m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00595)

Target Name	Tastin (TROAP)
Synonyms	Trophinin-assisting protein; Trophinin-associated protein Click to Show/Hide
Gene Name	TROAP
Chromosomal Location	12q13.12
Function	Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Click to Show/Hide
Gene ID	10024
Uniprot ID	TROAP_HUMAN
HGNC ID	HGNC:12327
KEGG ID	hsa:10024

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

TROAP can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 14 (METTL14) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL14*
Cell Line	IL7H6 cell line	Mus musculus
Treatment: METTL14 knockout IL7H6 cells Control: Wild type IL7H6 cells		GSE151071
Regulation		logFC: -1.07E+00 p-value: 3.99E-03
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL14 overexpression decreased ovarian cancer proliferation by inhibition of Tastin (TROAP) expression via an m6A RNA methylation-dependent mechanism.
Target Regulation	Down regulation
Responsed Disease	Ovarian cancer		ICD-11: 2C73	Disease Info
In-vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens	CVCL_0532
In-vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens	CVCL_0134
In-vivo Model	KOV-3 cells (1 ×10⁶) stable transfected with METTL14 or control lentivirus, were injected subcutaneously into the right flank of BALB/c nude mice.

Ovarian cancer [ICD-11: 2C73]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL14 overexpression decreased ovarian cancer proliferation by inhibition of Tastin (TROAP) expression via an m6A RNA methylation-dependent mechanism.
Responsed Disease	Ovarian cancer [ICD-11: 2C73]
Target Regulator	Methyltransferase-like 14 (METTL14)		WRITER	Regulator Info
Target Regulation	Down regulation
In-vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens	CVCL_0532
In-vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens	CVCL_0134
In-vivo Model	KOV-3 cells (1 ×10⁶) stable transfected with METTL14 or control lentivirus, were injected subcutaneously into the right flank of BALB/c nude mice.

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00595)

Tastin (TROAP)

Adenosine-to-Inosine editing (A-to-I)

In total 4 m6A sequence/site(s) in this target gene
mod ID: A2ISITE005522		Click to Show/Hide the Full List
mod site	chr12:49324228-49324229:+		[2]
Sequence	CAGCAAAATGTCATCTCGCCAGGTGCCATGGCTTGTACCTG
Transcript ID List	ENST00000550709.5; ENST00000546776.5; ENST00000548311.5; ENST00000546735.5; ENST00000549534.1; ENST00000549891.5; ENST00000257909.8; ENST00000549275.5; ENST00000380327.9; ENST00000551245.5; ENST00000550346.5; ENST00000551567.1; ENST00000547807.5; rmsk_3784253; ENST00000551192.5
External Link	RMBase: RNA-editing_site_28144
mod ID: A2ISITE005523		Click to Show/Hide the Full List
mod site	chr12:49324603-49324604:+		[2]
Sequence	TCTATGAACATTTGGTGACCAGGTGTGGTGGCTCACGCCTG
Transcript ID List	rmsk_3784255; ENST00000546776.5; ENST00000551192.5; ENST00000257909.8; ENST00000546735.5; ENST00000547807.5; ENST00000551245.5; ENST00000550346.5; ENST00000549891.5; ENST00000551567.1
External Link	RMBase: RNA-editing_site_28145
mod ID: A2ISITE005524		Click to Show/Hide the Full List
mod site	chr12:49324647-49324648:+		[2]
Sequence	TTCCAACACTCCTCCGAGGCAGGAGGATCATTTGAGCTCAG
Transcript ID List	ENST00000551192.5; ENST00000546776.5; ENST00000547807.5; ENST00000549891.5; ENST00000546735.5; ENST00000551245.5; ENST00000257909.8; ENST00000550346.5; rmsk_3784255; ENST00000551567.1
External Link	RMBase: RNA-editing_site_28146
mod ID: A2ISITE005525		Click to Show/Hide the Full List
mod site	chr12:49325277-49325278:+		[2]
Sequence	GTTGGCCGGGTTGGTCTCAAACTCCTGACCACAGGTGATCC
Transcript ID List	ENST00000549891.5; ENST00000547807.5; ENST00000546735.5; ENST00000546776.5; ENST00000550346.5; ENST00000551245.5; ENST00000551567.1; ENST00000551192.5; ENST00000257909.8
External Link	RMBase: RNA-editing_site_28147

