m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01046)

Target Name	Transcription factor SOX-8 (SOX8)
Gene Name	SOX8
Chromosomal Location	16p13.3
Function	Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). Click to Show/Hide
Gene ID	30812
Uniprot ID	SOX8_HUMAN
HGNC ID	HGNC:11203
KEGG ID	hsa:30812

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01046)

Transcription factor SOX-8 (SOX8)

N6-methyladenosine (m6A)

In total 37 m6A sequence/site(s) in this target gene
mod ID: M6ASITE025322		Click to Show/Hide the Full List
mod site	chr16:981929-981930:+		[2]
Sequence	GCGCGCGGCCCCGATGCTGGACATGAGCGAGGCCCGCTCCC
Motif Score	3.643047619
Cell/Tissue List	GSC-11; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000293894.4
External Link	RMBase: m6A_site_300052
mod ID: M6ASITE025323		Click to Show/Hide the Full List
mod site	chr16:982001-982002:+		[2]
Sequence	CTCCATGTCGCACGTGGAGGACTCGGACTCGGACGCGCCGC
Motif Score	4.065041667
Cell/Tissue List	GSC-11; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000293894.4
External Link	RMBase: m6A_site_300053
mod ID: M6ASITE025324		Click to Show/Hide the Full List
mod site	chr16:982007-982008:+		[2]
Sequence	GTCGCACGTGGAGGACTCGGACTCGGACGCGCCGCCGTCTC
Motif Score	4.065041667
Cell/Tissue List	GSC-11; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000293894.4
External Link	RMBase: m6A_site_300054
mod ID: M6ASITE025325		Click to Show/Hide the Full List
mod site	chr16:982304-982305:+		[3]
Sequence	CGACCAGTACCCGCACCTGCACAACGCCGAGCTCAGCAAGA
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300055
mod ID: M6ASITE025326		Click to Show/Hide the Full List
mod site	chr16:982377-982378:+		[2]
Sequence	CCCCGGGGGCGGGGTTCGGGACCTTGGCCGCCCCTGGTCTC
Motif Score	3.622404762
Cell/Tissue List	GSC-11
Seq Type List	m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300056
mod ID: M6ASITE025327		Click to Show/Hide the Full List
mod site	chr16:982400-982401:+		[2]
Sequence	TTGGCCGCCCCTGGTCTCGGACTGCGAGCGGGGGCCTGGAG
Motif Score	4.065041667
Cell/Tissue List	GSC-11
Seq Type List	m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300057
mod ID: M6ASITE025328		Click to Show/Hide the Full List
mod site	chr16:982974-982975:+		[4]
Sequence	TCAGTTTTCCAGAAATTAGGACTGCAGAGTGAAGAACTTGT
Motif Score	4.065041667
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300058
mod ID: M6ASITE025329		Click to Show/Hide the Full List
mod site	chr16:982989-982990:+		[4]
Sequence	TTAGGACTGCAGAGTGAAGAACTTGTTGCTCAGGACAGGCC
Motif Score	3.373380952
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300059
mod ID: M6ASITE025330		Click to Show/Hide the Full List
mod site	chr16:983003-983004:+		[4]
Sequence	TGAAGAACTTGTTGCTCAGGACAGGCCGCCCCCACCGAGTG
Motif Score	3.643047619
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300060
mod ID: M6ASITE025331		Click to Show/Hide the Full List
mod site	chr16:983318-983319:+		[4]
Sequence	GGGTGTCTGGGAATGGAGGGACAGCAGCCCAGCTGCCCGCC
Motif Score	3.643047619
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300061
mod ID: M6ASITE025332		Click to Show/Hide the Full List
mod site	chr16:983789-983790:+		[3]
Sequence	AGAGCGCCTTCGCGTGCAGCACAAGAAGGACCACCCCGACT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300062
mod ID: M6ASITE025333		Click to Show/Hide the Full List
mod site	chr16:983798-983799:+		[2]
Sequence	TCGCGTGCAGCACAAGAAGGACCACCCCGACTACAAGTACC
Motif Score	3.622404762
Cell/Tissue List	GSC-11; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300063
mod ID: M6ASITE025334		Click to Show/Hide the Full List
mod site	chr16:983883-983884:+		[2]
Sequence	GACTCGGGCGCGGAGCTGGGACCCCACCCTGGCGGCGGTGC
Motif Score	3.622404762
