m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00947)

Target Name	Interferon regulatory factor 8 (IRF8)
Synonyms	IRF-8; Interferon consensus sequence-binding protein; H-ICSBP; ICSBP Click to Show/Hide
Gene Name	IRF8
Chromosomal Location	16q24.1
Family	IRF family
Function	Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:25122610). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed:29434592). Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). Click to Show/Hide
Gene ID	3394
Uniprot ID	IRF8_HUMAN
HGNC ID	HGNC:5358
KEGG ID	hsa:3394

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00947)

Interferon regulatory factor 8 (IRF8)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE007567		Click to Show/Hide the Full List
mod site	chr16:85905007-85905008:+		[2]
Sequence	CTTTGTTGTAAGGGTTCCCTATGCCTTGTGGGATGTTTAGT
Transcript ID List	ENST00000564056.1; ENST00000564617.5; ENST00000268638.10; ENST00000564803.5; ENST00000563180.1
External Link	RMBase: RNA-editing_site_53328

N6-methyladenosine (m6A)

In total 24 m6A sequence/site(s) in this target gene
mod ID: M6ASITE028769		Click to Show/Hide the Full List
mod site	chr16:85902923-85902924:+		[3]
Sequence	AGCCAGCACCTTTGCTGCAAACCTCTGAGTTTCCTGTTAGC
Motif Score	2.185083333
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000563180.1; ENST00000565552.1; ENST00000570088.1; ENST00000564803.5; ENST00000564617.5; ENST00000268638.10
External Link	RMBase: m6A_site_334990
mod ID: M6ASITE028770		Click to Show/Hide the Full List
mod site	chr16:85902971-85902972:+		[4]
Sequence	GGGTTGCTGTGATGAATGAGACAATATCCGTAATATCACAG
Motif Score	2.897386905
Cell/Tissue List	MM6; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000565552.1; ENST00000564803.5; ENST00000268638.10; ENST00000564617.5; ENST00000563180.1; ENST00000570088.1
External Link	RMBase: m6A_site_334991
mod ID: M6ASITE028771		Click to Show/Hide the Full List
mod site	chr16:85903089-85903090:+		[5]
Sequence	GACAGTAGCATGTATCCAGGACTGATTTGGGAGAATGAGGA
Motif Score	4.065041667
Cell/Tissue List	CD34; MM6; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000563180.1; ENST00000570088.1; ENST00000564803.5; ENST00000268638.10; ENST00000564617.5; ENST00000565552.1
External Link	RMBase: m6A_site_334992
mod ID: M6ASITE028772		Click to Show/Hide the Full List
mod site	chr16:85903137-85903138:+		[5]
Sequence	ATGTTCCGGATCCCTTGGAAACACGCTGGCAAGCAAGATTA
Motif Score	2.20572619
Cell/Tissue List	CD34; MM6; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000570088.1; ENST00000564056.1; ENST00000268638.10; ENST00000564803.5; ENST00000563180.1; ENST00000564617.5; ENST00000565552.1
External Link	RMBase: m6A_site_334993
mod ID: M6ASITE028773		Click to Show/Hide the Full List
mod site	chr16:85909026-85909027:+		[5]
Sequence	AGGGAAGTTTAAAGAAGGGGACAAAGCTGAACCAGCCACTT
Motif Score	3.643047619
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000564617.5; ENST00000564056.1; ENST00000566369.1; ENST00000268638.10; ENST00000563180.1; ENST00000564803.5
External Link	RMBase: m6A_site_334994
mod ID: M6ASITE028774		Click to Show/Hide the Full List
mod site	chr16:85909036-85909037:+		[5]
Sequence	AAAGAAGGGGACAAAGCTGAACCAGCCACTTGGAAGACGAG
Motif Score	2.930744048
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000566369.1; ENST00000564056.1; ENST00000564803.5; ENST00000563180.1; ENST00000564617.5; ENST00000268638.10
External Link	RMBase: m6A_site_334995
mod ID: M6ASITE028775		Click to Show/Hide the Full List
mod site	chr16:85909104-85909105:+		[5]
Sequence	AGATTTTGAGGAAGTGACGGACCGGTCCCAACTGGACATTT