5-methylcytidine (m5C)

In total 4 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005505		Click to Show/Hide the Full List
mod site	chr12:49324208-49324209:+		[3]
Sequence	TAGAAGATCTCCCTTTCCTCCAGCAAAATGTCATCTCGCCA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000546776.5; ENST00000550346.5; ENST00000548311.5; ENST00000257909.8; ENST00000380327.9; ENST00000549275.5; ENST00000550709.5; ENST00000551192.5; ENST00000549534.1; ENST00000546735.5; ENST00000547807.5; ENST00000549891.5; ENST00000551567.1; ENST00000551245.5
External Link	RMBase: m5C_site_9971
mod ID: M5CSITE005506		Click to Show/Hide the Full List
mod site	chr12:49326687-49326688:+
Sequence	GACTTCAGTGAGCCAGGCCTCAGGATTGCTCCTGGAGACCC
Cell/Tissue List	testis
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000547807.5; ENST00000549891.5; ENST00000257909.8; ENST00000551245.5; ENST00000548817.1; ENST00000550346.5; ENST00000546776.5; ENST00000546735.5; ENST00000547923.1; ENST00000551192.5
External Link	RMBase: m5C_site_9972
mod ID: M5CSITE005507		Click to Show/Hide the Full List
mod site	chr12:49329514-49329515:+		[3]
Sequence	TGTGCTGCCAGCCTGGAGGCCCAGGAGTTTGAGGCACACGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000551245.5; ENST00000257909.8; ENST00000547923.1; ENST00000546735.5; ENST00000549891.5; ENST00000551192.5
External Link	RMBase: m5C_site_9973
mod ID: M5CSITE005508		Click to Show/Hide the Full List
mod site	chr12:49330843-49330844:+		[3]
Sequence	CCTGCTGCAGTCAGTGGGCTCCAGCAACCACCAGCCTGATC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000257909.8; ENST00000551245.5; ENST00000547923.1
External Link	RMBase: m5C_site_9974

N6-methyladenosine (m6A)

