m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00965)

Target Name	LIM domain kinase 1 (LIMK1)
Synonyms	LIMK-1; EC 2.7.11.1 Click to Show/Hide
Gene Name	LIMK1
Chromosomal Location	7q11.23
Family	Protein kinase superfamily, TKL Ser/Thr protein kinase family
Function	Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). Click to Show/Hide
Gene ID	3984
Uniprot ID	LIMK1_HUMAN
HGNC ID	HGNC:6613
KEGG ID	hsa:3984

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00965)

LIM domain kinase 1 (LIMK1)

Adenosine-to-Inosine editing (A-to-I)

In total 7 m6A sequence/site(s) in this target gene
mod ID: A2ISITE002222		Click to Show/Hide the Full List
mod site	chr7:74099456-74099457:+		[2]
Sequence	AAAGACATTTTCAACCGGGCATGGTGGCCCACACCTGTAAT
Transcript ID List	ENST00000483414.1; ENST00000435201.5; ENST00000491052.5; ENST00000336180.7; ENST00000538333.3; rmsk_2271509; ENST00000418310.5
External Link	RMBase: RNA-editing_site_124046
mod ID: A2ISITE002223		Click to Show/Hide the Full List
mod site	chr7:74099468-74099469:+		[2]
Sequence	AACCGGGCATGGTGGCCCACACCTGTAATCTCAGCACTTCG
Transcript ID List	ENST00000418310.5; rmsk_2271509; ENST00000538333.3; ENST00000336180.7; ENST00000435201.5; ENST00000483414.1; ENST00000491052.5
External Link	RMBase: RNA-editing_site_124047
mod ID: A2ISITE002224		Click to Show/Hide the Full List
mod site	chr7:74099474-74099475:+		[2]
Sequence	GCATGGTGGCCCACACCTGTAATCTCAGCACTTCGGGAGGC
Transcript ID List	ENST00000435201.5; ENST00000336180.7; ENST00000483414.1; rmsk_2271509; ENST00000491052.5; ENST00000418310.5; ENST00000538333.3
External Link	RMBase: RNA-editing_site_124048
mod ID: A2ISITE002225		Click to Show/Hide the Full List
mod site	chr7:74099498-74099499:+		[2]
Sequence	TCAGCACTTCGGGAGGCCGAAGTGGGTGGATCACCTGAGGT
Transcript ID List	ENST00000435201.5; ENST00000483414.1; ENST00000538333.3; ENST00000491052.5; ENST00000336180.7; ENST00000418310.5; rmsk_2271509
External Link	RMBase: RNA-editing_site_124049
mod ID: A2ISITE002226		Click to Show/Hide the Full List
mod site	chr7:74099544-74099545:+		[2]
Sequence	GTTCGAGACCAGCCTGGGCAATGTGGTGAAACCCCGTCTCT
Transcript ID List	ENST00000418310.5; ENST00000336180.7; rmsk_2271509; ENST00000483414.1; ENST00000491052.5; ENST00000435201.5; ENST00000538333.3
External Link	RMBase: RNA-editing_site_124050
mod ID: A2ISITE002227		Click to Show/Hide the Full List
mod site	chr7:74099569-74099570:+		[2]
Sequence	GTGAAACCCCGTCTCTACTAAAAATACAAACGTAGCCAGGC
Transcript ID List	ENST00000336180.7; ENST00000418310.5; ENST00000538333.3; ENST00000491052.5; ENST00000483414.1; rmsk_2271509; ENST00000435201.5
External Link	RMBase: RNA-editing_site_124051
mod ID: A2ISITE002228		Click to Show/Hide the Full List
mod site	chr7:74099850-74099851:+		[3]
Sequence	GTGAAGAAGCTGGGCGCAGTAACTCACACCTGTAATCTCAG
Transcript ID List	ENST00000336180.7; rmsk_2271510; ENST00000491052.5; ENST00000418310.5; ENST00000538333.3; ENST00000483414.1; ENST00000435201.5
External Link	RMBase: RNA-editing_site_124052

5-methylcytidine (m5C)

In total 5 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004138		Click to Show/Hide the Full List
mod site	chr7:74085803-74085804:+
Sequence	GGATCTATGATGGCCAGTACCTCCAGGCCCTGAACGCGGAC
Cell/Tissue List	frontalcortex
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000435201.5; ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m5C_site_39611
mod ID: M5CSITE004139		Click to Show/Hide the Full List
mod site	chr7:74106731-74106732:+
