m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00884)

Target Name	Ras-related protein Rab-27B (RAB27B)
Synonyms	EC 3.6.5.2; C25KG Click to Show/Hide
Gene Name	RAB27B
Chromosomal Location	18q21.2
Family	Small GTPase superfamily, Rab family
Function	Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). Click to Show/Hide
Gene ID	5874
Uniprot ID	RB27B_HUMAN
HGNC ID	HGNC:9767
KEGG ID	hsa:5874

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00884)

Ras-related protein Rab-27B (RAB27B)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE008635		Click to Show/Hide the Full List
mod site	chr18:54727051-54727052:+		[2]
Sequence	GAGTGCAATGGCACAATCTCAGCTCACTGCAACCTCCGCCT
Transcript ID List	ENST00000586570.5
External Link	RMBase: RNA-editing_site_63569

N6-methyladenosine (m6A)

In total 32 m6A sequence/site(s) in this target gene
mod ID: M6ASITE037301		Click to Show/Hide the Full List
mod site	chr18:54828521-54828522:+		[3]
Sequence	TGCGGACCGCCCGGCCTTGGACCCATCCGGAGCCACAGGTT
Motif Score	3.622404762
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000586570.5; ENST00000586594.1; ENST00000262094.10
External Link	RMBase: m6A_site_401795
mod ID: M6ASITE037302		Click to Show/Hide the Full List
mod site	chr18:54828648-54828649:+		[4]
Sequence	GGCTTGGGAAGGGGAAGGAAACCTCTCTGAAATCTGACACC
Motif Score	2.185083333
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000586594.1; ENST00000586570.5; ENST00000262094.10
External Link	RMBase: m6A_site_401796
mod ID: M6ASITE037303		Click to Show/Hide the Full List
mod site	chr18:54828687-54828688:+		[4]
Sequence	CCTGCTCTCCCGGCAAGGAAACTTCGCAGGCTGGTGAGTTG
Motif Score	2.627720238
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000586594.1; ENST00000586570.5; ENST00000262094.10
External Link	RMBase: m6A_site_401797
mod ID: M6ASITE037304		Click to Show/Hide the Full List
mod site	chr18:54877576-54877577:+		[4]
Sequence	TCCTATACAGACCGACCAAGACCATCACTATGACCGATGGA
Motif Score	2.876744048
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000262094.10; ENST00000586594.1; ENST00000586570.5
External Link	RMBase: m6A_site_401798
mod ID: M6ASITE037305		Click to Show/Hide the Full List
mod site	chr18:54888057-54888058:+		[5]
Sequence	ATTAATTGGCAACAAGGCAGACCTACCAGATCAGAGGGAAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000586594.1; ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401799
mod ID: M6ASITE037306		Click to Show/Hide the Full List
mod site	chr18:54888100-54888101:+		[5]
Sequence	AATGAACGGCAAGCTCGGGAACTGGCTGACAAATATGGGTA
Motif Score	3.373380952
Cell/Tissue List	HeLa; A549; HepG2; peripheral-blood; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592334.1; ENST00000586594.1; ENST00000262094.10
External Link	RMBase: m6A_site_401800
mod ID: M6ASITE037307		Click to Show/Hide the Full List
mod site	chr18:54889239-54889240:+		[5]
Sequence	CTAGCATACCATATTTTGAAACAAGTGCAGCAACTGGACAG
Motif Score	2.20572619
Cell/Tissue List	HeLa; A549; hESC-HEK293T; HepG2; fibroblasts; peripheral-blood; HEK293A-TOA; iSLK; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401801
mod ID: M6ASITE037308		Click to Show/Hide the Full List
mod site	chr18:54889251-54889252:+		[6]
Sequence	ATTTTGAAACAAGTGCAGCAACTGGACAGAATGTGGAGAAA
Motif Score	2.595904762
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401802
mod ID: M6ASITE037309		Click to Show/Hide the Full List
mod site	chr18:54889256-54889257:+		[5]
Sequence	GAAACAAGTGCAGCAACTGGACAGAATGTGGAGAAAGCTGT
