m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00818)

Target Name	Serine protease hepsin (HPN)
Synonyms	EC 3.4.21.106; Transmembrane protease serine 1 Click to Show/Hide
Gene Name	HPN
Chromosomal Location	19q13.11
Family	Peptidase S1 family
Function	Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890). Click to Show/Hide
Gene ID	3249
Uniprot ID	HEPS_HUMAN
HGNC ID	HGNC:5155
KEGG ID	hsa:3249

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00818)

Serine protease hepsin (HPN)

Adenosine-to-Inosine editing (A-to-I)

In total 7 m6A sequence/site(s) in this target gene
mod ID: A2ISITE009113		Click to Show/Hide the Full List
mod site	chr19:35050222-35050223:+		[2]
Sequence	ACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCTTCAGCC
Transcript ID List	ENST00000600390.1; ENST00000597419.1; ENST00000599363.5; ENST00000392226.5; ENST00000596662.5; ENST00000593305.1; ENST00000541345.6; ENST00000262626.6
External Link	RMBase: RNA-editing_site_69008
mod ID: A2ISITE009114		Click to Show/Hide the Full List
mod site	chr19:35051369-35051370:+		[2]
Sequence	CCACCCGTCTCGGCCTCCCAAAGTGCTGGGACTACAGGCAT
Transcript ID List	ENST00000600390.1; ENST00000392226.5; ENST00000599363.5; ENST00000262626.6; ENST00000596662.5; ENST00000593305.1; ENST00000597419.1; ENST00000541345.6
External Link	RMBase: RNA-editing_site_69009
mod ID: A2ISITE009115		Click to Show/Hide the Full List
mod site	chr19:35056596-35056597:+		[2]
Sequence	GTCTCCCGGGAGCTCCCTCTAGCCTTCTCGTATATCCCAGC
Transcript ID List	ENST00000262626.6; ENST00000600390.1; ENST00000541345.6; ENST00000593305.1; ENST00000392226.5; ENST00000599363.5; ENST00000597419.1; ENST00000596662.5
External Link	RMBase: RNA-editing_site_69010
mod ID: A2ISITE009116		Click to Show/Hide the Full List
mod site	chr19:35064441-35064442:+		[3]
Sequence	CCCTGCAAACTCTGCCTCCTAGGTTCAAGCGATTCTCCTGC
Transcript ID List	ENST00000593305.1; ENST00000597419.1; ENST00000392226.5; ENST00000262626.6; ENST00000599363.5; ENST00000541345.6
External Link	RMBase: RNA-editing_site_69011
mod ID: A2ISITE009117		Click to Show/Hide the Full List
mod site	chr19:35064448-35064449:+		[3]
Sequence	AACTCTGCCTCCTAGGTTCAAGCGATTCTCCTGCCTCAGCC
Transcript ID List	ENST00000599363.5; ENST00000392226.5; ENST00000597419.1; ENST00000541345.6; ENST00000262626.6; ENST00000593305.1
External Link	RMBase: RNA-editing_site_69012
mod ID: A2ISITE009118		Click to Show/Hide the Full List
mod site	chr19:35064552-35064553:+		[3]
Sequence	CAGGAGGATTGCTTGAGCCCAGGAGGTCGAGGCTGCAGTGA
Transcript ID List	ENST00000593305.1; ENST00000392226.5; rmsk_4984528; ENST00000541345.6; ENST00000597419.1; ENST00000599363.5; ENST00000262626.6
External Link	RMBase: RNA-editing_site_69013
mod ID: A2ISITE009119		Click to Show/Hide the Full List
mod site	chr19:35065083-35065084:+		[3]
Sequence	CTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATG
Transcript ID List	ENST00000593305.1; ENST00000541345.6; ENST00000599363.5; ENST00000262626.6; ENST00000392226.5; ENST00000597419.1
External Link	RMBase: RNA-editing_site_69014

N6-methyladenosine (m6A)

