m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00738)

Target Name	Mothers against decapentaplegic homolog 6 (SMAD6)
Synonyms	MAD homolog 6; Mothers against DPP homolog 6; SMAD family member 6; SMAD 6; Smad6; hSMAD6 Click to Show/Hide
Gene Name	SMAD6
Chromosomal Location	15q22.31
Family	Dwarfin/SMAD family
Function	Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta. Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes. Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding . Binds to regulatory elements in target promoter regions. Click to Show/Hide
Gene ID	4091
Uniprot ID	SMAD6_HUMAN
HGNC ID	HGNC:6772
KEGG ID	hsa:4091

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

SMAD6 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

RNA demethylase ALKBH5 (ALKBH5) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5*
Cell Line	THP1 cell line	Homo sapiens
Treatment: ALKBH5 knockdown THP1 cells Control: Wild type THP1 cells		GSE128574
Regulation		logFC: 7.02E-01 p-value: 2.75E-03
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	ALKBH5 weakens YTHDF1/3-mediated TGF-Beta-R2 and SMAD3 mRNA stabilization, and abolishes YTHDF2-mediated Mothers against decapentaplegic homolog 6 (SMAD6) mRNA degradation, supporting the notion that ALKBH5 inhibits TGF-Beta-induced EMT and invasion of NSCLC cells via YTHD1/2/3-mediated mechanism.
Target Regulation	Up regulation
Responsed Disease	Non-small-cell lung carcinoma		ICD-11: 2C25.Y	Disease Info
Pathway Response	TGF-beta signaling pathway			hsa04350
Cell Process	Epithelial-mesenchymal transition
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
	NCI-H1650	Minimally invasive lung adenocarcinoma	Homo sapiens	CVCL_1483
	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
In-vivo Model	The mice were divided into control group and ALKBH5-overexpressing group (9 mice per group). ALKBH5-overexpressing and control A549 cells (3 × 10⁶ cells/mouse) in 200 uL PBS were intravenously (i.v.) injected into the lateral tail vein of mice. At every 5th day post-inoculation, TGF-Beta-1 (4 ug/kg body weight) was intraperitoneally (i.p.) injected to promote tumor cell metastasis. Eight weeks later, the mice were euthanized, and then their lungs and livers were taken out and fixed in Bouin's solution (Sigma Aldrich, HT101128) or 4% Paraformaldehyde (Beyotime, p0099, Shanghai, China) for macroscopically metastatic nodule analysis.

Lung cancer [ICD-11: 2C25]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	ALKBH5 weakens YTHDF1/3-mediated TGF-Beta-R2 and SMAD3 mRNA stabilization, and abolishes YTHDF2-mediated Mothers against decapentaplegic homolog 6 (SMAD6) mRNA degradation, supporting the notion that ALKBH5 inhibits TGF-Beta-induced EMT and invasion of NSCLC cells via YTHD1/2/3-mediated mechanism.
Responsed Disease	Non-small-cell lung carcinoma [ICD-11: 2C25.Y]
Target Regulator	RNA demethylase ALKBH5 (ALKBH5)		ERASER	Regulator Info
Target Regulation	Up regulation
Pathway Response	TGF-beta signaling pathway			hsa04350
Cell Process	Epithelial-mesenchymal transition
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
	NCI-H1650	Minimally invasive lung adenocarcinoma	Homo sapiens	CVCL_1483
	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
In-vivo Model	The mice were divided into control group and ALKBH5-overexpressing group (9 mice per group). ALKBH5-overexpressing and control A549 cells (3 × 10⁶ cells/mouse) in 200 uL PBS were intravenously (i.v.) injected into the lateral tail vein of mice. At every 5th day post-inoculation, TGF-Beta-1 (4 ug/kg body weight) was intraperitoneally (i.p.) injected to promote tumor cell metastasis. Eight weeks later, the mice were euthanized, and then their lungs and livers were taken out and fixed in Bouin's solution (Sigma Aldrich, HT101128) or 4% Paraformaldehyde (Beyotime, p0099, Shanghai, China) for macroscopically metastatic nodule analysis.