In total 46 m6A sequence/site(s) in this target gene
mod ID: M6ASITE012141		Click to Show/Hide the Full List
mod site	chr12:49323261-49323262:+		[4]
Sequence	TCAAGAGCTTGGCGTATTTTACAAACTGAGAAAGTAGCTCC
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000257909.8; ENST00000380327.9; ENST00000550346.5; ENST00000546735.5; ENST00000551245.5; ENST00000549891.5; ENST00000550709.5; ENST00000549275.5; ENST00000548311.5
External Link	RMBase: m6A_site_186729
mod ID: M6ASITE012143		Click to Show/Hide the Full List
mod site	chr12:49323265-49323266:+		[5]
Sequence	GAGCTTGGCGTATTTTACAAACTGAGAAAGTAGCTCCAGCA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000549891.5; ENST00000380327.9; ENST00000549275.5; ENST00000551245.5; ENST00000550346.5; ENST00000257909.8; ENST00000548311.5; ENST00000550709.5; ENST00000546735.5
External Link	RMBase: m6A_site_186730
mod ID: M6ASITE012144		Click to Show/Hide the Full List
mod site	chr12:49323713-49323714:+		[4]
Sequence	GCACGCCTTTCCCCACTGTTACATCGTGCGCCGTGGACCAG
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000549891.5; ENST00000257909.8; ENST00000546776.5; ENST00000549534.1; ENST00000551567.1; ENST00000548311.5; ENST00000551245.5; ENST00000380327.9; ENST00000550346.5; ENST00000546735.5; ENST00000547807.5; ENST00000549275.5; ENST00000551192.5; ENST00000550709.5
External Link	RMBase: m6A_site_186731
mod ID: M6ASITE012145		Click to Show/Hide the Full List
mod site	chr12:49323729-49323730:+		[6]
Sequence	TGTTACATCGTGCGCCGTGGACCAGGAGAACCAAGATCCAA
Motif Score	3.622404762
Cell/Tissue List	A549; Huh7; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000551245.5; ENST00000547807.5; ENST00000549275.5; ENST00000550346.5; ENST00000549534.1; ENST00000546776.5; ENST00000548311.5; ENST00000550709.5; ENST00000380327.9; ENST00000546735.5; ENST00000549891.5; ENST00000551567.1; ENST00000551192.5; ENST00000257909.8
External Link	RMBase: m6A_site_186732
mod ID: M6ASITE012146		Click to Show/Hide the Full List
mod site	chr12:49323738-49323739:+		[6]
Sequence	GTGCGCCGTGGACCAGGAGAACCAAGATCCAAGGGTAAGAG
Motif Score	2.930744048
Cell/Tissue List	A549; Huh7; iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000549275.5; ENST00000551192.5; ENST00000550709.5; ENST00000547807.5; ENST00000257909.8; ENST00000380327.9; ENST00000549891.5; ENST00000548311.5; ENST00000550346.5; ENST00000546776.5; ENST00000546735.5; ENST00000551567.1; ENST00000549534.1; ENST00000551245.5
External Link	RMBase: m6A_site_186733
mod ID: M6ASITE012147		Click to Show/Hide the Full List
mod site	chr12:49323776-49323777:+		[6]
Sequence	GAGGGGCCTAATGGGGGAAGACAGTAGTCACACCAGTAATG
Motif Score	2.897386905
Cell/Tissue List	A549; Huh7; iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000549275.5; ENST00000550709.5; ENST00000551192.5; ENST00000257909.8; ENST00000551245.5; ENST00000546776.5; ENST00000547807.5; ENST00000546735.5; ENST00000549534.1; ENST00000549891.5; ENST00000550346.5; ENST00000548311.5; ENST00000551567.1; ENST00000380327.9
External Link	RMBase: m6A_site_186734
mod ID: M6ASITE012148		Click to Show/Hide the Full List
mod site	chr12:49323811-49323812:+		[7]
Sequence	GTAATGCACCCCAACACTAAACCTCACCTTTTTGTCCCCGC
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000547807.5; ENST00000546735.5; ENST00000551245.5; ENST00000549275.5; ENST00000549534.1; ENST00000550709.5; ENST00000549891.5; ENST00000551192.5; ENST00000550346.5; ENST00000548311.5; ENST00000546776.5; ENST00000380327.9; ENST00000257909.8; ENST00000551567.1
External Link	RMBase: m6A_site_186735
mod ID: M6ASITE012149		Click to Show/Hide the Full List
mod site	chr12:49323858-49323859:+		[8]
Sequence	CCCTAGAGATGGGTGCAGAAACCACCGCTCAATATTCAACG
Motif Score	2.185083333
