m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00948)

Target Name	F-box only protein 43 (FBXO43)
Synonyms	Endogenous meiotic inhibitor 2 Click to Show/Hide
Gene Name	FBXO43
Chromosomal Location	8q22.2
Function	Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. Click to Show/Hide
Gene ID	286151
Uniprot ID	FBX43_HUMAN
HGNC ID	HGNC:28521
KEGG ID	hsa:286151

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00948)

F-box only protein 43 (FBXO43)

N6-methyladenosine (m6A)

In total 31 m6A sequence/site(s) in this target gene
mod ID: M6ASITE086139		Click to Show/Hide the Full List
mod site	chr8:100133784-100133785:-		[2]
Sequence	CTGAAGAGACTAAATATAGAACTCCCCCATGCAGTGTTCTA
Motif Score	3.373380952
Cell/Tissue List	A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000517806.5; ENST00000428847.3
External Link	RMBase: m6A_site_804890
mod ID: M6ASITE086140		Click to Show/Hide the Full List
mod site	chr8:100133796-100133797:-		[2]
Sequence	TTTAAAACGCCTCTGAAGAGACTAAATATAGAACTCCCCCA
Motif Score	3.319380952
Cell/Tissue List	A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000517806.5; ENST00000428847.3
External Link	RMBase: m6A_site_804891
mod ID: M6ASITE086141		Click to Show/Hide the Full List
mod site	chr8:100133947-100133948:-		[3]
Sequence	AAAGGGGACTGTGTAGCCGAACAGCCTGTGGTTTTGACTTT
Motif Score	2.951386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000428847.3; ENST00000517806.5
External Link	RMBase: m6A_site_804892
mod ID: M6ASITE086142		Click to Show/Hide the Full List
mod site	chr8:100133960-100133961:-		[3]
Sequence	CAGCCATATAAGAAAAGGGGACTGTGTAGCCGAACAGCCTG
Motif Score	4.065041667
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000428847.3; ENST00000517806.5
External Link	RMBase: m6A_site_804893
mod ID: M6ASITE086143		Click to Show/Hide the Full List
mod site	chr8:100137575-100137576:-		[4]
Sequence	TTTATATCACACAACTGAAAACAGATTCTGAGGTAATGTAT
Motif Score	2.20572619
Cell/Tissue List	BGC823
Seq Type List	m6A-seq
Transcript ID List	ENST00000520987.1; ENST00000428847.3; ENST00000517806.5
External Link	RMBase: m6A_site_804894
mod ID: M6ASITE086144		Click to Show/Hide the Full List
mod site	chr8:100140766-100140767:-		[5]
Sequence	AATGGGTATAGAAAAACTGGACATCTTAACAGAATTAAAAT
Motif Score	3.643047619
Cell/Tissue List	HeLa; A549; BGC823; hESCs; GM12878; Huh7; iSLK; MSC; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000517806.5; ENST00000520987.1; ENST00000428847.3
External Link	RMBase: m6A_site_804895
mod ID: M6ASITE086145		Click to Show/Hide the Full List
mod site	chr8:100140771-100140772:-		[5]
Sequence	AAGAAAATGGGTATAGAAAAACTGGACATCTTAACAGAATT
Motif Score	2.627720238
Cell/Tissue List	HeLa; A549; BGC823; hESCs; GM12878; Huh7; iSLK; MSC; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000520987.1; ENST00000517806.5; ENST00000428847.3
External Link	RMBase: m6A_site_804896
mod ID: M6ASITE086146		Click to Show/Hide the Full List
mod site	chr8:100140801-100140802:-		[6]
Sequence	CTGCAGTGTATACTTGCAGGACTGATCGGCAAGAAAATGGG
Motif Score	4.065041667
Cell/Tissue List	HepG2; HeLa; A549; hNPCs; hESCs; GM12878; Huh7; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000517806.5; ENST00000428847.3; ENST00000520987.1
External Link	RMBase: m6A_site_804897
mod ID: M6ASITE086147		Click to Show/Hide the Full List
mod site	chr8:100140864-100140865:-		[6]
Sequence	AGATTACAGGAAAATAGTGGACATGAATTCTTAGAGCAAGG
Motif Score	3.643047619
Cell/Tissue List	HepG2; HeLa; A549; HEK293T; hNPCs; hESCs; GM12878; MM6; Huh7; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000517806.5; ENST00000520987.1; ENST00000428847.3
External Link	RMBase: m6A_site_804898
mod ID: M6ASITE086148		Click to Show/Hide the Full List
mod site	chr8:100140935-100140936:-		[5]
Sequence	GCTTAAAGAATTTATCAAAGACCCCAGCCTTGCAATTGGTA
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549; HEK293T; GM12878; MM6; Huh7; iSLK; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000520987.1; ENST00000428847.3; ENST00000517806.5
External Link	RMBase: m6A_site_804899
