m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00697)
Target Name miR-194-2
Synonyms
hsa-mir-194-2; MIRN194-2
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Gene Name MIR194-2
Chromosomal Location 11q13.1
Family MicroRNAs
Gene ID 406970
HGNC ID
HGNC:31565
miRBase ID
MI0000732
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR194-2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ALKBH5 demethylated pri-miR-194-2 and inhibited miR-194-2 biogenesis through an m6A/DGCR8-dependent manner. ALKBH5/miR-194-2/RAI1 axis was also validated in clinical samples. This study revealed ALKBH5 in miRNAs biogenesis and provide novel insight for developing treatment strategies in esophageal cancer.
Target Regulation Down regulation
Responsed Disease Esophageal cancer ICD-11: 2B70
 Disease Info 
Esophageal cancer [ICD-11: 2B70]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary ALKBH5 demethylated pri-miR-194-2 and inhibited miR-194-2 biogenesis through an m6A/DGCR8-dependent manner. ALKBH5/miR-194-2/RAI1 axis was also validated in clinical samples. This study revealed ALKBH5 in miRNAs biogenesis and provide novel insight for developing treatment strategies in esophageal cancer.
Responsed Disease Esophageal cancer [ICD-11: 2B70]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Down regulation
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05622
 Crosstalk Info 
Epigenetic Regulator MiR-194-2
Regulated Target Retinoic acid-induced protein 1 (RAI1)
Crosstalk relationship m6A → ncRNA
Disease Esophageal cancer
 Disease Info 
Drug Verteporfin
 Drug Info 
References
Ref 1 N(6)-methyladenosine demethylase ALKBH5 suppresses malignancy of esophageal cancer by regulating microRNA biogenesis and RAI1 expression. Oncogene. 2021 Sep;40(37):5600-5612. doi: 10.1038/s41388-021-01966-4. Epub 2021 Jul 26.