m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00887)

Target Name	Transcription factor GATA-6 (GATA6)
Synonyms	GATA-binding factor 6 Click to Show/Hide
Gene Name	GATA6
Chromosomal Location	18q11.2
Function	Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341). Click to Show/Hide
Gene ID	2627
Uniprot ID	GATA6_HUMAN
HGNC ID	HGNC:4174
KEGG ID	hsa:2627

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00887)

Transcription factor GATA-6 (GATA6)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE008607		Click to Show/Hide the Full List
mod site	chr18:22194964-22194965:+		[3]
Sequence	CACTTGAGGTCAGGAGTTCGAGATCAGCCTGGCCAATATGG
Transcript ID List	ENST00000581694.1; ENST00000269216.8; rmsk_4811339
External Link	RMBase: RNA-editing_site_62849

N1-methyladenosine (m1A)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M1ASITE000064		Click to Show/Hide the Full List
mod site	chr18:22171340-22171341:+		[4]
Sequence	CTGCGGGACGCCTCAGCTCGACACGGAGGCGGCGGCCGGAC
Cell/Tissue List	HEK293T
Seq Type List	m1A-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m1A_site_502

5-methylcytidine (m5C)

In total 8 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001475		Click to Show/Hide the Full List
mod site	chr18:22171664-22171665:+		[5]
Sequence	CGGCTTCGTGCACTCTGCGGCCGCGGCGGCAGCAGCCGCGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000581694.1; ENST00000269216.8; rmsk_4811315
External Link	RMBase: m5C_site_20830
mod ID: M5CSITE001476		Click to Show/Hide the Full List
mod site	chr18:22171665-22171666:+		[5]
Sequence	GGCTTCGTGCACTCTGCGGCCGCGGCGGCAGCAGCCGCGGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000581694.1; rmsk_4811315; ENST00000269216.8
External Link	RMBase: m5C_site_20831
mod ID: M5CSITE001477		Click to Show/Hide the Full List
mod site	chr18:22171667-22171668:+		[5]
Sequence	CTTCGTGCACTCTGCGGCCGCGGCGGCAGCAGCCGCGGCGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000581694.1; ENST00000269216.8; rmsk_4811315
External Link	RMBase: m5C_site_20832
mod ID: M5CSITE001478		Click to Show/Hide the Full List
mod site	chr18:22171670-22171671:+		[5]
Sequence	CGTGCACTCTGCGGCCGCGGCGGCAGCAGCCGCGGCGGCGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000581694.1; rmsk_4811315; ENST00000269216.8
External Link	RMBase: m5C_site_20833
mod ID: M5CSITE001479		Click to Show/Hide the Full List
mod site	chr18:22171679-22171680:+		[5]
Sequence	TGCGGCCGCGGCGGCAGCAGCCGCGGCGGCGGCCAGCTCCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000581694.1; rmsk_4811315; ENST00000269216.8
External Link	RMBase: m5C_site_20834
mod ID: M5CSITE001480		Click to Show/Hide the Full List
mod site	chr18:22171680-22171681:+		[5]
Sequence	GCGGCCGCGGCGGCAGCAGCCGCGGCGGCGGCCAGCTCCCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_4811315; ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m5C_site_20835
mod ID: M5CSITE001481		Click to Show/Hide the Full List
mod site	chr18:22171682-22171683:+		[5]
Sequence	GGCCGCGGCGGCAGCAGCCGCGGCGGCGGCCAGCTCCCCGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000581694.1; rmsk_4811315; ENST00000269216.8
External Link	RMBase: m5C_site_20836
mod ID: M5CSITE001482		Click to Show/Hide the Full List
mod site	chr18:22171685-22171686:+		[5]
Sequence	CGCGGCGGCAGCAGCCGCGGCGGCGGCCAGCTCCCCGGTCT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000581694.1; rmsk_4811315; ENST00000269216.8
External Link	RMBase: m5C_site_20837

N6-methyladenosine (m6A)