Sequence	GTCACGCCACTATACTCCAGCCTGGGCAACAGTGTGAGACT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000483414.1; rmsk_2271533; ENST00000418310.5; ENST00000336180.7; ENST00000538333.3; ENST00000435201.5
External Link	RMBase: m5C_site_39612
mod ID: M5CSITE004140		Click to Show/Hide the Full List
mod site	chr7:74115797-74115798:+		[4]
Sequence	CATGACCCGGCTTCACCTTCCCAGAACAAGAATGTGGTGGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000418310.5; ENST00000476792.1; ENST00000435201.5; ENST00000538333.3; ENST00000336180.7
External Link	RMBase: m5C_site_39613
mod ID: M5CSITE004141		Click to Show/Hide the Full List
mod site	chr7:74122117-74122118:+
Sequence	TGTCCACCAGCAGCTCAGCCCCTGCAGTCATCTCAGAGCCC
Cell/Tissue List	frontalcortex
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m5C_site_39614
mod ID: M5CSITE004142		Click to Show/Hide the Full List
mod site	chr7:74122130-74122131:+
Sequence	CTCAGCCCCTGCAGTCATCTCAGAGCCCCTTCCCGGGCCTC
Cell/Tissue List	frontalcortex
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m5C_site_39615

N6-methyladenosine (m6A)

In total 58 m6A sequence/site(s) in this target gene
mod ID: M6ASITE080518		Click to Show/Hide the Full List
mod site	chr7:74085822-74085823:+		[5]
Sequence	CCTCCAGGCCCTGAACGCGGACTGGCACGCAGACTGCTTCA
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000418310.5; ENST00000336180.7; ENST00000435201.5
External Link	RMBase: m6A_site_761015
mod ID: M6ASITE080519		Click to Show/Hide the Full List
mod site	chr7:74085834-74085835:+		[5]
Sequence	GAACGCGGACTGGCACGCAGACTGCTTCAGGTAGGGTGGGG
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5; ENST00000435201.5
External Link	RMBase: m6A_site_761016
mod ID: M6ASITE080520		Click to Show/Hide the Full List
mod site	chr7:74099111-74099112:+		[6]
Sequence	CCCTGGCTCCCACCTGCCCCACACCGTCACCCTGGTGTCCA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000435201.5; ENST00000336180.7; ENST00000491052.5; ENST00000418310.5; ENST00000538333.3; ENST00000483414.1
External Link	RMBase: m6A_site_761017
mod ID: M6ASITE080521		Click to Show/Hide the Full List
mod site	chr7:74099160-74099161:+		[5]
Sequence	TCATCTCATGGCAAGCGTGGACTTTCAGTCTCCATTGACCC
Motif Score	4.065041667
Cell/Tissue List	HeLa; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000538333.3; ENST00000435201.5; ENST00000483414.1; ENST00000491052.5; ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m6A_site_761018
mod ID: M6ASITE080522		Click to Show/Hide the Full List
mod site	chr7:74105927-74105928:+		[5]
Sequence	GAATTCCATCCACGTCGGAGACCGGATCTTGGAAATCAATG
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000538333.3; ENST00000336180.7; ENST00000418310.5; ENST00000435201.5; ENST00000483414.1
External Link	RMBase: m6A_site_761019
mod ID: M6ASITE080523		Click to Show/Hide the Full List
mod site	chr7:74106097-74106098:+		[5]
Sequence	TTGACCTGCTGATTCAGGAAACCAGCCGCCTGCTCCAGCTG
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000418310.5; ENST00000435201.5; ENST00000538333.3; ENST00000336180.7; ENST00000483414.1
External Link	RMBase: m6A_site_761020
mod ID: M6ASITE080524		Click to Show/Hide the Full List
mod site	chr7:74106142-74106143:+		[6]
Sequence	TCGAGCATGACCCTCACGATACACTGGGCCACGGGCTGGGG
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000483414.1; ENST00000336180.7; ENST00000418310.5; ENST00000538333.3; ENST00000435201.5
External Link	RMBase: m6A_site_761021
mod ID: M6ASITE080525		Click to Show/Hide the Full List
mod site	chr7:74106169-74106170:+		[5]
Sequence	GCCACGGGCTGGGGCCTGAGACCAGCCCCCTGAGCTCTCCG
