General Information of the m6A Target Gene (ID: M6ATAR01054)
Target Name Inosine triphosphate pyrophosphatase (ITPA)
Synonyms
ITPase; Inosine triphosphatase; EC 3.6.1.9; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; NTPase; Putative oncogene protein hlc14-06-p
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Gene Name ITPA
Chromosomal Location 20p13
Family HAM1 NTPase family
Function
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
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Gene ID 3704
Uniprot ID
ITPA_HUMAN
HGNC ID
HGNC:6176
KEGG ID
hsa:3704
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)
In total 5 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03259
Epigenetic Regulator Lysine-specific demethylase 4C (KDM4C)
Regulated Target Histone H3 lysine 9 trimethylation (H3K9me3)
Crosstalk relationship Histone modification → m6A
Disease Acute myeloid leukaemia
Crosstalk ID: M6ACROT03263
Epigenetic Regulator Histone-lysine N-methyltransferase 2A (KMT2A)
Regulated Target Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship Histone modification → m6A
Disease Acute myeloid leukaemia
Crosstalk ID: M6ACROT03267
Epigenetic Regulator Histone-lysine N-methyltransferase 2C (KMT2C)
Regulated Target Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship Histone modification → m6A
Disease Acute myeloid leukaemia
Crosstalk ID: M6ACROT03271
Epigenetic Regulator Lysine-specific demethylase 4B (KDM4B)
Regulated Target Histone H3 lysine 9 trimethylation (H3K9me3)
Crosstalk relationship Histone modification → m6A
Disease Acute myeloid leukaemia
Crosstalk ID: M6ACROT03275
Epigenetic Regulator Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C)
Regulated Target Histone H3 lysine 9 trimethylation (H3K9me3)
Crosstalk relationship Histone modification → m6A
Disease Acute myeloid leukaemia
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01054)
Inosine triphosphate pyrophosphatase (ITPA)
N4-acetylcytidine (ac4C)
In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000041 Click to Show/Hide the Full List
mod site chr20:3221894-3221895:+ [2]
Sequence TTGGCTGGGACCCCTGCTTTCAGCCTGATGGATATGAGCAG
Cell/Tissue List H1
Seq Type List ac4C-seq
Transcript ID List ENST00000460550.5; ENST00000461029.1; ENST00000472295.1; ENST00000490838.6; ENST00000455664.6; ENST00000399838.3; ENST00000483354.5; ENST00000380113.8
External Link RMBase: ac4C_site_1186
Adenosine-to-Inosine editing (A-to-I)
In total 14 m6A sequence/site(s) in this target gene
mod ID: A2ISITE010334 Click to Show/Hide the Full List
mod site chr20:3219346-3219347:+ [3]
Sequence GGCCAGGTTTGGTGATTTACACCTGTAATCCTAGCACTTTG
Transcript ID List rmsk_5052374; ENST00000399838.3; ENST00000490838.6; ENST00000461029.1; ENST00000460550.5; ENST00000380113.8; ENST00000455664.6; ENST00000483354.5
External Link RMBase: RNA-editing_site_85156
mod ID: A2ISITE010335 Click to Show/Hide the Full List
mod site chr20:3219393-3219394:+ [4]
Sequence CCCAGCGGGAGGCTTTCTTGAGCCCAGGTGTTCAAGATCAG
Transcript ID List ENST00000461029.1; ENST00000460550.5; rmsk_5052374; ENST00000455664.6; ENST00000483354.5; ENST00000380113.8; ENST00000490838.6; ENST00000399838.3