Cell/Tissue List	GSC-11; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300064
mod ID: M6ASITE025335		Click to Show/Hide the Full List
mod site	chr16:984705-984706:+		[2]
Sequence	CTCTCCTGTCCCCAGGGCAGACCCACGGGCCGCCCACCCCG
Motif Score	2.876744048
Cell/Tissue List	GSC-11; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300065
mod ID: M6ASITE025336		Click to Show/Hide the Full List
mod site	chr16:984802-984803:+		[5]
Sequence	GGAGGGACGCCGGCCGGTGGACAGCGGGCGCCAGAACATCG
Motif Score	3.643047619
Cell/Tissue List	H1A; H1B; GSC-11; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300066
mod ID: M6ASITE025337		Click to Show/Hide the Full List
mod site	chr16:984817-984818:+		[5]
Sequence	GGTGGACAGCGGGCGCCAGAACATCGACTTCAGCAACGTGG
Motif Score	2.951386905
Cell/Tissue List	H1A; H1B; GSC-11; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300067
mod ID: M6ASITE025338		Click to Show/Hide the Full List
mod site	chr16:984838-984839:+		[5]
Sequence	CATCGACTTCAGCAACGTGGACATCTCGGAGCTCAGCAGCG
Motif Score	3.643047619
Cell/Tissue List	H1A; H1B; GSC-11; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300068
mod ID: M6ASITE025339		Click to Show/Hide the Full List
mod site	chr16:985351-985352:+		[6]
Sequence	CAGCCCCACCAGTCACTGGGACCAGCCGGTGTACACCACCC
Motif Score	3.622404762
Cell/Tissue List	HepG2; HEK293T; H1A; H1B; hNPCs; hESCs; GSC-11; HEK293A-TOA; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300069
mod ID: M6ASITE025340		Click to Show/Hide the Full List
mod site	chr16:985406-985407:+		[6]
Sequence	GGGCCCAGCCGCGGGGAGGGACTCGCAGGCGTCAGGGGGCA
Motif Score	4.065041667
Cell/Tissue List	HepG2; HEK293T; H1A; H1B; hNPCs; hESCs; CD4T; GSC-11; HEK293A-TOA; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300070
mod ID: M6ASITE025341		Click to Show/Hide the Full List
mod site	chr16:985512-985513:+		[7]
Sequence	CTGCTGAAGTCTGCAGGGAAACACGCTTGCTGCCCGTGGCC
Motif Score	2.20572619
Cell/Tissue List	HepG2; HEK293T; A549; H1A; H1B; hESCs; CD4T; GSC-11; HEK293A-TOA; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300071
mod ID: M6ASITE025342		Click to Show/Hide the Full List
mod site	chr16:985570-985571:+		[7]
Sequence	CACACCTCTGCCGACGACGGACCAGCTCCCTCTCCCTTCTA
Motif Score	3.622404762
Cell/Tissue List	HepG2; HEK293T; A549; H1A; H1B; hESCs; GSC-11; HEK293A-TOA; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300072
mod ID: M6ASITE025343		Click to Show/Hide the Full List
mod site	chr16:985659-985660:+		[7]
Sequence	TTGGTCCCTCTTCCGTGAGGACTGGCGGCACCAGCACCTTC
Motif Score	4.065041667
Cell/Tissue List	HepG2; HEK293T; A549; Brain; H1A; H1B; hNPCs; hESCs; GSC-11; HEK293A-TOA; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300073
mod ID: M6ASITE025344		Click to Show/Hide the Full List
mod site	chr16:985704-985705:+		[8]
Sequence	TGCATCTCGGTAGAGGAGAAACGGCAGCACAGCCCAAGGAC
Motif Score	2.179660714
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300074
mod ID: M6ASITE025345		Click to Show/Hide the Full List
mod site	chr16:985723-985724:+		[7]
Sequence	AACGGCAGCACAGCCCAAGGACCAAAGGAGGGGGTGGCAGG
Motif Score	3.622404762
Cell/Tissue List	HepG2; HEK293T; A549; H1A; H1B; hNPCs; GSC-11; HEK293A-TOA; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300075
mod ID: M6ASITE025346		Click to Show/Hide the Full List
mod site	chr16:985865-985866:+		[7]
Sequence	TCCGGGGTGTCTGTCCGCAGACTGGGATGAGTCTACTCGAG
Motif Score	3.319380952
Cell/Tissue List	HepG2; HEK293T; A549; H1A; H1B; GSC-11; HEK293A-TOA; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300076
mod ID: M6ASITE025347		Click to Show/Hide the Full List
mod site	chr16:985896-985897:+		[7]
Sequence	TCTACTCGAGCATCTCCGGGACCTGCCTGTCAGATCTGAGG
Motif Score	3.622404762