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000538333.3; ENST00000483414.1; ENST00000418310.5; ENST00000435201.5; ENST00000336180.7
External Link	RMBase: m6A_site_761022
mod ID: M6ASITE080526		Click to Show/Hide the Full List
mod site	chr7:74106234-74106235:+		[5]
Sequence	GGCAGCTCTGCCCGGCAGAAACCTGTCTTGTAAGTCAGCCT
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000483414.1; ENST00000336180.7; ENST00000538333.3; ENST00000418310.5; ENST00000435201.5
External Link	RMBase: m6A_site_761023
mod ID: M6ASITE080527		Click to Show/Hide the Full List
mod site	chr7:74107077-74107078:+		[5]
Sequence	CCCGGCCTCCCAGCGCAAGGACCTGGGTCGCTCTGAGTCCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000483414.1; ENST00000538333.3; ENST00000435201.5; ENST00000418310.5
External Link	RMBase: m6A_site_761024
mod ID: M6ASITE080528		Click to Show/Hide the Full List
mod site	chr7:74107140-74107141:+		[5]
Sequence	CCGCATCTTCCGGCCGTCGGACCTCATCCACGGGGAGGTGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MM6; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5; ENST00000483414.1; ENST00000538333.3; ENST00000435201.5
External Link	RMBase: m6A_site_761025
mod ID: M6ASITE080529		Click to Show/Hide the Full List
mod site	chr7:74107885-74107886:+		[5]
Sequence	CGCAGGTGACACACCGTGAGACAGGTGAGGTGATGGTGATG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; MM6; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000483414.1; ENST00000538333.3; ENST00000418310.5; ENST00000435201.5; ENST00000336180.7
External Link	RMBase: m6A_site_761026
mod ID: M6ASITE080530		Click to Show/Hide the Full List
mod site	chr7:74107933-74107934:+		[5]
Sequence	TGATCCGGTTCGACGAGGAGACCCAGAGGACGTTCCTCAAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MM6; CD4T; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000483414.1; ENST00000538333.3; ENST00000435201.5; ENST00000418310.5
External Link	RMBase: m6A_site_761027
mod ID: M6ASITE080531		Click to Show/Hide the Full List
mod site	chr7:74108927-74108928:+		[5]
Sequence	AAGGTCATGCGATGCCTGGAACACCCCAACGTGCTCAAGTT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; CD4T; peripheral-blood; endometrial; HEC-1-A; MM6
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000483414.1; ENST00000435201.5; ENST00000336180.7; ENST00000418310.5; ENST00000538333.3
External Link	RMBase: m6A_site_761028
mod ID: M6ASITE080532		Click to Show/Hide the Full List
mod site	chr7:74108968-74108969:+		[5]
Sequence	CATCGGGGTGCTCTACAAGGACAAGAGGCTCAACTTCATCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; CD4T; peripheral-blood; endometrial; HEC-1-A; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000483414.1; ENST00000336180.7; ENST00000435201.5; ENST00000538333.3; ENST00000418310.5
External Link	RMBase: m6A_site_761029
mod ID: M6ASITE080533		Click to Show/Hide the Full List
mod site	chr7:74108995-74108996:+		[6]
Sequence	GCTCAACTTCATCACTGAGTACATCAAGGGCGGCACGCTCC
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000483414.1; ENST00000336180.7; ENST00000538333.3; ENST00000418310.5; ENST00000435201.5
External Link	RMBase: m6A_site_761030
mod ID: M6ASITE080534		Click to Show/Hide the Full List
mod site	chr7:74109158-74109159:+		[7]
Sequence	GGGTCTCAAAGGCCCTCTGAACCCTGATTCCTAATCAAAAA
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000483414.1; rmsk_2271537; ENST00000538333.3; ENST00000336180.7; ENST00000418310.5; ENST00000435201.5
External Link	RMBase: m6A_site_761031
mod ID: M6ASITE080535		Click to Show/Hide the Full List
mod site	chr7:74111427-74111428:+		[5]
