m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00643)
Target Name Dexamethasone-induced Ras-related protein 1 (RASD1)
Synonyms
Activator of G-protein signaling 1
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Gene Name RASD1
Chromosomal Location 17p11.2
Family Small GTPase superfamily, RasD family
Function
Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).
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Gene ID 51655
Uniprot ID
RASD1_HUMAN
HGNC ID
HGNC:15828
KEGG ID
hsa:51655
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
RASD1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line mouse embryonic stem cells Mus musculus
Treatment: METTL14-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: -1.81E+00
p-value: 2.87E-02
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Mettl14-mediated m6A modification inhibited Dexamethasone-induced Ras-related protein 1 (RASD1) and induced the apoptosis of spinal cord neurons in SCI by promoting the transformation of pri-miR-375 to mature miR-375.
Target Regulation Down regulation
Responsed Disease Injuries of spine or trunk ICD-11: ND51
 Disease Info 
Pathway Response mTOR signaling pathway hsa04150
In-vitro Model C8-D1A Normal Mus musculus CVCL_6379
C8-B4 Normal Mus musculus CVCL_6378
In-vivo Model An incision was made in the skin along the medial dorsal line to the aponeurotic and muscular planes, and the posterior vertebral arches were exposed from T8 to T12. Under the dissection stereomicroscope, 3-mm-long laminectomy was performed on the caudal end of T10 vertebra and the rostral end of T11 vertebra. The Infinite Horizons impactor (Infinite Horizons, L.L.C., Lexington, KY, USA) was adopted to produce the contusion SCI using a force of 60 kdyn/cm2. The SCI model rats were established and randomly assigned to SCI model group, ant-NC (negative control, SCI rats treated with lentiviral (lv)-shRNA NC of Mettl14) group and ant-Mettl14 group (SCI rats treated with lv-shRNA of Mettl14). Rats were subjected to laminectomy and then treated with lv-shRNA Mettl14/lv-shRNA-NC (50 ul/day, 100 nmoL/mL; RiboBio, Guangzhou, China) via an intrathecal injection through lumbar puncture for 3 days (0, 1, and 2 days) after 15 min of SCI modelling. In addition, the unmodeled rats were set as sham group.
Injuries of spine or trunk [ICD-11: ND51]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Mettl14-mediated m6A modification inhibited Dexamethasone-induced Ras-related protein 1 (RASD1) and induced the apoptosis of spinal cord neurons in SCI by promoting the transformation of pri-miR-375 to mature miR-375.
Responsed Disease Injuries of spine or trunk [ICD-11: ND51]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response mTOR signaling pathway hsa04150
In-vitro Model C8-D1A Normal Mus musculus CVCL_6379
C8-B4 Normal Mus musculus CVCL_6378
In-vivo Model An incision was made in the skin along the medial dorsal line to the aponeurotic and muscular planes, and the posterior vertebral arches were exposed from T8 to T12. Under the dissection stereomicroscope, 3-mm-long laminectomy was performed on the caudal end of T10 vertebra and the rostral end of T11 vertebra. The Infinite Horizons impactor (Infinite Horizons, L.L.C., Lexington, KY, USA) was adopted to produce the contusion SCI using a force of 60 kdyn/cm2. The SCI model rats were established and randomly assigned to SCI model group, ant-NC (negative control, SCI rats treated with lentiviral (lv)-shRNA NC of Mettl14) group and ant-Mettl14 group (SCI rats treated with lv-shRNA of Mettl14). Rats were subjected to laminectomy and then treated with lv-shRNA Mettl14/lv-shRNA-NC (50 ul/day, 100 nmoL/mL; RiboBio, Guangzhou, China) via an intrathecal injection through lumbar puncture for 3 days (0, 1, and 2 days) after 15 min of SCI modelling. In addition, the unmodeled rats were set as sham group.
