m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00869)

Target Name	Insulin-like growth factor-binding protein 4 (IGFBP4)
Synonyms	IBP-4; IGF-binding protein 4; IGFBP-4 Click to Show/Hide
Gene Name	IGFBP4
Chromosomal Location	17q21.2
Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Click to Show/Hide
Gene ID	3487
Uniprot ID	IBP4_HUMAN
HGNC ID	HGNC:5473
KEGG ID	hsa:3487

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00869)

Insulin-like growth factor-binding protein 4 (IGFBP4)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000221		Click to Show/Hide the Full List
mod site	chr17:40457312-40457313:+		[2]
Sequence	AGAGCCCTGCTGTGGGAGAGCGAAGGGGGTCAAAGGAAGAC
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: ac4C_site_793

N1-methyladenosine (m1A)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M1ASITE000057		Click to Show/Hide the Full List
mod site	chr17:40456880-40456881:+		[3]
Sequence	CCTGGTGTGTTTCCAGATCGATCCTGGATTCACTCACTCAC
Cell/Tissue List	HEK293T
Seq Type List	m1A-MAP-seq; m1A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m1A_site_458

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001115		Click to Show/Hide the Full List
mod site	chr17:40457516-40457517:+		[4]
Sequence	CATGAAGTCACCGGGATGAACCTATCCTTCCAGTGGCTCGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m5C_site_18840

N6-methyladenosine (m6A)

In total 20 m6A sequence/site(s) in this target gene
mod ID: M6ASITE032408		Click to Show/Hide the Full List
mod site	chr17:40452984-40452985:+		[5]
Sequence	TTATCGCTACCTGAATACAGACAAGGACGAGGGTGACCACC
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361923
mod ID: M6ASITE032409		Click to Show/Hide the Full List
mod site	chr17:40453077-40453078:+		[6]
Sequence	GCACTTCGCCAAAATTCGAGACCGGAGCACCAGTGGGGGCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; MM6; CD4T; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361924
mod ID: M6ASITE032410		Click to Show/Hide the Full List
mod site	chr17:40454003-40454004:+		[6]
Sequence	ACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361925
mod ID: M6ASITE032411		Click to Show/Hide the Full List
mod site	chr17:40456494-40456495:+		[6]
Sequence	TGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGAAGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361926
mod ID: M6ASITE032412		Click to Show/Hide the Full List
mod site	chr17:40456548-40456549:+		[6]
Sequence	GGAGCCAAAGGGGGAGCTGGACTGCCACCAGCTGGCTGACA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; H1A; H1B; A549; MM6; CD4T; peripheral-blood; GSC-11; MSC; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361927
mod ID: M6ASITE032413		Click to Show/Hide the Full List
mod site	chr17:40456603-40456604:+		[6]
Sequence	GGCCTGCCAGCAGGCCAGGGACTCAGCGTCCCCTGCTACTC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; H1A; H1B; A549; MM6; peripheral-blood; MSC; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361928
mod ID: M6ASITE032414		Click to Show/Hide the Full List
mod site	chr17:40456826-40456827:+		[7]
Sequence	GTGTTACACAGCCCAAGAGGACTGAGACTGGCACTTAGCCC
Motif Score	4.065041667
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361929
mod ID: M6ASITE032415		Click to Show/Hide the Full List
mod site	chr17:40456832-40456833:+		[7]
Sequence	CACAGCCCAAGAGGACTGAGACTGGCACTTAGCCCAAGAGG
Motif Score	3.319380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361930
mod ID: M6ASITE032416		Click to Show/Hide the Full List
mod site	chr17:40457089-40457090:+		[8]
Sequence	CCAGAGTCAGAGGAGAAGAGACATGTACCTTGACCATCGTC
Motif Score	2.897386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361931
mod ID: M6ASITE032417		Click to Show/Hide the Full List
mod site	chr17:40457188-40457189:+		[6]
Sequence	GTAATGGTCACGAGGTCCAGACCCACTCCCAAAGCTCAGAC
Motif Score	2.876744048
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361932
mod ID: M6ASITE032418		Click to Show/Hide the Full List
mod site	chr17:40457207-40457208:+		[6]
Sequence	GACCCACTCCCAAAGCTCAGACTTGCCAGGCTCCCTTTCTC
Motif Score	3.319380952
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361933
mod ID: M6ASITE032419		Click to Show/Hide the Full List
mod site	chr17:40457331-40457332:+		[6]
Sequence	GCGAAGGGGGTCAAAGGAAGACTTGAAGCACAGAGGGCTAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361934
mod ID: M6ASITE032420		Click to Show/Hide the Full List
mod site	chr17:40457409-40457410:+		[6]
Sequence	AAGAAAGAATGCAAGAGTGGACTGAATGTGCCTAATGGAGA
Motif Score	4.065041667
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361935
mod ID: M6ASITE032421		Click to Show/Hide the Full List
mod site	chr17:40457432-40457433:+		[6]
Sequence	GAATGTGCCTAATGGAGAAGACCCACGTGCTAGGGGATGAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361936
mod ID: M6ASITE032422		Click to Show/Hide the Full List
mod site	chr17:40457515-40457516:+		[6]
Sequence	CCATGAAGTCACCGGGATGAACCTATCCTTCCAGTGGCTCG
Motif Score	2.930744048
Cell/Tissue List	HeLa; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361937
mod ID: M6ASITE032423		Click to Show/Hide the Full List
mod site	chr17:40457641-40457642:+		[6]
Sequence	GCTTGACTGGATGGAAGGAGACTTAGGAACCTACCAGTTGG
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361938
mod ID: M6ASITE032424		Click to Show/Hide the Full List
mod site	chr17:40457649-40457650:+		[6]
Sequence	GGATGGAAGGAGACTTAGGAACCTACCAGTTGGCCATGATG
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361939
mod ID: M6ASITE032425		Click to Show/Hide the Full List
mod site	chr17:40457700-40457701:+		[6]
Sequence	TTTTTCTTTTTTTTAACAAAACAGAACAAAACCAAAAAATG
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361940
mod ID: M6ASITE032426		Click to Show/Hide the Full List
mod site	chr17:40457705-40457706:+		[6]
Sequence	CTTTTTTTTAACAAAACAGAACAAAACCAAAAAATGTCCAG
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361941
mod ID: M6ASITE032427		Click to Show/Hide the Full List
mod site	chr17:40457710-40457711:+		[6]
Sequence	TTTTAACAAAACAGAACAAAACCAAAAAATGTCCAGATGAT
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000269593.5
External Link	RMBase: m6A_site_361942

Ref 1	Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. doi: 10.1016/j.bmc.2008.10.090. Epub 2008 Nov 8.
Ref 2	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 3	Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Mol Cell. 2017 Dec 7;68(5):993-1005.e9. doi: 10.1016/j.molcel.2017.10.019. Epub 2017 Nov 5.
Ref 4	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 8	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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