mod ID: M6ASITE086149		Click to Show/Hide the Full List
mod site	chr8:100141067-100141068:-		[5]
Sequence	AACAAAGCTCGCAGTCAGAGACAGAAGAGGAAAAGCAGATT
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; GM12878; Jurkat; MSC; TIME; TREX; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000520987.1; ENST00000517806.5; ENST00000428847.3
External Link	RMBase: m6A_site_804900
mod ID: M6ASITE086150		Click to Show/Hide the Full List
mod site	chr8:100141086-100141087:-		[5]
Sequence	AGACTGTCCACCCTTCGGGAACAAAGCTCGCAGTCAGAGAC
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549; GM12878; Jurkat; MSC; TIME; TREX; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000428847.3; ENST00000520987.1; ENST00000517806.5
External Link	RMBase: m6A_site_804901
mod ID: M6ASITE086151		Click to Show/Hide the Full List
mod site	chr8:100141104-100141105:-		[5]
Sequence	CATCTTGGAAGGTCGAGAAGACTGTCCACCCTTCGGGAACA
Motif Score	3.319380952
Cell/Tissue List	HeLa; A549; GM12878; Jurkat; MSC; TREX; iSLK; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000517806.5; ENST00000428847.3; ENST00000520987.1
External Link	RMBase: m6A_site_804902
mod ID: M6ASITE086152		Click to Show/Hide the Full List
mod site	chr8:100141125-100141126:-		[5]
Sequence	GACACCATAAGAAAGACAAGACATCTTGGAAGGTCGAGAAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; GM12878; MSC; TREX; iSLK; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000520987.1; ENST00000517806.5; ENST00000428847.3
External Link	RMBase: m6A_site_804903
mod ID: M6ASITE086153		Click to Show/Hide the Full List
mod site	chr8:100141130-100141131:-		[5]
Sequence	TTGGGGACACCATAAGAAAGACAAGACATCTTGGAAGGTCG
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; GM12878; MSC; TREX; iSLK; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000428847.3; ENST00000520987.1; ENST00000517806.5
External Link	RMBase: m6A_site_804904
mod ID: M6ASITE086154		Click to Show/Hide the Full List
mod site	chr8:100141144-100141145:-		[5]
Sequence	GGGGACTCCCAAAGTTGGGGACACCATAAGAAAGACAAGAC
Motif Score	3.643047619
Cell/Tissue List	HeLa; A549; GM12878; MSC; TREX; iSLK; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000517806.5; ENST00000520987.1; ENST00000428847.3
External Link	RMBase: m6A_site_804905
mod ID: M6ASITE086155		Click to Show/Hide the Full List
mod site	chr8:100141160-100141161:-		[5]
Sequence	TACTGCAGAAACATAAGGGGACTCCCAAAGTTGGGGACACC
Motif Score	4.065041667
Cell/Tissue List	HeLa; A549; GM12878; TREX
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000428847.3; ENST00000520987.1; ENST00000517806.5
External Link	RMBase: m6A_site_804906
mod ID: M6ASITE086156		Click to Show/Hide the Full List
mod site	chr8:100141170-100141171:-		[5]
Sequence	TTTCAAGAACTACTGCAGAAACATAAGGGGACTCCCAAAGT
Motif Score	2.20572619
Cell/Tissue List	HeLa; A549; GM12878; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000428847.3; ENST00000520987.1; ENST00000517806.5
External Link	RMBase: m6A_site_804907
mod ID: M6ASITE086157		Click to Show/Hide the Full List
mod site	chr8:100141182-100141183:-		[5]
Sequence	CAGGAGGGTTCTTTTCAAGAACTACTGCAGAAACATAAGGG
Motif Score	3.373380952
Cell/Tissue List	HeLa; A549; GM12878; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000517806.5; ENST00000520987.1; ENST00000428847.3
External Link	RMBase: m6A_site_804908
mod ID: M6ASITE086158		Click to Show/Hide the Full List
mod site	chr8:100141255-100141256:-		[5]
Sequence	CAGTATTTCAACGCCTGAAGACAGTGGTTTTAACTCACTTA
Motif Score	2.897386905
Cell/Tissue List	HeLa; GM12878; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000520987.1; ENST00000428847.3; ENST00000517806.5
External Link	RMBase: m6A_site_804909
mod ID: M6ASITE086159		Click to Show/Hide the Full List
mod site	chr8:100141327-100141328:-		[5]
Sequence	GATAAGTAATCTTGTGGCAAACATTAGATTTAACGCAAGTC
Motif Score	2.20572619
Cell/Tissue List	HeLa; A549; GM12878; iSLK; MSC; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000517806.5; ENST00000428847.3; ENST00000520987.1
External Link	RMBase: m6A_site_804910
mod ID: M6ASITE086160		Click to Show/Hide the Full List