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00738)

Mothers against decapentaplegic homolog 6 (SMAD6)

Adenosine-to-Inosine editing (A-to-I)

In total 6 m6A sequence/site(s) in this target gene
mod ID: A2ISITE007026		Click to Show/Hide the Full List
mod site	chr15:66711090-66711091:+		[2]
Sequence	AAAATGCAGGATGCCCAGTTAAATTCGAGTATCAGATAAAC
Transcript ID List	ENST00000557916.5; ENST00000288840.10; rmsk_4367314
External Link	RMBase: RNA-editing_site_44734
mod ID: A2ISITE007027		Click to Show/Hide the Full List
mod site	chr15:66711109-66711110:+		[2]
Sequence	TAAATTCGAGTATCAGATAAACAACACACCATATTTTAGTA
Transcript ID List	ENST00000557916.5; ENST00000288840.10; rmsk_4367314
External Link	RMBase: RNA-editing_site_44735
mod ID: A2ISITE007028		Click to Show/Hide the Full List
mod site	chr15:66711193-66711194:+		[2]
Sequence	AATGATGCCATGTTTATCCAAAACTCAAATGTAACTGAGCA
Transcript ID List	ENST00000557916.5; ENST00000288840.10; rmsk_4367314
External Link	RMBase: RNA-editing_site_44736
mod ID: A2ISITE007029		Click to Show/Hide the Full List
mod site	chr15:66712748-66712749:+		[2]
Sequence	GGGAACGATGGCTCATGCCTATAATCCCAGCATTTTAGGAG
Transcript ID List	ENST00000288840.10; rmsk_4367317; ENST00000557916.5; ENST00000559931.5; ENST00000558937.1
External Link	RMBase: RNA-editing_site_44737
mod ID: A2ISITE007030		Click to Show/Hide the Full List
mod site	chr15:66721374-66721375:+		[2]
Sequence	TTCCTGCTGTTTTCTTGATTACAGGGACCAAGTGTGTTCTC
Transcript ID List	ENST00000557916.5; ENST00000288840.10; ENST00000559931.5
External Link	RMBase: RNA-editing_site_44738
mod ID: A2ISITE007031		Click to Show/Hide the Full List
mod site	chr15:66772722-66772723:+		[2]
Sequence	GTTAGGAAACTGAGGCCTAAAAGGGTGAAGTCACTCGTCCA
Transcript ID List	ENST00000288840.10; ENST00000557916.5; ENST00000559931.5
External Link	RMBase: RNA-editing_site_44739

5-methylcytidine (m5C)

In total 3 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000454		Click to Show/Hide the Full List
mod site	chr15:66703222-66703223:+		[3]
Sequence	GACCCCCGGTAACCGGAGACCGCCTCCCCCCCACCCCTGGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000612349.1; ENST00000288840.10
External Link	RMBase: m5C_site_14178
mod ID: M5CSITE000455		Click to Show/Hide the Full List
mod site	chr15:66704001-66704002:+
Sequence	AAGCCCCTGTGCGGCTGCCACAGCTTCGCCGCCGCCGCCGA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000612349.1; ENST00000288840.10; ENST00000557916.5
External Link	RMBase: m5C_site_14179
mod ID: M5CSITE000456		Click to Show/Hide the Full List
mod site	chr15:66781312-66781313:+
Sequence	CTGGACGCGCCCGGCGGCCGCGCCCTGGTCGTGCGCAAGGT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000557916.5; ENST00000559931.5; ENST00000288840.10
External Link	RMBase: m5C_site_14180

N6-methyladenosine (m6A)