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00643)
Dexamethasone-induced Ras-related protein 1 (RASD1)
5-methylcytidine (m5C)
In total 3 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000991 Click to Show/Hide the Full List
mod site chr17:17494981-17494982:- [2]
Sequence CCCCAGCACTGGGGAGGCGCCACTGAACCGAGAAGGGACGG
Seq Type List Bisulfite-seq
Transcript ID List ENST00000225688.4; ENST00000579152.1
External Link RMBase: m5C_site_18172
mod ID: M5CSITE000992 Click to Show/Hide the Full List
mod site chr17:17494982-17494983:- [2]
Sequence CCCCCAGCACTGGGGAGGCGCCACTGAACCGAGAAGGGACG
Seq Type List Bisulfite-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m5C_site_18173
mod ID: M5CSITE000993 Click to Show/Hide the Full List
mod site chr17:17494984-17494985:- [2]
Sequence CGCCCCCAGCACTGGGGAGGCGCCACTGAACCGAGAAGGGA
Seq Type List Bisulfite-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m5C_site_18174
N6-methyladenosine (m6A)
In total 31 m6A sequence/site(s) in this target gene
mod ID: M6ASITE030591 Click to Show/Hide the Full List
mod site chr17:17494533-17494534:- [3]
Sequence TCAACATGGACACGAACAAAACCTTACCCAGGTGTTTATAC
Motif Score 2.185083333
Cell/Tissue List HepG2; HeLa; A549; H1B; hNPCs; Huh7; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4
External Link RMBase: m6A_site_350788
mod ID: M6ASITE030592 Click to Show/Hide the Full List
mod site chr17:17494538-17494539:- [3]
Sequence CGGTGTCAACATGGACACGAACAAAACCTTACCCAGGTGTT
Motif Score 2.951386905
Cell/Tissue List HepG2; HeLa; A549; H1B; hNPCs; Huh7; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4
External Link RMBase: m6A_site_350789
mod ID: M6ASITE030593 Click to Show/Hide the Full List
mod site chr17:17494544-17494545:- [3]
Sequence TAGTTCCGGTGTCAACATGGACACGAACAAAACCTTACCCA
Motif Score 3.643047619
Cell/Tissue List HepG2; HeLa; A549; H1B; hNPCs; Huh7; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4
External Link RMBase: m6A_site_350790
mod ID: M6ASITE030594 Click to Show/Hide the Full List
mod site chr17:17494580-17494581:- [3]
Sequence ACAAAGGAACACAAAACAAAACTTGCACTTTAACGGTAGTT
Motif Score 2.627720238
Cell/Tissue List HepG2; HeLa; A549; H1B; hNPCs; Huh7; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4
External Link RMBase: m6A_site_350791
mod ID: M6ASITE030595 Click to Show/Hide the Full List
mod site chr17:17494585-17494586:- [3]
Sequence ACTGCACAAAGGAACACAAAACAAAACTTGCACTTTAACGG
Motif Score 2.20572619
Cell/Tissue List HepG2; HeLa; A549; H1B; hNPCs; Huh7; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4
External Link RMBase: m6A_site_350792
mod ID: M6ASITE030596 Click to Show/Hide the Full List
mod site chr17:17494592-17494593:- [3]
Sequence GAGTGAAACTGCACAAAGGAACACAAAACAAAACTTGCACT
Motif Score 2.951386905
Cell/Tissue List HepG2; HeLa; A549; H1A; H1B; hNPCs; hESCs; Huh7; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4
External Link RMBase: m6A_site_350793
mod ID: M6ASITE030597 Click to Show/Hide the Full List
mod site chr17:17494605-17494606:- [3]
Sequence CTTGTTTACATGTGAGTGAAACTGCACAAAGGAACACAAAA
Motif Score 2.627720238
Cell/Tissue List HepG2; HeLa; A549; H1A; H1B; hNPCs; hESCs; Huh7; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4
External Link RMBase: m6A_site_350794
mod ID: M6ASITE030598 Click to Show/Hide the Full List
mod site chr17:17494664-17494665:- [3]
Sequence AGAGCCTCTGCCCTCCCAAAACTAAGCGGGGGGGCGTGGGT
Motif Score 2.627720238
Cell/Tissue List HepG2; HeLa; A549; H1B; hNPCs; Huh7; MSC; TIME; TREX; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4