Motif Score	3.643047619
Cell/Tissue List	HeLa; A549; HepG2; fibroblasts; peripheral-blood; HEK293A-TOA; iSLK; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401803
mod ID: M6ASITE037310		Click to Show/Hide the Full List
mod site	chr18:54889281-54889282:+		[5]
Sequence	ATGTGGAGAAAGCTGTAGAAACCCTTTTGGACTTAATCATG
Motif Score	2.185083333
Cell/Tissue List	HeLa; A549; HepG2; fibroblasts; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401804
mod ID: M6ASITE037311		Click to Show/Hide the Full List
mod site	chr18:54889291-54889292:+		[5]
Sequence	AGCTGTAGAAACCCTTTTGGACTTAATCATGAAGCGAATGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; A549; HepG2; fibroblasts; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401805
mod ID: M6ASITE037312		Click to Show/Hide the Full List
mod site	chr18:54889313-54889314:+		[5]
Sequence	TTAATCATGAAGCGAATGGAACAGTGTGTGGAGAAGACACA
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549; HepG2; fibroblasts; H1299; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401806
mod ID: M6ASITE037313		Click to Show/Hide the Full List
mod site	chr18:54889329-54889330:+		[5]
Sequence	TGGAACAGTGTGTGGAGAAGACACAAATCCCTGATACTGTC
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; HepG2; H1B; H1A; fibroblasts; H1299; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401807
mod ID: M6ASITE037314		Click to Show/Hide the Full List
mod site	chr18:54889369-54889370:+		[5]
Sequence	CAATGGTGGAAATTCTGGAAACTTGGATGGGGAAAAGCCAC
Motif Score	2.627720238
Cell/Tissue List	HeLa; A549; HepG2; H1B; H1A; fibroblasts; H1299; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401808
mod ID: M6ASITE037315		Click to Show/Hide the Full List
mod site	chr18:54889413-54889414:+		[5]
Sequence	AGAAGAAATGTATCTGCTAGACTCTACATAGAAACTGAACA
Motif Score	3.319380952
Cell/Tissue List	HeLa; A549; HepG2; U2OS; fibroblasts; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401809
mod ID: M6ASITE037316		Click to Show/Hide the Full List
mod site	chr18:54889426-54889427:+		[5]
Sequence	CTGCTAGACTCTACATAGAAACTGAACATCAAGAACCCCAC
Motif Score	2.627720238
Cell/Tissue List	HeLa; A549; HepG2; U2OS; fibroblasts; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401810
mod ID: M6ASITE037317		Click to Show/Hide the Full List
mod site	chr18:54889431-54889432:+		[5]
Sequence	AGACTCTACATAGAAACTGAACATCAAGAACCCCACCAAAA
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549; HepG2; U2OS; fibroblasts; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401811
mod ID: M6ASITE037318		Click to Show/Hide the Full List
mod site	chr18:54889440-54889441:+		[5]
Sequence	ATAGAAACTGAACATCAAGAACCCCACCAAAATATTACTTT
Motif Score	2.930744048
Cell/Tissue List	HeLa; A549; HepG2; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401812
mod ID: M6ASITE037319		Click to Show/Hide the Full List
mod site	chr18:54889466-54889467:+		[5]
Sequence	CCAAAATATTACTTTTAAAAACAATGACAAACCACACAATT
Motif Score	2.20572619
Cell/Tissue List	HeLa; A549; HepG2; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401813
mod ID: M6ASITE037320		Click to Show/Hide the Full List
mod site	chr18:54889476-54889477:+		[5]
Sequence	ACTTTTAAAAACAATGACAAACCACACAATTGTTGTTGAGT
Motif Score	2.185083333
Cell/Tissue List	HeLa; A549; HepG2; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401814
mod ID: M6ASITE037321		Click to Show/Hide the Full List
mod site	chr18:54889499-54889500:+		[7]
Sequence	ACACAATTGTTGTTGAGTAAACCACGCACAATGGCATGTCT
