m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01008)

Target Name	Prostaglandin E2 receptor EP4 subtype (PTGER2)
Synonyms	PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostanoid EP4 receptor Click to Show/Hide
Gene Name	PTGER2
Chromosomal Location	5p13.1
Family	G-protein coupled receptor 1 family
Function	Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Click to Show/Hide
Gene ID	5734
Uniprot ID	PE2R4_HUMAN
HGNC ID	HGNC:9596
KEGG ID	hsa:5734

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01008)

Prostaglandin E2 receptor EP4 subtype (PTGER2)

N6-methyladenosine (m6A)

In total 27 m6A sequence/site(s) in this target gene
mod ID: M6ASITE019501		Click to Show/Hide the Full List
mod site	chr14:52314485-52314486:+		[2]
Sequence	CGGAACGCTCCGGCTCTCAGACCCTCTTCCTCCCAGGTAAA
Motif Score	2.876744048
Cell/Tissue List	CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000245457.6; ENST00000557436.1
External Link	RMBase: m6A_site_246920
mod ID: M6ASITE019502		Click to Show/Hide the Full List
mod site	chr14:52314582-52314583:+		[2]
Sequence	CAATGACTCCCAGTCTGAGGACTGCGAGACGCGACAGTGGC
Motif Score	4.065041667
Cell/Tissue List	CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000245457.6; ENST00000557436.1
External Link	RMBase: m6A_site_246921
mod ID: M6ASITE019503		Click to Show/Hide the Full List
mod site	chr14:52315068-52315069:+		[3]
Sequence	CTGCTCGCTGCCGCTGCTGGACTATGGGCAGTACGTCCAGT
Motif Score	4.065041667
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000557436.1; ENST00000245457.6
External Link	RMBase: m6A_site_246922
mod ID: M6ASITE019504		Click to Show/Hide the Full List
mod site	chr14:52315100-52315101:+		[3]
Sequence	ACGTCCAGTACTGCCCCGGGACCTGGTGCTTCATCCGGCAC
Motif Score	3.622404762
Cell/Tissue List	MSC; iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6; ENST00000557436.1
External Link	RMBase: m6A_site_246923
mod ID: M6ASITE019505		Click to Show/Hide the Full List
mod site	chr14:52315127-52315128:+		[3]
Sequence	GCTTCATCCGGCACGGGCGGACCGCTTACCTGCAGCTGTAC
Motif Score	3.622404762
Cell/Tissue List	MSC; iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6; ENST00000557436.1
External Link	RMBase: m6A_site_246924
mod ID: M6ASITE019506		Click to Show/Hide the Full List
mod site	chr14:52315252-52315253:+		[2]
Sequence	AGCCGGAGAAGCCGCTGCGGACCTTCCCTGGGCAGTGGCCG
Motif Score	3.622404762
Cell/Tissue List	CD4T; MSC; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000557436.1; ENST00000245457.6
External Link	RMBase: m6A_site_246925
mod ID: M6ASITE019507		Click to Show/Hide the Full List
mod site	chr14:52315329-52315330:+		[2]
Sequence	GTCCATGGCGGAGGAGACGGACCACCTCATTCTCCTGGCTA
Motif Score	3.622404762
Cell/Tissue List	HEK293T; CD4T; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000557436.1; ENST00000245457.6
External Link	RMBase: m6A_site_246926
mod ID: M6ASITE019508		Click to Show/Hide the Full List
mod site	chr14:52327241-52327242:+		[3]
Sequence	TTTTTGCATATATGAATGAAACCTCTTCCCGAAAGGAAAAA
Motif Score	2.185083333
Cell/Tissue List	HEK293T; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000557436.1; ENST00000245457.6
External Link	RMBase: m6A_site_246927
mod ID: M6ASITE019509		Click to Show/Hide the Full List
mod site	chr14:52327266-52327267:+		[3]
Sequence	TTCCCGAAAGGAAAAATGGGACCTCCAAGCTCTTAGGTTTT
Motif Score	3.622404762
Cell/Tissue List	HEK293T; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6; ENST00000557436.1
External Link	RMBase: m6A_site_246928
mod ID: M6ASITE019510		Click to Show/Hide the Full List
mod site	chr14:52327348-52327349:+		[3]
Sequence	CTTAGGCCTCCTGTTCTGAGACTAATGCGTTCAGTCCTCTG
Motif Score	3.319380952
Cell/Tissue List	HEK293T; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6; ENST00000557436.1
External Link	RMBase: m6A_site_246929
mod ID: M6ASITE019511		Click to Show/Hide the Full List
mod site	chr14:52327388-52327389:+		[4]
Sequence	GTTGTCGGATTTCATTAAGAACACAAGATGCAACACAAACT
Motif Score	2.951386905
Cell/Tissue List	HEK293T; hESC-HEK293T; A549; CD8T; MSC
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000245457.6; ENST00000557436.1
External Link	RMBase: m6A_site_246930
mod ID: M6ASITE019512		Click to Show/Hide the Full List
mod site	chr14:52327406-52327407:+		[5]
Sequence	GAACACAAGATGCAACACAAACTTCCTGTTCTACACAGTCA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; A549; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000245457.6; ENST00000557436.1
External Link	RMBase: m6A_site_246931
mod ID: M6ASITE019513		Click to Show/Hide the Full List
mod site	chr14:52327438-52327439:+		[3]
Sequence	ACACAGTCAGATGCCAGTAAACAGGCTGACCTTTGAGGTCA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; iSLK; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6; ENST00000557436.1
