m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00862)

Target Name	Retinaldehyde dehydrogenase 3 (ALDH1A3)
Synonyms	RALDH-3; RalDH3; EC 1.2.1.36; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3 Click to Show/Hide
Gene Name	ALDH1A3
Chromosomal Location	15q26.3
Family	Aldehyde dehydrogenase family
Function	Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity) (PubMed:27759097). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (PubMed:27759097). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity). Click to Show/Hide
Gene ID	220
Uniprot ID	AL1A3_HUMAN
HGNC ID	HGNC:409
KEGG ID	hsa:220

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00862)

Retinaldehyde dehydrogenase 3 (ALDH1A3)

N6-methyladenosine (m6A)

In total 34 m6A sequence/site(s) in this target gene
mod ID: M6ASITE025048		Click to Show/Hide the Full List
mod site	chr15:100879871-100879872:+		[2]
Sequence	GCCGAGCCGGTGCGCCGCAGACTAGGGCGCCTCGGGCCAGG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; A549; GSC-11; HEK293T; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000560555.1; ENST00000558568.1; ENST00000557963.1; ENST00000329841.10; ENST00000561338.5; ENST00000558033.5
External Link	RMBase: m6A_site_297596
mod ID: M6ASITE025049		Click to Show/Hide the Full List
mod site	chr15:100879947-100879948:+		[2]
Sequence	CGTGGAAAACGGGCAGCCGGACAGGAAGCCGCCGGCCCTGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; A549; HepG2; GSC-11; HEK293T; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000329841.10; ENST00000561338.5; ENST00000558568.1; ENST00000346623.6; ENST00000557963.1; ENST00000560555.1; ENST00000558033.5
External Link	RMBase: m6A_site_297597
mod ID: M6ASITE025050		Click to Show/Hide the Full List
mod site	chr15:100880062-100880063:+		[3]
Sequence	CCCCTGCGCTGGGCAGCCAGACTCGGGGCGGCGGGGGCGAG
Motif Score	3.319380952
Cell/Tissue List	HEK293T; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000329841.10; ENST00000558033.5; ENST00000346623.6; ENST00000557963.1; ENST00000558568.1; ENST00000561338.5; ENST00000560555.1
External Link	RMBase: m6A_site_297598
mod ID: M6ASITE025051		Click to Show/Hide the Full List
mod site	chr15:100880887-100880888:+		[4]
Sequence	GGAGCGCGACCCGATGGAGGACACCCCCAGGCTGTCTGGCG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000558568.1; ENST00000329841.10; ENST00000561338.5; ENST00000346623.6; ENST00000560555.1; ENST00000557963.1; ENST00000558033.5
External Link	RMBase: m6A_site_297599
mod ID: M6ASITE025052		Click to Show/Hide the Full List
mod site	chr15:100885317-100885318:+		[5]
Sequence	AGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGG
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000346623.6; ENST00000558033.5; ENST00000560555.1; ENST00000558568.1; ENST00000329841.10; ENST00000561338.5
External Link	RMBase: m6A_site_297600
mod ID: M6ASITE025053		Click to Show/Hide the Full List
mod site	chr15:100887581-100887582:+		[2]
Sequence	GGTCGCTCAGCCCGACGTGGACAAGGCTGTGGAGGCTGCAC
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T; HEC-1-A
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000561338.5; ENST00000329841.10; ENST00000558033.5; ENST00000346623.6; ENST00000560555.1
External Link	RMBase: m6A_site_297601
mod ID: M6ASITE025054		Click to Show/Hide the Full List
mod site	chr15:100887695-100887696:+		[2]
Sequence	GGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGTGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000560555.1; ENST00000558033.5; ENST00000561338.5; ENST00000346623.6; ENST00000329841.10
External Link	RMBase: m6A_site_297602
mod ID: M6ASITE025055		Click to Show/Hide the Full List
mod site	chr15:100892125-100892126:+		[2]
Sequence	CTTCAGAGAGCTTCCTGGGAACACACAAGCACACACGACTG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6; ENST00000558033.5; ENST00000561338.5; ENST00000560555.1
External Link	RMBase: m6A_site_297603
mod ID: M6ASITE025056		Click to Show/Hide the Full List
mod site	chr15:100894011-100894012:+		[5]
Sequence	ACCCGCCCTCTGCTGTGGGAACACCATGGTCCTGAAGCCTG
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10; ENST00000558033.5
