m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01048)

Target Name	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (PDE6B)
Synonyms	GMP-PDE beta; EC 3.1.4.35 Click to Show/Hide
Gene Name	PDE6B
Chromosomal Location	4p16.3
Family	Cyclic nucleotide phosphodiesterase family
Function	Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP (PubMed:20940301). Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal (PubMed:8394174). Click to Show/Hide
Gene ID	5158
Uniprot ID	PDE6B_HUMAN
HGNC ID	HGNC:8786
KEGG ID	hsa:5158

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01048)

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (PDE6B)

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000327		Click to Show/Hide the Full List
mod site	chr4:670473-670474:+		[2]
Sequence	GCTGGTCTCGAACTCCTGACCTCAGGTGATCACCCGCCTCA
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000496514.5; ENST00000255622.10
External Link	RMBase: Nm_site_5111

N6-methyladenosine (m6A)

In total 35 m6A sequence/site(s) in this target gene
mod ID: M6ASITE064650		Click to Show/Hide the Full List
mod site	chr4:625613-625614:+		[3]
Sequence	GAGCAGCAGCGTCTCCAGGGACAGGCAGCCACCATGAGCCT
Motif Score	3.643047619
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000496514.5; ENST00000255622.10
External Link	RMBase: m6A_site_626135
mod ID: M6ASITE064651		Click to Show/Hide the Full List
mod site	chr4:625663-625664:+		[3]
Sequence	GCAGGCCCGGAGCTTTCTGGACCAGAACCCCGATTTTGCCC
Motif Score	3.622404762
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000255622.10; ENST00000496514.5
External Link	RMBase: m6A_site_626136
mod ID: M6ASITE064652		Click to Show/Hide the Full List
mod site	chr4:625669-625670:+		[3]
Sequence	CCGGAGCTTTCTGGACCAGAACCCCGATTTTGCCCGCCAGT
Motif Score	2.930744048
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000496514.5; ENST00000255622.10
External Link	RMBase: m6A_site_626137
mod ID: M6ASITE064653		Click to Show/Hide the Full List
mod site	chr4:625703-625704:+		[3]
Sequence	CGCCAGTACTTTGGGAAGAAACTGAGCCCTGAGAATGTGGC
Motif Score	2.627720238
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000496514.5; ENST00000255622.10
External Link	RMBase: m6A_site_626138
mod ID: M6ASITE064654		Click to Show/Hide the Full List
mod site	chr4:625753-625754:+		[4]
Sequence	CGAGGACGGGTGCCCGCCGGACTGCGACAGCCTCCGGGACC
Motif Score	4.065041667
Cell/Tissue List	H1A; H1B; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000496514.5; ENST00000255622.10
External Link	RMBase: m6A_site_626139
mod ID: M6ASITE064655		Click to Show/Hide the Full List
mod site	chr4:625771-625772:+		[4]
Sequence	GGACTGCGACAGCCTCCGGGACCTCTGCCAGGTGGAGGAGA
Motif Score	3.622404762
Cell/Tissue List	H1A; H1B; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000496514.5; ENST00000255622.10
External Link	RMBase: m6A_site_626140
mod ID: M6ASITE064656		Click to Show/Hide the Full List
mod site	chr4:625972-625973:+		[3]
Sequence	GCTTTTCAGCGTGCAGCCGGACAGCGTCCTGGAGGACTGCC
Motif Score	3.643047619
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000255622.10; ENST00000496514.5
External Link	RMBase: m6A_site_626141
mod ID: M6ASITE064657		Click to Show/Hide the Full List
mod site	chr4:625987-625988:+		[3]
Sequence	GCCGGACAGCGTCCTGGAGGACTGCCTGGTGCCCCCCGACT
Motif Score	4.065041667
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000255622.10; ENST00000496514.5