External Link	RMBase: m6A_site_246932
mod ID: M6ASITE019514		Click to Show/Hide the Full List
mod site	chr14:52327529-52327530:+		[4]
Sequence	TGTTCCTTGGAGAAATGAAAACAGTGTGTAAACAAAATGAA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hESC-HEK293T; CD8T; iSLK; MSC
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246933
mod ID: M6ASITE019515		Click to Show/Hide the Full List
mod site	chr14:52327540-52327541:+		[6]
Sequence	GAAATGAAAACAGTGTGTAAACAAAATGAAGCTGCCCTAAT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; iSLK; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246934
mod ID: M6ASITE019516		Click to Show/Hide the Full List
mod site	chr14:52327577-52327578:+		[3]
Sequence	TAATAAAAAGGAGTATACAAACATTTAAGCTGTGGTCAAGG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; iSLK; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246935
mod ID: M6ASITE019517		Click to Show/Hide the Full List
mod site	chr14:52327651-52327652:+		[7]
Sequence	GTGTCAGAAGGAGCTACAAAACCTACCCTCAGTGAGCATGG
Motif Score	2.185083333
Cell/Tissue List	HEK293T; A549; iSLK; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246936
mod ID: M6ASITE019518		Click to Show/Hide the Full List
mod site	chr14:52327690-52327691:+		[7]
Sequence	GGTACTTGGCCTTTGGAGGAACAATCGGCTGCATTGAAGAT
Motif Score	2.951386905
Cell/Tissue List	HEK293T; A549; iSLK; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246937
mod ID: M6ASITE019519		Click to Show/Hide the Full List
mod site	chr14:52327778-52327779:+		[3]
Sequence	GGTTTTGTAATTTGTTTGAAACCCCAAACAGTGACTGTACT
Motif Score	2.185083333
Cell/Tissue List	HEK293T; iSLK; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246938
mod ID: M6ASITE019520		Click to Show/Hide the Full List
mod site	chr14:52327785-52327786:+		[3]
Sequence	TAATTTGTTTGAAACCCCAAACAGTGACTGTACTTTCTATT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; iSLK; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246939
mod ID: M6ASITE019521		Click to Show/Hide the Full List
mod site	chr14:52327791-52327792:+		[8]
Sequence	GTTTGAAACCCCAAACAGTGACTGTACTTTCTATTTTAATC
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246940
mod ID: M6ASITE019522		Click to Show/Hide the Full List
mod site	chr14:52327849-52327850:+		[3]
Sequence	CACATATAGTGTACAGCCAGACCAGATTAAACTTCATATGT
Motif Score	2.876744048
Cell/Tissue List	HEK293T; iSLK; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246941
mod ID: M6ASITE019523		Click to Show/Hide the Full List
mod site	chr14:52327859-52327860:+		[3]
Sequence	GTACAGCCAGACCAGATTAAACTTCATATGTAATCTCTAGG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; iSLK; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246942
mod ID: M6ASITE019524		Click to Show/Hide the Full List
mod site	chr14:52327931-52327932:+		[3]
Sequence	GTCTTGTGATCACTTAGCGAACCCTTTATTTGAACAATGAA
Motif Score	2.930744048
Cell/Tissue List	HEK293T; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246943
mod ID: M6ASITE019525		Click to Show/Hide the Full List
mod site	chr14:52327944-52327945:+		[3]
Sequence	TTAGCGAACCCTTTATTTGAACAATGAAGTTGAAAATCATA
Motif Score	2.951386905
Cell/Tissue List	HEK293T; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246944
mod ID: M6ASITE019526		Click to Show/Hide the Full List
mod site	chr14:52328037-52328038:+		[3]
Sequence	TATTACTCTTACAAGAGTGGACTCAGTGGGTTAACATCAGT
Motif Score	4.065041667
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246945
mod ID: M6ASITE019527		Click to Show/Hide the Full List
mod site	chr14:52328080-52328081:+		[3]
Sequence	TGTTTACTCATCCTCCAGGAACTGCAGGTCAAGTTGTCAGG
Motif Score	3.373380952
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000245457.6
External Link	RMBase: m6A_site_246946

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000086		Click to Show/Hide the Full List
mod site	chr14:52327378-52327379:+		[9]
Sequence	TCAGTCCTCTGTTGTCGGATTTCATTAAGAACACAAGATGC
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000245457.6; ENST00000557436.1
External Link	RMBase: Nm_site_1748

Ref 1	Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with CYP2C8*3 and CYP2C9. J Pain Res. 2017 Jul 6;10:1581-1589. doi: 10.2147/JPR.S138147. eCollection 2017.
Ref 2	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife. 2016 Jul 2;5:e15528. doi: 10.7554/eLife.15528.
Ref 3	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 4	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 5	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 6	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 7	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 8	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 9	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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