Motif Score	2.185083333
Cell/Tissue List	HeLa; A549; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401815
mod ID: M6ASITE037322		Click to Show/Hide the Full List
mod site	chr18:54889552-54889553:+		[7]
Sequence	CAGAAAATCTATTTTAAGAAACCAGAATAGTCAACAGTGTT
Motif Score	2.185083333
Cell/Tissue List	HeLa; A549; Huh7; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401816
mod ID: M6ASITE037323		Click to Show/Hide the Full List
mod site	chr18:54889610-54889611:+		[7]
Sequence	TATCCCTGAGGCCCTTTCAAACATGATCAAAGATTTCCCAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; A549; Huh7; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401817
mod ID: M6ASITE037324		Click to Show/Hide the Full List
mod site	chr18:54889693-54889694:+		[8]
Sequence	AGAGAAAATGAGTATATAAGACAATATACAAGAAGAAATAT
Motif Score	2.897386905
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401818
mod ID: M6ASITE037325		Click to Show/Hide the Full List
mod site	chr18:54889733-54889734:+		[8]
Sequence	TCAGTGAGTTTTAAATCAGAACAAGTTACCTGTCACATTGA
Motif Score	2.951386905
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401819
mod ID: M6ASITE037326		Click to Show/Hide the Full List
mod site	chr18:54891152-54891153:+		[8]
Sequence	CATTCAGCTTACCTCTGCGAACTTCTATCTGGTATTGAATC
Motif Score	3.373380952
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401820
mod ID: M6ASITE037327		Click to Show/Hide the Full List
mod site	chr18:54891183-54891184:+		[8]
Sequence	GTATTGAATCAGTTTCAGAAACACAGACAGATCCAAGGAAA
Motif Score	2.20572619
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000262094.10; ENST00000592334.1
External Link	RMBase: m6A_site_401822
mod ID: M6ASITE037328		Click to Show/Hide the Full List
mod site	chr18:54891189-54891190:+		[8]
Sequence	AATCAGTTTCAGAAACACAGACAGATCCAAGGAAATGTCTC
Motif Score	2.897386905
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401823
mod ID: M6ASITE037329		Click to Show/Hide the Full List
mod site	chr18:54891231-54891232:+		[8]
Sequence	TTATAATGTTCTTAGGATGGACTAGACCCATAAATGTGCCA
Motif Score	4.065041667
Cell/Tissue List	A549
Seq Type List	m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401826
mod ID: M6ASITE037330		Click to Show/Hide the Full List
mod site	chr18:54891236-54891237:+		[8]
Sequence	ATGTTCTTAGGATGGACTAGACCCATAAATGTGCCATGAAT
Motif Score	2.876744048
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401827
mod ID: M6ASITE037331		Click to Show/Hide the Full List
mod site	chr18:54892316-54892317:+		[9]
Sequence	GACCAAATTTGTCTCCAACCACATAGCTCATTTCCTATAAT
Motif Score	2.053113095
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401828
mod ID: M6ASITE037332		Click to Show/Hide the Full List
mod site	chr18:54892858-54892859:+		[9]
Sequence	ATTGTTCTTTGCCAACCTGTACAGGTAGATGAACCAGGCGA
Motif Score	2.856142857
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000592334.1; ENST00000262094.10
External Link	RMBase: m6A_site_401829

Ref 1	Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships. Iran J Pharm Res. 2011 Autumn; 10(4): 655-683.
Ref 2	A survey of RNA editing in human brain. Genome Res. 2004 Dec;14(12):2379-87. doi: 10.1101/gr.2951204. Epub 2004 Nov 15.
Ref 3	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 4	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 7	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 8	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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