Cell/Tissue List	MT4; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000547807.5; ENST00000551245.5; ENST00000257909.8; ENST00000550346.5; ENST00000551567.1; ENST00000546776.5; ENST00000549275.5; ENST00000549891.5; ENST00000546735.5; ENST00000550709.5; ENST00000380327.9; ENST00000549534.1; ENST00000551192.5; ENST00000548311.5
External Link	RMBase: m6A_site_186736
mod ID: M6ASITE012150		Click to Show/Hide the Full List
mod site	chr12:49323931-49323932:+		[5]
Sequence	AAGCCAGGCACCAGGCAGAGACATCACAAAGATTGGTGGGG
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T; MT4; peripheral-blood
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000551192.5; ENST00000549534.1; ENST00000550709.5; ENST00000257909.8; ENST00000546776.5; ENST00000549275.5; ENST00000550346.5; ENST00000547807.5; ENST00000380327.9; ENST00000549891.5; ENST00000546735.5; ENST00000548311.5; ENST00000551245.5; ENST00000551567.1
External Link	RMBase: m6A_site_186737
mod ID: M6ASITE012151		Click to Show/Hide the Full List
mod site	chr12:49323936-49323937:+		[4]
Sequence	AGGCACCAGGCAGAGACATCACAAAGATTGGTGGGGATCAG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000546735.5; ENST00000551567.1; ENST00000550346.5; ENST00000549275.5; ENST00000549534.1; ENST00000550709.5; ENST00000547807.5; ENST00000551192.5; ENST00000549891.5; ENST00000380327.9; ENST00000551245.5; ENST00000548311.5; ENST00000257909.8; ENST00000546776.5
External Link	RMBase: m6A_site_186738
mod ID: M6ASITE012152		Click to Show/Hide the Full List
mod site	chr12:49323968-49323969:+		[5]
Sequence	GGGGATCAGTCAGCCTCGGAACCCCTTGGAAGAGCTCAGGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; MT4; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000549275.5; ENST00000547807.5; ENST00000257909.8; ENST00000546776.5; ENST00000551567.1; ENST00000550709.5; ENST00000550346.5; ENST00000546735.5; ENST00000380327.9; ENST00000551245.5; ENST00000549891.5; ENST00000549534.1; ENST00000548311.5; ENST00000551192.5
External Link	RMBase: m6A_site_186739
mod ID: M6ASITE012154		Click to Show/Hide the Full List
mod site	chr12:49324033-49324034:+		[5]
Sequence	GGCCTGGGCCCCCTGCCCAGACAGGTACCTGTTGGAGCCAT
Motif Score	2.897386905
Cell/Tissue List	HeLa; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000550709.5; ENST00000549534.1; ENST00000257909.8; ENST00000551567.1; ENST00000547807.5; ENST00000549891.5; ENST00000546776.5; ENST00000549275.5; ENST00000550346.5; ENST00000546735.5; ENST00000380327.9; ENST00000551192.5; ENST00000551245.5; ENST00000548311.5
External Link	RMBase: m6A_site_186740
mod ID: M6ASITE012155		Click to Show/Hide the Full List
mod site	chr12:49324084-49324085:+		[5]
Sequence	CCTCCATGGCTGAGTAGGGGACTAGGAAGGGTAAAAGTGGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; peripheral-blood; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000551192.5; ENST00000546776.5; ENST00000380327.9; ENST00000547807.5; ENST00000550709.5; ENST00000546735.5; ENST00000549275.5; ENST00000257909.8; ENST00000551567.1; ENST00000549534.1; ENST00000551245.5; ENST00000548311.5; ENST00000549891.5; ENST00000550346.5
External Link	RMBase: m6A_site_186741
mod ID: M6ASITE012156		Click to Show/Hide the Full List
mod site	chr12:49325779-49325780:+		[5]
Sequence	CTGCATATTTGGCCCCCAGAACCCCCACCCACCGACTGGAC
Motif Score	2.930744048
Cell/Tissue List	HeLa; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547807.5; ENST00000550346.5; ENST00000548817.1; ENST00000546776.5; ENST00000549891.5; ENST00000257909.8; ENST00000546735.5; ENST00000551245.5; ENST00000551192.5
External Link	RMBase: m6A_site_186742
mod ID: M6ASITE012157		Click to Show/Hide the Full List
mod site	chr12:49325798-49325799:+		[5]
Sequence	AACCCCCACCCACCGACTGGACCCTGCCAGGGCTTCCTGCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548817.1; ENST00000546735.5; ENST00000551245.5; ENST00000551192.5; ENST00000257909.8; ENST00000546776.5; ENST00000550346.5; ENST00000549891.5; ENST00000547807.5
