m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00753)

Target Name	Interferon gamma receptor 1 (IFNGR1)
Synonyms	IFN-gamma receptor 1; IFN-gamma-R1; CDw119; Interferon gamma receptor alpha-chain; IFN-gamma-R-alpha; CD119 Click to Show/Hide
Gene Name	IFNGR1
Chromosomal Location	6q23.3
Family	Type II cytokine receptor family
Function	Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription . STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). Click to Show/Hide
Gene ID	3459
Uniprot ID	INGR1_HUMAN
HGNC ID	HGNC:5439
KEGG ID	hsa:3459

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

IFNGR1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

YTH domain-containing family protein 1 (YTHDF1) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Loss of YTHDF1 mediated the overexpression of Interferon gamma receptor 1 (IFNGR1) and JAK/STAT1 signaling pathway in tumor cells, which contributes to restored sensitivity to antitumor immunity. YTHDF1 is overexpressed in GC and promotes GC by inducing cell proliferation and repression of DCs-mediated antitumor immune response.
Target Regulation	Down regulation
Responsed Disease	Gastric cancer		ICD-11: 2B72	Disease Info
Pathway Response	JAK-STAT signaling pathway			hsa04630
Cell Process	Immunity
In-vitro Model	YTN16 (Mouse gastric cancer cell line (YTN16))
	MKN74	Gastric tubular adenocarcinoma	Homo sapiens	CVCL_2791
	BGC-823	Gastric carcinoma	Homo sapiens	CVCL_3360
	AGS	Gastric adenocarcinoma	Homo sapiens	CVCL_0139
In-vivo Model	MKN74 cells (5×10⁶/tumor) expressing shNC, shYTHDF1-1, or shYTHDF1-2 were suspended in ice-cold 100 ul PBS:Matrigel gel (1:1, v/v) (Corning, USA), and subcutaneously implanted into the right dorsal flank of 4-week-old NOD.

Gastric cancer [ICD-11: 2B72]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	Loss of YTHDF1 mediated the overexpression of Interferon gamma receptor 1 (IFNGR1) and JAK/STAT1 signaling pathway in tumor cells, which contributes to restored sensitivity to antitumor immunity. YTHDF1 is overexpressed in GC and promotes GC by inducing cell proliferation and repression of DCs-mediated antitumor immune response.
Responsed Disease	Gastric cancer [ICD-11: 2B72]
Target Regulator	YTH domain-containing family protein 1 (YTHDF1)		READER	Regulator Info
Target Regulation	Down regulation
Pathway Response	JAK-STAT signaling pathway			hsa04630
Cell Process	Immunity
In-vitro Model	YTN16 (Mouse gastric cancer cell line (YTN16))
	MKN74	Gastric tubular adenocarcinoma	Homo sapiens	CVCL_2791
	BGC-823	Gastric carcinoma	Homo sapiens	CVCL_3360
	AGS	Gastric adenocarcinoma	Homo sapiens	CVCL_0139
In-vivo Model	MKN74 cells (5×10⁶/tumor) expressing shNC, shYTHDF1-1, or shYTHDF1-2 were suspended in ice-cold 100 ul PBS:Matrigel gel (1:1, v/v) (Corning, USA), and subcutaneously implanted into the right dorsal flank of 4-week-old NOD.

