m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00843)

Target Name	Baculoviral IAP repeat-containing protein 5 (BIRC5)
Synonyms	Apoptosis inhibitor 4; Apoptosis inhibitor survivin Click to Show/Hide
Gene Name	BIRC5
Chromosomal Location	17q25.3
Family	IAP family
Function	Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126, PubMed:25778398, PubMed:28218735). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797). Click to Show/Hide
Gene ID	332
Uniprot ID	BIRC5_HUMAN
HGNC ID	HGNC:593
KEGG ID	hsa:332

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00843)

Baculoviral IAP repeat-containing protein 5 (BIRC5)

N6-methyladenosine (m6A)

In total 57 m6A sequence/site(s) in this target gene
mod ID: M6ASITE035587		Click to Show/Hide the Full List
mod site	chr17:78214217-78214218:+		[3]
Sequence	CAGAAGGCCGCGGGGGGTGGACCGCCTAAGAGGGCGTGCGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; fibroblasts; A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000301633.8
External Link	RMBase: m6A_site_385230
mod ID: M6ASITE035588		Click to Show/Hide the Full List
mod site	chr17:78214243-78214244:+		[4]
Sequence	TAAGAGGGCGTGCGCTCCCGACATGCCCCGCGGCGCGCCAT
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000301633.8
External Link	RMBase: m6A_site_385231
mod ID: M6ASITE035589		Click to Show/Hide the Full List
mod site	chr17:78214288-78214289:+		[3]
Sequence	CGCCAGATTTGAATCGCGGGACCCGTTGGCAGAGGTGGCGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; fibroblasts; A549; MM6; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000350051.8; ENST00000590449.1; ENST00000374948.6; ENST00000590925.6; ENST00000301633.8
External Link	RMBase: m6A_site_385232
mod ID: M6ASITE035590		Click to Show/Hide the Full List
mod site	chr17:78214362-78214363:+		[3]
Sequence	CTGGCAGCCCTTTCTCAAGGACCACCGCATCTCTACATTCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; fibroblasts; A549; MT4; MM6; peripheral-blood; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000374948.6; ENST00000301633.8; ENST00000350051.8; ENST00000592734.5; ENST00000590449.1; ENST00000590925.6
External Link	RMBase: m6A_site_385233
mod ID: M6ASITE035591		Click to Show/Hide the Full List
mod site	chr17:78214376-78214377:+		[4]
Sequence	TCAAGGACCACCGCATCTCTACATTCAAGAACTGGCCCTTC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000350051.8; ENST00000590449.1; ENST00000590925.6; ENST00000592734.5; ENST00000592115.5; ENST00000374948.6; ENST00000301633.8
External Link	RMBase: m6A_site_385234
mod ID: M6ASITE035592		Click to Show/Hide the Full List
mod site	chr17:78214386-78214387:+		[3]
Sequence	CCGCATCTCTACATTCAAGAACTGGCCCTTCTTGGAGGGCT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; MT4; A549; MM6; Huh7; peripheral-blood; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000374948.6; ENST00000590449.1; ENST00000592734.5; ENST00000591800.1; ENST00000590925.6; ENST00000301633.8; ENST00000592115.5; ENST00000350051.8; ENST00000586192.5; ENST00000587746.5
External Link	RMBase: m6A_site_385235
mod ID: M6ASITE035593		Click to Show/Hide the Full List
mod site	chr17:78214725-78214726:+		[5]
Sequence	CCCCACTGAGAACGAGCCAGACTTGGCCCAGTGTTTCTTCT
Motif Score	3.319380952
Cell/Tissue List	HepG2; MT4; peripheral-blood; HEK293T; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000350051.8; ENST00000592734.5; ENST00000301633.8; ENST00000590925.6; ENST00000590449.1; ENST00000374948.6; ENST00000587746.5; ENST00000591800.1; ENST00000586192.5; ENST00000592115.5
External Link	RMBase: m6A_site_385236
mod ID: M6ASITE035594		Click to Show/Hide the Full List
mod site	chr17:78214829-78214830:+		[6]
