m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01320)

Target Name	Microfibril-associated glycoprotein 4 (MFAP4)
Gene Name	MFAP4
Chromosomal Location	17p11.2
Function	Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed:26601954). Click to Show/Hide
Gene ID	4239
Uniprot ID	MFAP4_HUMAN
HGNC ID	HGNC:7035
KEGG ID	hsa:4239

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01320)

Microfibril-associated glycoprotein 4 (MFAP4)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE007781		Click to Show/Hide the Full List
mod site	chr17:19384460-19384461:-		[2]
Sequence	TGAAAATCCGCCGGGCCTGAAGGGCTGGCCCCCTCAGGCAC
Transcript ID List	ENST00000497081.6; ENST00000395592.6; ENST00000299610.4; ENST00000571210.1
External Link	RMBase: RNA-editing_site_55682

N6-methyladenosine (m6A)

In total 27 m6A sequence/site(s) in this target gene
mod ID: M6ASITE030932		Click to Show/Hide the Full List
mod site	chr17:19383638-19383639:-		[3]
Sequence	AACTGGCTTCATACACACAAACATATTTGTTTATCCCCCAA
Motif Score	2.20572619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000497081.6; ENST00000299610.4; ENST00000574313.2; ENST00000395592.6
External Link	RMBase: m6A_site_352301
mod ID: M6ASITE030933		Click to Show/Hide the Full List
mod site	chr17:19383657-19383658:-		[3]
Sequence	AACCTTCAGAACCTGAATGAACTGGCTTCATACACACAAAC
Motif Score	3.373380952
Cell/Tissue List	endometrial; AML
Seq Type List	m6A-seq; miCLIP
Transcript ID List	ENST00000574313.2; ENST00000395592.6; ENST00000497081.6; ENST00000299610.4
External Link	RMBase: m6A_site_352302
mod ID: M6ASITE030934		Click to Show/Hide the Full List
mod site	chr17:19383667-19383668:-		[3]
Sequence	GGTCTCAATAAACCTTCAGAACCTGAATGAACTGGCTTCAT
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000395592.6; ENST00000299610.4; ENST00000497081.6; ENST00000574313.2
External Link	RMBase: m6A_site_352303
mod ID: M6ASITE030935		Click to Show/Hide the Full List
mod site	chr17:19383676-19383677:-		[3]
Sequence	GGGACTGAAGGTCTCAATAAACCTTCAGAACCTGAATGAAC
Motif Score	2.185083333
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000299610.4; ENST00000574313.2; ENST00000395592.6; ENST00000497081.6
External Link	RMBase: m6A_site_352304
mod ID: M6ASITE030936		Click to Show/Hide the Full List
mod site	chr17:19383693-19383694:-		[3]
Sequence	AGGGCTGGGAGTGGGTAGGGACTGAAGGTCTCAATAAACCT
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000395592.6; ENST00000574313.2; ENST00000299610.4; ENST00000497081.6
External Link	RMBase: m6A_site_352305
mod ID: M6ASITE030937		Click to Show/Hide the Full List
mod site	chr17:19383724-19383725:-		[4]
Sequence	GCCACATGAGGGAGCAGAGGACAATCTCTGCAGGGCTGGGA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; endometrial; AML
Seq Type List	MAZTER-seq; m6A-seq; miCLIP
Transcript ID List	ENST00000574313.2; ENST00000299610.4; ENST00000497081.6; ENST00000395592.6
External Link	RMBase: m6A_site_352306
mod ID: M6ASITE030938		Click to Show/Hide the Full List
mod site	chr17:19383741-19383742:-		[5]
Sequence	GGGTGTTGAGAGGTTTAGCCACATGAGGGAGCAGAGGACAA
Motif Score	2.053113095
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000299610.4; ENST00000395592.6; ENST00000574313.2; ENST00000497081.6
External Link	RMBase: m6A_site_352307
mod ID: M6ASITE030939		Click to Show/Hide the Full List
mod site	chr17:19384029-19384030:-		[3]
Sequence	AGCTGAGCAGTGCAGTGTGAACAGGGCCCATGGTGTATTCT
Motif Score	2.951386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000497081.6; ENST00000395592.6; ENST00000574313.2; ENST00000299610.4