Motif Score	3.622404762
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000566369.1; ENST00000564617.5; ENST00000563180.1; ENST00000564056.1; ENST00000268638.10; ENST00000564803.5
External Link	RMBase: m6A_site_334996
mod ID: M6ASITE028776		Click to Show/Hide the Full List
mod site	chr16:85909119-85909120:+		[5]
Sequence	GACGGACCGGTCCCAACTGGACATTTCCGAGCCATACAAAG
Motif Score	3.643047619
Cell/Tissue List	CD34; hESC-HEK293T; AML
Seq Type List	m6A-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000564617.5; ENST00000563180.1; ENST00000564056.1; ENST00000566369.1; ENST00000564803.5; ENST00000268638.10
External Link	RMBase: m6A_site_334997
mod ID: M6ASITE028777		Click to Show/Hide the Full List
mod site	chr16:85909197-85909198:+		[6]
Sequence	CTATCCTTTATGGGCATGAAACCTTCCAGAAGCTGCCCTGG
Motif Score	2.185083333
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000564803.5; ENST00000564617.5; ENST00000563180.1; ENST00000564056.1; ENST00000268638.10; ENST00000566369.1
External Link	RMBase: m6A_site_334998
mod ID: M6ASITE028778		Click to Show/Hide the Full List
mod site	chr16:85909238-85909239:+		[6]
Sequence	CCTGTAGCCTTCACCACAGAACTTGGGTCTGGGGTAGACAC
Motif Score	3.373380952
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000268638.10; ENST00000563180.1; ENST00000566369.1; ENST00000564056.1; ENST00000564617.5; ENST00000564803.5
External Link	RMBase: m6A_site_334999
mod ID: M6ASITE028779		Click to Show/Hide the Full List
mod site	chr16:85909255-85909256:+		[6]
Sequence	AGAACTTGGGTCTGGGGTAGACACAGGGTCTGGGGCACATA
Motif Score	2.897386905
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000563180.1; ENST00000564617.5; ENST00000564056.1; ENST00000566369.1; ENST00000564803.5; ENST00000268638.10
External Link	RMBase: m6A_site_335000
mod ID: M6ASITE028780		Click to Show/Hide the Full List
mod site	chr16:85909287-85909288:+		[6]
Sequence	GGGCACATAGTTTCAGTTAAACAAAGCAGTTCTCTCCTTCG
Motif Score	2.20572619
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000564056.1; ENST00000268638.10; ENST00000564803.5; ENST00000566369.1; ENST00000563180.1; ENST00000564617.5
External Link	RMBase: m6A_site_335001
mod ID: M6ASITE028781		Click to Show/Hide the Full List
mod site	chr16:85909408-85909409:+		[6]
Sequence	CACTTGCTGCCTGACCACAGACATTTGTAGGGCCTCCCTGG
Motif Score	2.897386905
Cell/Tissue List	GM12878; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000563180.1; ENST00000564056.1; ENST00000566369.1; ENST00000564617.5; ENST00000268638.10; ENST00000564803.5
External Link	RMBase: m6A_site_335002
mod ID: M6ASITE028782		Click to Show/Hide the Full List
mod site	chr16:85909429-85909430:+		[6]
Sequence	CATTTGTAGGGCCTCCCTGGACAGGAACAAGCATCCTCCAG
Motif Score	3.643047619
Cell/Tissue List	GM12878; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000564617.5; ENST00000564056.1; ENST00000563180.1; ENST00000566369.1; ENST00000268638.10; ENST00000564803.5
External Link	RMBase: m6A_site_335003
mod ID: M6ASITE028783		Click to Show/Hide the Full List
mod site	chr16:85909435-85909436:+		[6]
Sequence	TAGGGCCTCCCTGGACAGGAACAAGCATCCTCCAGCAGTTT
Motif Score	2.951386905
Cell/Tissue List	GM12878; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000566369.1; ENST00000564617.5; ENST00000268638.10; ENST00000564803.5; ENST00000564056.1; ENST00000563180.1
External Link	RMBase: m6A_site_335004
mod ID: M6ASITE028784		Click to Show/Hide the Full List
mod site	chr16:85909729-85909730:+		[6]
Sequence	TTGTGACAGATTAAAGCAGGACAGCAAAAACATGCCGCACC
Motif Score	3.643047619