External Link	RMBase: m6A_site_186743
mod ID: M6ASITE012158		Click to Show/Hide the Full List
mod site	chr12:49325835-49325836:+		[8]
Sequence	TGCTTCTCTAGGCTGGAGGGACCAGGACCTCGAGGCCGGAC
Motif Score	3.622404762
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000547807.5; ENST00000550346.5; ENST00000551245.5; ENST00000549891.5; ENST00000548817.1; ENST00000546735.5; ENST00000551192.5; ENST00000257909.8; ENST00000546776.5
External Link	RMBase: m6A_site_186744
mod ID: M6ASITE012159		Click to Show/Hide the Full List
mod site	chr12:49325841-49325842:+		[8]
Sequence	TCTAGGCTGGAGGGACCAGGACCTCGAGGCCGGACATTGTG
Motif Score	3.622404762
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000549891.5; ENST00000550346.5; ENST00000548817.1; ENST00000551192.5; ENST00000547807.5; ENST00000546776.5; ENST00000546735.5; ENST00000257909.8; ENST00000551245.5
External Link	RMBase: m6A_site_186745
mod ID: M6ASITE012160		Click to Show/Hide the Full List
mod site	chr12:49329211-49329212:+		[4]
Sequence	TTCAACCTAAAACCCGGTTCACACCCATGCCATCAACCCCC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000551192.5; ENST00000551245.5; ENST00000546735.5; ENST00000257909.8; ENST00000549891.5; ENST00000547923.1
External Link	RMBase: m6A_site_186746
mod ID: M6ASITE012161		Click to Show/Hide the Full List
mod site	chr12:49329921-49329922:+
Sequence	TCACTGGAGGGTTCTGGGAAACCACCGGTGGCCACTCCTTC
Motif Score	2.185083333
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000551245.5; ENST00000257909.8; ENST00000547923.1
External Link	RMBase: m6A_site_186747
mod ID: M6ASITE012162		Click to Show/Hide the Full List
mod site	chr12:49329945-49329946:+
Sequence	CCGGTGGCCACTCCTTCTGGACCCCACTCTAACAGAACCCC
Motif Score	3.622404762
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000551245.5; ENST00000547923.1; ENST00000257909.8
External Link	RMBase: m6A_site_186748
mod ID: M6ASITE012163		Click to Show/Hide the Full List
mod site	chr12:49329961-49329962:+		[9]
Sequence	CTGGACCCCACTCTAACAGAACCCCCAGCCTCCAGGAGGTG
Motif Score	2.930744048
Cell/Tissue List	HEK293T; HeLa; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000547923.1; ENST00000257909.8; ENST00000551245.5
External Link	RMBase: m6A_site_186749
mod ID: M6ASITE012165		Click to Show/Hide the Full List
mod site	chr12:49330173-49330174:+		[5]
Sequence	ATCCTGCAACAGCTGTTGAGACAGGAAGTAGAGGGGCTGGT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; HEK293A-TOA; iSLK; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000551245.5; ENST00000547923.1; ENST00000257909.8
External Link	RMBase: m6A_site_186750
mod ID: M6ASITE012166		Click to Show/Hide the Full List
mod site	chr12:49330245-49330246:+		[5]
Sequence	TCTTCTCTGGATATGGTTGAACTTCAGCCCCTGCTGACTGA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; hNPCs; hESCs; fibroblasts; GM12878; MM6; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000257909.8; ENST00000547923.1; ENST00000551245.5
External Link	RMBase: m6A_site_186751
mod ID: M6ASITE012167		Click to Show/Hide the Full List
mod site	chr12:49330261-49330262:+		[10]
Sequence	TTGAACTTCAGCCCCTGCTGACTGAGATTTCTAGAACTCTG
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000547923.1; ENST00000257909.8; ENST00000551245.5
External Link	RMBase: m6A_site_186752
mod ID: M6ASITE012168		Click to Show/Hide the Full List
mod site	chr12:49330276-49330277:+		[5]
Sequence	TGCTGACTGAGATTTCTAGAACTCTGAATGCCACAGAGCAT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547923.1; ENST00000257909.8; ENST00000551245.5
External Link	RMBase: m6A_site_186753
mod ID: M6ASITE012169		Click to Show/Hide the Full List
mod site	chr12:49330306-49330307:+		[5]