External Link	RMBase: m6A_site_352308
mod ID: M6ASITE030940		Click to Show/Hide the Full List
mod site	chr17:19384078-19384079:-		[3]
Sequence	GTCCTGCTTCCTCACTGTGGACCCCTGTCTGGGCCACCCTA
Motif Score	3.622404762
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000395592.6; ENST00000574313.2; ENST00000497081.6; ENST00000299610.4
External Link	RMBase: m6A_site_352309
mod ID: M6ASITE030941		Click to Show/Hide the Full List
mod site	chr17:19384197-19384198:-		[6]
Sequence	GGCACATGGTTCTAGCCTGGACCTGGCTGGGCTCCATGAGA
Motif Score	3.622404762
Cell/Tissue List	MM6; endometrial; AML
Seq Type List	m6A-seq; miCLIP
Transcript ID List	ENST00000497081.6; ENST00000299610.4; ENST00000395592.6; ENST00000574313.2
External Link	RMBase: m6A_site_352310
mod ID: M6ASITE030942		Click to Show/Hide the Full List
mod site	chr17:19384276-19384277:-		[3]
Sequence	GGCATCCATTCCTAAGCCAGACCCGGCTCCCCTACACCTGA
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000497081.6; ENST00000299610.4; ENST00000395592.6
External Link	RMBase: m6A_site_352311
mod ID: M6ASITE030943		Click to Show/Hide the Full List
mod site	chr17:19384425-19384426:-		[7]
Sequence	AGGCACCTTTCCTCCCCTGGACACCCATGGTCTCCATGAGT
Motif Score	3.643047619
Cell/Tissue List	H1A; H1B; MM6; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000395592.6; ENST00000571210.1; ENST00000299610.4; ENST00000497081.6
External Link	RMBase: m6A_site_352312
mod ID: M6ASITE030944		Click to Show/Hide the Full List
mod site	chr17:19384636-19384637:-		[8]
Sequence	CCAGGACCTCTTTGTGCAGAACTGCGCAGCTCTCTCCTCAG
Motif Score	3.373380952
Cell/Tissue List	HeLa; endometrial; AML
Seq Type List	m6A-seq; miCLIP
Transcript ID List	ENST00000299610.4; ENST00000395592.6; ENST00000497081.6; ENST00000571210.1
External Link	RMBase: m6A_site_352313
mod ID: M6ASITE030945		Click to Show/Hide the Full List
mod site	chr17:19384651-19384652:-		[8]
Sequence	TACCTTCGACCGGGACCAGGACCTCTTTGTGCAGAACTGCG
Motif Score	3.622404762
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000497081.6; ENST00000571210.1; ENST00000299610.4; ENST00000395592.6
External Link	RMBase: m6A_site_352314
mod ID: M6ASITE030946		Click to Show/Hide the Full List
mod site	chr17:19384657-19384658:-		[8]
Sequence	GTTCTCTACCTTCGACCGGGACCAGGACCTCTTTGTGCAGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000497081.6; ENST00000571210.1; ENST00000299610.4; ENST00000395592.6
External Link	RMBase: m6A_site_352315
mod ID: M6ASITE030947		Click to Show/Hide the Full List
mod site	chr17:19385208-19385209:-		[3]
Sequence	GGACTTGGAGGACTTTGAGAACAACACGGCCTATGCCAAGT
Motif Score	2.951386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000497081.6; ENST00000571210.1; ENST00000395592.6; ENST00000299610.4
External Link	RMBase: m6A_site_352316
mod ID: M6ASITE030948		Click to Show/Hide the Full List
mod site	chr17:19385217-19385218:-		[3]
Sequence	GCTGCGAGTGGACTTGGAGGACTTTGAGAACAACACGGCCT
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000299610.4; ENST00000497081.6; ENST00000571210.1; ENST00000395592.6
External Link	RMBase: m6A_site_352317
mod ID: M6ASITE030949		Click to Show/Hide the Full List
mod site	chr17:19385226-19385227:-		[3]
Sequence	GAAGTATGAGCTGCGAGTGGACTTGGAGGACTTTGAGAACA
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000395592.6; ENST00000497081.6; ENST00000299610.4; ENST00000571210.1
External Link	RMBase: m6A_site_352318
mod ID: M6ASITE030950		Click to Show/Hide the Full List
mod site	chr17:19385271-19385272:-		[3]
Sequence	CTCCTCCCCAGGGCTGCAGAACATGCACCTCCTGACACTGA