Sequence	CTCGATGGGCTTTGTTTTGAACTGAGTTGTCAAAAGATTTG
Motif Score	3.373380952
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000591800.1; ENST00000374948.6; ENST00000350051.8; ENST00000592734.5; ENST00000590449.1; ENST00000586192.5; ENST00000301633.8; ENST00000592115.5; ENST00000590925.6; ENST00000587746.5
External Link	RMBase: m6A_site_385237
mod ID: M6ASITE035595		Click to Show/Hide the Full List
mod site	chr17:78216669-78216670:+		[4]
Sequence	TTTGATTTTTCTAGAGAGGAACATAAAAAGCATTCGTCCGG
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000592115.5; ENST00000301633.8; ENST00000587746.5; ENST00000586192.5; ENST00000350051.8; ENST00000589892.1; ENST00000591800.1; ENST00000374948.6; ENST00000590925.6; ENST00000592734.5
External Link	RMBase: m6A_site_385238
mod ID: M6ASITE035596		Click to Show/Hide the Full List
mod site	chr17:78216750-78216751:+		[3]
Sequence	ACCCTTGGTGAATTTTTGAAACTGGACAGAGAAAGAGCCAA
Motif Score	2.627720238
Cell/Tissue List	HeLa; hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000586192.5; ENST00000374948.6; ENST00000592734.5; ENST00000587746.5; ENST00000592115.5; ENST00000590925.6; ENST00000350051.8; ENST00000591800.1; ENST00000301633.8; ENST00000589892.1
External Link	RMBase: m6A_site_385239
mod ID: M6ASITE035597		Click to Show/Hide the Full List
mod site	chr17:78216755-78216756:+		[3]
Sequence	TGGTGAATTTTTGAAACTGGACAGAGAAAGAGCCAAGAACA
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T; hNPCs
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000591800.1; ENST00000586192.5; ENST00000374948.6; ENST00000590925.6; ENST00000301633.8; ENST00000592115.5; ENST00000587746.5; ENST00000592734.5; ENST00000589892.1; ENST00000350051.8
External Link	RMBase: m6A_site_385240
mod ID: M6ASITE035598		Click to Show/Hide the Full List
mod site	chr17:78216773-78216774:+		[3]
Sequence	GGACAGAGAAAGAGCCAAGAACAAAATTGTATGTATTGGGA
Motif Score	2.951386905
Cell/Tissue List	HeLa; hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000592734.5; ENST00000586192.5; ENST00000590925.6; ENST00000587746.5; ENST00000301633.8; ENST00000589892.1; ENST00000591800.1; ENST00000350051.8; ENST00000374948.6; ENST00000592115.5
External Link	RMBase: m6A_site_385241
mod ID: M6ASITE035599		Click to Show/Hide the Full List
mod site	chr17:78222879-78222880:+		[3]
Sequence	GAAGCCAGATTCAGGGAGGGACTGGAAGCAAAAGAATTTCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000374948.6; ENST00000350051.8; ENST00000301633.8; ENST00000591800.1; ENST00000590925.6; ENST00000592115.5; ENST00000589892.1; ENST00000592734.5; ENST00000587746.5; ENST00000586192.5
External Link	RMBase: m6A_site_385242
mod ID: M6ASITE035600		Click to Show/Hide the Full List
mod site	chr17:78222943-78222944:+		[7]
Sequence	GCCAGGGTCTGTTTAACTGGACATGAAGAGGAAGGCTCTGG
Motif Score	3.643047619
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000587746.5; ENST00000350051.8; ENST00000301633.8; ENST00000592115.5; ENST00000592734.5; ENST00000589892.1; ENST00000591800.1; ENST00000586192.5; ENST00000374948.6; ENST00000590925.6
External Link	RMBase: m6A_site_385243
mod ID: M6ASITE035601		Click to Show/Hide the Full List
mod site	chr17:78222964-78222965:+		[7]
Sequence	CATGAAGAGGAAGGCTCTGGACTTTCCTCCAGGAGTTTCAG
Motif Score	4.065041667
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000592115.5; ENST00000590925.6; ENST00000301633.8; ENST00000587746.5; ENST00000589892.1; ENST00000586192.5; ENST00000591800.1; ENST00000374948.6; ENST00000350051.8; ENST00000592734.5
External Link	RMBase: m6A_site_385244
mod ID: M6ASITE035602		Click to Show/Hide the Full List