External Link RMBase: m6A_site_350795
mod ID: M6ASITE030599 Click to Show/Hide the Full List
mod site chr17:17494693-17494694:- [4]
Sequence TGTGATTCCGGGTTGCTGTGACAGCCGGTAGAGCCTCTGCC
Motif Score 2.859755952
Cell/Tissue List kidney
Seq Type List m6A-REF-seq
Transcript ID List ENST00000225688.4
External Link RMBase: m6A_site_350796
mod ID: M6ASITE030600 Click to Show/Hide the Full List
mod site chr17:17494735-17494736:- [3]
Sequence ATGCCCGCTTGAGGGTCAGGACCCACGGGGCATTATCTTGT
Motif Score 3.622404762
Cell/Tissue List HepG2; HeLa; A549; H1A; H1B; hNPCs; Huh7; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350797
mod ID: M6ASITE030601 Click to Show/Hide the Full List
mod site chr17:17494761-17494762:- [3]
Sequence CCTCTGCTAGGCTTCAAGAAACCGTCATGCCCGCTTGAGGG
Motif Score 2.185083333
Cell/Tissue List HepG2; HeLa; A549; H1A; H1B; hNPCs; Huh7; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350798
mod ID: M6ASITE030602 Click to Show/Hide the Full List
mod site chr17:17494827-17494828:- [3]
Sequence GTGGATTTATCTTCTCAAAGACCTAAGAGTGAGCGCGGGGT
Motif Score 2.876744048
Cell/Tissue List HepG2; HEK293T; HeLa; A549; H1A; H1B; hNPCs; Huh7; Jurkat; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350799
mod ID: M6ASITE030603 Click to Show/Hide the Full List
mod site chr17:17494920-17494921:- [5]
Sequence GAGAACGGGCCAAGACTGGGACTATTCCCCACCCCCGGTCC
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; Jurkat; GSC-11; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350800
mod ID: M6ASITE030604 Click to Show/Hide the Full List
mod site chr17:17494926-17494927:- [5]
Sequence AGGAAAGAGAACGGGCCAAGACTGGGACTATTCCCCACCCC
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; Jurkat; GSC-11; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4; ENST00000579152.1
External Link RMBase: m6A_site_350801
mod ID: M6ASITE030605 Click to Show/Hide the Full List
mod site chr17:17494975-17494976:- [5]
Sequence CACTGGGGAGGCGCCACTGAACCGAGAAGGGACGGTCATCT
Motif Score 2.930744048
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; Jurkat; GSC-11; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4; ENST00000579152.1
External Link RMBase: m6A_site_350802
mod ID: M6ASITE030606 Click to Show/Hide the Full List
mod site chr17:17495029-17495030:- [5]
Sequence CAGGCCGGGAGCGCGCGCGGACTGGCGTCTCCCCTCCCGGC
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; Jurkat; GSC-11; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350803
mod ID: M6ASITE030607 Click to Show/Hide the Full List
mod site chr17:17495088-17495089:- [5]
Sequence GGCGACACAACCTAAGGAGGACCTTTTTGTTAAGTCAAATC
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; Jurkat; GSC-11; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350804
mod ID: M6ASITE030608 Click to Show/Hide the Full List
mod site chr17:17495149-17495150:- [5]
Sequence CGCCGGCAGCCAGGCCAAGGACAAGGAGCGCTGCGTCATCA
Motif Score 3.643047619
Cell/Tissue List HeLa; HepG2; A549; H1A; H1B; hNPCs; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4; ENST00000579152.1
External Link RMBase: m6A_site_350805
mod ID: M6ASITE030609 Click to Show/Hide the Full List
mod site chr17:17495299-17495300:- [3]
Sequence GCACAAGAAGGCGCTGCGGAACAAGAAGCTGCTGCGGGCCG
Motif Score 2.951386905
Cell/Tissue List HepG2; brain; MSC; TIME; endometrial
Seq Type List m6A-seq; m6A-REF-seq; MeRIP-seq
Transcript ID List ENST00000225688.4; ENST00000579152.1
External Link RMBase: m6A_site_350806