External Link RMBase: RNA-editing_site_85157
mod ID: A2ISITE010336 Click to Show/Hide the Full List
mod site chr20:3219398-3219399:+ [4]
Sequence CGGGAGGCTTTCTTGAGCCCAGGTGTTCAAGATCAGCCTGG
Transcript ID List ENST00000399838.3; ENST00000460550.5; ENST00000380113.8; ENST00000455664.6; ENST00000490838.6; rmsk_5052374; ENST00000483354.5; ENST00000461029.1
External Link RMBase: RNA-editing_site_85158
mod ID: A2ISITE010337 Click to Show/Hide the Full List
mod site chr20:3219406-3219407:+ [4]
Sequence TTTCTTGAGCCCAGGTGTTCAAGATCAGCCTGGACACCATA
Transcript ID List ENST00000483354.5; ENST00000399838.3; ENST00000461029.1; ENST00000380113.8; ENST00000455664.6; ENST00000460550.5; ENST00000490838.6; rmsk_5052374
External Link RMBase: RNA-editing_site_85159
mod ID: A2ISITE010338 Click to Show/Hide the Full List
mod site chr20:3219437-3219438:+ [4]
Sequence GGACACCATAACAAGACCCCATCTTTGCAAAAAATTTTAAA
Transcript ID List ENST00000460550.5; ENST00000399838.3; rmsk_5052374; ENST00000380113.8; ENST00000490838.6; ENST00000483354.5; ENST00000461029.1; ENST00000455664.6
External Link RMBase: RNA-editing_site_85160
mod ID: A2ISITE010339 Click to Show/Hide the Full List
mod site chr20:3219836-3219837:+ [3]
Sequence CAGGAGGATTGCTTGAGGCCAGGAGTTTGAGACCAGCCTGG
Transcript ID List ENST00000399838.3; ENST00000490838.6; ENST00000460550.5; ENST00000455664.6; ENST00000461029.1; rmsk_5052376; ENST00000380113.8; ENST00000483354.5
External Link RMBase: RNA-editing_site_85161
mod ID: A2ISITE010340 Click to Show/Hide the Full List
mod site chr20:3219920-3219921:+ [5]
Sequence ACATGGTGGTGCACACCTGTAGTCCTAGCTACTTGGGAGGC
Transcript ID List ENST00000460550.5; ENST00000490838.6; ENST00000380113.8; ENST00000455664.6; ENST00000483354.5; ENST00000461029.1; rmsk_5052376; ENST00000399838.3
External Link RMBase: RNA-editing_site_85162
mod ID: A2ISITE010341 Click to Show/Hide the Full List
mod site chr20:3220186-3220187:+ [4]
Sequence GATCTCCCACCCTGGAGAGTAACTGGGACTACAGGCGTGCA
Transcript ID List ENST00000380113.8; ENST00000461029.1; ENST00000483354.5; ENST00000399838.3; ENST00000460550.5; ENST00000490838.6; ENST00000455664.6
External Link RMBase: RNA-editing_site_85163
mod ID: A2ISITE010342 Click to Show/Hide the Full List
mod site chr20:3220257-3220258:+ [4]
Sequence GGTAGAGACAGGGTTTCACTATGTTGCCCAGGCTGGTCTTG
Transcript ID List ENST00000399838.3; ENST00000455664.6; ENST00000490838.6; ENST00000483354.5; ENST00000460550.5; ENST00000461029.1; ENST00000380113.8
External Link RMBase: RNA-editing_site_85164
mod ID: A2ISITE010343 Click to Show/Hide the Full List
mod site chr20:3220292-3220293:+ [4]
Sequence GTCTTGAACTCCCGACCTTAAGTGATCCGCTGGCCTCATTC
Transcript ID List ENST00000460550.5; ENST00000455664.6; ENST00000490838.6; ENST00000483354.5; ENST00000399838.3; ENST00000461029.1; ENST00000380113.8
External Link RMBase: RNA-editing_site_85165
mod ID: A2ISITE010344 Click to Show/Hide the Full List
mod site chr20:3220648-3220649:+ [4]
Sequence GCCTTGATCTCTCAGGCTCAAGTCATCCTCCCACCTCAGCC
