m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00983)

Target Name	Tumor-associated calcium signal transducer 2 (TROP2)
Synonyms	Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1 Click to Show/Hide
Gene Name	TROP2
Chromosomal Location	1p32.1
Family	EPCAM family
Function	May function as a growth factor receptor. Click to Show/Hide
Gene ID	4070
Uniprot ID	TACD2_HUMAN
HGNC ID	HGNC:11530
KEGG ID	hsa:4070

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00983)

Tumor-associated calcium signal transducer 2 (TROP2)

N6-methyladenosine (m6A)

In total 17 m6A sequence/site(s) in this target gene
mod ID: M6ASITE028305		Click to Show/Hide the Full List
mod site	chr1:58575581-58575582:-		[2]
Sequence	AGGACAGACATTGCCCGGAAACTCAGTCTATTTATTCTTCA
Motif Score	2.627720238
Cell/Tissue List	HepG2; GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32923
mod ID: M6ASITE028306		Click to Show/Hide the Full List
mod site	chr1:58575594-58575595:-		[3]
Sequence	TTGGATGTCTTTGAGGACAGACATTGCCCGGAAACTCAGTC
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32924
mod ID: M6ASITE028307		Click to Show/Hide the Full List
mod site	chr1:58575598-58575599:-		[2]
Sequence	CAGTTTGGATGTCTTTGAGGACAGACATTGCCCGGAAACTC
Motif Score	3.643047619
Cell/Tissue List	HepG2; GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32925
mod ID: M6ASITE028308		Click to Show/Hide the Full List
mod site	chr1:58576129-58576130:-		[4]
Sequence	GGATTTCGGTATCGTCCCAGACCCAAGTGAGTCACGCTTCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; H1A; H1B; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32926
mod ID: M6ASITE028309		Click to Show/Hide the Full List
mod site	chr1:58576196-58576197:-		[4]
Sequence	CTGGGGGAGTTGAGAAAGGAACCGAGCTTGTAGGTACCCGG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; H1B; H1A; GM12878; iSLK; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32927
mod ID: M6ASITE028310		Click to Show/Hide the Full List
mod site	chr1:58576217-58576218:-		[4]
Sequence	AAGAAGGTGGAGATCAAGGAACTGGGGGAGTTGAGAAAGGA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; H1B; H1A; GM12878; iSLK; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32928
mod ID: M6ASITE028311		Click to Show/Hide the Full List
mod site	chr1:58576409-58576410:-		[2]
Sequence	GACTTGCGCGTGCGCGGAGAACCCCTGCAGGTGGAGCGCAC
Motif Score	2.930744048
Cell/Tissue List	HepG2; GM12878; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32929
mod ID: M6ASITE028312		Click to Show/Hide the Full List
mod site	chr1:58576428-58576429:-		[2]
Sequence	CCAGGGCCGCGGCGGCCTGGACTTGCGCGTGCGCGGAGAAC
Motif Score	4.065041667
Cell/Tissue List	HepG2; GM12878; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32930
mod ID: M6ASITE028313		Click to Show/Hide the Full List
mod site	chr1:58576470-58576471:-		[2]
Sequence	CGCCTACTACTTCGAGAGGGACATCAAGGGCGAGTCTCTAT
Motif Score	3.643047619
Cell/Tissue List	HepG2; GM12878; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32931
mod ID: M6ASITE028314		Click to Show/Hide the Full List
mod site	chr1:58576533-58576534:-		[2]
Sequence	CCAGATCGAGCTGCGGCAGAACACGTCTCAGAAGGCCGCCG
Motif Score	2.951386905
Cell/Tissue List	HepG2; GM12878; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32932
mod ID: M6ASITE028315		Click to Show/Hide the Full List
mod site	chr1:58576644-58576645:-		[4]
Sequence	CGGCGCCTTCAACCACTCAGACCTGGACGCCGAGCTGAGGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; H1A; H1B; GM12878; iSLK; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32933
mod ID: M6ASITE028316		Click to Show/Hide the Full List
mod site	chr1:58576746-58576747:-		[4]
Sequence	GGTGGGCGTGCGCCGCACGGACAAGGGCGACCTGAGCCTAC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; H1A; H1B; GM12878; iSLK; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32934
mod ID: M6ASITE028317		Click to Show/Hide the Full List
mod site	chr1:58576770-58576771:-		[4]
Sequence	GTCGGTGTGCTGGTGCGTGAACTCGGTGGGCGTGCGCCGCA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; H1A; H1B; GM12878; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32935
mod ID: M6ASITE028318		Click to Show/Hide the Full List
mod site	chr1:58576860-58576861:-		[2]
Sequence	GAGTGAGCACGCGCTCGTGGACAACGATGGCCTCTACGACC
Motif Score	3.643047619
Cell/Tissue List	HepG2; GM12878; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32936
mod ID: M6ASITE028319		Click to Show/Hide the Full List
mod site	chr1:58577061-58577062:-		[5]
Sequence	CGGCCACACGGCCGCGCAGGACAACTGCACGTGTCCCACCA
Motif Score	3.643047619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32937
mod ID: M6ASITE028320		Click to Show/Hide the Full List
mod site	chr1:58577239-58577240:-		[6]
Sequence	CGGGCGGCAGACGCCTGCAGACCATCCCAGACGCCGGAGCC
Motif Score	2.876744048
Cell/Tissue List	TIME
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32938
mod ID: M6ASITE028321		Click to Show/Hide the Full List
mod site	chr1:58577305-58577306:-		[6]
Sequence	TGGGGACGGTCGGTGGTGGAACCAGCCGGGCAGGTCGGGTA
Motif Score	2.930744048
Cell/Tissue List	TIME
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000371225.3
External Link	RMBase: m6A_site_32939

Ref 1	Metabolism, excretion and pharmacokinetics of [(14)C]glasdegib (PF-04449913) in healthy volunteers following oral administration. Xenobiotica. 2017 Dec;47(12):1064-1076. doi: 10.1080/00498254.2016.1261307. Epub 2017 Jan 3.
Ref 2	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 3	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 4	RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat Commun. 2019 May 6;10(1):2065. doi: 10.1038/s41467-019-09865-9.
Ref 5	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 6	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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