Sequence	ACCCTGGGTGACAGAGTGAGACTCCATCTAAAGAAAAAAAA
Motif Score	3.319380952
Cell/Tissue List	HeLa; MT4; CD4T; peripheral-blood; GSC-11; endometrial; HEC-1-A; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000538333.3; ENST00000435201.5; ENST00000418310.5; ENST00000483414.1; ENST00000336180.7; rmsk_2271544
External Link	RMBase: m6A_site_761032
mod ID: M6ASITE080536		Click to Show/Hide the Full List
mod site	chr7:74111690-74111691:+		[5]
Sequence	GAGAGTGAGCTTTGCCAAGGACATCGCATCAGGGATGGTGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; MT4; CD4T; peripheral-blood; GSC-11; endometrial; HEC-1-A; NB4; MM6
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000435201.5; ENST00000538333.3; ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m6A_site_761033
mod ID: M6ASITE080537		Click to Show/Hide the Full List
mod site	chr7:74111951-74111952:+		[5]
Sequence	GGCCTACCTCCACTCCATGAACATCATCCACCGAGACCTCA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; MT4; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000435201.5; ENST00000418310.5; ENST00000336180.7; ENST00000538333.3
External Link	RMBase: m6A_site_761034
mod ID: M6ASITE080538		Click to Show/Hide the Full List
mod site	chr7:74111966-74111967:+		[5]
Sequence	CATGAACATCATCCACCGAGACCTCAACTCCCACAACTGCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MT4; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000538333.3; ENST00000418310.5; ENST00000435201.5; ENST00000336180.7
External Link	RMBase: m6A_site_761035
mod ID: M6ASITE080539		Click to Show/Hide the Full List
mod site	chr7:74115412-74115413:+		[5]
Sequence	AGCCTGGGTGACAGAGCAAGACTCCGTCTGAAAAAAAAAAC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; CD4T; peripheral-blood; GSC-11; endometrial; HEC-1-A; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000435201.5; ENST00000336180.7; ENST00000476792.1; ENST00000538333.3; ENST00000418310.5; rmsk_2271557
External Link	RMBase: m6A_site_761036
mod ID: M6ASITE080540		Click to Show/Hide the Full List
mod site	chr7:74115431-74115432:+		[5]
Sequence	GACTCCGTCTGAAAAAAAAAACAAAAGAATTCCTGTCTTCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	rmsk_2271557; ENST00000336180.7; ENST00000435201.5; ENST00000476792.1; ENST00000418310.5; ENST00000538333.3
External Link	RMBase: m6A_site_761037
mod ID: M6ASITE080541		Click to Show/Hide the Full List
mod site	chr7:74115459-74115460:+		[5]
Sequence	ATTCCTGTCTTCTCTCCGAAACAAAGCAGCATCAGTGCCCC
Motif Score	2.20572619
Cell/Tissue List	HeLa; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000538333.3; ENST00000435201.5; ENST00000418310.5; ENST00000336180.7; ENST00000476792.1
External Link	RMBase: m6A_site_761038
mod ID: M6ASITE080542		Click to Show/Hide the Full List
mod site	chr7:74115802-74115803:+		[5]
Sequence	CCCGGCTTCACCTTCCCAGAACAAGAATGTGGTGGTGGCTG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; CD4T; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000538333.3; ENST00000336180.7; ENST00000435201.5; ENST00000418310.5; ENST00000476792.1
External Link	RMBase: m6A_site_761039
mod ID: M6ASITE080543		Click to Show/Hide the Full List
mod site	chr7:74115858-74115859:+		[5]
Sequence	GTCTCATGGTGGACGAGAAGACTCAGCCTGAGGGCCTGCGG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; MM6; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000418310.5; ENST00000538333.3; ENST00000435201.5; ENST00000336180.7; ENST00000476792.1
External Link	RMBase: m6A_site_761040
mod ID: M6ASITE080544		Click to Show/Hide the Full List
