
Sequence	ACCCACTACAGCCATCGAGAACAGCAGCAGGAGGCTGGATG
Motif Score	2.951386905
Cell/Tissue List	HEK293T; HeLa; MM6; iSLK; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000597430.2
External Link	RMBase: m6A_site_414516
mod ID: M6ASITE038903		Click to Show/Hide the Full List
mod site	chr19:6592547-6592548:-		[10]
Sequence	AGGCCATGAATTCTGGGAGGACACCGTTAACCCACTACAGC
Motif Score	3.643047619
Cell/Tissue List	HEK293T; HeLa; MM6; iSLK; TREX; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000597430.2
External Link	RMBase: m6A_site_414517
mod ID: M6ASITE038904		Click to Show/Hide the Full List
mod site	chr19:6603947-6603948:-		[10]
Sequence	GAGATGACATGCCAGCCCAGACTTTCATGTAGGTGAAAATT
Motif Score	3.319380952
Cell/Tissue List	HEK293T; HeLa; TREX; iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000597430.2
External Link	RMBase: m6A_site_414524
mod ID: M6ASITE038905		Click to Show/Hide the Full List
mod site	chr19:6603970-6603971:-		[10]
Sequence	GCTCCTAAAGATTTTGCAGAACAGAGATGACATGCCAGCCC
Motif Score	2.951386905
Cell/Tissue List	HEK293T; HeLa; TREX
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000597430.2
External Link	RMBase: m6A_site_414525
mod ID: M6ASITE038906		Click to Show/Hide the Full List
mod site	chr19:6604041-6604042:-		[10]
Sequence	TGTCACTTTGTACTTTGCAGACAAGGGCATCACCTTTGATG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; TREX
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000597430.2
External Link	RMBase: m6A_site_414526
mod ID: M6ASITE038907		Click to Show/Hide the Full List
mod site	chr19:6604078-6604079:-		[15]
Sequence	TGACCTTCCTGTTTCCTGGAACTCAGCCATGGTGGTGTGTC
Motif Score	3.373380952
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000597430.2; rmsk_4925639
External Link	RMBase: m6A_site_414527

Ref 1	Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling. MAbs. 2014 May-Jun;6(3):774-82. doi: 10.4161/mabs.28612. Epub 2014 Apr 2.
Ref 2	Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2012 Jan;22(1):142-50. doi: 10.1101/gr.124107.111. Epub 2011 Sep 29.
Ref 3	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 4	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 5	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 6	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 7	Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. J Am Chem Soc. 2015 Feb 11;137(5):2107-15. doi: 10.1021/ja513080v. Epub 2015 Feb 2.
Ref 8	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 9	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
Ref 10	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 11	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 12	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 13	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell. 2017 Jan 9;31(1):127-141. doi: 10.1016/j.ccell.2016.11.017. Epub 2016 Dec 22.
Ref 14	RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat Commun. 2019 May 6;10(1):2065. doi: 10.1038/s41467-019-09865-9.
Ref 15	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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