In total 27 m6A sequence/site(s) in this target gene
mod ID: M6ASITE036744		Click to Show/Hide the Full List
mod site	chr18:22169590-22169591:+		[6]
Sequence	CAGCGCGGCGCAGACCCCGGACTCGCGCTCGCCCGCTGGCG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396034
mod ID: M6ASITE036748		Click to Show/Hide the Full List
mod site	chr18:22171012-22171013:+		[6]
Sequence	AGAAGTCAGATCCCATTTGAACTAGAAAAAGGAGTGGAGGC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m6A_site_396038
mod ID: M6ASITE036749		Click to Show/Hide the Full List
mod site	chr18:22171137-22171138:+		[6]
Sequence	TCAGCTTGGAGCGGCGCCGGACCGTGGATGGCCTTGACTGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; H1B; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m6A_site_396039
mod ID: M6ASITE036750		Click to Show/Hide the Full List
mod site	chr18:22171359-22171360:+		[6]
Sequence	GACACGGAGGCGGCGGCCGGACCCCCGGCCCGCTCGCTGCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m6A_site_396040
mod ID: M6ASITE036751		Click to Show/Hide the Full List
mod site	chr18:22171422-22171423:+		[6]
Sequence	CCCTTCGGGGCTCCCCACGGACCTTCGGCGCCTGGGGTCGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m6A_site_396041
mod ID: M6ASITE036752		Click to Show/Hide the Full List
mod site	chr18:22171475-22171476:+		[6]
Sequence	CAACCTGTCGAGCTGGGAGGACTTGCTGCTGTTCACTGACC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; H1299; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000581694.1; ENST00000269216.8
External Link	RMBase: m6A_site_396042
mod ID: M6ASITE036753		Click to Show/Hide the Full List
mod site	chr18:22171591-22171592:+		[6]
Sequence	AGCCGGAGGAGATGTACCAGACCCTCGCCGCTCTCTCCAGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; H1A; H1B; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m6A_site_396043
mod ID: M6ASITE036754		Click to Show/Hide the Full List
mod site	chr18:22172199-22172200:+		[6]
Sequence	ACGCCTGCCTGGCCCGCCGGACCCTTCGAGACCCCGGTGCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000581694.1; ENST00000269216.8
External Link	RMBase: m6A_site_396044
mod ID: M6ASITE036755		Click to Show/Hide the Full List
mod site	chr18:22172209-22172210:+		[6]
Sequence	GGCCCGCCGGACCCTTCGAGACCCCGGTGCTGCACAGCCTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m6A_site_396045
mod ID: M6ASITE036756		Click to Show/Hide the Full List
mod site	chr18:22176966-22176967:+		[6]
Sequence	CGCCGCAGACCTGCTGGAGGACCTGTCCGAGAGCCGCGAGT
Motif Score	3.622404762
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000581694.1; ENST00000269216.8
External Link	RMBase: m6A_site_396046
mod ID: M6ASITE036757		Click to Show/Hide the Full List
mod site	chr18:22176993-22176994:+		[7]
Sequence	CGAGAGCCGCGAGTGCGTGAACTGCGGCTCCATCCAGACGC
Motif Score	3.373380952
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m6A_site_396047
mod ID: M6ASITE036758		Click to Show/Hide the Full List
mod site	chr18:22182764-22182765:+		[8]
Sequence	AAAATTTTTTAGGTGCCCAGACCACTTGCTATGAAAAAAGA
Motif Score	2.876744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m6A_site_396048
mod ID: M6ASITE036759		Click to Show/Hide the Full List
mod site	chr18:22182795-22182796:+		[8]
Sequence	TGAAAAAAGAGGGAATTCAAACCAGGAAACGAAAACCTAAG
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m6A_site_396049
mod ID: M6ASITE036760		Click to Show/Hide the Full List
mod site	chr18:22182809-22182810:+		[8]
Sequence	ATTCAAACCAGGAAACGAAAACCTAAGAACATAAATAAATC
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m6A_site_396050
mod ID: M6ASITE036761		Click to Show/Hide the Full List
mod site	chr18:22182817-22182818:+		[8]
Sequence	CAGGAAACGAAAACCTAAGAACATAAATAAATCAAAGACTT
Motif Score	2.951386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000581694.1; ENST00000269216.8
External Link	RMBase: m6A_site_396051
mod ID: M6ASITE036762		Click to Show/Hide the Full List