In total 61 m6A sequence/site(s) in this target gene
mod ID: M6ASITE023861		Click to Show/Hide the Full List
mod site	chr15:66702303-66702304:+		[4]
Sequence	TCAGTGTGCGTTTGAGGAGAACAAAAAAGAGAGAGAGAGCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; H1A; H1B; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284225
mod ID: M6ASITE023862		Click to Show/Hide the Full List
mod site	chr15:66702387-66702388:+		[4]
Sequence	GCCGGGCGCTGCCTCGCCAGACCTCGCTGGGACCCCGGGGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284226
mod ID: M6ASITE023863		Click to Show/Hide the Full List
mod site	chr15:66702398-66702399:+		[4]
Sequence	CCTCGCCAGACCTCGCTGGGACCCCGGGGCCACCGGGAGGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284227
mod ID: M6ASITE023864		Click to Show/Hide the Full List
mod site	chr15:66702500-66702501:+		[5]
Sequence	GCAGCGTGGGGCGGGCTGCGACCTCTGCATCGGTGGACTGC
Motif Score	2.844928571
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284228
mod ID: M6ASITE023865		Click to Show/Hide the Full List
mod site	chr15:66702516-66702517:+		[4]
Sequence	TGCGACCTCTGCATCGGTGGACTGCATTTTTAATTAAGGAT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; fibroblasts; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284229
mod ID: M6ASITE023866		Click to Show/Hide the Full List
mod site	chr15:66702582-66702583:+		[6]
Sequence	CAGCTTCCACTCATGTGTTGACACCCGCGTCCAGGAGAAAC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T; A549
Seq Type List	MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284230
mod ID: M6ASITE023867		Click to Show/Hide the Full List
mod site	chr15:66702601-66702602:+		[4]
Sequence	GACACCCGCGTCCAGGAGAAACTCGCTCCAAGTGCATCTAG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; fibroblasts; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284231
mod ID: M6ASITE023868		Click to Show/Hide the Full List
mod site	chr15:66702630-66702631:+		[4]
Sequence	AAGTGCATCTAGCGCCTGGGACCTGAGACGGCGTTGGCCTT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; fibroblasts; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284232
mod ID: M6ASITE023869		Click to Show/Hide the Full List
mod site	chr15:66702847-66702848:+		[4]
Sequence	GTAAAGGCAGGGCTTTCCAGACACATTTAGGGGTTCGCGCG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284233
mod ID: M6ASITE023870		Click to Show/Hide the Full List
mod site	chr15:66702886-66702887:+		[4]
Sequence	CGAGCGCTTTGTGCTCATGGACCAGCCGCACAACTTTTGAA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284234
mod ID: M6ASITE023871		Click to Show/Hide the Full List
mod site	chr15:66702895-66702896:+		[6]
Sequence	TGTGCTCATGGACCAGCCGCACAACTTTTGAAGGCTCGCCG
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284235
mod ID: M6ASITE023872		Click to Show/Hide the Full List
mod site	chr15:66702898-66702899:+		[5]
Sequence	GCTCATGGACCAGCCGCACAACTTTTGAAGGCTCGCCGGCC
Motif Score	2.595904762
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284236
mod ID: M6ASITE023873		Click to Show/Hide the Full List
mod site	chr15:66703030-66703031:+		[4]
Sequence	TAGCCGCTGGCCGCGCGCGGACTGCGGCTCGGCGTGCGCGT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; HEK293A-TOA; iSLK; TIME; TREX; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284237
mod ID: M6ASITE023874		Click to Show/Hide the Full List
mod site	chr15:66703203-66703204:+		[4]
Sequence	GCGCCTCGCTGAGGGAACGGACCCCCGGTAACCGGAGACCG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10; ENST00000612349.1
External Link	RMBase: m6A_site_284238
mod ID: M6ASITE023875		Click to Show/Hide the Full List
mod site	chr15:66703220-66703221:+		[4]
Sequence	CGGACCCCCGGTAACCGGAGACCGCCTCCCCCCCACCCCTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10; ENST00000612349.1
