m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00787)
Target Name hsa_circ_0000417 (circ_CPSF6)
Gene Name Circ_CPSF6
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Circ_CPSF6 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary CircCPSF6 was dominated by ALKBH5-mediated demethylation, followed by the recognization and destabilization by YTHDF2. Meanwhile, circCPSF6 was upregulated in HCC specimens, and elevated hsa_circ_0000417 (circCPSF6) expression served as an independent prognostic factor for worse survival of patients with HCC.
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Cell Process Cell proliferation
In-vitro Model Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
B76.1/Huh7 Adult hepatocellular carcinoma Homo sapiens CVCL_U443
SNU-449 Adult hepatocellular carcinoma Homo sapiens CVCL_0454
PLC/PRF/5 Adult hepatocellular carcinoma Homo sapiens CVCL_0485
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
In-vivo Model HCC cells stably transfected with empty vector or circCPSF6 were subject to construct animal models, followed by the regular treatment of verteporfin, an inhibitor of YAP signaling.
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary CircCPSF6 was dominated by ALKBH5-mediated demethylation, followed by the recognization and destabilization by YTHDF2. Meanwhile, circCPSF6 was upregulated in HCC specimens, and elevated hsa_circ_0000417 (circCPSF6) expression served as an independent prognostic factor for worse survival of patients with HCC.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Cell Process Cell proliferation
In-vitro Model Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
B76.1/Huh7 Adult hepatocellular carcinoma Homo sapiens CVCL_U443
SNU-449 Adult hepatocellular carcinoma Homo sapiens CVCL_0454
PLC/PRF/5 Adult hepatocellular carcinoma Homo sapiens CVCL_0485
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
In-vivo Model HCC cells stably transfected with empty vector or circCPSF6 were subject to construct animal models, followed by the regular treatment of verteporfin, an inhibitor of YAP signaling.
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03532
 Crosstalk Info 
Epigenetic Regulator WD repeat-containing protein 5 (WDR5)
Regulated Target Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship Histone modification → m6A
Disease Liver cancer
 Disease Info 
Non-coding RNA
m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05559
 Crosstalk Info 
Epigenetic Regulator hsa_circ_0000417 (Circ_CPSF6)
Regulated Target Poly(rC)-binding protein 2
Crosstalk relationship m6A → ncRNA
Disease Liver cancer
 Disease Info 
References
Ref 1 Activation of YAP1 by N6-Methyladenosine-Modified circCPSF6 Drives Malignancy in Hepatocellular Carcinoma. Cancer Res. 2022 Feb 15;82(4):599-614. doi: 10.1158/0008-5472.CAN-21-1628.