In total 21 m6A sequence/site(s) in this target gene
mod ID: M6ASITE040907		Click to Show/Hide the Full List
mod site	chr19:35041816-35041817:+		[4]
Sequence	GCTCCTGCCCAGGCCTGGAGACTGACCCGACCCCGGCACTA
Motif Score	3.319380952
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000599363.5; ENST00000262626.6; ENST00000392226.5; ENST00000597419.1; ENST00000600390.1
External Link	RMBase: m6A_site_434373
mod ID: M6ASITE040908		Click to Show/Hide the Full List
mod site	chr19:35041864-35041865:+		[5]
Sequence	GCTCCGCCCCCACCTGCTGGACCCCAGGGTAAGGACAAGGG
Motif Score	3.622404762
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000597419.1; ENST00000392226.5; ENST00000600390.1; ENST00000262626.6; ENST00000599363.5
External Link	RMBase: m6A_site_434374
mod ID: M6ASITE040909		Click to Show/Hide the Full List
mod site	chr19:35041878-35041879:+		[5]
Sequence	TGCTGGACCCCAGGGTAAGGACAAGGGCCCCCAGACTCACA
Motif Score	3.643047619
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000600390.1; ENST00000392226.5; ENST00000262626.6; ENST00000597419.1; ENST00000599363.5
External Link	RMBase: m6A_site_434375
mod ID: M6ASITE040910		Click to Show/Hide the Full List
mod site	chr19:35041892-35041893:+		[5]
Sequence	GTAAGGACAAGGGCCCCCAGACTCACAGTTCCAGCCCTGAG
Motif Score	3.319380952
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000262626.6; ENST00000597419.1; ENST00000392226.5; ENST00000600390.1; ENST00000599363.5
External Link	RMBase: m6A_site_434376
mod ID: M6ASITE040911		Click to Show/Hide the Full List
mod site	chr19:35041896-35041897:+		[6]
Sequence	GGACAAGGGCCCCCAGACTCACAGTTCCAGCCCTGAGGACA
Motif Score	2.047297619
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000599363.5; ENST00000392226.5; ENST00000597419.1; ENST00000262626.6; ENST00000600390.1
External Link	RMBase: m6A_site_434377
mod ID: M6ASITE040912		Click to Show/Hide the Full List
mod site	chr19:35041914-35041915:+		[5]
Sequence	TCACAGTTCCAGCCCTGAGGACAGGGGTTCCCTCATCCCCC
Motif Score	3.643047619
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000597419.1; ENST00000600390.1; ENST00000262626.6; ENST00000599363.5; ENST00000392226.5
External Link	RMBase: m6A_site_434378
mod ID: M6ASITE040913		Click to Show/Hide the Full List
mod site	chr19:35041978-35041979:+		[7]
Sequence	TAATAGAGGGGTTCCTGGGGACCTGAAGAGGGGGCACTATG
Motif Score	3.622404762
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000599363.5; ENST00000262626.6; ENST00000597419.1; ENST00000392226.5; ENST00000600390.1
External Link	RMBase: m6A_site_434379
mod ID: M6ASITE040914		Click to Show/Hide the Full List
mod site	chr19:35042044-35042045:+		[8]
Sequence	CTGTCCTGCTCTTCCTTCAGACTCAGCCGTTGGACCCCAGT
Motif Score	3.319380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000392226.5; ENST00000599363.5; ENST00000597419.1; ENST00000262626.6; rmsk_4984455; ENST00000600390.1
External Link	RMBase: m6A_site_434380
mod ID: M6ASITE040915		Click to Show/Hide the Full List
mod site	chr19:35042057-35042058:+		[8]
Sequence	CCTTCAGACTCAGCCGTTGGACCCCAGTCCTTTCCTCCCCA
Motif Score	3.622404762
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000262626.6; ENST00000599363.5; ENST00000600390.1; ENST00000392226.5; rmsk_4984455; ENST00000597419.1
External Link	RMBase: m6A_site_434381
mod ID: M6ASITE040916		Click to Show/Hide the Full List
mod site	chr19:35042079-35042080:+		[8]
Sequence	CCCAGTCCTTTCCTCCCCAGACCCAGGAGTTCCAGCCCTCA
Motif Score	2.876744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000262626.6; ENST00000392226.5; ENST00000597419.1; ENST00000599363.5; ENST00000600390.1; rmsk_4984455
External Link	RMBase: m6A_site_434382
mod ID: M6ASITE040917		Click to Show/Hide the Full List
mod site	chr19:35042357-35042358:+		[6]
Sequence	CTGGCCAAGGCCCAGTCCCTACAGCCTGCCTGGATGGACGC
Motif Score	2.078666667
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000262626.6; ENST00000600390.1; ENST00000597419.1; ENST00000392226.5; ENST00000599363.5
External Link	RMBase: m6A_site_434383
mod ID: M6ASITE040918		Click to Show/Hide the Full List
mod site	chr19:35049297-35049298:+		[9]
Sequence	TGTCTGTTGCAGGTGGCCGGACTGTGCCATGCTGCTCCAGA
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000597419.1; ENST00000596662.5; ENST00000541345.6; ENST00000262626.6; ENST00000600390.1; ENST00000599363.5; ENST00000392226.5
