m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00830)

Target Name	Peroxiredoxin-5, mitochondrial (PRDX5)
Synonyms	EC 1.11.1.24; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 71B; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; TPx type VI; Thioredoxin peroxidase PMP20; Thioredoxin-dependent peroxiredoxin 5 Click to Show/Hide
Gene Name	PRDX5
Chromosomal Location	11q13.1
Family	Peroxiredoxin family, Prx5 subfamily
Function	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Click to Show/Hide
Gene ID	25824
Uniprot ID	PRDX5_HUMAN
HGNC ID	HGNC:9355
KEGG ID	hsa:25824

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00830)

Peroxiredoxin-5, mitochondrial (PRDX5)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000157		Click to Show/Hide the Full List
mod site	chr11:64318308-64318309:+		[2]
Sequence	CTGCGGCAGCGGCAGCAAGACGGTACAGTGAAGGAGAGTGG
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000265462.9; ENST00000352435.8; ENST00000347941.4
External Link	RMBase: ac4C_site_305

N1-methyladenosine (m1A)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M1ASITE000018		Click to Show/Hide the Full List
mod site	chr11:64321056-64321057:+		[3]
Sequence	GTGTCCATCTTTGGGAATCGACGTCTCAAGAGGTAAAAGTG
Cell/Tissue List	HEK293T
Seq Type List	m1A-seq
Transcript ID List	ENST00000265462.9; ENST00000352435.8; ENST00000347941.4
External Link	RMBase: m1A_site_200

5-methylcytidine (m5C)

In total 4 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005191		Click to Show/Hide the Full List
mod site	chr11:64319721-64319722:+		[4]
Sequence	CACCCCCCTTACCCTGGAGTCCTTCCTTCTAGGTGGGAGAT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265462.9; ENST00000347941.4; ENST00000352435.8
External Link	RMBase: m5C_site_7748
mod ID: M5CSITE005192		Click to Show/Hide the Full List
mod site	chr11:64319722-64319723:+		[4]
Sequence	ACCCCCCTTACCCTGGAGTCCTTCCTTCTAGGTGGGAGATG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265462.9; ENST00000347941.4; ENST00000352435.8
External Link	RMBase: m5C_site_7749
mod ID: M5CSITE005193		Click to Show/Hide the Full List
mod site	chr11:64321578-64321579:+		[4]
Sequence	AGCTGGCTGGGCCCCTCTTTCCGGCAGGTTCTCCATGGTGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000347941.4; ENST00000265462.9; ENST00000352435.8
External Link	RMBase: m5C_site_7750
mod ID: M5CSITE005194		Click to Show/Hide the Full List
mod site	chr11:64321579-64321580:+		[4]
Sequence	GCTGGCTGGGCCCCTCTTTCCGGCAGGTTCTCCATGGTGGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265462.9; ENST00000352435.8; ENST00000347941.4
External Link	RMBase: m5C_site_7751

N6-methyladenosine (m6A)