External Link	RMBase: m6A_site_284239
mod ID: M6ASITE023876		Click to Show/Hide the Full List
mod site	chr15:66703476-66703477:+		[4]
Sequence	CGGCCCCGGGACGCAGTGGGACAGCGAGGCGCCCAGGGCGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; Jurkat; GSC-11; HEK293A-TOA; MSC; TIME; iSLK; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000288840.10; ENST00000612349.1; ENST00000557916.5
External Link	RMBase: m6A_site_284240
mod ID: M6ASITE023877		Click to Show/Hide the Full List
mod site	chr15:66703574-66703575:+		[5]
Sequence	CGCTGGGAGCTCCCTGCTGGACGTGGCGGAGCCGGGAGGCC
Motif Score	3.616982143
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000557916.5; ENST00000288840.10; ENST00000612349.1
External Link	RMBase: m6A_site_284241
mod ID: M6ASITE023878		Click to Show/Hide the Full List
mod site	chr15:66703676-66703677:+		[7]
Sequence	CGCCGCCGGCGCGCCCCGGGACGCCAGCGACCCCCTGGCCG
Motif Score	3.616982143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000557916.5; ENST00000612349.1; ENST00000288840.10
External Link	RMBase: m6A_site_284242
mod ID: M6ASITE023879		Click to Show/Hide the Full List
mod site	chr15:66703770-66703771:+		[4]
Sequence	CTGCTGCTGCTGGAGCAGGAACTCAAAACCGTCACGTACTC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; fibroblasts; Jurkat; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000557916.5; ENST00000612349.1; ENST00000288840.10
External Link	RMBase: m6A_site_284243
mod ID: M6ASITE023880		Click to Show/Hide the Full List
mod site	chr15:66703777-66703778:+		[4]
Sequence	TGCTGGAGCAGGAACTCAAAACCGTCACGTACTCGCTGCTG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; fibroblasts; Jurkat; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10; ENST00000557916.5; ENST00000612349.1
External Link	RMBase: m6A_site_284244
mod ID: M6ASITE023881		Click to Show/Hide the Full List
mod site	chr15:66703823-66703824:+		[4]
Sequence	GCTCAAGGAGCGCTCGCTGGACACGCTGCTGGAGGCGGTGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; fibroblasts; Jurkat; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000557916.5; ENST00000612349.1; ENST00000288840.10
External Link	RMBase: m6A_site_284245
mod ID: M6ASITE023882		Click to Show/Hide the Full List
mod site	chr15:66704225-66704226:+		[4]
Sequence	CACCAGGGGAGGCGCCTCAGACCGGCCGAGGGGAGTGGGTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10; ENST00000557916.5; ENST00000612349.1
External Link	RMBase: m6A_site_284246
mod ID: M6ASITE023883		Click to Show/Hide the Full List
mod site	chr15:66704293-66704294:+		[4]
Sequence	TTATCTCAAGGCTCCGGTAAACTTAAAAGGGTACATGTCGT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; A549; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000612349.1; ENST00000557916.5; ENST00000288840.10
External Link	RMBase: m6A_site_284247
mod ID: M6ASITE023884		Click to Show/Hide the Full List
mod site	chr15:66704338-66704339:+		[8]
Sequence	TTCTCTGTGCAGTTTCAGGGACATGATGTAGGCTCCAACTT
Motif Score	3.643047619
Cell/Tissue List	HEK293T; HeLa; A549; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000288840.10; ENST00000612349.1; ENST00000557916.5
External Link	RMBase: m6A_site_284248
mod ID: M6ASITE023885		Click to Show/Hide the Full List
mod site	chr15:66704816-66704817:+		[4]
Sequence	ATACTGGATTACCTCTGAGAACTGCCCCCCTTCTTTGTTCT
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000612349.1; ENST00000557916.5; ENST00000288840.10
External Link	RMBase: m6A_site_284249
mod ID: M6ASITE023886		Click to Show/Hide the Full List
mod site	chr15:66705820-66705821:+		[4]
Sequence	GGCCAGGTCATTGGGTGTGAACTACCAGAAGGCTGTGGGTG
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000612349.1; ENST00000288840.10; ENST00000557916.5
External Link	RMBase: m6A_site_284250