External Link	RMBase: m6A_site_626142
mod ID: M6ASITE064658		Click to Show/Hide the Full List
mod site	chr4:626029-626030:+		[3]
Sequence	CGAGATCGTCTTCCCACTGGACATCGGGGTCGTGGGCCACG
Motif Score	3.643047619
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000255622.10; ENST00000496514.5
External Link	RMBase: m6A_site_626143
mod ID: M6ASITE064659		Click to Show/Hide the Full List
mod site	chr4:626058-626059:+		[3]
Sequence	TCGTGGGCCACGTGGCTCAGACCAAAAAGATGGTGAACGTC
Motif Score	2.876744048
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000255622.10; ENST00000496514.5
External Link	RMBase: m6A_site_626144
mod ID: M6ASITE064660		Click to Show/Hide the Full List
mod site	chr4:653474-653475:+		[4]
Sequence	AGGCGGCCTGACGTGCGGAAACCACGGCCCGATGTTCTCAA
Motif Score	2.185083333
Cell/Tissue List	H1A; Jurkat
Seq Type List	m6A-seq
Transcript ID List	ENST00000476034.5; ENST00000488061.5; ENST00000487902.5; ENST00000496514.5; ENST00000474251.5; ENST00000465426.5; ENST00000467152.1; ENST00000429163.6; ENST00000255622.10
External Link	RMBase: m6A_site_626148
mod ID: M6ASITE064661		Click to Show/Hide the Full List
mod site	chr4:653618-653619:+		[5]
Sequence	CCACTCCTGAGTGATCAGGGACACGACCGCAGCCTCGAGGC
Motif Score	3.643047619
Cell/Tissue List	Jurkat
Seq Type List	m6A-seq
Transcript ID List	ENST00000474251.5; ENST00000496514.5; ENST00000476034.5; ENST00000488061.5; ENST00000487902.5; ENST00000429163.6; ENST00000255622.10; ENST00000467152.1; ENST00000465426.5
External Link	RMBase: m6A_site_626152
mod ID: M6ASITE064662		Click to Show/Hide the Full List
mod site	chr4:653681-653682:+		[5]
Sequence	GCCCCACAAGCTCAGATGAAACCTGGCCACGGAGCCACCAA
Motif Score	2.185083333
Cell/Tissue List	Jurkat
Seq Type List	m6A-seq
Transcript ID List	ENST00000487902.5; ENST00000255622.10; ENST00000496514.5; ENST00000465426.5; ENST00000474251.5; ENST00000429163.6; ENST00000488061.5; ENST00000467152.1; ENST00000476034.5
External Link	RMBase: m6A_site_626153
mod ID: M6ASITE064663		Click to Show/Hide the Full List
mod site	chr4:663769-663770:+		[6]
Sequence	GCTGGGCATAACCTCCGCAGACCCTGAACATCTACCAGAAC
Motif Score	2.876744048
Cell/Tissue List	hESCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000460119.1; ENST00000429163.6; ENST00000471824.6; ENST00000496514.5; ENST00000255622.10
External Link	RMBase: m6A_site_626161
mod ID: M6ASITE064664		Click to Show/Hide the Full List
mod site	chr4:663776-663777:+		[6]
Sequence	ATAACCTCCGCAGACCCTGAACATCTACCAGAACCTGAACC
Motif Score	2.951386905
Cell/Tissue List	hESCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000460119.1; ENST00000496514.5; ENST00000429163.6; ENST00000255622.10; ENST00000471824.6
External Link	RMBase: m6A_site_626162
mod ID: M6ASITE064665		Click to Show/Hide the Full List
mod site	chr4:663788-663789:+		[6]
Sequence	GACCCTGAACATCTACCAGAACCTGAACCGGCGGCAGCACG
Motif Score	2.930744048
Cell/Tissue List	hESCs; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000460119.1; ENST00000496514.5; ENST00000471824.6; ENST00000429163.6; ENST00000255622.10
External Link	RMBase: m6A_site_626163
mod ID: M6ASITE064666		Click to Show/Hide the Full List
mod site	chr4:663794-663795:+		[6]
Sequence	GAACATCTACCAGAACCTGAACCGGCGGCAGCACGAGCACG
Motif Score	2.930744048
Cell/Tissue List	hESCs; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000255622.10; ENST00000471824.6; ENST00000496514.5; ENST00000460119.1; ENST00000429163.6