mod site	chr17:78223473-78223474:+		[7]
Sequence	TTTATTTCCAGGCAAAGGAAACCAACAATAAGAAGAAAGAA
Motif Score	2.185083333
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000590925.6; ENST00000589892.1; ENST00000350051.8; ENST00000374948.6; ENST00000301633.8
External Link	RMBase: m6A_site_385245
mod ID: M6ASITE035603		Click to Show/Hide the Full List
mod site	chr17:78223477-78223478:+		[4]
Sequence	TTTCCAGGCAAAGGAAACCAACAATAAGAAGAAAGAATTTG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000590925.6; ENST00000589892.1; ENST00000350051.8; ENST00000301633.8; ENST00000374948.6
External Link	RMBase: m6A_site_385246
mod ID: M6ASITE035604		Click to Show/Hide the Full List
mod site	chr17:78223503-78223504:+		[7]
Sequence	AGAAGAAAGAATTTGAGGAAACTGCGGAGAAAGTGCGCCGT
Motif Score	2.627720238
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000374948.6; ENST00000350051.8; ENST00000589892.1; ENST00000301633.8; ENST00000590925.6
External Link	RMBase: m6A_site_385247
mod ID: M6ASITE035605		Click to Show/Hide the Full List
mod site	chr17:78223669-78223670:+		[8]
Sequence	TGTCTTAGGAAAGGAGATCAACATTTTCAAATTAGATGTTT
Motif Score	2.173910714
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000350051.8; ENST00000589892.1; ENST00000374948.6; ENST00000301633.8
External Link	RMBase: m6A_site_385248
mod ID: M6ASITE035606		Click to Show/Hide the Full List
mod site	chr17:78223883-78223884:+		[8]
Sequence	TGTCCCTTTTGCTAGAGCTGACAGCTTTGTTCGCGTGGGCA
Motif Score	2.859755952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000301633.8; ENST00000350051.8; ENST00000374948.6
External Link	RMBase: m6A_site_385249
mod ID: M6ASITE035607		Click to Show/Hide the Full List
mod site	chr17:78224015-78224016:+		[4]
Sequence	CTGCAGGTTCCTTATCTGTCACACCTGTGCCTCCTCAGAGG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000301633.8; ENST00000374948.6; ENST00000350051.8
External Link	RMBase: m6A_site_385250
mod ID: M6ASITE035608		Click to Show/Hide the Full List
mod site	chr17:78224089-78224090:+		[8]
Sequence	TTTTTTTTGGTAGATGCATGACTTGTGTGTGATGAGAGAAT
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000350051.8; ENST00000301633.8; ENST00000374948.6
External Link	RMBase: m6A_site_385251
mod ID: M6ASITE035609		Click to Show/Hide the Full List
mod site	chr17:78224134-78224135:+		[8]
Sequence	ACAGAGTCCCTGGCTCCTCTACTGTTTAACAACATGGCTTT
Motif Score	2.500660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000350051.8; ENST00000301633.8; rmsk_4772298; ENST00000374948.6
External Link	RMBase: m6A_site_385252
mod ID: M6ASITE035610		Click to Show/Hide the Full List
mod site	chr17:78224180-78224181:+		[8]
Sequence	TTTGTTTGAATTGTTAATTCACAGAATAGCACAAACTACAA
Motif Score	2.047297619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000374948.6; ENST00000301633.8; ENST00000350051.8; rmsk_4772298
External Link	RMBase: m6A_site_385253
mod ID: M6ASITE035611		Click to Show/Hide the Full List
mod site	chr17:78224194-78224195:+		[3]
Sequence	TAATTCACAGAATAGCACAAACTACAATTAAAACTAAGCAC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; hNPCs; hESCs; fibroblasts
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000301633.8; ENST00000374948.6; rmsk_4772298; ENST00000350051.8
External Link	RMBase: m6A_site_385254
mod ID: M6ASITE035612		Click to Show/Hide the Full List
mod site	chr17:78224197-78224198:+		[8]
Sequence	TTCACAGAATAGCACAAACTACAATTAAAACTAAGCACAAA
Motif Score	2.078666667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000301633.8; rmsk_4772298; ENST00000374948.6; ENST00000350051.8
External Link	RMBase: m6A_site_385255
mod ID: M6ASITE035613		Click to Show/Hide the Full List