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00753)

Interferon gamma receptor 1 (IFNGR1)

Adenosine-to-Inosine editing (A-to-I)

In total 12 m6A sequence/site(s) in this target gene
mod ID: A2ISITE001769		Click to Show/Hide the Full List
mod site	chr6:137199258-137199259:-		[2]
Sequence	ATATAAAGGGGAGTTTATTTAGTATTATTTAGTATTAACTC
Transcript ID List	ENST00000645045.1; ENST00000642390.1; ENST00000645753.1; ENST00000643119.1; ENST00000644894.1; ENST00000367739.8; ENST00000646036.1; ENST00000647124.1; ENST00000646898.1
External Link	RMBase: RNA-editing_site_119118
mod ID: A2ISITE001770		Click to Show/Hide the Full List
mod site	chr6:137199607-137199608:-		[3]
Sequence	TATATATATAATACCAAATAAACTCCCCTTTATATAAATCT
Transcript ID List	ENST00000644894.1; ENST00000645045.1; ENST00000646036.1; ENST00000642390.1; ENST00000646898.1; ENST00000643119.1; ENST00000647124.1; ENST00000645753.1; ENST00000367739.8
External Link	RMBase: RNA-editing_site_119119
mod ID: A2ISITE001771		Click to Show/Hide the Full List
mod site	chr6:137199608-137199609:-		[3]
Sequence	ATATATATATAATACCAAATAAACTCCCCTTTATATAAATC
Transcript ID List	ENST00000646898.1; ENST00000642390.1; ENST00000367739.8; ENST00000645753.1; ENST00000647124.1; ENST00000646036.1; ENST00000643119.1; ENST00000644894.1; ENST00000645045.1
External Link	RMBase: RNA-editing_site_119120
mod ID: A2ISITE001772		Click to Show/Hide the Full List
mod site	chr6:137199611-137199612:-		[3]
Sequence	AAGATATATATATAATACCAAATAAACTCCCCTTTATATAA
Transcript ID List	ENST00000645753.1; ENST00000646898.1; ENST00000644894.1; ENST00000645045.1; ENST00000646036.1; ENST00000643119.1; ENST00000647124.1; ENST00000642390.1; ENST00000367739.8
External Link	RMBase: RNA-editing_site_119121
mod ID: A2ISITE001773		Click to Show/Hide the Full List
mod site	chr6:137199615-137199616:-		[3]
Sequence	TATAAAGATATATATATAATACCAAATAAACTCCCCTTTAT
Transcript ID List	ENST00000646898.1; ENST00000645045.1; ENST00000645753.1; ENST00000646036.1; ENST00000642390.1; ENST00000647124.1; ENST00000367739.8; ENST00000644894.1; ENST00000643119.1
External Link	RMBase: RNA-editing_site_119122
mod ID: A2ISITE001774		Click to Show/Hide the Full List
mod site	chr6:137199617-137199618:-		[3]
Sequence	TATATAAAGATATATATATAATACCAAATAAACTCCCCTTT
Transcript ID List	ENST00000645045.1; ENST00000646036.1; ENST00000645753.1; ENST00000643119.1; ENST00000367739.8; ENST00000642390.1; ENST00000644894.1; ENST00000646898.1; ENST00000647124.1
External Link	RMBase: RNA-editing_site_119123
mod ID: A2ISITE001775		Click to Show/Hide the Full List
mod site	chr6:137210179-137210180:-		[2]
Sequence	ACAGGCCTCTTCACCTGGCTAATTTTTTAATTATTTGCGGA
Transcript ID List	ENST00000643119.1; ENST00000645045.1; ENST00000478333.1; ENST00000642390.1; ENST00000645753.1; ENST00000644894.1; ENST00000367739.8; ENST00000414770.5; ENST00000458076.5; ENST00000646898.1; ENST00000646036.1; ENST00000647124.1
External Link	RMBase: RNA-editing_site_119124
mod ID: A2ISITE001776		Click to Show/Hide the Full List
mod site	chr6:137212555-137212556:-		[3]
Sequence	ATAATTAAAAAGAGAGCCTTAGGCTGGGCCCGGTGGCTCAC
Transcript ID List	ENST00000458076.5; ENST00000645753.1; ENST00000647124.1; ENST00000644894.1; ENST00000414770.5; ENST00000478333.1; ENST00000642390.1; ENST00000646036.1; ENST00000646898.1; ENST00000643119.1; ENST00000367739.8; ENST00000645045.1
External Link	RMBase: RNA-editing_site_119125
mod ID: A2ISITE001777		Click to Show/Hide the Full List
mod site	chr6:137216830-137216831:-		[3]
Sequence	AAGCCTTTCCTGACTCCCCTAGAAGAGACAAGCACCCCGGC
Transcript ID List	ENST00000645753.1; ENST00000646898.1; ENST00000646036.1; ENST00000414770.5; ENST00000645045.1; ENST00000478333.1; ENST00000642390.1; ENST00000644894.1; ENST00000367739.8; ENST00000647124.1; ENST00000643119.1; ENST00000458076.5
External Link	RMBase: RNA-editing_site_119126
mod ID: A2ISITE001778		Click to Show/Hide the Full List