mod ID: M6ASITE023887		Click to Show/Hide the Full List
mod site	chr15:66705893-66705894:+		[4]
Sequence	CAGCTCCAACCTGGAGCCGGACCTTGGAGGATGGGTCAGAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; U2OS; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000612349.1; ENST00000288840.10; ENST00000557916.5
External Link	RMBase: m6A_site_284251
mod ID: M6ASITE023888		Click to Show/Hide the Full List
mod site	chr15:66706029-66706030:+		[4]
Sequence	GAAAAAGTTGGAGACGATGGACAGGACCACTCCTGCTACTA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; Huh7; peripheral-blood; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000557916.5; ENST00000612349.1; ENST00000288840.10
External Link	RMBase: m6A_site_284252
mod ID: M6ASITE023889		Click to Show/Hide the Full List
mod site	chr15:66706034-66706035:+		[4]
Sequence	AGTTGGAGACGATGGACAGGACCACTCCTGCTACTACTCCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; Huh7; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10; ENST00000557916.5; ENST00000612349.1
External Link	RMBase: m6A_site_284253
mod ID: M6ASITE023890		Click to Show/Hide the Full List
mod site	chr15:66706058-66706059:+		[4]
Sequence	CTCCTGCTACTACTCCTGGGACTAGGAGTTGGCTTGGGTGT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; Huh7; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10; ENST00000612349.1; ENST00000557916.5
External Link	RMBase: m6A_site_284254
mod ID: M6ASITE023891		Click to Show/Hide the Full List
mod site	chr15:66706142-66706143:+		[4]
Sequence	ACCTGGCAAGCTGCAGTAGAACAGTTCTTGACCATGGACCT
Motif Score	2.951386905
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000612349.1; ENST00000288840.10; ENST00000557916.5
External Link	RMBase: m6A_site_284255
mod ID: M6ASITE023892		Click to Show/Hide the Full List
mod site	chr15:66706417-66706418:+		[4]
Sequence	CCCATTCAGCCACCCTGGGGACAGCTGGGAGGACCGATGGT
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000288840.10; ENST00000612349.1; ENST00000557916.5
External Link	RMBase: m6A_site_284256
mod ID: M6ASITE023893		Click to Show/Hide the Full List
mod site	chr15:66706429-66706430:+		[4]
Sequence	CCCTGGGGACAGCTGGGAGGACCGATGGTCCGGGAAGAGTT
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000557916.5; ENST00000288840.10; ENST00000612349.1
External Link	RMBase: m6A_site_284257
mod ID: M6ASITE023894		Click to Show/Hide the Full List
mod site	chr15:66706604-66706605:+		[4]
Sequence	GTGCGCGTCCTGATAAGGAGACTGCGCCTTCCAGGGCTCTG
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000557916.5; ENST00000288840.10; ENST00000612349.1
External Link	RMBase: m6A_site_284258
mod ID: M6ASITE023895		Click to Show/Hide the Full List
mod site	chr15:66706650-66706651:+		[4]
Sequence	AGGGCCGGGGCACCGGGCAGACAGATGCGCGCACACACATA
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000557916.5; ENST00000288840.10; ENST00000612349.1
External Link	RMBase: m6A_site_284259
mod ID: M6ASITE023896		Click to Show/Hide the Full List
mod site	chr15:66706707-66706708:+		[4]
Sequence	AGCGAGCAAAGTACACTGGAACACCGGCACTGAGGGACTCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000557916.5; ENST00000612349.1; ENST00000288840.10
External Link	RMBase: m6A_site_284260
mod ID: M6ASITE023897		Click to Show/Hide the Full List
mod site	chr15:66706723-66706724:+		[4]
Sequence	TGGAACACCGGCACTGAGGGACTCCCACCTGGCAGCAGTCA
Motif Score	4.065041667
Cell/Tissue List	HeLa; A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000612349.1; ENST00000557916.5; ENST00000288840.10
External Link	RMBase: m6A_site_284261
mod ID: M6ASITE023898		Click to Show/Hide the Full List
mod site	chr15:66706790-66706791:+		[4]
Sequence	GGGAGCCCCGGTGACAGAAGACCCCTTCCTGGGCAGTGTGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000612349.1; ENST00000557916.5; ENST00000288840.10