In total 11 m6A sequence/site(s) in this target gene
mod ID: M6ASITE006501		Click to Show/Hide the Full List
mod site	chr11:64318220-64318221:+		[5]
Sequence	GGCCGTGGGGCGGGTATGGGACTAGCTGGCGTGTGCGCCCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; MT4; MM6; Huh7; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265462.9; ENST00000352435.8; ENST00000347941.4
External Link	RMBase: m6A_site_146270
mod ID: M6ASITE006502		Click to Show/Hide the Full List
mod site	chr11:64319782-64319783:+		[6]
Sequence	GTTTGAAGGGGAGCCAGGGAACAAGGTGAACCTGGCAGAGC
Motif Score	2.951386905
Cell/Tissue List	HepG2; hESC-HEK293T; MT4; A549; MM6; Huh7; peripheral-blood; GSC-11; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000265462.9; ENST00000352435.8; ENST00000347941.4
External Link	RMBase: m6A_site_146271
mod ID: M6ASITE006503		Click to Show/Hide the Full List
mod site	chr11:64319791-64319792:+		[7]
Sequence	GGAGCCAGGGAACAAGGTGAACCTGGCAGAGCTGTTCAAGG
Motif Score	2.930744048
Cell/Tissue List	HepG2; MT4; A549; MM6; Huh7; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000347941.4; ENST00000352435.8; ENST00000265462.9
External Link	RMBase: m6A_site_146272
mod ID: M6ASITE006504		Click to Show/Hide the Full List
mod site	chr11:64320660-64320661:+		[8]
Sequence	CCTTTGTTCCCCTTCCTCAGACACACCTGCCAGGGTTTGTG
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000265462.9; ENST00000347941.4; ENST00000352435.8
External Link	RMBase: m6A_site_146273
mod ID: M6ASITE006505		Click to Show/Hide the Full List
mod site	chr11:64320753-64320754:+		[9]
Sequence	GTGTTAATGATGCCTTTGTGACTGGCGAGTGGGGCCGAGCC
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000265462.9; ENST00000352435.8; ENST00000347941.4
External Link	RMBase: m6A_site_146274
mod ID: M6ASITE006506		Click to Show/Hide the Full List
mod site	chr11:64320775-64320776:+		[10]
Sequence	TGGCGAGTGGGGCCGAGCCCACAAGGCGGAAGGCAAGGTGA
Motif Score	2.053113095
Cell/Tissue List	kidney; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000265462.9; ENST00000347941.4; ENST00000352435.8
External Link	RMBase: m6A_site_146275
mod ID: M6ASITE006507		Click to Show/Hide the Full List
mod site	chr11:64321009-64321010:+		[11]
Sequence	TCTCTGTCTCTTCTTAGGAGACAGACTTATTACTAGATGAT
Motif Score	2.897386905
Cell/Tissue List	Huh7; peripheral-blood
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000352435.8; ENST00000347941.4; ENST00000265462.9
External Link	RMBase: m6A_site_146276
mod ID: M6ASITE006508		Click to Show/Hide the Full List
mod site	chr11:64321633-64321634:+		[11]
Sequence	GTGAAGGCCCTGAATGTGGAACCAGATGGCACAGGCCTCAC
Motif Score	2.930744048
Cell/Tissue List	Huh7; peripheral-blood
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000352435.8; rmsk_3566889; ENST00000265462.9; ENST00000347941.4
External Link	RMBase: m6A_site_146277
mod ID: M6ASITE006509		Click to Show/Hide the Full List
mod site	chr11:64321681-64321682:+		[10]
Sequence	CTGGCACCCAATATCATCTCACAGCTCTGAGGCCCTGGGCC
Motif Score	2.047297619
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	rmsk_3566889; ENST00000352435.8; ENST00000265462.9; ENST00000347941.4
External Link	RMBase: m6A_site_146278
mod ID: M6ASITE006510		Click to Show/Hide the Full List
mod site	chr11:64321707-64321708:+		[9]
Sequence	CTGAGGCCCTGGGCCAGATTACTTCCTCCACCCCTCCCTAT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000265462.9; ENST00000347941.4; ENST00000352435.8; rmsk_3566889
External Link	RMBase: m6A_site_146279
mod ID: M6ASITE006511		Click to Show/Hide the Full List
mod site	chr11:64321791-64321792:+		[5]
Sequence	TGGCCAGATTTCTGCAATAAACACTTGTGGTTTGCGGCCAT
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T; peripheral-blood
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000265462.9
External Link	RMBase: m6A_site_146280

N7-methylguanosine (m7G)

In total 1 m6A sequence/site(s) in this target gene
mod ID: m7GSITE000006		Click to Show/Hide the Full List
mod site	chr11:64318160-64318161:+		[12]
Sequence	TGTGCCGCTAGCGGTGCCCCGCCTGCTGCGGTGGCACCAGC
Cell/Tissue List	A549; HeLa; HepG2
Seq Type List	BoRed-seq&m7G-RIP-seq; m7G-seq
Transcript ID List	ENST00000265462.9
External Link	RMBase: m7G_site_162

2'-O-Methylation (2'-O-Me)

In total 2 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000612		Click to Show/Hide the Full List
mod site	chr11:64320878-64320879:+		[13]
Sequence	CTGCAGGTTCGGCTCCTGGCTGATCCCACTGGGGCCTTTGG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000352435.8; ENST00000347941.4; ENST00000265462.9
External Link	RMBase: Nm_site_993
mod ID: 2OMSITE000613		Click to Show/Hide the Full List
mod site	chr11:64321629-64321630:+		[13]
Sequence	CATAGTGAAGGCCCTGAATGTGGAACCAGATGGCACAGGCC
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	rmsk_3566889; ENST00000352435.8; ENST00000265462.9; ENST00000347941.4
External Link	RMBase: Nm_site_994

Ref 1	GEMSTONE-301: a phase III clinical trial of CS1001 as consolidation therapy in patients with locally advanced/unresectable (stage III) non-small cell lung cancer (NSCLC) who did not have disease progression after prior concurrent/sequential chemoradiotherapy. Transl Lung Cancer Res. 2020 Oct;9(5):2008-2015. doi: 10.21037/tlcr-20-608.
Ref 2	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 3	The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Nature. 2017 Nov 9;551(7679):251-255. doi: 10.1038/nature24456. Epub 2017 Oct 25.
Ref 4	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 7	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 8	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 9	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 10	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 11	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 12	METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25.
Ref 13	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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