mod site	chr6:137217966-137217967:-		[3]
Sequence	GCGGGGTGCTTGTCTCTTTTAGGGAAGTCAGTGAAGACTTC
Transcript ID List	ENST00000367739.8; ENST00000646036.1; ENST00000642390.1; ENST00000646898.1; ENST00000458076.5; ENST00000644894.1; ENST00000414770.5; ENST00000478333.1; ENST00000647124.1; ENST00000643119.1; ENST00000645753.1; ENST00000645045.1
External Link	RMBase: RNA-editing_site_119127
mod ID: A2ISITE001779		Click to Show/Hide the Full List
mod site	chr6:137217988-137217989:-		[4]
Sequence	GCACAGACTAGTGGAAAGCAAGGCGGGGTGCTTGTCTCTTT
Transcript ID List	ENST00000645753.1; ENST00000645045.1; ENST00000643119.1; ENST00000367739.8; ENST00000458076.5; ENST00000642390.1; ENST00000646036.1; ENST00000646898.1; ENST00000647124.1; ENST00000414770.5; ENST00000478333.1; ENST00000644894.1
External Link	RMBase: RNA-editing_site_119128
mod ID: A2ISITE001780		Click to Show/Hide the Full List
mod site	chr6:137217999-137218000:-		[3]
Sequence	CTTGCACTTAGGCACAGACTAGTGGAAAGCAAGGCGGGGTG
Transcript ID List	ENST00000644894.1; ENST00000414770.5; ENST00000647124.1; ENST00000642390.1; ENST00000645045.1; ENST00000646036.1; ENST00000458076.5; ENST00000643119.1; ENST00000645753.1; ENST00000478333.1; ENST00000367739.8; ENST00000646898.1
External Link	RMBase: RNA-editing_site_119129

N6-methyladenosine (m6A)

In total 46 m6A sequence/site(s) in this target gene
mod ID: M6ASITE077356		Click to Show/Hide the Full List
mod site	chr6:137197487-137197488:-		[5]
Sequence	TTTAAATAAAGAATTTTAAAACTCGTTTTTGTATTCATTTA
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000643119.1; ENST00000645045.1; ENST00000367739.8
External Link	RMBase: m6A_site_735264
mod ID: M6ASITE077357		Click to Show/Hide the Full List
mod site	chr6:137197520-137197521:-		[6]
Sequence	TATATTTTTTATGAAACATTACAGTTAGAGATTTTTAAATA
Motif Score	2.07285119
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000645753.1; ENST00000644894.1; ENST00000645045.1; ENST00000643119.1; ENST00000647124.1; ENST00000367739.8; ENST00000646036.1; ENST00000642390.1; ENST00000646898.1
External Link	RMBase: m6A_site_735265
mod ID: M6ASITE077358		Click to Show/Hide the Full List
mod site	chr6:137197525-137197526:-		[6]
Sequence	ACGTGTATATTTTTTATGAAACATTACAGTTAGAGATTTTT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; Huh7
Seq Type List	DART-seq; MeRIP-seq
Transcript ID List	ENST00000643119.1; ENST00000646898.1; ENST00000642390.1; ENST00000645753.1; ENST00000645045.1; ENST00000367739.8; ENST00000647124.1; ENST00000646036.1; ENST00000644894.1
External Link	RMBase: m6A_site_735266
mod ID: M6ASITE077359		Click to Show/Hide the Full List
mod site	chr6:137197577-137197578:-		[6]
Sequence	GGACTTAAAATCTAATTCAAACTAATAGAATTAATGGAATA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; hNPCs; Huh7
Seq Type List	MeRIP-seq; DART-seq; m6A-seq
Transcript ID List	ENST00000645045.1; ENST00000644894.1; ENST00000646898.1; ENST00000642390.1; ENST00000647124.1; ENST00000367739.8; ENST00000643119.1; ENST00000645753.1; ENST00000646036.1
External Link	RMBase: m6A_site_735267
mod ID: M6ASITE077360		Click to Show/Hide the Full List
mod site	chr6:137197595-137197596:-		[7]
Sequence	TGCAAGCTTTTCAAAATTGGACTTAAAATCTAATTCAAACT
Motif Score	4.065041667
Cell/Tissue List	HEK293T; hNPCs; CD8T; A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000646036.1; ENST00000642390.1; ENST00000367739.8; ENST00000645753.1; ENST00000644894.1; ENST00000645045.1; ENST00000646898.1; ENST00000643119.1; ENST00000647124.1
External Link	RMBase: m6A_site_735268
mod ID: M6ASITE077361		Click to Show/Hide the Full List
mod site	chr6:137197647-137197648:-		[6]
Sequence	GTTTTTGTAAGTTTATGCATACAGTAATTTTAAGTAATTTC
Motif Score	2.110482143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000644894.1; ENST00000646036.1; ENST00000645753.1; ENST00000367739.8; ENST00000645045.1; ENST00000646898.1; ENST00000642390.1; ENST00000647124.1; ENST00000643119.1