mod site	chr7:74115895-74115896:+		[5]
Sequence	GCGGAGCCTCAAGAAGCCAGACCGCAAGAAGCGCTACACCG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MM6; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000538333.3; ENST00000476792.1; ENST00000418310.5; ENST00000435201.5
External Link	RMBase: m6A_site_761041
mod ID: M6ASITE080545		Click to Show/Hide the Full List
mod site	chr7:74115910-74115911:+		[6]
Sequence	GCCAGACCGCAAGAAGCGCTACACCGTGGTGGGCAACCCCT
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000476792.1; ENST00000538333.3; ENST00000418310.5; ENST00000435201.5; ENST00000336180.7
External Link	RMBase: m6A_site_761042
mod ID: M6ASITE080546		Click to Show/Hide the Full List
mod site	chr7:74120913-74120914:+		[5]
Sequence	CATCGGGCGGGTGAACGCAGACCCTGACTACCTGCCCCGCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MM6; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000476792.1; ENST00000435201.5; ENST00000336180.7; ENST00000418310.5; ENST00000538333.3
External Link	RMBase: m6A_site_761043
mod ID: M6ASITE080547		Click to Show/Hide the Full List
mod site	chr7:74120940-74120941:+		[5]
Sequence	CTACCTGCCCCGCACCATGGACTTTGGCCTCAACGTGCGAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; MM6; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000418310.5; ENST00000476792.1; ENST00000435201.5; ENST00000336180.7; ENST00000538333.3
External Link	RMBase: m6A_site_761044
mod ID: M6ASITE080548		Click to Show/Hide the Full List
mod site	chr7:74120970-74120971:+		[5]
Sequence	CAACGTGCGAGGATTCCTGGACCGCTACTGCCCCCCAAACT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MM6; Huh7; Jurkat; peripheral-blood; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000435201.5; ENST00000336180.7; ENST00000418310.5; ENST00000538333.3; ENST00000476792.1
External Link	RMBase: m6A_site_761045
mod ID: M6ASITE080549		Click to Show/Hide the Full List
mod site	chr7:74120988-74120989:+		[5]
Sequence	GGACCGCTACTGCCCCCCAAACTGCCCCCCGAGCTTCTTCC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; MM6; Huh7; Jurkat; peripheral-blood; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000476792.1; ENST00000538333.3; ENST00000435201.5; ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m6A_site_761046
mod ID: M6ASITE080550		Click to Show/Hide the Full List
mod site	chr7:74121036-74121037:+		[5]
Sequence	CGTGCGCTGTTGCGATCTGGACCCCGAGAAGAGGTGAGTGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; hESCs; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000435201.5; ENST00000418310.5; ENST00000538333.3; ENST00000336180.7
External Link	RMBase: m6A_site_761047
mod ID: M6ASITE080551		Click to Show/Hide the Full List
mod site	chr7:74121159-74121160:+		[5]
Sequence	CCATCCTTTGTGAAGCTGGAACACTGGCTGGAGACCCTCCG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; hESCs; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000418310.5; ENST00000435201.5; ENST00000336180.7; ENST00000538333.3
External Link	RMBase: m6A_site_761048
mod ID: M6ASITE080552		Click to Show/Hide the Full List
mod site	chr7:74121172-74121173:+		[5]
Sequence	AGCTGGAACACTGGCTGGAGACCCTCCGCATGCACCTGGCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; hESCs; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000418310.5; ENST00000336180.7; ENST00000435201.5; ENST00000538333.3
External Link	RMBase: m6A_site_761049
mod ID: M6ASITE080553		Click to Show/Hide the Full List
mod site	chr7:74121230-74121231:+		[5]
