m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01380)

Target Name	Transcription factor E2F2 (E2F2)
Synonyms	E2F-2 Click to Show/Hide
Gene Name	E2F2
Chromosomal Location	1p36.12
Family	E2F/DP family
Function	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Click to Show/Hide
Gene ID	1870
Uniprot ID	E2F2_HUMAN
HGNC ID	HGNC:3114
KEGG ID	hsa:1870

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01380)

Transcription factor E2F2 (E2F2)

Adenosine-to-Inosine editing (A-to-I)

In total 2 m6A sequence/site(s) in this target gene
mod ID: A2ISITE005297		Click to Show/Hide the Full List
mod site	chr1:23512952-23512953:-		[2]
Sequence	GGAGGTGGTGGTGCATGCCTATAATCCCAGTTACTCAGGAG
Transcript ID List	rmsk_50887; ENST00000361729.3
External Link	RMBase: RNA-editing_site_2585
mod ID: A2ISITE005298		Click to Show/Hide the Full List
mod site	chr1:23523973-23523974:-		[3]
Sequence	TCAAGCAACTCTCTCACCTCAGCCTCCCAGGTAGCTGGGAC
Transcript ID List	ENST00000361729.3
External Link	RMBase: RNA-editing_site_2586

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000582		Click to Show/Hide the Full List
mod site	chr1:23507845-23507846:-		[4]
Sequence	AGAAAAGGAAGAAGGGGCCTGCAGGACCCATTGGGAATGAG
Cell/Tissue List	HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: Nm_site_87

5-methylcytidine (m5C)

In total 3 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000523		Click to Show/Hide the Full List
mod site	chr1:23506824-23506825:-		[5]
Sequence	AACCTCCATTCTGCAGTGTTCAGAGTTTTAGGGAAAGGGTT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m5C_site_1469
mod ID: M5CSITE000534		Click to Show/Hide the Full List
mod site	chr1:23509582-23509583:-
Sequence	GCAGGTGAGGTGGCCAAGTCCAGGGAAAGGCCCTGCTACCT
Cell/Tissue List	HeLa
Seq Type List	m5C-RIP-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m5C_site_1470
mod ID: M5CSITE000535		Click to Show/Hide the Full List
mod site	chr1:23531071-23531072:-		[5]
Sequence	TGCCGAGGCCTTGGGGAGCGCGGGGCGTCCCGGGTCGCGGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m5C_site_1471

N6-methyladenosine (m6A)

