m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01084)

Target Name	Phosphoserine phosphatase (PSPH)
Synonyms	PSP; PSPase; EC 3.1.3.3; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase Click to Show/Hide
Gene Name	Psph
Chromosomal Location	7p11.2
Family	HAD-like hydrolase superfamily, SerB family
Function	Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:15291819, PubMed:9222972, PubMed:14673469, PubMed:25080166). L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator (PubMed:14673469). May also act on O-phospho-D-serine (Probable). Click to Show/Hide
Gene ID	5723
Uniprot ID	SERB_HUMAN
HGNC ID	HGNC:9577
KEGG ID	hsa:5723

References

Ref 1	Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407. doi: 10.1124/jpet.300.2.399.
Ref 2	ATP-binding cassette transporters in human heart failure. Naunyn Schmiedebergs Arch Pharmacol. 2008 May;377(3):231-43. doi: 10.1007/s00210-008-0279-6. Epub 2008 Apr 8.