External Link	RMBase: m6A_site_735269
mod ID: M6ASITE077362		Click to Show/Hide the Full List
mod site	chr6:137197707-137197708:-		[6]
Sequence	CCCCAGGGACCTTTGTAGCCACTTCACTTTTTTTCTTTTCT
Motif Score	2.475107143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000646036.1; ENST00000645753.1; ENST00000643119.1; ENST00000642390.1; ENST00000644894.1; ENST00000367739.8; ENST00000646898.1; ENST00000645045.1; ENST00000647124.1
External Link	RMBase: m6A_site_735270
mod ID: M6ASITE077363		Click to Show/Hide the Full List
mod site	chr6:137197719-137197720:-		[8]
Sequence	GAGCAGGTGATGCCCCAGGGACCTTTGTAGCCACTTCACTT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; A549; LCLs; Huh7; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367739.8; ENST00000644894.1; ENST00000645045.1; ENST00000646898.1; ENST00000646036.1; ENST00000647124.1; ENST00000643119.1; ENST00000645753.1; ENST00000642390.1
External Link	RMBase: m6A_site_735271
mod ID: M6ASITE077364		Click to Show/Hide the Full List
mod site	chr6:137197756-137197757:-		[6]
Sequence	GTAACGGAACAGTATCCAGTACTCCTGGTTCCTAGGTGAGC
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000643119.1; ENST00000646898.1; ENST00000644894.1; ENST00000647124.1; ENST00000645753.1; ENST00000646036.1; ENST00000367739.8; ENST00000642390.1; ENST00000645045.1
External Link	RMBase: m6A_site_735272
mod ID: M6ASITE077365		Click to Show/Hide the Full List
mod site	chr6:137197768-137197769:-		[9]
Sequence	GATAGGTTACCAGTAACGGAACAGTATCCAGTACTCCTGGT
Motif Score	2.951386905
Cell/Tissue List	HEK293T; liver; hESC-HEK293T; HeLa; A549; LCLs; Huh7; HEK293A-TOA; MSC
Seq Type List	MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000645753.1; ENST00000644894.1; ENST00000646036.1; ENST00000647124.1; ENST00000646898.1; ENST00000367739.8; ENST00000645045.1; ENST00000642390.1; ENST00000643119.1
External Link	RMBase: m6A_site_735273
mod ID: M6ASITE077366		Click to Show/Hide the Full List
mod site	chr6:137197801-137197802:-		[10]
Sequence	AAAAGCATTGTAACTTATGAACCTTTACATCCAGATAGGTT
Motif Score	2.930744048
Cell/Tissue List	HEK293T; HeLa; A549; LCLs; Huh7; HEK293A-TOA; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000367739.8; ENST00000646898.1; ENST00000645753.1; ENST00000647124.1; ENST00000644894.1; ENST00000643119.1; ENST00000642390.1; ENST00000646036.1; ENST00000645045.1
External Link	RMBase: m6A_site_735274
mod ID: M6ASITE077367		Click to Show/Hide the Full List
mod site	chr6:137197826-137197827:-		[10]
Sequence	AGACTTTTTTTTTTTTTTAAACAAAAAAAGCATTGTAACTT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HeLa; hESCs; A549; LCLs; Huh7; HEK293A-TOA; MSC; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000647124.1; ENST00000367739.8; ENST00000646036.1; ENST00000644894.1; ENST00000646898.1; ENST00000645045.1; ENST00000645753.1; ENST00000642390.1; ENST00000643119.1
External Link	RMBase: m6A_site_735275
mod ID: M6ASITE077368		Click to Show/Hide the Full List
mod site	chr6:137197844-137197845:-		[8]
Sequence	TTTTGGCTTGTAAAGTACAGACTTTTTTTTTTTTTTAAACA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; hESCs; A549; LCLs; Huh7; HEK293A-TOA; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000646898.1; ENST00000642390.1; ENST00000645753.1; ENST00000367739.8; ENST00000644894.1; ENST00000646036.1; ENST00000645045.1; ENST00000647124.1; ENST00000643119.1
External Link	RMBase: m6A_site_735276
mod ID: M6ASITE077369		Click to Show/Hide the Full List
mod site	chr6:137197866-137197867:-		[6]
Sequence	AGAGGATGTGTGGCATTTTCACTTTTGGCTTGTAAAGTACA
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000647124.1; ENST00000645753.1; ENST00000643119.1; ENST00000645045.1; ENST00000646036.1; ENST00000644894.1; ENST00000642390.1; ENST00000646898.1; ENST00000367739.8
External Link	RMBase: m6A_site_735277
mod ID: M6ASITE077370		Click to Show/Hide the Full List
mod site	chr6:137197900-137197901:-		[6]