Transcript ID List ENST00000399838.3; ENST00000461029.1; ENST00000460550.5; ENST00000483354.5; ENST00000455664.6; ENST00000490838.6; ENST00000380113.8
External Link RMBase: RNA-editing_site_85166
mod ID: A2ISITE010345 Click to Show/Hide the Full List
mod site chr20:3220681-3220682:+ [4]
Sequence CCTCAGCCTTCCGAGTAGCTAGGACCTCAGGTGTGAGCTAC
Transcript ID List ENST00000490838.6; ENST00000399838.3; ENST00000461029.1; ENST00000483354.5; ENST00000460550.5; ENST00000455664.6; ENST00000380113.8
External Link RMBase: RNA-editing_site_85167
mod ID: A2ISITE010346 Click to Show/Hide the Full List
mod site chr20:3220744-3220745:+ [4]
Sequence AAAAAAAAATTGGTAGAGATAGAGTCTGACTGTGTTGCCCA
Transcript ID List ENST00000460550.5; ENST00000483354.5; ENST00000399838.3; ENST00000455664.6; ENST00000380113.8; ENST00000490838.6; ENST00000461029.1
External Link RMBase: RNA-editing_site_85168
mod ID: A2ISITE010347 Click to Show/Hide the Full List
mod site chr20:3220824-3220825:+ [4]
Sequence CTCGGCCTCCCCAAGCGCTGAGATTACAGGCGTGAGCTACC
Transcript ID List ENST00000455664.6; ENST00000461029.1; ENST00000490838.6; ENST00000399838.3; ENST00000483354.5; ENST00000460550.5; ENST00000380113.8
External Link RMBase: RNA-editing_site_85169
N1-methyladenosine (m1A)
In total 1 m6A sequence/site(s) in this target gene
mod ID: M1ASITE000077 Click to Show/Hide the Full List
mod site chr20:3223585-3223586:+ [6]
Sequence TCCCCTTTGTGAGGGTGTCGAGTAGCCTCACCGGCCTGTCT
Cell/Tissue List HEK293T
Seq Type List m1A-seq
Transcript ID List ENST00000460550.5; ENST00000483354.5; ENST00000455664.6; ENST00000380113.8; ENST00000399838.3; ENST00000472295.1; ENST00000490838.6
External Link RMBase: m1A_site_617
5-methylcytidine (m5C)
In total 6 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002570 Click to Show/Hide the Full List
mod site chr20:3219675-3219676:+
Sequence AATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000483354.5; ENST00000380113.8; ENST00000455664.6; ENST00000461029.1; ENST00000490838.6; rmsk_5052375; ENST00000460550.5; ENST00000399838.3
External Link RMBase: m5C_site_28339
mod ID: M5CSITE002571 Click to Show/Hide the Full List
mod site chr20:3219712-3219713:+
Sequence TGAGATCTCGCCACTGCACTCCAGCCTGGGCAACAAGAGTG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000460550.5; ENST00000399838.3; ENST00000380113.8; ENST00000461029.1; rmsk_5052375; ENST00000483354.5; ENST00000455664.6; ENST00000490838.6
External Link RMBase: m5C_site_28340
mod ID: M5CSITE002572 Click to Show/Hide the Full List
mod site chr20:3219716-3219717:+
Sequence ATCTCGCCACTGCACTCCAGCCTGGGCAACAAGAGTGAGAC
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5052375; ENST00000455664.6; ENST00000461029.1; ENST00000399838.3; ENST00000460550.5; ENST00000380113.8; ENST00000490838.6; ENST00000483354.5
External Link RMBase: m5C_site_28341
mod ID: M5CSITE002573 Click to Show/Hide the Full List
mod site chr20:3219717-3219718:+
Sequence TCTCGCCACTGCACTCCAGCCTGGGCAACAAGAGTGAGACT
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000455664.6; ENST00000399838.3; ENST00000490838.6; ENST00000461029.1; ENST00000380113.8; ENST00000460550.5; rmsk_5052375; ENST00000483354.5
External Link RMBase: m5C_site_28342
