General Information of the m6A Target Gene (ID: M6ATAR00832)
Target Name
M-phase inducer phosphatase 1 (CDC25A)
Synonyms
EC 3.1.3.48; Dual specificity phosphatase Cdc25A
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Gene Name
Cdc25A
Chromosomal Location
3p21.31
Family
MPI phosphatase family
Function
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
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Gene ID
993
Uniprot ID
MPIP1_HUMAN
HGNC ID
HGNC:1725
KEGG ID
hsa:993
References
Ref 1
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells. Biochem Pharmacol. 2007 Jun 30;74(1):41-53.
Ref 2
Sirukumab: A Potential Treatment for Mood Disorders?. Adv Ther. 2017 Jan;34(1):78-90. doi: 10.1007/s12325-016-0455-x. Epub 2016 Dec 2.