Sequence	CAAATGGAGTGACTTAGTGTACATGAAAGCGTAAAGAGGAT
Motif Score	2.856142857
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000646898.1; ENST00000645045.1; ENST00000643119.1; ENST00000645753.1; ENST00000646036.1; ENST00000642390.1; ENST00000647124.1; ENST00000644894.1; ENST00000367739.8
External Link	RMBase: m6A_site_735278
mod ID: M6ASITE077371		Click to Show/Hide the Full List
mod site	chr6:137197909-137197910:-		[6]
Sequence	GGTATCAACCAAATGGAGTGACTTAGTGTACATGAAAGCGT
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000644894.1; ENST00000646898.1; ENST00000642390.1; ENST00000645045.1; ENST00000643119.1; ENST00000645753.1; ENST00000647124.1; ENST00000646036.1; ENST00000367739.8
External Link	RMBase: m6A_site_735279
mod ID: M6ASITE077372		Click to Show/Hide the Full List
mod site	chr6:137197987-137197988:-		[8]
Sequence	TTGAAGTCTGATTTTCCTGGACAGTTTTCTGCTTTAATTTC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; A549; LCLs; Huh7
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000642390.1; ENST00000645753.1; ENST00000647124.1; ENST00000646036.1; ENST00000646898.1; ENST00000367739.8; ENST00000643119.1; ENST00000644894.1; ENST00000645045.1
External Link	RMBase: m6A_site_735280
mod ID: M6ASITE077373		Click to Show/Hide the Full List
mod site	chr6:137198060-137198061:-		[8]
Sequence	GAGTCCTTGATTGGTTATAGACCAACAGAAGATTCCAAAGA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; A549; hNPCs; fibroblasts; LCLs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000645753.1; ENST00000643119.1; ENST00000367739.8; ENST00000647124.1; ENST00000642390.1; ENST00000645045.1; ENST00000646036.1; ENST00000644894.1; ENST00000646898.1
External Link	RMBase: m6A_site_735281
mod ID: M6ASITE077374		Click to Show/Hide the Full List
mod site	chr6:137198102-137198103:-		[6]
Sequence	CCACATGTGCTAGTGGATCTACTTGTGGATGATAGCGGTAA
Motif Score	2.500660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000642390.1; ENST00000646036.1; ENST00000367739.8; ENST00000647124.1; ENST00000643119.1; ENST00000646898.1; ENST00000645753.1; ENST00000645045.1; ENST00000644894.1
External Link	RMBase: m6A_site_735282
mod ID: M6ASITE077375		Click to Show/Hide the Full List
mod site	chr6:137198120-137198121:-		[9]
Sequence	TCCTTTGGTTATGATAAACCACATGTGCTAGTGGATCTACT
Motif Score	2.053113095
Cell/Tissue List	brain; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000645045.1; ENST00000644894.1; ENST00000367739.8; ENST00000642390.1; ENST00000647124.1; ENST00000646036.1; ENST00000645753.1; ENST00000643119.1; ENST00000646898.1
External Link	RMBase: m6A_site_735283
mod ID: M6ASITE077376		Click to Show/Hide the Full List
mod site	chr6:137198123-137198124:-		[8]
Sequence	ACCTCCTTTGGTTATGATAAACCACATGTGCTAGTGGATCT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; A549; hNPCs; hESCs; fibroblasts; LCLs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000643119.1; ENST00000646036.1; ENST00000642390.1; ENST00000367739.8; ENST00000645753.1; ENST00000647124.1; ENST00000644894.1; ENST00000646898.1; ENST00000645045.1
External Link	RMBase: m6A_site_735284
mod ID: M6ASITE077377		Click to Show/Hide the Full List
mod site	chr6:137198174-137198175:-		[8]
Sequence	GGTGAAATAAAAACAGAAGGACAAGAGCTCATAACCGTAAT
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HEK293T; A549; hESC-HEK293T; hNPCs; hESCs; fibroblasts; LCLs; CD8T; Huh7; MSC; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000646898.1; ENST00000646036.1; ENST00000644894.1; ENST00000642390.1; ENST00000645753.1; ENST00000643119.1; ENST00000645045.1; ENST00000367739.8; ENST00000647124.1
External Link	RMBase: m6A_site_735285
mod ID: M6ASITE077378		Click to Show/Hide the Full List
mod site	chr6:137198182-137198183:-		[8]
Sequence	ATAATAAAGGTGAAATAAAAACAGAAGGACAAGAGCTCATA