External Link	RMBase: m6A_site_297608
mod ID: M6ASITE025057		Click to Show/Hide the Full List
mod site	chr15:100895957-100895958:+		[2]
Sequence	GTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGC
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000346623.6; ENST00000558033.5; ENST00000329841.10
External Link	RMBase: m6A_site_297622
mod ID: M6ASITE025058		Click to Show/Hide the Full List
mod site	chr15:100898155-100898156:+		[6]
Sequence	GCTGGAGCTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGG
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10; ENST00000558869.1
External Link	RMBase: m6A_site_297623
mod ID: M6ASITE025059		Click to Show/Hide the Full List
mod site	chr15:100900724-100900725:+		[2]
Sequence	CAAGAAACGGCCCGTGGGAGACCCCTTCGATGTCAAAACAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6; ENST00000558869.1
External Link	RMBase: m6A_site_297624
mod ID: M6ASITE025060		Click to Show/Hide the Full List
mod site	chr15:100900741-100900742:+		[2]
Sequence	GAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGGTA
Motif Score	2.20572619
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10; ENST00000558869.1
External Link	RMBase: m6A_site_297625
mod ID: M6ASITE025061		Click to Show/Hide the Full List
mod site	chr15:100900746-100900747:+		[2]
Sequence	CCCTTCGATGTCAAAACAGAACAGGGGCCTCAGGTAATCCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10; ENST00000558869.1
External Link	RMBase: m6A_site_297626
mod ID: M6ASITE025062		Click to Show/Hide the Full List
mod site	chr15:100905541-100905542:+		[5]
Sequence	GATTGATCAAAAGCAGTTCGACAAAATCTTAGAGCTGATCG
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000558869.1; ENST00000329841.10; ENST00000346623.6
External Link	RMBase: m6A_site_297627
mod ID: M6ASITE025063		Click to Show/Hide the Full List
mod site	chr15:100905616-100905617:+		[2]
Sequence	CGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAAC
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10; ENST00000558869.1
External Link	RMBase: m6A_site_297628
mod ID: M6ASITE025064		Click to Show/Hide the Full List
mod site	chr15:100905635-100905636:+		[2]
Sequence	GACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAAGT
Motif Score	2.185083333
Cell/Tissue List	HeLa; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6; ENST00000558869.1
External Link	RMBase: m6A_site_297629
mod ID: M6ASITE025065		Click to Show/Hide the Full List
mod site	chr15:100905661-100905662:+		[2]
Sequence	TGTCTTCTCAGAAGTCACAGACAACATGCGGATTGCCAAAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000558869.1; ENST00000329841.10; ENST00000346623.6
External Link	RMBase: m6A_site_297630
mod ID: M6ASITE025066		Click to Show/Hide the Full List
mod site	chr15:100907200-100907201:+		[2]
Sequence	GCGAATAGCACCGACTATGGACTCACAGCAGCCGTGTTCAC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6; ENST00000558869.1
External Link	RMBase: m6A_site_297631
mod ID: M6ASITE025067		Click to Show/Hide the Full List
mod site	chr15:100908479-100908480:+		[2]
Sequence	ATGTCAGGAAATGGCAGAGAACTGTAAGTGTTTCCATCATT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6
External Link	RMBase: m6A_site_297632
mod ID: M6ASITE025068		Click to Show/Hide the Full List
mod site	chr15:100914737-100914738:+		[2]
Sequence	CCGAATACACAGAAGTGAAAACTGTCACCATCAAACTTGGC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; HepG2; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10
External Link	RMBase: m6A_site_297637
mod ID: M6ASITE025069		Click to Show/Hide the Full List
mod site	chr15:100914751-100914752:+		[2]
Sequence	GTGAAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; HepG2; A549; MM6; HEK293A-TOA; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6
External Link	RMBase: m6A_site_297638
mod ID: M6ASITE025070		Click to Show/Hide the Full List
mod site	chr15:100914765-100914766:+		[2]
Sequence	CATCAAACTTGGCGACAAGAACCCCTGAAGGAAAGGCGGGG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; HepG2; A549; MM6; HEK293A-TOA; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10
External Link	RMBase: m6A_site_297639
