m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00864)

Target Name	Dual specificity protein phosphatase 1 (DUSP1)
Synonyms	EC 3.1.3.16; EC 3.1.3.48; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100 Click to Show/Hide
Gene Name	DUSP1
Chromosomal Location	5q35.1
Family	Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Function	Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. Click to Show/Hide
Gene ID	1843
Uniprot ID	DUS1_HUMAN
HGNC ID	HGNC:3064
KEGG ID	hsa:1843

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00864)

Dual specificity protein phosphatase 1 (DUSP1)

5-methylcytidine (m5C)

In total 8 m6A sequence/site(s) in this target gene
mod ID: M5CSITE003687		Click to Show/Hide the Full List
mod site	chr5:172768770-172768771:-		[2]
Sequence	AGCCCCATTACGACCTCTCCCAGCTGCTGAAAGGCCACGGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m5C_site_36357
mod ID: M5CSITE003688		Click to Show/Hide the Full List
mod site	chr5:172770592-172770593:-		[2]
Sequence	CGCGCCGCGCAAGTCTTCTTCCTCAAAGGTACGCCCTCGGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m5C_site_36358
mod ID: M5CSITE003689		Click to Show/Hide the Full List
mod site	chr5:172770775-172770776:-		[3]
Sequence	CGGCGCCGGGCCAAGGGCGCCATGGGCCTGGAGCACATCGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m5C_site_36359
mod ID: M5CSITE003690		Click to Show/Hide the Full List
mod site	chr5:172770776-172770777:-		[3]
Sequence	GCGGCGCCGGGCCAAGGGCGCCATGGGCCTGGAGCACATCG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m5C_site_36360
mod ID: M5CSITE003691		Click to Show/Hide the Full List
mod site	chr5:172770778-172770779:-		[3]
Sequence	GTGCGGCGCCGGGCCAAGGGCGCCATGGGCCTGGAGCACAT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m5C_site_36361
mod ID: M5CSITE003692		Click to Show/Hide the Full List
mod site	chr5:172770789-172770790:-		[3]
Sequence	TCAGCACCATCGTGCGGCGCCGGGCCAAGGGCGCCATGGGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m5C_site_36362
mod ID: M5CSITE003693		Click to Show/Hide the Full List
mod site	chr5:172770790-172770791:-		[3]
Sequence	TTCAGCACCATCGTGCGGCGCCGGGCCAAGGGCGCCATGGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m5C_site_36363
mod ID: M5CSITE003694		Click to Show/Hide the Full List
mod site	chr5:172770792-172770793:-		[3]
Sequence	GCTTCAGCACCATCGTGCGGCGCCGGGCCAAGGGCGCCATG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m5C_site_36364

N6-methyladenosine (m6A)