mod ID: M6ASITE030610 Click to Show/Hide the Full List
mod site chr17:17495359-17495360:- [3]
Sequence GCCCAGCGAGATGAGCCCAGACCTGCACCGCAAGGTCTCGG
Motif Score 2.876744048
Cell/Tissue List HepG2; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350807
mod ID: M6ASITE030611 Click to Show/Hide the Full List
mod site chr17:17495416-17495417:- [3]
Sequence CAAGAAGAACAGCAGCCTGGACCAGATGTTCCGCGCGCTCT
Motif Score 3.622404762
Cell/Tissue List HepG2; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350808
mod ID: M6ASITE030612 Click to Show/Hide the Full List
mod site chr17:17495428-17495429:- [3]
Sequence CGAGATCTCGGCCAAGAAGAACAGCAGCCTGGACCAGATGT
Motif Score 2.951386905
Cell/Tissue List HepG2; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000225688.4; ENST00000579152.1
External Link RMBase: m6A_site_350809
mod ID: M6ASITE030613 Click to Show/Hide the Full List
mod site chr17:17495503-17495504:- [3]
Sequence CGACTTCTACCGCGAGGTGGACCAGCGCGAGATCGAGCAGC
Motif Score 3.622404762
Cell/Tissue List HepG2; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350810
mod ID: M6ASITE030614 Click to Show/Hide the Full List
mod site chr17:17495536-17495537:- [4]
Sequence GCCCCTGGTCATCTGCGGCAACAAGGGTGACCGCGACTTCT
Motif Score 2.173910714
Cell/Tissue List kidney
Seq Type List m6A-REF-seq
Transcript ID List ENST00000225688.4; ENST00000579152.1
External Link RMBase: m6A_site_350811
mod ID: M6ASITE030615 Click to Show/Hide the Full List
mod site chr17:17495576-17495577:- [3]
Sequence AGTCTTGCCTCAAGAACAAAACCAAGGAGAACGTGGACGTG
Motif Score 2.185083333
Cell/Tissue List HepG2; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350812
mod ID: M6ASITE030616 Click to Show/Hide the Full List
mod site chr17:17495581-17495582:- [3]
Sequence CACCAAGTCTTGCCTCAAGAACAAAACCAAGGAGAACGTGG
Motif Score 2.951386905
Cell/Tissue List HepG2; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350813
mod ID: M6ASITE030617 Click to Show/Hide the Full List
mod site chr17:17495653-17495654:- [5]
Sequence CATCCTGGTGTTCAGTCTGGACAACCGCGACTCCTTCGAGG
Motif Score 3.643047619
Cell/Tissue List HeLa; HepG2; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000225688.4; ENST00000579152.1
External Link RMBase: m6A_site_350814
mod ID: M6ASITE030618 Click to Show/Hide the Full List
mod site chr17:17496005-17496006:- [3]
Sequence CTACACGCCTACCATCGAGGACTTCCACCGCAAGTTCTACT
Motif Score 4.065041667
Cell/Tissue List HepG2; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000225688.4; ENST00000579152.1
External Link RMBase: m6A_site_350815
mod ID: M6ASITE030619 Click to Show/Hide the Full List
mod site chr17:17496113-17496114:- [3]
Sequence GCTGAGTATCCCGGCCAAGAACTGCTATCGCATGGTCATCC
Motif Score 3.373380952
Cell/Tissue List HepG2; A549; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000225688.4; ENST00000579152.1
External Link RMBase: m6A_site_350816
mod ID: M6ASITE030620 Click to Show/Hide the Full List
mod site chr17:17496175-17496176:- [3]
Sequence CGGCCCCTCTGCCCAATGAAACTGGCCGCGATGATCAAGAA
Motif Score 2.627720238
Cell/Tissue List HepG2; A549; H1A; Jurkat; GSC-11; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350817
mod ID: M6ASITE030621 Click to Show/Hide the Full List
mod site chr17:17496361-17496362:- [3]
Sequence TGTGCCCAGATCCTGGGAGAACCCCAGCCGAGCCCAGCCTA
Motif Score 2.930744048
Cell/Tissue List HepG2; HeLa; A549; H1A; Jurkat; GSC-11; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000579152.1; ENST00000225688.4
External Link RMBase: m6A_site_350818