Cell/Tissue List	HepG2; HEK293T; A549; H1A; H1B; GSC-11; HEK293A-TOA; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300077
mod ID: M6ASITE025348		Click to Show/Hide the Full List
mod site	chr16:985965-985966:+		[9]
Sequence	GCGAGGGCTGGCTGTGATGAACACATCTCTCTTTTATTTTT
Motif Score	2.951386905
Cell/Tissue List	HEK293T; H1A; H1B; GSC-11; HEK293A-TOA; endometrial; GSCs
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300078
mod ID: M6ASITE025349		Click to Show/Hide the Full List
mod site	chr16:986254-986255:+		[2]
Sequence	GTCCCAAGGTCCCTGGGAGGACTGGGCCCCTCATGCCTCGA
Motif Score	4.065041667
Cell/Tissue List	GSC-11
Seq Type List	m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300079
mod ID: M6ASITE025350		Click to Show/Hide the Full List
mod site	chr16:986290-986291:+		[2]
Sequence	CTCGAGCTTGGCAACCGAAAACCCGAGGGAGGAGAAGGGAC
Motif Score	2.185083333
Cell/Tissue List	HEK293T; GSC-11; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300080
mod ID: M6ASITE025351		Click to Show/Hide the Full List
mod site	chr16:986309-986310:+		[2]
Sequence	AACCCGAGGGAGGAGAAGGGACCTGCCTTGTGACATCTCTG
Motif Score	3.622404762
Cell/Tissue List	HEK293T; GSC-11; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300081
mod ID: M6ASITE025352		Click to Show/Hide the Full List
mod site	chr16:986383-986384:+		[5]
Sequence	TTTGGGGTTTGGGAAGCAGGACTCCGTCCCTGTCCCCGACT
Motif Score	4.065041667
Cell/Tissue List	HEK293T; H1A; GSC-11; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300082
mod ID: M6ASITE025353		Click to Show/Hide the Full List
mod site	chr16:986419-986420:+		[5]
Sequence	CGACTGTGCCACGTGGTAGGACACATAGGACACAGGAATTC
Motif Score	3.643047619
Cell/Tissue List	HEK293T; H1A; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300083
mod ID: M6ASITE025354		Click to Show/Hide the Full List
mod site	chr16:986428-986429:+		[5]
Sequence	CACGTGGTAGGACACATAGGACACAGGAATTCCTGGGTCCT
Motif Score	3.643047619
Cell/Tissue List	HEK293T; H1A; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300084
mod ID: M6ASITE025355		Click to Show/Hide the Full List
mod site	chr16:986475-986476:+		[4]
Sequence	TGACTGTGCCATGTGGTAGGACACAGGACACAGGAATTCCT
Motif Score	3.643047619
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300085
mod ID: M6ASITE025356		Click to Show/Hide the Full List
mod site	chr16:986482-986483:+		[4]
Sequence	GCCATGTGGTAGGACACAGGACACAGGAATTCCTGGAAAGT
Motif Score	3.643047619
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000566034.1; ENST00000293894.4
External Link	RMBase: m6A_site_300086
mod ID: M6ASITE025357		Click to Show/Hide the Full List
mod site	chr16:986660-986661:+		[3]
Sequence	GTGTGCTGAGCATAGAGCATACAATAGCGCCTACTTCACGG
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300087
mod ID: M6ASITE025358		Click to Show/Hide the Full List
mod site	chr16:986712-986713:+		[3]
Sequence	TTTAAACTTTGTAAACTTAAACACAGCCGAGAAGTTGCTTC
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000293894.4; ENST00000566034.1
External Link	RMBase: m6A_site_300088

Ref 1	Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20. doi: 10.1016/0006-291x(86)90965-4.
Ref 2	m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell. 2017 Apr 10;31(4):591-606.e6. doi: 10.1016/j.ccell.2017.02.013. Epub 2017 Mar 23.
Ref 3	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 4	The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003.
Ref 5	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 6	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 7	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 8	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 9	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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