mod site	chr17:78224206-78224207:+		[3]
Sequence	TAGCACAAACTACAATTAAAACTAAGCACAAAGCCATTCTA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; hNPCs; hESCs; fibroblasts
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000374948.6; rmsk_4772298; ENST00000350051.8; ENST00000301633.8
External Link	RMBase: m6A_site_385256
mod ID: M6ASITE035614		Click to Show/Hide the Full List
mod site	chr17:78224213-78224214:+		[4]
Sequence	AACTACAATTAAAACTAAGCACAAAGCCATTCTAAGTCATT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	rmsk_4772298; ENST00000374948.6; ENST00000350051.8; ENST00000301633.8
External Link	RMBase: m6A_site_385257
mod ID: M6ASITE035615		Click to Show/Hide the Full List
mod site	chr17:78224240-78224241:+		[8]
Sequence	CATTCTAAGTCATTGGGGAAACGGGGTGAACTTCAGGTGGA
Motif Score	2.179660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000301633.8; ENST00000374948.6; ENST00000350051.8
External Link	RMBase: m6A_site_385258
mod ID: M6ASITE035616		Click to Show/Hide the Full List
mod site	chr17:78224249-78224250:+		[3]
Sequence	TCATTGGGGAAACGGGGTGAACTTCAGGTGGATGAGGAGAC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; hNPCs; hESCs; fibroblasts
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000350051.8; ENST00000301633.8; ENST00000374948.6
External Link	RMBase: m6A_site_385259
mod ID: M6ASITE035617		Click to Show/Hide the Full List
mod site	chr17:78224268-78224269:+		[3]
Sequence	AACTTCAGGTGGATGAGGAGACAGAATAGAGTGATAGGAAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; hNPCs; hESCs; fibroblasts
Seq Type List	m6A-seq
Transcript ID List	ENST00000301633.8; ENST00000374948.6; ENST00000350051.8
External Link	RMBase: m6A_site_385260
mod ID: M6ASITE035618		Click to Show/Hide the Full List
mod site	chr17:78224301-78224302:+		[8]
Sequence	ATAGGAAGCGTCTGGCAGATACTCCTTTTGCCACTGCTGTG
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000374948.6; ENST00000350051.8; ENST00000301633.8
External Link	RMBase: m6A_site_385261
mod ID: M6ASITE035619		Click to Show/Hide the Full List
mod site	chr17:78224329-78224330:+		[7]
Sequence	TGCCACTGCTGTGTGATTAGACAGGCCCAGTGAGCCGCGGG
Motif Score	2.897386905
Cell/Tissue List	hNPCs; hESCs; fibroblasts; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000350051.8; ENST00000301633.8; ENST00000374948.6
External Link	RMBase: m6A_site_385262
mod ID: M6ASITE035620		Click to Show/Hide the Full List
mod site	chr17:78224352-78224353:+		[9]
Sequence	GGCCCAGTGAGCCGCGGGGCACATGCTGGCCGCTCCTCCCT
Motif Score	2.830589286
Cell/Tissue List	HEK293; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000301633.8; ENST00000350051.8; ENST00000374948.6
External Link	RMBase: m6A_site_385263
mod ID: M6ASITE035621		Click to Show/Hide the Full List
mod site	chr17:78224430-78224431:+		[5]
Sequence	TTGGCTCGATGCTGTGGGGGACTGGCTGGGCTGCTGCAGGC
Motif Score	4.065041667
Cell/Tissue List	HepG2; HeLa; hESCs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000350051.8; ENST00000301633.8; ENST00000374948.6
External Link	RMBase: m6A_site_385264
mod ID: M6ASITE035622		Click to Show/Hide the Full List
mod site	chr17:78224475-78224476:+		[4]
Sequence	TGTCTGTCAGCCCAACCTTCACATCTGTCACGTTCTCCACA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000350051.8; ENST00000374948.6; ENST00000301633.8
External Link	RMBase: m6A_site_385265
mod ID: M6ASITE035623		Click to Show/Hide the Full List
mod site	chr17:78224493-78224494:+		[4]
Sequence	TCACATCTGTCACGTTCTCCACACGGGGGAGAGACGCAGTC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000301633.8; ENST00000350051.8; ENST00000374948.6
External Link	RMBase: m6A_site_385266