External Link	RMBase: m6A_site_626164
mod ID: M6ASITE064667		Click to Show/Hide the Full List
mod site	chr4:663830-663831:+		[6]
Sequence	GCACGTGATCCACCTGATGGACATCGCCATCATCGCCACGG
Motif Score	3.643047619
Cell/Tissue List	hESCs; MM6; Jurkat; CD4T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000496514.5; ENST00000460119.1; ENST00000429163.6; ENST00000471824.6; ENST00000255622.10
External Link	RMBase: m6A_site_626165
mod ID: M6ASITE064668		Click to Show/Hide the Full List
mod site	chr4:663851-663852:+		[6]
Sequence	CATCGCCATCATCGCCACGGACCTGGCCCTGTACTTCAAGT
Motif Score	3.622404762
Cell/Tissue List	hESCs; MM6; Jurkat; CD4T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000255622.10; ENST00000471824.6; ENST00000460119.1; ENST00000429163.6; ENST00000496514.5
External Link	RMBase: m6A_site_626166
mod ID: M6ASITE064669		Click to Show/Hide the Full List
mod site	chr4:663921-663922:+		[5]
Sequence	GGGCGGGCGGGTAGCCTGGGACCCCCGGCAGACACGGGGGC
Motif Score	3.622404762
Cell/Tissue List	Jurkat; CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000460119.1; ENST00000429163.6; ENST00000255622.10; ENST00000471824.6; ENST00000496514.5
External Link	RMBase: m6A_site_626167
mod ID: M6ASITE064670		Click to Show/Hide the Full List
mod site	chr4:663932-663933:+		[5]
Sequence	TAGCCTGGGACCCCCGGCAGACACGGGGGCGCAGCGGCGGC
Motif Score	2.897386905
Cell/Tissue List	Jurkat; CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000471824.6; ENST00000460119.1; ENST00000496514.5; ENST00000255622.10; ENST00000429163.6
External Link	RMBase: m6A_site_626168
mod ID: M6ASITE064671		Click to Show/Hide the Full List
mod site	chr4:664154-664155:+		[5]
Sequence	GATCGTGGATGAGTCCAAGAACTACCAGGACAAGAAGAGCT
Motif Score	3.373380952
Cell/Tissue List	Jurkat; CD4T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000471824.6; ENST00000255622.10; ENST00000496514.5; ENST00000429163.6; ENST00000460119.1
External Link	RMBase: m6A_site_626169
mod ID: M6ASITE064672		Click to Show/Hide the Full List
mod site	chr4:664163-664164:+		[5]
Sequence	TGAGTCCAAGAACTACCAGGACAAGAAGAGCTGGGTGGAGT
Motif Score	3.643047619
Cell/Tissue List	CD4T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000255622.10; ENST00000496514.5; ENST00000471824.6; ENST00000429163.6; ENST00000460119.1
External Link	RMBase: m6A_site_626170
mod ID: M6ASITE064673		Click to Show/Hide the Full List
mod site	chr4:664539-664540:+		[7]
Sequence	TCCCCAGGCTGGTCCCAGGGACCCAGTGAGAAAATACACAT
Motif Score	3.622404762
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000471824.6; rmsk_1219585; ENST00000255622.10; ENST00000429163.6; ENST00000460119.1; ENST00000496514.5
External Link	RMBase: m6A_site_626171
mod ID: M6ASITE064674		Click to Show/Hide the Full List
mod site	chr4:665305-665306:+		[8]
Sequence	AGCAAGGTGACTTGGAAAGGACAGTCTTGGATCAGCAGCCC
Motif Score	3.643047619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000471824.6; ENST00000429163.6; ENST00000461490.1; ENST00000496514.5; ENST00000255622.10
External Link	RMBase: m6A_site_626172
mod ID: M6ASITE064675		Click to Show/Hide the Full List
mod site	chr4:666540-666541:+		[8]
Sequence	CTCCCACCAGCCTATGATGGACCGGAACAAGGCGGCCGAGC
Motif Score	3.622404762
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000461490.1; ENST00000496514.5; ENST00000429163.6; ENST00000255622.10; ENST00000471824.6
External Link	RMBase: m6A_site_626173