Sequence	CCCACAGCTGGAGCAGCTGGACAGAGGTTTCTGGGAGACCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; hESC-HEK293T; H1A; H1B; hESCs; A549; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000538333.3; ENST00000435201.5; ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m6A_site_761050
mod ID: M6ASITE080554		Click to Show/Hide the Full List
mod site	chr7:74121247-74121248:+		[5]
Sequence	TGGACAGAGGTTTCTGGGAGACCTACCGGCGCGGCGAGAGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000538333.3; ENST00000336180.7; ENST00000435201.5; ENST00000418310.5
External Link	RMBase: m6A_site_761051
mod ID: M6ASITE080555		Click to Show/Hide the Full List
mod site	chr7:74121270-74121271:+		[5]
Sequence	TACCGGCGCGGCGAGAGCGGACTGCCTGCCCACCCTGAGGT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000418310.5; ENST00000336180.7; ENST00000435201.5; ENST00000538333.3
External Link	RMBase: m6A_site_761052
mod ID: M6ASITE080556		Click to Show/Hide the Full List
mod site	chr7:74121387-74121388:+		[5]
Sequence	GGAGGTGGCCCTCAGCTGGGACAGTGGGGACCCAGGCTTCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hESCs; GM12878; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000418310.5; ENST00000538333.3; ENST00000336180.7
External Link	RMBase: m6A_site_761053
mod ID: M6ASITE080557		Click to Show/Hide the Full List
mod site	chr7:74121396-74121397:+		[5]
Sequence	CCTCAGCTGGGACAGTGGGGACCCAGGCTTCTCCTCAGAGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hESCs; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000538333.3; ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m6A_site_761054
mod ID: M6ASITE080558		Click to Show/Hide the Full List
mod site	chr7:74121449-74121450:+		[5]
Sequence	TGCCTTCTCCCACCCCGTGGACCGCTTCCCCTGCCTTCTCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hESCs; GM12878; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000336180.7; ENST00000538333.3; ENST00000418310.5
External Link	RMBase: m6A_site_761055
mod ID: M6ASITE080559		Click to Show/Hide the Full List
mod site	chr7:74121608-74121609:+		[6]
Sequence	TGTGAGTTACGCCCCTTTCCACACGCCGCTGCCCCAGCAAC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m6A_site_761056
mod ID: M6ASITE080560		Click to Show/Hide the Full List
mod site	chr7:74121733-74121734:+		[6]
Sequence	TTGGGTGCGTGGGAGGGCGCACATCAGGGCAGAGGCCAAGT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m6A_site_761057
mod ID: M6ASITE080561		Click to Show/Hide the Full List
mod site	chr7:74121777-74121778:+		[5]
Sequence	AGGTGTCTGTGTTCCCAGGAACCAAATGGGGAGTCTGGGGC
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m6A_site_761058
mod ID: M6ASITE080562		Click to Show/Hide the Full List
mod site	chr7:74121843-74121844:+		[5]
Sequence	GGTAGCAACAGGTATCGAGGACTCTCCAAACCCCCAAAGCA
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m6A_site_761059
mod ID: M6ASITE080563		Click to Show/Hide the Full List
mod site	chr7:74121852-74121853:+		[5]
Sequence	AGGTATCGAGGACTCTCCAAACCCCCAAAGCAGAGAGAGGG
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m6A_site_761060
mod ID: M6ASITE080564		Click to Show/Hide the Full List
mod site	chr7:74121911-74121912:+		[5]
Sequence	GGTCCCCAGTGGCTGAGCAAACAGCCCCTTCTCTCGCTTTG
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m6A_site_761061
mod ID: M6ASITE080565		Click to Show/Hide the Full List
mod site	chr7:74122087-74122088:+		[5]
Sequence	TGAGAGGATAGGCACAGTGGACCGGGCAGGTGTCCACCAGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m6A_site_761062
mod ID: M6ASITE080566		Click to Show/Hide the Full List
mod site	chr7:74122247-74122248:+		[8]
Sequence	AGTTTGTATTATTTTTTCATACGGCTGCAGCAGCAGCTGCC