mod ID: M6ASITE035624		Click to Show/Hide the Full List
mod site	chr17:78224644-78224645:+		[3]
Sequence	TTGTTACAGCTTCGCTGGAAACCTCTGGAGGTCATCTCGGC
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000374948.6; ENST00000350051.8; ENST00000301633.8
External Link	RMBase: m6A_site_385267
mod ID: M6ASITE035625		Click to Show/Hide the Full List
mod site	chr17:78224698-78224699:+		[4]
Sequence	TAAAAAGCCTGTCATTTCAAACACTGCTGTGGACCCTACTG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hESC-HEK293T; HeLa; U2OS; A549; iSLK
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000301633.8; ENST00000350051.8; ENST00000374948.6
External Link	RMBase: m6A_site_385268
mod ID: M6ASITE035626		Click to Show/Hide the Full List
mod site	chr17:78224710-78224711:+		[10]
Sequence	CATTTCAAACACTGCTGTGGACCCTACTGGGTTTTTAAAAT
Motif Score	3.622404762
Cell/Tissue List	HEK293T; HeLa; U2OS; A549; iSLK
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000350051.8; ENST00000374948.6; ENST00000301633.8
External Link	RMBase: m6A_site_385269
mod ID: M6ASITE035627		Click to Show/Hide the Full List
mod site	chr17:78224782-78224783:+		[3]
Sequence	GCCAACAGCCATCTGCCCAGACAGCCGCAGTGAGGATGAGC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; hNPCs; hESCs; fibroblasts; GM12878; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000301633.8; ENST00000374948.6; ENST00000350051.8
External Link	RMBase: m6A_site_385270
mod ID: M6ASITE035628		Click to Show/Hide the Full List
mod site	chr17:78224850-78224851:+		[3]
Sequence	GGCGCTTGCCAGAGCCACGAACCCCAGACCTGTTTGTATCA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000301633.8; ENST00000374948.6; ENST00000350051.8
External Link	RMBase: m6A_site_385271
mod ID: M6ASITE035629		Click to Show/Hide the Full List
mod site	chr17:78224857-78224858:+		[3]
Sequence	GCCAGAGCCACGAACCCCAGACCTGTTTGTATCATCCGGGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000374948.6; ENST00000301633.8; ENST00000350051.8
External Link	RMBase: m6A_site_385272
mod ID: M6ASITE035630		Click to Show/Hide the Full List
mod site	chr17:78224893-78224894:+		[3]
Sequence	CGGGCTCCTTCCGGGCAGAAACAACTGAAAATGCACTTCAG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1B; H1A; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000374948.6; ENST00000350051.8; ENST00000301633.8
External Link	RMBase: m6A_site_385273
mod ID: M6ASITE035631		Click to Show/Hide the Full List
mod site	chr17:78224907-78224908:+		[8]
Sequence	GCAGAAACAACTGAAAATGCACTTCAGACCCACTTATTTCT
Motif Score	3.252583333
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000374948.6; ENST00000301633.8; ENST00000350051.8
External Link	RMBase: m6A_site_385274
mod ID: M6ASITE035632		Click to Show/Hide the Full List
mod site	chr17:78224914-78224915:+		[3]
Sequence	CAACTGAAAATGCACTTCAGACCCACTTATTTCTGCCACAT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000350051.8; ENST00000301633.8; ENST00000374948.6
External Link	RMBase: m6A_site_385275
mod ID: M6ASITE035633		Click to Show/Hide the Full List
mod site	chr17:78224931-78224932:+		[4]
Sequence	CAGACCCACTTATTTCTGCCACATCTGAGTCGGCCTGAGAT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000350051.8; ENST00000301633.8; ENST00000374948.6
External Link	RMBase: m6A_site_385276
mod ID: M6ASITE035634		Click to Show/Hide the Full List
mod site	chr17:78224954-78224955:+		[3]
Sequence	TCTGAGTCGGCCTGAGATAGACTTTTCCCTCTAAACTGGGA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; hNPCs; hESCs; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000301633.8; ENST00000374948.6; ENST00000350051.8
External Link	RMBase: m6A_site_385277
mod ID: M6ASITE035635		Click to Show/Hide the Full List