mod ID: M6ASITE064676		Click to Show/Hide the Full List
mod site	chr4:666546-666547:+		[8]
Sequence	CCAGCCTATGATGGACCGGAACAAGGCGGCCGAGCTCCCCA
Motif Score	2.951386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000429163.6; ENST00000255622.10; ENST00000461490.1; ENST00000496514.5; ENST00000471824.6
External Link	RMBase: m6A_site_626174
mod ID: M6ASITE064677		Click to Show/Hide the Full List
mod site	chr4:670621-670622:+		[3]
Sequence	TGGATAGTTACCACTGGGAGACCTTTGAAAAGGGTCCATGA
Motif Score	2.876744048
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000496514.5; ENST00000255622.10
External Link	RMBase: m6A_site_626175
mod ID: M6ASITE064678		Click to Show/Hide the Full List
mod site	chr4:670642-670643:+		[3]
Sequence	CCTTTGAAAAGGGTCCATGAACTCTGAAATCACTGAGAACA
Motif Score	3.373380952
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000496514.5; ENST00000255622.10
External Link	RMBase: m6A_site_626176
mod ID: M6ASITE064679		Click to Show/Hide the Full List
mod site	chr4:670660-670661:+		[3]
Sequence	GAACTCTGAAATCACTGAGAACATTTGCAGCCACACATGTA
Motif Score	2.951386905
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000496514.5; ENST00000255622.10
External Link	RMBase: m6A_site_626177
mod ID: M6ASITE064680		Click to Show/Hide the Full List
mod site	chr4:670700-670701:+		[3]
Sequence	ACATATGTGTACACAGGTAGACAGATGGACACAGGCCGTTT
Motif Score	2.897386905
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000496514.5; ENST00000255622.10
External Link	RMBase: m6A_site_626178
mod ID: M6ASITE064681		Click to Show/Hide the Full List
mod site	chr4:670708-670709:+		[3]
Sequence	GTACACAGGTAGACAGATGGACACAGGCCGTTTCTCATCCA
Motif Score	3.643047619
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000255622.10; ENST00000496514.5
External Link	RMBase: m6A_site_626179
mod ID: M6ASITE064682		Click to Show/Hide the Full List
mod site	chr4:670739-670740:+		[3]
Sequence	TTCTCATCCAGTTTAGGAAAACACACATGCTCAGGAATTCA
Motif Score	2.20572619
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000255622.10; ENST00000496514.5
External Link	RMBase: m6A_site_626180
mod ID: M6ASITE064683		Click to Show/Hide the Full List
mod site	chr4:670771-670772:+		[3]
Sequence	AGGAATTCAGAATAAAATAAACAGAAAACTACTTGCCCATT
Motif Score	2.20572619
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000255622.10
External Link	RMBase: m6A_site_626181
mod ID: M6ASITE064684		Click to Show/Hide the Full List
mod site	chr4:670778-670779:+		[3]
Sequence	CAGAATAAAATAAACAGAAAACTACTTGCCCATTATCTGTG
Motif Score	2.627720238
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000255622.10
External Link	RMBase: m6A_site_626182

Ref 1	Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory prediction using inhibitors and substrates as marker probes. Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):127-35. doi: 10.1007/s13318-014-0190-0.
Ref 2	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.
Ref 3	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 4	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 5	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife. 2016 Jul 2;5:e15528. doi: 10.7554/eLife.15528.
Ref 6	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 7	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 8	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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