External Link	RMBase: m6A_site_434384
mod ID: M6ASITE040919		Click to Show/Hide the Full List
mod site	chr19:35049317-35049318:+		[9]
Sequence	ACTGTGCCATGCTGCTCCAGACCCAAGGTGGCAGCTCTCAC
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000600390.1; ENST00000597419.1; ENST00000541345.6; ENST00000599363.5; ENST00000593305.1; ENST00000392226.5; ENST00000596662.5; ENST00000262626.6
External Link	RMBase: m6A_site_434385
mod ID: M6ASITE040920		Click to Show/Hide the Full List
mod site	chr19:35049345-35049346:+		[9]
Sequence	TGGCAGCTCTCACTGCGGGGACCCTGCTACTTCTGACAGCC
Motif Score	3.622404762
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000600390.1; ENST00000262626.6; ENST00000541345.6; ENST00000599363.5; ENST00000593305.1; ENST00000392226.5; ENST00000596662.5; ENST00000597419.1
External Link	RMBase: m6A_site_434386
mod ID: M6ASITE040921		Click to Show/Hide the Full List
mod site	chr19:35060754-35060755:+		[6]
Sequence	TCTTCCCTTTCGGGACCCCAACAGCGAGGAGAACAGCAACG
Motif Score	2.173910714
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000262626.6; ENST00000597419.1; ENST00000599363.5; ENST00000593305.1; ENST00000392226.5; ENST00000541345.6
External Link	RMBase: m6A_site_434387
mod ID: M6ASITE040922		Click to Show/Hide the Full List
mod site	chr19:35065985-35065986:+		[6]
Sequence	GGCCCAGAAGCCAGGCGTCTACACCAAAGTCAGTGACTTCC
Motif Score	2.078666667
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000597419.1; ENST00000541345.6; ENST00000599363.5; ENST00000262626.6; ENST00000593305.1; ENST00000392226.5
External Link	RMBase: m6A_site_434388
mod ID: M6ASITE040923		Click to Show/Hide the Full List
mod site	chr19:35066153-35066154:+		[9]
Sequence	GAAGAGGGCCCCCCTTGGGAACAGATGGACTTTGAAGGGTT
Motif Score	2.951386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000541345.6; ENST00000392226.5; ENST00000593305.1; ENST00000599363.5; ENST00000597419.1; ENST00000262626.6
External Link	RMBase: m6A_site_434389
mod ID: M6ASITE040924		Click to Show/Hide the Full List
mod site	chr19:35066161-35066162:+		[9]
Sequence	CCCCCCTTGGGAACAGATGGACTTTGAAGGGTTCCTGGGGA
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000593305.1; ENST00000599363.5; ENST00000597419.1; ENST00000262626.6; ENST00000392226.5; ENST00000541345.6
External Link	RMBase: m6A_site_434390
mod ID: M6ASITE040925		Click to Show/Hide the Full List
mod site	chr19:35066217-35066218:+		[5]
Sequence	GGGACGTGGAAGCCTCTCAGACCTCGGGAGCCCCCAGCTGT
Motif Score	2.876744048
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000599363.5; ENST00000597419.1; ENST00000541345.6; ENST00000392226.5; ENST00000262626.6; ENST00000593305.1
External Link	RMBase: m6A_site_434391
mod ID: M6ASITE040926		Click to Show/Hide the Full List
mod site	chr19:35066248-35066249:+		[5]
Sequence	CCCCAGCTGTCTTTCCCCAGACTCACTCCGAAGCCAGCGGC
Motif Score	3.319380952
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000593305.1; ENST00000392226.5; ENST00000541345.6; ENST00000262626.6; ENST00000599363.5; ENST00000597419.1
External Link	RMBase: m6A_site_434392
mod ID: M6ASITE040927		Click to Show/Hide the Full List
mod site	chr19:35066401-35066402:+		[9]
Sequence	CCCGGTCCACAGGTCCAAGGACACCCTCCCTCCAGGGTCCT
Motif Score	3.643047619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000593305.1; ENST00000262626.6; ENST00000392226.5; ENST00000599363.5; ENST00000597419.1; ENST00000541345.6
External Link	RMBase: m6A_site_434393

Ref 1	Acyltransferase inhibitors: a patent review (2010-present). Expert Opin Ther Pat. 2015 Feb;25(2):145-58. doi: 10.1517/13543776.2014.989833. Epub 2014 Dec 3.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol. 2004 Aug;22(8):1001-5. doi: 10.1038/nbt996. Epub 2004 Jul 18.
Ref 4	[Action myoclonias and paranoid alternative psychosis in progressive myoclonic epilepsy (late form of the Lafora type)]. Nervenarzt. 1986 Apr;57(4):233-7.
Ref 5	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 6	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 7	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 8	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 9	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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