mod site	chr17:78224968-78224969:+		[3]
Sequence	AGATAGACTTTTCCCTCTAAACTGGGAGAATATCACAGTGG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; hNPCs; hESCs; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000374948.6; ENST00000301633.8; ENST00000350051.8
External Link	RMBase: m6A_site_385278
mod ID: M6ASITE035636		Click to Show/Hide the Full List
mod site	chr17:78224982-78224983:+		[8]
Sequence	CTCTAAACTGGGAGAATATCACAGTGGTTTTTGTTAGCAGA
Motif Score	2.047297619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000301633.8; ENST00000350051.8; ENST00000374948.6
External Link	RMBase: m6A_site_385279
mod ID: M6ASITE035637		Click to Show/Hide the Full List
mod site	chr17:78225009-78225010:+		[8]
Sequence	TTTTTGTTAGCAGAAAATGCACTCCAGCCTCTGTACTCATC
Motif Score	3.252583333
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000350051.8; ENST00000374948.6; ENST00000301633.8
External Link	RMBase: m6A_site_385280
mod ID: M6ASITE035638		Click to Show/Hide the Full List
mod site	chr17:78225023-78225024:+		[8]
Sequence	AAATGCACTCCAGCCTCTGTACTCATCTAAGCTGCTTATTT
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000374948.6; ENST00000301633.8; ENST00000350051.8
External Link	RMBase: m6A_site_385281
mod ID: M6ASITE035639		Click to Show/Hide the Full List
mod site	chr17:78225078-78225079:+		[8]
Sequence	AGTCTGTAAATGGATACTTCACTTTAATAACTGTTGCTTAG
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000301633.8; ENST00000374948.6; ENST00000350051.8
External Link	RMBase: m6A_site_385282
mod ID: M6ASITE035640		Click to Show/Hide the Full List
mod site	chr17:78225087-78225088:+		[11]
Sequence	ATGGATACTTCACTTTAATAACTGTTGCTTAGTAATTGGCT
Motif Score	2.590089286
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000350051.8; ENST00000374948.6; ENST00000301633.8
External Link	RMBase: m6A_site_385283
mod ID: M6ASITE035641		Click to Show/Hide the Full List
mod site	chr17:78225515-78225516:+		[3]
Sequence	TGCCATCCTGGAAAGTAGAGACAGCAGTGCCCGCTGCCCAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; hESCs; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000374948.6; ENST00000350051.8; ENST00000301633.8
External Link	RMBase: m6A_site_385284
mod ID: M6ASITE035642		Click to Show/Hide the Full List
mod site	chr17:78225541-78225542:+		[3]
Sequence	GTGCCCGCTGCCCAGAAGAGACCAGCAAGCCAAACTGGAGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; hESCs; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000350051.8; ENST00000374948.6; ENST00000301633.8
External Link	RMBase: m6A_site_385285
mod ID: M6ASITE035643		Click to Show/Hide the Full List
mod site	chr17:78225554-78225555:+		[3]
Sequence	AGAAGAGACCAGCAAGCCAAACTGGAGCCCCCATTGCAGGC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; hESCs; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000374948.6; ENST00000350051.8; ENST00000301633.8
External Link	RMBase: m6A_site_385286

Ref 1	Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer. Cancer Chemother Pharmacol. 2017 Sep;80(3):653-659. doi: 10.1007/s00280-017-3379-5. Epub 2017 Jul 4.
Ref 2	Clinical pipeline report, company report or official report of Daiichi Sankyo.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 5	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 6	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.
Ref 7	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 8	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 10	N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27.
Ref 11	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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