mod ID: M5CSITE002574 Click to Show/Hide the Full List
mod site chr20:3219722-3219723:+
Sequence CCACTGCACTCCAGCCTGGGCAACAAGAGTGAGACTCCGTC
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000490838.6; ENST00000483354.5; ENST00000461029.1; ENST00000460550.5; rmsk_5052375; ENST00000399838.3; ENST00000455664.6; ENST00000380113.8
External Link RMBase: m5C_site_28343
mod ID: M5CSITE002575 Click to Show/Hide the Full List
mod site chr20:3222737-3222738:+
Sequence TGTGAGGCCCCACAATAGCCCCAGCAGGGGTGAGGACATTG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000461029.1; ENST00000483354.5; ENST00000490838.6; ENST00000455664.6; ENST00000380113.8; ENST00000399838.3; ENST00000460550.5; ENST00000472295.1
External Link RMBase: m5C_site_28344
N6-methyladenosine (m6A)
In total 14 m6A sequence/site(s) in this target gene
mod ID: M6ASITE051160 Click to Show/Hide the Full List
mod site chr20:3208870-3208871:+ [7]
Sequence TATCAGCAGAGGTTCAGCAGACCCACCTTTGAGAGGGCACT
Motif Score 2.876744048
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000483354.5
External Link RMBase: m6A_site_521082
mod ID: M6ASITE051161 Click to Show/Hide the Full List
mod site chr20:3208993-3208994:+ [8]
Sequence GAGGGATGAGGAAGTGAGGAACTCTACATACTGAGCTCTCA
Motif Score 3.373380952
Cell/Tissue List HEK293T; HepG2; A549; Huh7; HEK293A-TOA; TREX
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000460676.5; ENST00000483354.5
External Link RMBase: m6A_site_521083
mod ID: M6ASITE051162 Click to Show/Hide the Full List
mod site chr20:3218546-3218547:+ [9]
Sequence GCTCCTGGCCGGGTTCGAGGACAAGTCAGCCTATGCGCTCT
Motif Score 3.643047619
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000380113.8; ENST00000460676.5; ENST00000461029.1; ENST00000460550.5; ENST00000609835.5; ENST00000455664.6; ENST00000399838.3; ENST00000483354.5; ENST00000490838.6
External Link RMBase: m6A_site_521084
mod ID: M6ASITE051163 Click to Show/Hide the Full List
mod site chr20:3218591-3218592:+ [9]
Sequence GTTTGCACTCAGCACCGGGGACCCAAGCCAGCCCGTGCGCC
Motif Score 3.622404762
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000461029.1; ENST00000460550.5; ENST00000483354.5; ENST00000455664.6; ENST00000490838.6; ENST00000460676.5; ENST00000609835.5; ENST00000399838.3; ENST00000380113.8
External Link RMBase: m6A_site_521085
mod ID: M6ASITE051164 Click to Show/Hide the Full List
mod site chr20:3218626-3218627:+ [9]
Sequence TGCGCCTGTTCAGGGGCCGGACCTCGGTGCGTACCCACCTT
Motif Score 3.622404762
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000609835.5; ENST00000380113.8; ENST00000460550.5; ENST00000399838.3; ENST00000483354.5; ENST00000455664.6; ENST00000490838.6; ENST00000461029.1
External Link RMBase: m6A_site_521086
mod ID: M6ASITE051165 Click to Show/Hide the Full List
mod site chr20:3218880-3218881:+ [9]
Sequence GAGGGGTGCCCCTGGGCAGGACAATGGAAGTGTTGTCAATT
Motif Score 3.643047619
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000380113.8; ENST00000460550.5; ENST00000483354.5; ENST00000490838.6; ENST00000461029.1; ENST00000455664.6; ENST00000609835.5; ENST00000399838.3
External Link RMBase: m6A_site_521087