Motif Score	2.084416667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m6A_site_761063
mod ID: M6ASITE080567		Click to Show/Hide the Full List
mod site	chr7:74122357-74122358:+		[9]
Sequence	AGCATCTAGGAAGTATTAAAACTGTGAAGCTTTCTCAGTGC
Motif Score	2.627720238
Cell/Tissue List	HEK293T; hNPCs; A549; MT4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m6A_site_761064
mod ID: M6ASITE080568		Click to Show/Hide the Full List
mod site	chr7:74122385-74122386:+		[9]
Sequence	GCTTTCTCAGTGCACTTTGAACCTGGAAAACAATCCCAACA
Motif Score	2.930744048
Cell/Tissue List	HEK293T; hNPCs; hESCs; fibroblasts; A549; MT4; H1299; Huh7; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m6A_site_761065
mod ID: M6ASITE080569		Click to Show/Hide the Full List
mod site	chr7:74122394-74122395:+		[9]
Sequence	GTGCACTTTGAACCTGGAAAACAATCCCAACAGGCCCGTGG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hNPCs; hESCs; fibroblasts; A549; MT4; H1299; Huh7; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m6A_site_761066
mod ID: M6ASITE080570		Click to Show/Hide the Full List
mod site	chr7:74122416-74122417:+		[9]
Sequence	AATCCCAACAGGCCCGTGGGACCATGACTTAGGGAGGTGGG
Motif Score	3.622404762
Cell/Tissue List	HEK293T; hNPCs; hESCs; fibroblasts; A549; MT4; H1299; Huh7; TREX
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m6A_site_761067
mod ID: M6ASITE080571		Click to Show/Hide the Full List
mod site	chr7:74122437-74122438:+		[9]
Sequence	CCATGACTTAGGGAGGTGGGACCCACCCACCCCCATCCAGG
Motif Score	3.622404762
Cell/Tissue List	HEK293T; hNPCs; hESCs; fibroblasts; A549; MT4; H1299; Huh7; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m6A_site_761068
mod ID: M6ASITE080572		Click to Show/Hide the Full List
mod site	chr7:74122459-74122460:+		[9]
Sequence	CCACCCACCCCCATCCAGGAACCGTGACGTCCAAGGAACCA
Motif Score	2.930744048
Cell/Tissue List	HEK293T; hNPCs; hESCs; fibroblasts; A549; MT4; H1299; Huh7; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000418310.5; ENST00000336180.7
External Link	RMBase: m6A_site_761069
mod ID: M6ASITE080573		Click to Show/Hide the Full List
mod site	chr7:74122476-74122477:+		[9]
Sequence	GGAACCGTGACGTCCAAGGAACCAAACCCAGACGCAGAACA
Motif Score	2.930744048
Cell/Tissue List	HEK293T; hNPCs; hESCs; fibroblasts; A549; MT4; H1299; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m6A_site_761070
mod ID: M6ASITE080574		Click to Show/Hide the Full List
mod site	chr7:74122481-74122482:+		[9]
Sequence	CGTGACGTCCAAGGAACCAAACCCAGACGCAGAACAATAAA
Motif Score	2.185083333
Cell/Tissue List	HEK293T; hNPCs; hESCs; fibroblasts; A549; MT4; H1299; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m6A_site_761071
mod ID: M6ASITE080575		Click to Show/Hide the Full List
mod site	chr7:74122494-74122495:+		[9]
Sequence	GAACCAAACCCAGACGCAGAACAATAAAATAAATTCCGTAC
Motif Score	2.951386905
Cell/Tissue List	HEK293T; hNPCs; hESCs; A549; MT4; H1299; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000336180.7; ENST00000418310.5
External Link	RMBase: m6A_site_761072

Ref 1	Riociguat (adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. P T. 2014 Nov;39(11):749-58.
Ref 2	Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol. 2004 Aug;22(8):1001-5. doi: 10.1038/nbt996. Epub 2004 Jul 18.
Ref 3	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 4	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 8	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 9	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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