External Link	RMBase: m6A_site_284262
mod ID: M6ASITE023899		Click to Show/Hide the Full List
mod site	chr15:66706811-66706812:+		[4]
Sequence	CCCCTTCCTGGGCAGTGTGGACCCCTGCTGTTCAGAGCCCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; A549
Seq Type List	m6A-seq
Transcript ID List	rmsk_4367306; ENST00000612349.1; ENST00000557916.5; ENST00000288840.10
External Link	RMBase: m6A_site_284263
mod ID: M6ASITE023900		Click to Show/Hide the Full List
mod site	chr15:66707933-66707934:+		[4]
Sequence	GGCACTGGGAGAGGCTGTGAACTCTTTTCTGGCTTTAGAAT
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000557916.5; ENST00000288840.10; ENST00000612349.1
External Link	RMBase: m6A_site_284264
mod ID: M6ASITE023901		Click to Show/Hide the Full List
mod site	chr15:66708023-66708024:+		[4]
Sequence	GCATGCCTGGGCTGAGCTGAACCTTCTGGTGCACTGGCCCC
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000288840.10; ENST00000612349.1; ENST00000557916.5
External Link	RMBase: m6A_site_284265
mod ID: M6ASITE023902		Click to Show/Hide the Full List
mod site	chr15:66708261-66708262:+		[5]
Sequence	ATTATTTTAAAATCAATAAAACTTTTAAAAGTACTAAGACA
Motif Score	2.627720238
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000557916.5; ENST00000288840.10; ENST00000612349.1
External Link	RMBase: m6A_site_284266
mod ID: M6ASITE023903		Click to Show/Hide the Full List
mod site	chr15:66708635-66708636:+		[5]
Sequence	ACGTGCTACAACATGGATGAACTTCGATGACTTTGTGCCAC
Motif Score	3.373380952
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000557916.5; rmsk_4367309; ENST00000288840.10
External Link	RMBase: m6A_site_284267
mod ID: M6ASITE023904		Click to Show/Hide the Full List
mod site	chr15:66711712-66711713:+		[9]
Sequence	GCTGTCTCCTCGCGACGAGTACAAGCCACTGGGTAAGTGTG
Motif Score	2.856142857
Cell/Tissue List	kidney; liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000559931.5; ENST00000558937.1; ENST00000557916.5; ENST00000288840.10
External Link	RMBase: m6A_site_284268
mod ID: M6ASITE023905		Click to Show/Hide the Full List
mod site	chr15:66717038-66717039:+		[4]
Sequence	TGGGATAGGAAGCCGAGGGAACCGTGGTTTGGAGTCCTCTG
Motif Score	2.930744048
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000558937.1; ENST00000559931.5; ENST00000557916.5; ENST00000288840.10
External Link	RMBase: m6A_site_284269
mod ID: M6ASITE023906		Click to Show/Hide the Full List
mod site	chr15:66717088-66717089:+		[4]
Sequence	GTTAGAAGCTGGTCATAGGGACCCCTACATCCGGAGGAATA
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000288840.10; ENST00000559931.5; ENST00000557916.5; ENST00000558937.1
External Link	RMBase: m6A_site_284270
mod ID: M6ASITE023907		Click to Show/Hide the Full List
mod site	chr15:66717119-66717120:+		[4]
Sequence	CGGAGGAATACCTGAATCAAACTTTCCTTGAGAAATGAGAG
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000557916.5; ENST00000559931.5; ENST00000558937.1; ENST00000288840.10
External Link	RMBase: m6A_site_284271
mod ID: M6ASITE023908		Click to Show/Hide the Full List
mod site	chr15:66717151-66717152:+		[4]
Sequence	AAATGAGAGGTTGGTGTTGGACTGGGGACATCGAGGGCCAG
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000557916.5; ENST00000559931.5; ENST00000558937.1; ENST00000288840.10
External Link	RMBase: m6A_site_284272
mod ID: M6ASITE023909		Click to Show/Hide the Full List
mod site	chr15:66717158-66717159:+		[4]
Sequence	AGGTTGGTGTTGGACTGGGGACATCGAGGGCCAGGACCAAG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000557916.5; ENST00000559931.5; ENST00000558937.1; ENST00000288840.10
External Link	RMBase: m6A_site_284273
mod ID: M6ASITE023910		Click to Show/Hide the Full List
mod site	chr15:66717173-66717174:+		[4]