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HEK293T; A549; hNPCs; hESCs; fibroblasts; LCLs; Huh7; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000643119.1; ENST00000646036.1; ENST00000646898.1; ENST00000647124.1; ENST00000645045.1; ENST00000367739.8; ENST00000644894.1; ENST00000645753.1; ENST00000642390.1
External Link	RMBase: m6A_site_735286
mod ID: M6ASITE077379		Click to Show/Hide the Full List
mod site	chr6:137198237-137198238:-		[9]
Sequence	GATTCCAGCTGTCTGGAATCACATAGCTCCTTATCTGACTC
Motif Score	2.047297619
Cell/Tissue List	brain; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000645045.1; ENST00000644894.1; ENST00000647124.1; ENST00000645753.1; ENST00000643119.1; ENST00000646898.1; ENST00000367739.8; ENST00000646036.1; ENST00000642390.1
External Link	RMBase: m6A_site_735287
mod ID: M6ASITE077380		Click to Show/Hide the Full List
mod site	chr6:137198260-137198261:-		[6]
Sequence	ACTCCAGAAATGGTTTTGATACTGATTCCAGCTGTCTGGAA
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000646036.1; ENST00000646898.1; ENST00000642390.1; ENST00000367739.8; ENST00000644894.1; ENST00000647124.1; ENST00000645753.1; ENST00000643119.1; ENST00000645045.1
External Link	RMBase: m6A_site_735288
mod ID: M6ASITE077381		Click to Show/Hide the Full List
mod site	chr6:137198316-137198317:-		[8]
Sequence	ACCTGGCAGCATCGCTTTAAACTCGTATCACTCCAGAAATT
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; LCLs; Huh7; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367739.8; ENST00000647124.1; ENST00000642390.1; ENST00000646898.1; ENST00000646036.1; ENST00000644894.1; ENST00000645753.1; ENST00000643119.1; ENST00000645045.1
External Link	RMBase: m6A_site_735289
mod ID: M6ASITE077382		Click to Show/Hide the Full List
mod site	chr6:137198336-137198337:-		[8]
Sequence	TTAAGTAGTAACCAGTCTGAACCTGGCAGCATCGCTTTAAA
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HEK293T; A549; HepG2; U2OS; hNPCs; hESCs; fibroblasts; LCLs; Huh7; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000645753.1; ENST00000646036.1; ENST00000643119.1; ENST00000645045.1; ENST00000642390.1; ENST00000647124.1; ENST00000644894.1; ENST00000367739.8; ENST00000646898.1
External Link	RMBase: m6A_site_735290
mod ID: M6ASITE077383		Click to Show/Hide the Full List
mod site	chr6:137198409-137198410:-		[11]
Sequence	TACTGAAGAAAATATTCCTGACGTGGTCCCGGGCAGCCATC
Motif Score	2.833690476
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000647124.1; ENST00000643119.1; ENST00000646898.1; ENST00000645753.1; ENST00000646036.1; ENST00000367739.8; ENST00000642390.1; ENST00000645045.1; ENST00000644894.1
External Link	RMBase: m6A_site_735291
mod ID: M6ASITE077384		Click to Show/Hide the Full List
mod site	chr6:137198456-137198457:-		[8]
Sequence	AAAGTGGAACATACAGAAGAACTTTCTAGTATAACAGAAGT
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HEK293T; U2OS; hNPCs; hESCs; fibroblasts; A549; LCLs; CD8T; Huh7; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000646898.1; ENST00000642390.1; ENST00000645045.1; ENST00000644894.1; ENST00000643119.1; ENST00000645753.1; ENST00000367739.8; ENST00000647124.1; ENST00000646036.1
External Link	RMBase: m6A_site_735292
mod ID: M6ASITE077385		Click to Show/Hide the Full List
mod site	chr6:137198468-137198469:-		[8]
Sequence	GACAATCCAGGAAAAGTGGAACATACAGAAGAACTTTCTAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HEK293T; hESC-HEK293T; U2OS; hNPCs; hESCs; fibroblasts; A549; LCLs; CD8T; HEK293A-TOA; MSC; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000644894.1; ENST00000643119.1; ENST00000645045.1; ENST00000647124.1; ENST00000646036.1; ENST00000646898.1; ENST00000367739.8; ENST00000645753.1; ENST00000642390.1
External Link	RMBase: m6A_site_735293
mod ID: M6ASITE077386		Click to Show/Hide the Full List
mod site	chr6:137198487-137198488:-		[8]
Sequence	TCCAGGCATGCATACCGAAGACAATCCAGGAAAAGTGGAAC