mod ID: M6ASITE025071		Click to Show/Hide the Full List
mod site	chr15:100914798-100914799:+		[2]
Sequence	AGGCGGGGCTCCTTCCTCAAACATCGGACGGCGGAATGTGG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; H1A; H1B; MM6; GSC-11; HEK293A-TOA; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6
External Link	RMBase: m6A_site_297640
mod ID: M6ASITE025072		Click to Show/Hide the Full List
mod site	chr15:100914868-100914869:+		[2]
Sequence	ACATTTCTGACCTTCCCGGGACACATTCTTCTGGAGGCTTT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; H1A; H1B; hESCs; fibroblasts; MM6; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10
External Link	RMBase: m6A_site_297641
mod ID: M6ASITE025073		Click to Show/Hide the Full List
mod site	chr15:100914947-100914948:+		[2]
Sequence	CTCTCCTGTTTATTCACCAGACTGGGGATGCCTATAGGTTG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; H1A; H1B; GM12878; MM6; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6
External Link	RMBase: m6A_site_297644
mod ID: M6ASITE025074		Click to Show/Hide the Full List
mod site	chr15:100915030-100915031:+		[2]
Sequence	ATTTCTGTGTTTCCCTTTAAACCAGATCCTGGAGACAGTGA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; A549; GM12878; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10
External Link	RMBase: m6A_site_297648
mod ID: M6ASITE025075		Click to Show/Hide the Full List
mod site	chr15:100915044-100915045:+		[2]
Sequence	CTTTAAACCAGATCCTGGAGACAGTGAGATACTCAGGGCGT
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; HEK293A-TOA; iSLK; TIME; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10
External Link	RMBase: m6A_site_297649
mod ID: M6ASITE025076		Click to Show/Hide the Full List
mod site	chr15:100915148-100915149:+		[2]
Sequence	TCCAGTAAGAATGTGGGAAAACCCCCTGTGTGTTCTGCAAG
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6
External Link	RMBase: m6A_site_297651
mod ID: M6ASITE025077		Click to Show/Hide the Full List
mod site	chr15:100915203-100915204:+		[7]
Sequence	CAGCGGTCTCCTCAGGGTGGACCTGCTTACAGAGCAAGCCA
Motif Score	3.622404762
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6
External Link	RMBase: m6A_site_297654
mod ID: M6ASITE025078		Click to Show/Hide the Full List
mod site	chr15:100915249-100915250:+		[7]
Sequence	CTTTCCGAGGTGAAGGTGGGACCATTCCTTGGGAAAGGATT
Motif Score	3.622404762
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6
External Link	RMBase: m6A_site_297655
mod ID: M6ASITE025079		Click to Show/Hide the Full List
mod site	chr15:100915755-100915756:+		[7]
Sequence	AAGCGTACACAACTGGAAAGACTGCTGTAATAACACAGCCT
Motif Score	3.319380952
Cell/Tissue List	GM12878
Seq Type List	m6A-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10
External Link	RMBase: m6A_site_297665
mod ID: M6ASITE025080		Click to Show/Hide the Full List
mod site	chr15:100916119-100916120:+		[2]
Sequence	AAATGAGGGCCCGTAACAGAACCAGTGTGTGTATAACGAAA
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000329841.10; ENST00000346623.6
External Link	RMBase: m6A_site_297667
mod ID: M6ASITE025081		Click to Show/Hide the Full List
mod site	chr15:100916140-100916141:+		[2]
Sequence	CCAGTGTGTGTATAACGAAAACCATGTATAAAATGGGCCTA
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10
External Link	RMBase: m6A_site_297668

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000128		Click to Show/Hide the Full List
mod site	chr15:100898184-100898185:+		[8]
Sequence	TCGTGTGTGCGGACGCTGACTGTGAGTCTCTGCCCTCCTGG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000346623.6; ENST00000329841.10; ENST00000558869.1
External Link	RMBase: Nm_site_2019

Ref 1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012566)
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016 Nov 9;20(5):666-673. doi: 10.1016/j.chom.2016.10.002. Epub 2016 Oct 20.
Ref 4	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 7	Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. J Am Chem Soc. 2015 Feb 11;137(5):2107-15. doi: 10.1021/ja513080v. Epub 2015 Feb 2.
Ref 8	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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