Sequence	TGGGGACATCGAGGGCCAGGACCAAGGTCTGTGGGGCCCTT
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000288840.10; ENST00000557916.5; ENST00000558937.1; ENST00000559931.5
External Link	RMBase: m6A_site_284274
mod ID: M6ASITE023911		Click to Show/Hide the Full List
mod site	chr15:66717241-66717242:+		[4]
Sequence	CTGGTGGCATGCTGGCTGGGACTGACAGCCCCTCAGGCTGG
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000558937.1; ENST00000557916.5; ENST00000288840.10; ENST00000559931.5
External Link	RMBase: m6A_site_284275
mod ID: M6ASITE023912		Click to Show/Hide the Full List
mod site	chr15:66781521-66781522:+		[6]
Sequence	CTGGCTGGAGATCCTCCTCAACAACCCCAGATAGTGGCGGC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284276
mod ID: M6ASITE023913		Click to Show/Hide the Full List
mod site	chr15:66781615-66781616:+		[4]
Sequence	AGAGGGGCCGATGCCCAGAGACACAGCCCCCACGGACAAAA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549; hESC-HEK293T; HepG2; H1A; H1B; hNPCs; MM6; GSC-11; HEK293A-TOA; MSC; TIME; iSLK; HEC-1-A; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284277
mod ID: M6ASITE023914		Click to Show/Hide the Full List
mod site	chr15:66781630-66781631:+		[4]
Sequence	CAGAGACACAGCCCCCACGGACAAAACCCCCCAGATATCAT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; H1A; H1B; hNPCs; MM6; Huh7; GSC-11; HEK293A-TOA; MSC; TIME; iSLK; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284278
mod ID: M6ASITE023915		Click to Show/Hide the Full List
mod site	chr15:66781635-66781636:+		[4]
Sequence	ACACAGCCCCCACGGACAAAACCCCCCAGATATCATCTACC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; MM6; Huh7; GSC-11; HEK293A-TOA; MSC; TIME; iSLK; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284279
mod ID: M6ASITE023916		Click to Show/Hide the Full List
mod site	chr15:66781767-66781768:+		[4]
Sequence	GGTGCAATGTGTGTATATGGACAAAACAAGAAAGACGCACT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; hESC-HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284280
mod ID: M6ASITE023917		Click to Show/Hide the Full List
mod site	chr15:66781772-66781773:+		[10]
Sequence	AATGTGTGTATATGGACAAAACAAGAAAGACGCACTTTGGC
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HeLa; A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284281
mod ID: M6ASITE023918		Click to Show/Hide the Full List
mod site	chr15:66781809-66781810:+		[9]
Sequence	TGGCTTATAATTCTTTCAATACAGATATATTTTCTTTCTCT
Motif Score	2.110482143
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284282
mod ID: M6ASITE023919		Click to Show/Hide the Full List
mod site	chr15:66781941-66781942:+		[11]
Sequence	TTTGAGATATTAATGCCCAGACAAAAAGCTAATACCAGTCA
Motif Score	2.897386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284283
mod ID: M6ASITE023920		Click to Show/Hide the Full List
mod site	chr15:66781999-66782000:+		[11]
Sequence	CGCATTATAGTTTTTTTTAAACTGTCTTCTTTTTACAAAGA
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284284
mod ID: M6ASITE023921		Click to Show/Hide the Full List
mod site	chr15:66782844-66782845:+		[11]
Sequence	GCATAATAAATTATCCCCAAACTTAGCAGCTTAAAATAACT
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000288840.10
External Link	RMBase: m6A_site_284285

Ref 1	RNA demethylase ALKBH5 inhibits TGF-Beta-induced EMT by regulating TGF-Beta/SMAD signaling in non-small cell lung?cancer. FASEB J. 2022 May;36(5):e22283. doi: 10.1096/fj.202200005RR.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 5	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 8	N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 10	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 11	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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