Motif Score	2.951386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000571210.1; ENST00000497081.6; ENST00000395592.6; ENST00000299610.4
External Link	RMBase: m6A_site_352319
mod ID: M6ASITE030951		Click to Show/Hide the Full List
mod site	chr17:19385345-19385346:-		[8]
Sequence	ACTGGCTGGGTAAGGCAGGGACCAGGTGGGCTGAGGGGCTG
Motif Score	3.622404762
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000571210.1; ENST00000299610.4; ENST00000497081.6; ENST00000395592.6
External Link	RMBase: m6A_site_352320
mod ID: M6ASITE030952		Click to Show/Hide the Full List
mod site	chr17:19386337-19386338:-		[5]
Sequence	GCCTGTGCCCGTCTTCTGTGACATGACCACCGAGGGCGGGA
Motif Score	2.859755952
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000299610.4; ENST00000395592.6; ENST00000497081.6; ENST00000571210.1
External Link	RMBase: m6A_site_352321
mod ID: M6ASITE030953		Click to Show/Hide the Full List
mod site	chr17:19386421-19386422:-		[5]
Sequence	GCAACCCCTGGACTGTGACGACATCTATGCCCAGGGCTACC
Motif Score	2.865571429
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000299610.4; ENST00000497081.6; ENST00000395592.6; ENST00000571210.1
External Link	RMBase: m6A_site_352322
mod ID: M6ASITE030954		Click to Show/Hide the Full List
mod site	chr17:19386430-19386431:-		[3]
Sequence	TTGCCTTCAGCAACCCCTGGACTGTGACGACATCTATGCCC
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000497081.6; ENST00000299610.4; ENST00000395592.6; ENST00000571210.1
External Link	RMBase: m6A_site_352323
mod ID: M6ASITE030955		Click to Show/Hide the Full List
mod site	chr17:19386894-19386895:-		[7]
Sequence	TGGGGGCAAATGCAAAGAGAACAGGGGATCTCTGGAGCTGG
Motif Score	2.951386905
Cell/Tissue List	H1A; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000571210.1; ENST00000497081.6; ENST00000395592.6; ENST00000299610.4
External Link	RMBase: m6A_site_352324
mod ID: M6ASITE030956		Click to Show/Hide the Full List
mod site	chr17:19387109-19387110:-		[7]
Sequence	GGGACTCATAGCATGGGGGAACTGAGCCCACTCCAGAGGCC
Motif Score	3.373380952
Cell/Tissue List	H1A
Seq Type List	m6A-seq
Transcript ID List	ENST00000299610.4; ENST00000571210.1; ENST00000395592.6
External Link	RMBase: m6A_site_352325
mod ID: M6ASITE030957		Click to Show/Hide the Full List
mod site	chr17:19387126-19387127:-		[7]
Sequence	ACGGGGCCCAGGGTCGGGGGACTCATAGCATGGGGGAACTG
Motif Score	4.065041667
Cell/Tissue List	H1A
Seq Type List	m6A-seq
Transcript ID List	ENST00000571210.1; ENST00000395592.6; ENST00000299610.4
External Link	RMBase: m6A_site_352326
mod ID: M6ASITE030958		Click to Show/Hide the Full List
mod site	chr17:19387163-19387164:-		[7]
Sequence	ACCCAGCCACTCTGAGCAGAACTGACAGCATGAAGGTACGG
Motif Score	3.373380952
Cell/Tissue List	H1A
Seq Type List	m6A-seq
Transcript ID List	ENST00000395592.6; ENST00000299610.4; ENST00000571210.1
External Link	RMBase: m6A_site_352327

Ref 1	Effect of ABCG2 on cytotoxicity of platinum drugs: interference of EGFP. Toxicol In Vitro. 2008 Dec;22(8):1846-52.
Ref 2	Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. Science. 2009 May 29;324(5931):1210-3. doi: 10.1126/science.1170995.
Ref 3	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 4	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 5	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 6	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell. 2017 Jan 9;31(1):127-141. doi: 10.1016/j.ccell.2016.11.017. Epub 2016 Dec 22.
Ref 7	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 8	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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