mod site	chr18:22182834-22182835:+		[8]
Sequence	AGAACATAAATAAATCAAAGACTTGCTCTGGTAAATATACT
Motif Score	3.319380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000269216.8; ENST00000581694.1
External Link	RMBase: m6A_site_396052
mod ID: M6ASITE036763		Click to Show/Hide the Full List
mod site	chr18:22200901-22200902:+		[6]
Sequence	GCTTTTGTGCAGCGGTCCAGACAGTGGCGACTGCGCTGACA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; H1A; H1B; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396056
mod ID: M6ASITE036764		Click to Show/Hide the Full List
mod site	chr18:22201059-22201060:+		[6]
Sequence	CCAGCCCGCCTCCGGGGCGGACCCTGCTCCACTTCCAGAAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396058
mod ID: M6ASITE036765		Click to Show/Hide the Full List
mod site	chr18:22201085-22201086:+		[6]
Sequence	CTCCACTTCCAGAAGCCAGGACTAGGACCTGGGCCTTGCCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396059
mod ID: M6ASITE036766		Click to Show/Hide the Full List
mod site	chr18:22201091-22201092:+		[6]
Sequence	TTCCAGAAGCCAGGACTAGGACCTGGGCCTTGCCTGCTATG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396060
mod ID: M6ASITE036767		Click to Show/Hide the Full List
mod site	chr18:22201333-22201334:+		[6]
Sequence	AATATTACTCAGTTTGCAAGACTGCATTGTAACTTTAACAT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; fibroblasts; CD8T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396061
mod ID: M6ASITE036768		Click to Show/Hide the Full List
mod site	chr18:22201366-22201367:+		[9]
Sequence	TTTAACATACACTGTGACTGACGTTTCTCAAAGTTCATATT
Motif Score	2.833690476
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396062
mod ID: M6ASITE036769		Click to Show/Hide the Full List
mod site	chr18:22201421-22201422:+		[10]
Sequence	AAGTCAGTCGGAATTTGTAAACAGGGTAGCAAACAAGATAT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HeLa; fibroblasts; A549; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396063
mod ID: M6ASITE036770		Click to Show/Hide the Full List
mod site	chr18:22201433-22201434:+		[10]
Sequence	ATTTGTAAACAGGGTAGCAAACAAGATATTTTTCTTCCATG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HeLa; fibroblasts; A549; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396064
mod ID: M6ASITE036771		Click to Show/Hide the Full List
mod site	chr18:22201551-22201552:+		[8]
Sequence	ATTTTTTATAATGAATGTAAACATTTTAACTTAATGGTACT
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396065
mod ID: M6ASITE036772		Click to Show/Hide the Full List
mod site	chr18:22201604-22201605:+		[8]
Sequence	AAAGAAAAATGTTAACTTAGACATTCTTATGCTTCTTTTAC
Motif Score	2.897386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396066
mod ID: M6ASITE036773		Click to Show/Hide the Full List
mod site	chr18:22201675-22201676:+		[8]
Sequence	TAAAGAAAAATATTTCAAGAACAAATCTTCTCTCAGGAAAA
Motif Score	2.951386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000269216.8
External Link	RMBase: m6A_site_396067

Ref 1	Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, in?vitro. Pulm Pharmacol Ther. 2014 Aug;28(2):130-7. doi: 10.1016/j.pupt.2014.02.004. Epub 2014 Mar 21.
Ref 2	Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARAlpha agonist with moderate PPARGamma agonist activity in healthy human subjects. Clin Drug Investig. 2013 Nov;33(11):809-16. doi: 10.1007/s40261-013-0128-3.
Ref 3	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 4	The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Nature. 2017 Nov 9;551(7679):251-255. doi: 10.1038/nature24456. Epub 2017 Oct 25.
Ref 5	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 8	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 9	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 10	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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