mod ID: M6ASITE051166 Click to Show/Hide the Full List
mod site chr20:3218906-3218907:+ [9]
Sequence GAAGTGTTGTCAATTCTGAAACCTGTTTGACCCCTGAGGCT
Motif Score 2.185083333
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000380113.8; ENST00000609835.5; ENST00000399838.3; ENST00000460550.5; ENST00000461029.1; ENST00000455664.6; ENST00000483354.5; ENST00000490838.6
External Link RMBase: m6A_site_521088
mod ID: M6ASITE051167 Click to Show/Hide the Full List
mod site chr20:3218941-3218942:+ [9]
Sequence GAGGCTGTTGTTTCAGGGAAACAGTTGGCTAACAGCTCCTG
Motif Score 2.20572619
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000455664.6; ENST00000483354.5; ENST00000461029.1; ENST00000380113.8; ENST00000609835.5; ENST00000460550.5; ENST00000490838.6; ENST00000399838.3
External Link RMBase: m6A_site_521089
mod ID: M6ASITE051168 Click to Show/Hide the Full List
mod site chr20:3221871-3221872:+ [10]
Sequence GGCACCCAGAGGCTGCCAGGACTTTGGCTGGGACCCCTGCT
Motif Score 4.065041667
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000483354.5; ENST00000380113.8; ENST00000461029.1; ENST00000490838.6; ENST00000472295.1; ENST00000399838.3; ENST00000460550.5; ENST00000455664.6
External Link RMBase: m6A_site_521090
mod ID: M6ASITE051169 Click to Show/Hide the Full List
mod site chr20:3221883-3221884:+ [10]
Sequence CTGCCAGGACTTTGGCTGGGACCCCTGCTTTCAGCCTGATG
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000483354.5; ENST00000490838.6; ENST00000399838.3; ENST00000461029.1; ENST00000380113.8; ENST00000472295.1; ENST00000455664.6; ENST00000460550.5
External Link RMBase: m6A_site_521091
mod ID: M6ASITE051170 Click to Show/Hide the Full List
mod site chr20:3223518-3223519:+ [10]
Sequence CTGGGGAGGGCTAGCCCAAAACCTCCCGCATCGGGCAGGCA
Motif Score 2.185083333
Cell/Tissue List HeLa; HepG2; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000455664.6; ENST00000460550.5; ENST00000472295.1; ENST00000490838.6; ENST00000380113.8; ENST00000399838.3; ENST00000483354.5
External Link RMBase: m6A_site_521092
mod ID: M6ASITE051171 Click to Show/Hide the Full List
mod site chr20:3223634-3223635:+ [11]
Sequence AGCTGGCTCTGCTCTGAGAAACTCTGGCAAGTGGACGCCAT
Motif Score 2.627720238
Cell/Tissue List HepG2; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000472295.1; ENST00000399838.3; ENST00000460550.5; ENST00000380113.8; ENST00000483354.5; ENST00000490838.6
External Link RMBase: m6A_site_521093
mod ID: M6ASITE051172 Click to Show/Hide the Full List
mod site chr20:3223716-3223717:+ [10]
Sequence AGGCCTGGGGTCCTGAAAGGACCTTGGGTGGTAAAGCTGTA
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000472295.1; ENST00000483354.5; ENST00000490838.6; ENST00000399838.3; ENST00000380113.8; ENST00000460550.5
External Link RMBase: m6A_site_521094
mod ID: M6ASITE051173 Click to Show/Hide the Full List
mod site chr20:3223736-3223737:+ [12]
Sequence ACCTTGGGTGGTAAAGCTGTACTTGGTGGGAGTGAGGGCGT
Motif Score 3.278136905
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000472295.1; ENST00000380113.8; ENST00000460550.5; ENST00000483354.5; ENST00000399838.3; ENST00000490838.6
External Link RMBase: m6A_site_521095