In total 34 m6A sequence/site(s) in this target gene
mod ID: M6ASITE072752		Click to Show/Hide the Full List
mod site	chr5:172768158-172768159:-		[4]
Sequence	ATATTTCTTCTTCTAAGAAGACATTTTGTTACATAAGGATG
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697807
mod ID: M6ASITE072753		Click to Show/Hide the Full List
mod site	chr5:172768190-172768191:-		[5]
Sequence	ATGTTTGCTGATTATTTATGACCTGAAATAATATATTTCTT
Motif Score	2.839113095
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697808
mod ID: M6ASITE072754		Click to Show/Hide the Full List
mod site	chr5:172768300-172768301:-		[5]
Sequence	TTTTTGTTTTTGAGTACTGTACTATCCTGTAAATATATCTT
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697809
mod ID: M6ASITE072755		Click to Show/Hide the Full List
mod site	chr5:172768334-172768335:-		[6]
Sequence	CATTGTCTACTCCTAGAAGAACCAAATACCTCAATTTTTGT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697810
mod ID: M6ASITE072756		Click to Show/Hide the Full List
mod site	chr5:172768346-172768347:-		[5]
Sequence	CTTCACAAATGTCATTGTCTACTCCTAGAAGAACCAAATAC
Motif Score	2.500660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697811
mod ID: M6ASITE072757		Click to Show/Hide the Full List
mod site	chr5:172768362-172768363:-		[4]
Sequence	TTGTGTAGGTGTCTGCCTTCACAAATGTCATTGTCTACTCC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697812
mod ID: M6ASITE072758		Click to Show/Hide the Full List
mod site	chr5:172768409-172768410:-		[4]
Sequence	TTATTCCCGACGACACATATACATATGAGAATATACCTTAT
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697813
mod ID: M6ASITE072759		Click to Show/Hide the Full List
mod site	chr5:172768420-172768421:-		[5]
Sequence	ACCTACCAGTATTATTCCCGACGACACATATACATATGAGA
Motif Score	2.839505952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697814
mod ID: M6ASITE072760		Click to Show/Hide the Full List
mod site	chr5:172768444-172768445:-		[5]
Sequence	GTAGAATCTCTTCATGCTTGACATACCTACCAGTATTATTC
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697815
mod ID: M6ASITE072761		Click to Show/Hide the Full List
mod site	chr5:172768508-172768509:-		[6]
Sequence	AATGGGGCAGAAGAGAAAGGACTCAGTGTGTGATCCGGTTT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; U2OS; fibroblasts; MT4; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697816
mod ID: M6ASITE072762		Click to Show/Hide the Full List
mod site	chr5:172768532-172768533:-		[5]
Sequence	GGGTACATCAAGTCCATCTGACAAAATGGGGCAGAAGAGAA
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697817
mod ID: M6ASITE072763		Click to Show/Hide the Full List
mod site	chr5:172768565-172768566:-		[6]
Sequence	CTGAACTCAGCACATTCGGGACCAATATATAGTGGGTACAT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697818
mod ID: M6ASITE072764		Click to Show/Hide the Full List
mod site	chr5:172768581-172768582:-		[6]
Sequence	AGCGTCAAGACATTTGCTGAACTCAGCACATTCGGGACCAA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; GM12878; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq; DART-seq; m6A-CLIP/IP
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697819
mod ID: M6ASITE072765		Click to Show/Hide the Full List
mod site	chr5:172768592-172768593:-		[6]
Sequence	GGTGATGACTTAGCGTCAAGACATTTGCTGAACTCAGCACA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; brain; kidney; liver; A549; hESC-HEK293T; U2OS; hNPCs; hESCs; fibroblasts; GM12878; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697820
mod ID: M6ASITE072766		Click to Show/Hide the Full List
mod site	chr5:172768649-172768650:-		[5]
Sequence	GGCTGGTCCTTATTTATTTAACTTCACCCGAGTTCCTCTGG
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697821
mod ID: M6ASITE072767		Click to Show/Hide the Full List
mod site	chr5:172768690-172768691:-		[7]
Sequence	TTGAGAGGAGAAATGCAATAACTCTGGGAGGGGCTCGAGAG
Motif Score	2.590089286
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697822
mod ID: M6ASITE072768		Click to Show/Hide the Full List
mod site	chr5:172768722-172768723:-		[6]
Sequence	GCTCTTCACATCCCATTGGGACTCCATGCTCCTTGAGAGGA
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; CD8T; H1299; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697823
mod ID: M6ASITE072769		Click to Show/Hide the Full List
mod site	chr5:172768735-172768736:-		[4]
Sequence	CACGGGAGGTGAGGCTCTTCACATCCCATTGGGACTCCATG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697824
mod ID: M6ASITE072770		Click to Show/Hide the Full List
mod site	chr5:172768778-172768779:-		[5]
Sequence	ACCTTCAGAGCCCCATTACGACCTCTCCCAGCTGCTGAAAG