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; HEK293T; hESC-HEK293T; U2OS; hNPCs; hESCs; fibroblasts; A549; LCLs; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000645753.1; ENST00000647124.1; ENST00000644894.1; ENST00000642390.1; ENST00000646036.1; ENST00000367739.8; ENST00000646898.1; ENST00000643119.1; ENST00000645045.1
External Link	RMBase: m6A_site_735294
mod ID: M6ASITE077387		Click to Show/Hide the Full List
mod site	chr6:137198603-137198604:-		[8]
Sequence	AGTGCTACTTTAGAGACAAAACCTGAATCAAAATATGTATC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000645045.1; ENST00000646898.1; ENST00000643119.1; ENST00000647124.1; ENST00000646036.1; ENST00000642390.1; ENST00000645753.1; ENST00000644894.1; ENST00000367739.8
External Link	RMBase: m6A_site_735295
mod ID: M6ASITE077388		Click to Show/Hide the Full List
mod site	chr6:137198608-137198609:-		[8]
Sequence	TAAGAAGTGCTACTTTAGAGACAAAACCTGAATCAAAATAT
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000643119.1; ENST00000642390.1; ENST00000645045.1; ENST00000646036.1; ENST00000644894.1; ENST00000646898.1; ENST00000645753.1; ENST00000647124.1; ENST00000367739.8
External Link	RMBase: m6A_site_735296
mod ID: M6ASITE077389		Click to Show/Hide the Full List
mod site	chr6:137200973-137200974:-		[6]
Sequence	CCAGTTGTTGCTGCTTTACTACTCTTTCTAGTGCTTAGCCT
Motif Score	2.500660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000647124.1; ENST00000644894.1; ENST00000643119.1; ENST00000646036.1; ENST00000642390.1; ENST00000645753.1; ENST00000645045.1; ENST00000646898.1; ENST00000367739.8
External Link	RMBase: m6A_site_735297
mod ID: M6ASITE077390		Click to Show/Hide the Full List
mod site	chr6:137203568-137203569:-		[12]
Sequence	GTTTCAGCAGAAGGAGTCTTACATGTGTGGGGTGTTACAAC
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000644894.1; ENST00000458076.5; ENST00000367739.8; ENST00000646898.1; ENST00000646036.1; ENST00000647124.1; ENST00000642390.1; ENST00000643119.1; ENST00000645753.1; ENST00000645045.1
External Link	RMBase: m6A_site_735298
mod ID: M6ASITE077391		Click to Show/Hide the Full List
mod site	chr6:137204362-137204363:-		[12]
Sequence	TACCTGTTACATTAGGGTGTACAATGTGTATGTGAGAATGA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000646036.1; ENST00000644894.1; ENST00000645753.1; ENST00000643119.1; ENST00000647124.1; ENST00000642390.1; ENST00000367739.8; ENST00000646898.1; ENST00000458076.5; ENST00000645045.1; ENST00000414770.5
External Link	RMBase: m6A_site_735299
mod ID: M6ASITE077392		Click to Show/Hide the Full List
mod site	chr6:137204374-137204375:-		[12]
Sequence	TGATCCCGAAACTACCTGTTACATTAGGGTGTACAATGTGT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000644894.1; ENST00000642390.1; ENST00000458076.5; ENST00000367739.8; ENST00000645753.1; ENST00000646898.1; ENST00000645045.1; ENST00000647124.1; ENST00000414770.5; ENST00000643119.1; ENST00000646036.1
External Link	RMBase: m6A_site_735300
mod ID: M6ASITE077393		Click to Show/Hide the Full List
mod site	chr6:137204446-137204447:-		[12]
Sequence	GGAGAAGCAAATCATGATTGACATATTTCACCCTTCAGTTT
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000645045.1; ENST00000414770.5; ENST00000642390.1; ENST00000647124.1; ENST00000646036.1; ENST00000645753.1; ENST00000458076.5; ENST00000367739.8; ENST00000643119.1; ENST00000646898.1; ENST00000644894.1
External Link	RMBase: m6A_site_735301
mod ID: M6ASITE077394		Click to Show/Hide the Full List
mod site	chr6:137204484-137204485:-		[13]
Sequence	GGAAAAATTGGACCACCTAAACTGGATATCAGAAAGGAGGA
Motif Score	2.627720238
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000646898.1; ENST00000458076.5; ENST00000645753.1; ENST00000646036.1; ENST00000644894.1; ENST00000643119.1; ENST00000645045.1; ENST00000647124.1; ENST00000642390.1; ENST00000414770.5; ENST00000367739.8
External Link	RMBase: m6A_site_735302
mod ID: M6ASITE077395		Click to Show/Hide the Full List
mod site	chr6:137204493-137204494:-		[13]
Sequence	CCTTCCCCAGGAAAAATTGGACCACCTAAACTGGATATCAG
Motif Score	3.622404762