In total 25 m6A sequence/site(s) in this target gene
mod ID: M6ASITE005273		Click to Show/Hide the Full List
mod site	chr1:23506872-23506873:-		[6]
Sequence	CTGGCTTTAGGATGGTTCTGACTTTGTTCTCCCTCCCCAAG
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13842
mod ID: M6ASITE005274		Click to Show/Hide the Full List
mod site	chr1:23507196-23507197:-		[6]
Sequence	GGGACCAGGTAGACTTTAAAACGAGGGTAAGAGAAAAGCCA
Motif Score	2.179660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13843
mod ID: M6ASITE005275		Click to Show/Hide the Full List
mod site	chr1:23507204-23507205:-		[6]
Sequence	TTTCTTTAGGGACCAGGTAGACTTTAAAACGAGGGTAAGAG
Motif Score	3.319380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13844
mod ID: M6ASITE005276		Click to Show/Hide the Full List
mod site	chr1:23507260-23507261:-		[6]
Sequence	CCTCCCAAAGTGTTGAGATGACAGGCACGAGCCACCAGGCC
Motif Score	2.859755952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13845
mod ID: M6ASITE005277		Click to Show/Hide the Full List
mod site	chr1:23507287-23507288:-		[6]
Sequence	CTGACCTCAAGTGATCCACCACCTCGGCCTCCCAAAGTGTT
Motif Score	2.032470238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13846
mod ID: M6ASITE005278		Click to Show/Hide the Full List
mod site	chr1:23507311-23507312:-		[6]
Sequence	GTTAGTCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCC
Motif Score	3.373380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13847
mod ID: M6ASITE005279		Click to Show/Hide the Full List
mod site	chr1:23507389-23507390:-		[6]
Sequence	CAGAGTAGCTGGGACTATAGACATGCACCACCACGCCCGGC
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13848
mod ID: M6ASITE005280		Click to Show/Hide the Full List
mod site	chr1:23507588-23507589:-		[6]
Sequence	GTGACACTTGAAGCCTCCCGACTTCCACAGAGTGCTTCAGG
Motif Score	3.287565476
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13849
mod ID: M6ASITE005281		Click to Show/Hide the Full List
mod site	chr1:23507693-23507694:-		[7]
Sequence	CCCCCTCTACTGTCCCTTTCACACCTTGCCTGGCCAAGGGG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13850
mod ID: M6ASITE005282		Click to Show/Hide the Full List
mod site	chr1:23507872-23507873:-		[7]
Sequence	TGGAGCTTTCCCCAAGAATTACATCAGAGAAAAGGAAGAAG
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13851
mod ID: M6ASITE005283		Click to Show/Hide the Full List
mod site	chr1:23508358-23508359:-		[6]
Sequence	CAGAGGCTCAGCTGGACAGCACTTTTTAGAAAAGTTTGTAG
Motif Score	3.252583333
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13852
mod ID: M6ASITE005284		Click to Show/Hide the Full List
mod site	chr1:23509790-23509791:-		[8]
Sequence	TGCCTGCACAGGGACATTGGACACTAGGTGCTGCCCTCAGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13853
mod ID: M6ASITE005285		Click to Show/Hide the Full List
mod site	chr1:23509797-23509798:-		[8]
Sequence	GCCCCTCTGCCTGCACAGGGACATTGGACACTAGGTGCTGC
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13854
mod ID: M6ASITE005286		Click to Show/Hide the Full List
mod site	chr1:23509820-23509821:-		[7]
Sequence	ACCTCCTCACAGACAGGCTGACAGCCCCTCTGCCTGCACAG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13855
mod ID: M6ASITE005287		Click to Show/Hide the Full List
mod site	chr1:23509828-23509829:-		[8]
Sequence	CCGACTCTACCTCCTCACAGACAGGCTGACAGCCCCTCTGC
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T; A549
Seq Type List	m6A-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13856
mod ID: M6ASITE005288		Click to Show/Hide the Full List
mod site	chr1:23509895-23509896:-		[8]
Sequence	CGACTCCTACGACCTTGGGGACCTGTTGATTAATTGAGTGG
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13857
mod ID: M6ASITE005289		Click to Show/Hide the Full List
mod site	chr1:23509970-23509971:-		[8]
Sequence	CAGCTTCTCCCCATCCTTGGACCAGGACGACTACCTGTGGG
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13858
mod ID: M6ASITE005290		Click to Show/Hide the Full List
mod site	chr1:23510033-23510034:-		[8]
Sequence	ACTCCTGCAGCAGACTGAGGACCAGTTCCTGTCCCCGACCC
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13859
mod ID: M6ASITE005291		Click to Show/Hide the Full List
mod site	chr1:23510040-23510041:-		[8]
Sequence	CGCACCCACTCCTGCAGCAGACTGAGGACCAGTTCCTGTCC
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13860
mod ID: M6ASITE005292		Click to Show/Hide the Full List
mod site	chr1:23516525-23516526:-		[7]
Sequence	GCTTCTCTTCCTCCTCCAGGACAACCTGCAGATATATCTCA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000361729.3; ENST00000487237.1
External Link	RMBase: m6A_site_13861
mod ID: M6ASITE005293		Click to Show/Hide the Full List
mod site	chr1:23520927-23520928:-		[7]
Sequence	CTTCAAGCACCTGACTGAGGACAAGGCCAACAAGAGATATC
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13862
mod ID: M6ASITE005294		Click to Show/Hide the Full List
mod site	chr1:23520993-23520994:-		[7]
Sequence	GGAGCTGAAGGAGCTGATGAACACGGAGCAGGCCTTGGACC
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13863
mod ID: M6ASITE005295		Click to Show/Hide the Full List
mod site	chr1:23521851-23521852:-		[7]
Sequence	CATCCGCAAGAAGGCCAAGAACAACATCCAGTGGGTGTGAG
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13864
mod ID: M6ASITE005306		Click to Show/Hide the Full List
mod site	chr1:23521902-23521903:-		[7]
Sequence	GCAGAAGCGGCGCATCTATGACATCACCAACGTGCTGGAAG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13865
mod ID: M6ASITE005317		Click to Show/Hide the Full List
mod site	chr1:23522022-23522023:-		[7]
Sequence	CGGGGAGAAGACTCGGTATGACACTTCGCTGGGGCTGCTCA
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000361729.3
External Link	RMBase: m6A_site_13866

Ref 1	Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin. Pharm Res. 2004 Sep;21(9):1686-91.
Ref 2	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 3	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 4	High-throughput identification of C/D box snoRNA targets with CLIP and RiboMeth-seq. Nucleic Acids Res. 2017 Mar 17;45(5):2341-2353. doi: 10.1093/nar/gkw1321.
Ref 5	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 6	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

Visitor Map