General Information of the m6A Target Gene (ID: M6ATAR00828)
Target Name Microtubule cross-linking factor 2 (SOGA1)
Synonyms
SOGA family member 1; Suppressor of glucose by autophagy; Suppressor of glucose, autophagy-associated protein 1; 80-kDa SOGA fragment
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Gene Name Soga1
Chromosomal Location 20q11.23
Family MTCL family
Function
Microtubule-associated factor that enables integration of the centrosomal and Golgi-associated microtubules on the Golgi membrane, supporting directional migration. Preferentially acts on the perinuclear microtubules accumulated around the Golgi. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain (By similarity). Required for faithful chromosome segregation during mitosis (PubMed:33587225). Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner (By similarity).
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Gene ID 140710
Uniprot ID
MTCL2_HUMAN
HGNC ID
HGNC:16111
KEGG ID
hsa:140710
References
Ref 1 Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. Xenobiotica. 1999 Feb;29(2):187-93. doi: 10.1080/004982599238731.
Ref 2 Anti-ageing pipeline starts to mature. Nat Rev Drug Discov. 2018 Sep;17(9):609-612. doi: 10.1038/nrd.2018.134. Epub 2018 Aug 3.