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000566369.1; ENST00000563180.1; ENST00000564803.5; ENST00000564056.1; ENST00000268638.10; ENST00000564617.5
External Link	RMBase: m6A_site_335005
mod ID: M6ASITE028785		Click to Show/Hide the Full List
mod site	chr16:85909738-85909739:+		[6]
Sequence	ATTAAAGCAGGACAGCAAAAACATGCCGCACCCTGGTCCTA
Motif Score	2.20572619
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000564056.1; ENST00000563180.1; ENST00000268638.10; ENST00000566369.1; ENST00000564617.5; ENST00000564803.5
External Link	RMBase: m6A_site_335006
mod ID: M6ASITE028786		Click to Show/Hide the Full List
mod site	chr16:85909868-85909869:+		[3]
Sequence	TAGCTGATTTATGAGATAAAACCTAATTACCAGCGCTGGTT
Motif Score	2.185083333
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000564803.5; ENST00000566369.1; ENST00000564617.5; ENST00000564056.1; ENST00000563180.1; ENST00000268638.10
External Link	RMBase: m6A_site_335007
mod ID: M6ASITE028787		Click to Show/Hide the Full List
mod site	chr16:85911573-85911574:+		[3]
Sequence	GTCTGGTTTTCTGTAGGCAAACTAGGCGTGGCAACTGCTGG
Motif Score	2.627720238
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000564803.5; ENST00000564056.1; ENST00000268638.10; ENST00000564617.5; ENST00000566369.1
External Link	RMBase: m6A_site_335008
mod ID: M6ASITE028788		Click to Show/Hide the Full List
mod site	chr16:85913209-85913210:+		[3]
Sequence	TCGGAGTCAGCTCCTTCCAGACTGGTGGGCGCAGCAGCCCA
Motif Score	3.319380952
Cell/Tissue List	peripheral-blood; AML
Seq Type List	m6A-seq; miCLIP
Transcript ID List	ENST00000268638.10; ENST00000564056.1; ENST00000566369.1; ENST00000564803.5
External Link	RMBase: m6A_site_335009
mod ID: M6ASITE028789		Click to Show/Hide the Full List
mod site	chr16:85920208-85920209:+		[5]
Sequence	ATGGCCCCCTTGCGCTCCAAACTCATTCTCGTGCAGGTAAG
Motif Score	2.627720238
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000566369.1; ENST00000562492.5; ENST00000268638.10; ENST00000569607.1
External Link	RMBase: m6A_site_335010
mod ID: M6ASITE028790		Click to Show/Hide the Full List
mod site	chr16:85920939-85920940:+		[7]
Sequence	ACAGTACTGGGGAGTATGGAACAGTTTTGGCAGGAGTACTG
Motif Score	2.951386905
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000569607.1; ENST00000566369.1; ENST00000268638.10; ENST00000562492.5
External Link	RMBase: m6A_site_335011
mod ID: M6ASITE028791		Click to Show/Hide the Full List
mod site	chr16:85921199-85921200:+		[5]
Sequence	CCCCGAGGAGCCGCCGCCAGACCAGGTCTTCCGGATGTTTC
Motif Score	2.876744048
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000268638.10; ENST00000566369.1; ENST00000562492.5; ENST00000569607.1
External Link	RMBase: m6A_site_335012
mod ID: M6ASITE028792		Click to Show/Hide the Full List
mod site	chr16:85921262-85921263:+		[7]
Sequence	GAGATCATTTTTCAGAGAAAACCAACAGATCACCGTCTAAG
Motif Score	2.185083333
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000569607.1; ENST00000268638.10; ENST00000562492.5; ENST00000566369.1
External Link	RMBase: m6A_site_335013

Ref 1	US patent application no. 6,277,636, Antisense inhibition of MADH6 expression.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.
Ref 4	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell. 2017 Jan 9;31(1):127-141. doi: 10.1016/j.ccell.2016.11.017. Epub 2016 Dec 22.
Ref 5	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 6	Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. J Am Chem Soc. 2015 Feb 11;137(5):2107-15. doi: 10.1021/ja513080v. Epub 2015 Feb 2.
Ref 7	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

Visitor Map