Sequence	CCACAGAGCATAACTCTGGGACTTCCCACCTTCCTGGACTG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000551245.5; ENST00000547923.1; ENST00000257909.8
External Link	RMBase: m6A_site_186754
mod ID: M6ASITE012170		Click to Show/Hide the Full List
mod site	chr12:49330323-49330324:+		[5]
Sequence	GGGACTTCCCACCTTCCTGGACTGTTAAAACACTCAGGGCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547923.1; ENST00000551245.5; ENST00000257909.8
External Link	RMBase: m6A_site_186755
mod ID: M6ASITE012171		Click to Show/Hide the Full List
mod site	chr12:49330332-49330333:+		[5]
Sequence	CACCTTCCTGGACTGTTAAAACACTCAGGGCTGCCAAAGCC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; DART-seq; MAZTER-seq
Transcript ID List	ENST00000547923.1; ENST00000257909.8; ENST00000551245.5
External Link	RMBase: m6A_site_186756
mod ID: M6ASITE012172		Click to Show/Hide the Full List
mod site	chr12:49330377-49330378:+		[5]
Sequence	CTTCCAGAGGAGTGCGGGGAACCACAGCCCTGCCCTCCGGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547923.1; ENST00000551245.5; ENST00000257909.8
External Link	RMBase: m6A_site_186757
mod ID: M6ASITE012173		Click to Show/Hide the Full List
mod site	chr12:49330464-49330465:+		[5]
Sequence	CCAGAGCCCTCCCTCCAGGAACAGCTTGAAGTACCAGAGCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; TIME; TREX; MSC; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000257909.8; ENST00000547923.1; ENST00000551245.5
External Link	RMBase: m6A_site_186758
mod ID: M6ASITE012174		Click to Show/Hide the Full List
mod site	chr12:49330500-49330501:+		[5]
Sequence	GAGCCCTACCCTCCAGCAGAACCCAGGCCCCTAGAGTCCTG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; Huh7; Jurkat; peripheral-blood; GSC-11; iSLK; TIME; MSC; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000257909.8; ENST00000547923.1; ENST00000551245.5
External Link	RMBase: m6A_site_186759
mod ID: M6ASITE012176		Click to Show/Hide the Full List
mod site	chr12:49330563-49330564:+		[5]
Sequence	CCGGAGTCCTCTCGCCAGGAACAGCTTGAGGTACCTGAGCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293T; iSLK; MSC; endometrial; HEC-1-A; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000551245.5; ENST00000257909.8; ENST00000547923.1
External Link	RMBase: m6A_site_186760
mod ID: M6ASITE012177		Click to Show/Hide the Full List
mod site	chr12:49330599-49330600:+		[5]
Sequence	GAGCCCTGCCCTCCAGCAGAACCCAGGCCCCTAGAGTCCTA
Motif Score	2.930744048
Cell/Tissue List	HeLa; Jurkat; peripheral-blood; GSC-11; HEK293T; MSC; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000257909.8; ENST00000551245.5; ENST00000547923.1
External Link	RMBase: m6A_site_186761
mod ID: M6ASITE012178		Click to Show/Hide the Full List
mod site	chr12:49330662-49330663:+		[5]
Sequence	CCGGAGTCCTCTCGCCAGGAACAGCTTGAGGTACCTGAGCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; peripheral-blood; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000257909.8; ENST00000547923.1; ENST00000551245.5
External Link	RMBase: m6A_site_186762
mod ID: M6ASITE012179		Click to Show/Hide the Full List
mod site	chr12:49330698-49330699:+		[11]
Sequence	GAGCCCTGCCCTCCAGCAGAACCCGGGCCCCTTCAGCCCAG
Motif Score	2.930744048
Cell/Tissue List	peripheral-blood; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000547923.1; ENST00000257909.8; ENST00000551245.5
External Link	RMBase: m6A_site_186763
mod ID: M6ASITE012180		Click to Show/Hide the Full List
mod site	chr12:49330737-49330738:+		[12]
Sequence	AGCACCCAGGGGCAGTCTGGACCCCCAGGGCCCTGCCCTAG
Motif Score	3.622404762
Cell/Tissue List	HepG2; Huh7; peripheral-blood; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000551245.5; ENST00000547923.1; ENST00000257909.8
External Link	RMBase: m6A_site_186764
mod ID: M6ASITE012181		Click to Show/Hide the Full List
mod site	chr12:49330794-49330795:+		[13]