mod site	chr8:100141363-100141364:-		[5]
Sequence	AACTTGTGGAACAGATGAGGACATATTTGTGACTCCGATAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; A549; GM12878; iSLK; MSC; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000517806.5; ENST00000520987.1; ENST00000428847.3
External Link	RMBase: m6A_site_804911
mod ID: M6ASITE086161		Click to Show/Hide the Full List
mod site	chr8:100141373-100141374:-		[5]
Sequence	TTAGTGGAACAACTTGTGGAACAGATGAGGACATATTTGTG
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549; GM12878; iSLK; MSC; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000520987.1; ENST00000517806.5; ENST00000428847.3
External Link	RMBase: m6A_site_804912
mod ID: M6ASITE086162		Click to Show/Hide the Full List
mod site	chr8:100141385-100141386:-		[5]
Sequence	TGGGCTCCTCTGTTAGTGGAACAACTTGTGGAACAGATGAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549; GM12878; iSLK; MSC; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000428847.3; ENST00000517806.5; ENST00000520987.1
External Link	RMBase: m6A_site_804913
mod ID: M6ASITE086163		Click to Show/Hide the Full List
mod site	chr8:100141474-100141475:-		[5]
Sequence	TCAGGGCAATAATTTTAAAGACTCTATCACACATGACTTTA
Motif Score	3.319380952
Cell/Tissue List	HeLa; GM12878; MSC; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000428847.3; ENST00000517806.5; ENST00000520987.1
External Link	RMBase: m6A_site_804914
mod ID: M6ASITE086164		Click to Show/Hide the Full List
mod site	chr8:100141823-100141824:-		[7]
Sequence	AAACCCCAGAACTTTGTGAAACACCTAAAATCAGTGGGAAA
Motif Score	2.20572619
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000428847.3; ENST00000517806.5; ENST00000520987.1
External Link	RMBase: m6A_site_804915
mod ID: M6ASITE086165		Click to Show/Hide the Full List
mod site	chr8:100141833-100141834:-		[7]
Sequence	GAAAAGGATAAAACCCCAGAACTTTGTGAAACACCTAAAAT
Motif Score	3.373380952
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000520987.1; ENST00000517806.5; ENST00000428847.3
External Link	RMBase: m6A_site_804916
mod ID: M6ASITE086166		Click to Show/Hide the Full List
mod site	chr8:100141841-100141842:-		[7]
Sequence	CTAGAAAGGAAAAGGATAAAACCCCAGAACTTTGTGAAACA
Motif Score	2.185083333
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000520987.1; ENST00000517806.5; ENST00000428847.3
External Link	RMBase: m6A_site_804917
mod ID: M6ASITE086167		Click to Show/Hide the Full List
mod site	chr8:100141925-100141926:-		[2]
Sequence	TACTCTATGAGCACCCTGAAACTTCAGGCCTGGGCTTAACA
Motif Score	2.627720238
Cell/Tissue List	A549; GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000520987.1; ENST00000517806.5; ENST00000428847.3
External Link	RMBase: m6A_site_804918
mod ID: M6ASITE086168		Click to Show/Hide the Full List
mod site	chr8:100145271-100145272:-		[2]
Sequence	GGAAATTCAAAATGATTTAGACCTTCTCAAGTGTTAGGAAT
Motif Score	2.876744048
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000428847.3; ENST00000520987.1; ENST00000517806.5
External Link	RMBase: m6A_site_804919
mod ID: M6ASITE086169		Click to Show/Hide the Full List
mod site	chr8:100145814-100145815:-		[8]
Sequence	ACCCCGGGCGGGCCGTTCAAACCTAAGGAGGTAAAGGCAGC
Motif Score	2.185083333
Cell/Tissue List	TREX
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000428847.3
External Link	RMBase: m6A_site_804920

Ref 1	Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor. J Med Chem. 2009 Jun 25;52(12):3627-35. doi: 10.1021/jm801300c.
Ref 2	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 3	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 4	METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer. Mol Cancer. 2019 Oct 13;18(1):142. doi: 10.1186/s12943-019-1065-4.
Ref 5	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 6	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 7	Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. J Am Chem Soc. 2015 Feb 11;137(5):2107-15. doi: 10.1021/ja513080v. Epub 2015 Feb 2.
Ref 8	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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