Motif Score	2.844928571
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697825
mod ID: M6ASITE072771		Click to Show/Hide the Full List
mod site	chr5:172768813-172768814:-		[6]
Sequence	CATCCCTGTCCACTCCACGAACAGTGCGCTGAGCTACCTTC
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; brain; A549; hESC-HEK293T; U2OS; hNPCs; hESCs; fibroblasts; GM12878; MT4; H1299; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697826
mod ID: M6ASITE072772		Click to Show/Hide the Full List
mod site	chr5:172769039-172769040:-		[6]
Sequence	GCCTTGCTTACCTTATGAGGACTAATCGAGTCAAGCTGGAC
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; A549; HEK293T; endometrial
Seq Type List	m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697827
mod ID: M6ASITE072773		Click to Show/Hide the Full List
mod site	chr5:172769612-172769613:-		[8]
Sequence	GGAGGACAACCACAAGGCAGACATCAGCTCCTGGTTCAACG
Motif Score	2.897386905
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697828
mod ID: M6ASITE072774		Click to Show/Hide the Full List
mod site	chr5:172769627-172769628:-		[8]
Sequence	CAAGAGCATCCCTGTGGAGGACAACCACAAGGCAGACATCA
Motif Score	3.643047619
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697829
mod ID: M6ASITE072775		Click to Show/Hide the Full List
mod site	chr5:172769648-172769649:-		[4]
Sequence	TTTTGAGGGTCACTACCAGTACAAGAGCATCCCTGTGGAGG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697830
mod ID: M6ASITE072776		Click to Show/Hide the Full List
mod site	chr5:172769729-172769730:-		[6]
Sequence	GTATCACGCTTCCCGCAAGGACATGCTGGATGCCTTGGGCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; kidney; hESC-HEK293T; HepG2
Seq Type List	m6A-seq; m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697831
mod ID: M6ASITE072777		Click to Show/Hide the Full List
mod site	chr5:172769762-172769763:-		[5]
Sequence	GGAAATCCTGCCCTTTCTGTACCTGGGCAGTGCGTATCACG
Motif Score	2.8355
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697832
mod ID: M6ASITE072778		Click to Show/Hide the Full List
mod site	chr5:172769881-172769882:-		[7]
Sequence	TCACTCGGTATCTGAAATTGACTTTTCCAGCAGAAAGTTTT
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697833
mod ID: M6ASITE072779		Click to Show/Hide the Full List
mod site	chr5:172770259-172770260:-		[6]
Sequence	TGCCCGGAGCTGTGCAGCAAACAGTCGACCCCCATGGGGCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697834
mod ID: M6ASITE072780		Click to Show/Hide the Full List
mod site	chr5:172770869-172770870:-		[6]
Sequence	GGCGCAATGCCTGCTGCTGGACTGCCGCTCCTTCTTCGCTT
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; GM12878; H1299; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697835
mod ID: M6ASITE072781		Click to Show/Hide the Full List
mod site	chr5:172770999-172771000:-		[4]
Sequence	GCCCTTGGCCCCGAGAACAGACAAAGAGCACCGCAGGGCCG
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T; A549
Seq Type List	MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697836
mod ID: M6ASITE072782		Click to Show/Hide the Full List
mod site	chr5:172771003-172771004:-		[6]
Sequence	CCCTGCCCTTGGCCCCGAGAACAGACAAAGAGCACCGCAGG
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; H1A; H1B; fibroblasts; GM12878; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697837
mod ID: M6ASITE072783		Click to Show/Hide the Full List
mod site	chr5:172771057-172771058:-		[6]
Sequence	TTTTGGTTCGGCGCAGAGAGACCCGGGGGTCTAGCTTTTCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697838
mod ID: M6ASITE072784		Click to Show/Hide the Full List
mod site	chr5:172771140-172771141:-		[6]
Sequence	TCGGAGGGGCAGTCGGGGGAACCGCGAAGAAGCCGAGGAGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; A549; HEK293T; Jurkat; CD4T; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697839
mod ID: M6ASITE072785		Click to Show/Hide the Full List
mod site	chr5:172771187-172771188:-		[6]
Sequence	GGCCAGGCTCGCTGCGAAGGACATTTGGGCTGTGTGTGCGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; hESC-HEK293T; A549; Jurkat; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000239223.4
External Link	RMBase: m6A_site_697840

Ref 1	Clinical pipeline report, company report or official report of AffyImmune Therapeutics.
Ref 2	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 3	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 4	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 5	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 8	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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