Sequence	TCAGAGCCCTGCACCCTGGAACATAGAAGTCTAGAGTCCAG
Motif Score	2.951386905
Cell/Tissue List	HepG2; hESC-HEK293T; HeLa; Huh7; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000547923.1; ENST00000551245.5; ENST00000257909.8
External Link	RMBase: m6A_site_186765
mod ID: M6ASITE012182		Click to Show/Hide the Full List
mod site	chr12:49330875-49330876:+		[4]
Sequence	AGCCTGATCTTCTCTTCCCAACACCCGCTTTGTGCCAGCCC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000551245.5; ENST00000547923.1; ENST00000257909.8
External Link	RMBase: m6A_site_186766
mod ID: M6ASITE012183		Click to Show/Hide the Full List
mod site	chr12:49330923-49330924:+		[14]
Sequence	TGCTCACTCCAGTCTTTGAGACCCCCAGCAGGCCAGGCAGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000257909.8; ENST00000547923.1; ENST00000551245.5
External Link	RMBase: m6A_site_186767
mod ID: M6ASITE012184		Click to Show/Hide the Full List
mod site	chr12:49330971-49330972:+		[5]
Sequence	TTGGCTGGGAAGGAGTGTGAACACAAGAGGTCCTCACCTCA
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000257909.8; ENST00000547923.1; ENST00000551245.5
External Link	RMBase: m6A_site_186768
mod ID: M6ASITE012185		Click to Show/Hide the Full List
mod site	chr12:49331183-49331184:+		[7]
Sequence	GTGGAAGTATAGGACCCCAGACCTCCCTCTAAATTTTCCAT
Motif Score	2.876744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000547923.1; ENST00000257909.8; ENST00000551245.5
External Link	RMBase: m6A_site_186769
mod ID: M6ASITE012187		Click to Show/Hide the Full List
mod site	chr12:49331236-49331237:+		[7]
Sequence	TCAGCAATCTGGCCCCTCGAACCCTAGCCCTGAGGGAGCGC
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000257909.8; ENST00000551245.5; ENST00000547923.1
External Link	RMBase: m6A_site_186770
mod ID: M6ASITE012188		Click to Show/Hide the Full List
mod site	chr12:49331324-49331325:+		[4]
Sequence	GGACGATGAGTGTGCCTTTTACACCAGCCGAGCCCCTCCCT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000547923.1; ENST00000257909.8; ENST00000551245.5
External Link	RMBase: m6A_site_186771
mod ID: M6ASITE012189		Click to Show/Hide the Full List
mod site	chr12:49331380-49331381:+		[4]
Sequence	TCTGCACCAACCCTGTGGCTACATTACTCGAATGGCAGGAT
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000551245.5; ENST00000257909.8; ENST00000547923.1
External Link	RMBase: m6A_site_186772
mod ID: M6ASITE012190		Click to Show/Hide the Full List
mod site	chr12:49331621-49331622:+		[5]
Sequence	CCAGGGCTCTCCATGATGAGACAACCACTCCTGCCCTGCCG
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T; Huh7
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000551245.5; ENST00000547923.1; ENST00000257909.8
External Link	RMBase: m6A_site_186773
mod ID: M6ASITE012191		Click to Show/Hide the Full List
mod site	chr12:49331687-49331688:+		[5]
Sequence	ATTGTCGGTCTGCCCATGGGACTGGGAGCCGCCCACTTTTG
Motif Score	4.065041667
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000257909.8; ENST00000547923.1
External Link	RMBase: m6A_site_186774

Ref 1	Downregulation of Methyltransferase-Like 14 Promotes Ovarian Cancer Cell Proliferation Through Stabilizing TROAP mRNA. Front Oncol. 2022 Feb 18;12:824258. doi: 10.3389/fonc.2022.824258. eCollection 2022.
Ref 2	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 7	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 8	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 9	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 10	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 11	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.
Ref 12	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 13	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 14	N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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