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000646036.1; ENST00000645045.1; ENST00000646898.1; ENST00000642390.1; ENST00000645753.1; ENST00000647124.1; ENST00000367739.8; ENST00000458076.5; ENST00000643119.1; ENST00000644894.1; ENST00000414770.5
External Link	RMBase: m6A_site_735303
mod ID: M6ASITE077396		Click to Show/Hide the Full List
mod site	chr6:137206187-137206188:-		[13]
Sequence	AGAGTTAAAGCCAGGGTTGGACAAAAAGAATCTGCCTATGC
Motif Score	3.643047619
Cell/Tissue List	CD34; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000647124.1; ENST00000367739.8; ENST00000642390.1; ENST00000646898.1; ENST00000645753.1; ENST00000646036.1; ENST00000414770.5; ENST00000645045.1; ENST00000644894.1; ENST00000643119.1; ENST00000458076.5
External Link	RMBase: m6A_site_735304
mod ID: M6ASITE077397		Click to Show/Hide the Full List
mod site	chr6:137207034-137207035:-		[13]
Sequence	AATTGAATCCTATAACATGAACCCTATCGTATATTGGGAGT
Motif Score	2.930744048
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000644894.1; ENST00000646036.1; ENST00000414770.5; ENST00000478333.1; ENST00000645045.1; ENST00000647124.1; ENST00000642390.1; ENST00000646898.1; ENST00000458076.5; ENST00000645753.1; ENST00000367739.8; ENST00000643119.1
External Link	RMBase: m6A_site_735305
mod ID: M6ASITE077398		Click to Show/Hide the Full List
mod site	chr6:137207040-137207041:-		[12]
Sequence	TGTTACAATTGAATCCTATAACATGAACCCTATCGTATATT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000647124.1; ENST00000642390.1; ENST00000458076.5; ENST00000643119.1; ENST00000644894.1; ENST00000645045.1; ENST00000645753.1; ENST00000646036.1; ENST00000414770.5; ENST00000367739.8; ENST00000478333.1; ENST00000646898.1
External Link	RMBase: m6A_site_735306
mod ID: M6ASITE077399		Click to Show/Hide the Full List
mod site	chr6:137207071-137207072:-		[12]
Sequence	TTTATTTTCTTACAGTGCCTACACCAACTAATGTTACAATT
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000458076.5; ENST00000647124.1; ENST00000646898.1; ENST00000645045.1; ENST00000478333.1; ENST00000646036.1; ENST00000644894.1; ENST00000367739.8; ENST00000414770.5; ENST00000645753.1; ENST00000643119.1; ENST00000642390.1
External Link	RMBase: m6A_site_735307
mod ID: M6ASITE077400		Click to Show/Hide the Full List
mod site	chr6:137209882-137209883:-		[13]
Sequence	GAGAGCAGAGTGTTGATGAAACTGGAATGTGTGGCTCCATT
Motif Score	2.627720238
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000478333.1; ENST00000646036.1; ENST00000643119.1; ENST00000645045.1; ENST00000458076.5; ENST00000647124.1; ENST00000646898.1; ENST00000644894.1; ENST00000645753.1; ENST00000642390.1; ENST00000414770.5; ENST00000367739.8
External Link	RMBase: m6A_site_735308
mod ID: M6ASITE077401		Click to Show/Hide the Full List
mod site	chr6:137219425-137219426:-		[8]
Sequence	TCCTGCCGACGCCGGCACAGACCCCGGTGACGGAAGTGACG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000414770.5; ENST00000478333.1; ENST00000458076.5; ENST00000367739.8
External Link	RMBase: m6A_site_735309

Ref 1	Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells. J Immunother Cancer. 2022 Feb;10(2):e003663. doi: 10.1136/jitc-2021-003663.
Ref 2	Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2012 Jan;22(1):142-50. doi: 10.1101/gr.124107.111. Epub 2011 Sep 29.
Ref 3	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 4	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 5	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 6	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 7	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 8	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 10	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 11	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 12	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 13	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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