m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00594)

Target Name	Axin-1 (AXIN1)
Synonyms	Axis inhibition protein 1; hAxin Click to Show/Hide
Gene Name	AXIN1
Chromosomal Location	16p13.3
Function	Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Click to Show/Hide
Gene ID	8312
Uniprot ID	AXIN1_HUMAN
HGNC ID	HGNC:903
KEGG ID	hsa:8312

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

AXIN1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

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YTH domain-containing family protein 2 (YTHDF2) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[3]
Response Summary	YTHDF2 interference could suppress the EMT of cervical cancer cells and enhance cisplatin chemosensitivity by regulating Axin-1 (AXIN1).
Target Regulation	Up regulation
Responsed Disease	Cervical cancer		ICD-11: 2C77	Disease Info
Responsed Drug	Cisplatin		Approved	Drug Info
Pathway Response	Wnt signaling pathway			hsa04310
Cell Process	Epithelial-mesenchymal transition
In-vitro Model	SiHa	Cervical squamous cell carcinoma	Homo sapiens	CVCL_0032
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Ect1/E6E7	Normal	Homo sapiens	CVCL_3679
	Ca Ski	Cervical squamous cell carcinoma	Homo sapiens	CVCL_1100
	C-33 A	Cervical squamous cell carcinoma	Homo sapiens	CVCL_1094

Cervical cancer [ICD-11: 2C77]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[3]
Response Summary	YTHDF2 interference could suppress the EMT of cervical cancer cells and enhance cisplatin chemosensitivity by regulating Axin-1 (AXIN1).
Responsed Disease	Cervical cancer [ICD-11: 2C77]
Target Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
Target Regulation	Up regulation
Responsed Drug	Cisplatin		Approved	Drug Info
Pathway Response	Wnt signaling pathway			hsa04310
Cell Process	Epithelial-mesenchymal transition
In-vitro Model	SiHa	Cervical squamous cell carcinoma	Homo sapiens	CVCL_0032
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Ect1/E6E7	Normal	Homo sapiens	CVCL_3679
	Ca Ski	Cervical squamous cell carcinoma	Homo sapiens	CVCL_1100
	C-33 A	Cervical squamous cell carcinoma	Homo sapiens	CVCL_1094

Cisplatin [Approved]

Drug Info

In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response				[3]
Response Summary	YTHDF2 interference could suppress the EMT of cervical cancer cells and enhance cisplatin chemosensitivity by regulating Axin-1 (AXIN1).
Target Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
Target Regulation	Up regulation
Responsed Disease	Cervical cancer		ICD-11: 2C77	Disease Info
Pathway Response	Wnt signaling pathway			hsa04310
Cell Process	Epithelial-mesenchymal transition
In-vitro Model	SiHa	Cervical squamous cell carcinoma	Homo sapiens	CVCL_0032
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Ect1/E6E7	Normal	Homo sapiens	CVCL_3679
	Ca Ski	Cervical squamous cell carcinoma	Homo sapiens	CVCL_1100
	C-33 A	Cervical squamous cell carcinoma	Homo sapiens	CVCL_1094

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00594)

Axin-1 (AXIN1)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE007067		Click to Show/Hide the Full List
mod site	chr16:320244-320245:-		[5]
Sequence	AAGACCAGCCTGGGTGACATAGTGAGACCTCATCTATATAA
Transcript ID List	ENST00000262320.8; ENST00000461023.5; ENST00000354866.7; rmsk_4437485; ENST00000481769.1
External Link	RMBase: RNA-editing_site_46748

5-methylcytidine (m5C)

In total 3 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000498		Click to Show/Hide the Full List
mod site	chr16:291818-291819:-
Sequence	GTCAGAGTAGAAACCACCATCAAGGTCGCCCAGTGTACCCC
Cell/Tissue List	testis
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000262320.8; ENST00000461023.5; ENST00000354866.7; ENST00000457798.1
External Link	RMBase: m5C_site_14640
mod ID: M5CSITE000499		Click to Show/Hide the Full List
mod site	chr16:318155-318156:-
Sequence	TCGTTCTGCTGTATGTGGCTCCCAAGTGACGGGACAGGTGT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000461023.5; ENST00000481769.1; ENST00000354866.7; ENST00000262320.8
External Link	RMBase: m5C_site_14641
mod ID: M5CSITE000500		Click to Show/Hide the Full List
mod site	chr16:346921-346922:-
Sequence	GGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCT
Cell/Tissue List	liver
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000481769.1
External Link	RMBase: m5C_site_14642

N6-methyladenosine (m6A)

In total 61 m6A sequence/site(s) in this target gene
mod ID: M6ASITE025110		Click to Show/Hide the Full List
mod site	chr16:287477-287478:-		[6]
Sequence	TTAATTATCTTTTCAAAGGTACTTGGATAATAATGAAATAA
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000461023.5; ENST00000354866.7; ENST00000262320.8
External Link	RMBase: m6A_site_298573
mod ID: M6ASITE025111		Click to Show/Hide the Full List
mod site	chr16:287507-287508:-		[6]
Sequence	TCTGTTTTTCATGCGATGACACTTGTACAATTAATTATCTT
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000461023.5
External Link	RMBase: m6A_site_298574
mod ID: M6ASITE025112		Click to Show/Hide the Full List
mod site	chr16:287509-287510:-		[6]
Sequence	AGTCTGTTTTTCATGCGATGACACTTGTACAATTAATTATC
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000354866.7; ENST00000461023.5; ENST00000262320.8
External Link	RMBase: m6A_site_298575
mod ID: M6ASITE025113		Click to Show/Hide the Full List
mod site	chr16:287563-287564:-		[7]
Sequence	GAGGGCCCGTGTAAATATGTACATTTCTCAGGCTAGGCCAG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000262320.8; ENST00000461023.5; ENST00000354866.7
External Link	RMBase: m6A_site_298576
mod ID: M6ASITE025114		Click to Show/Hide the Full List
mod site	chr16:287679-287680:-		[7]
Sequence	CGCGCCACCGAGTGCCTTCAACACAGCTTGTCTCTTGCCTG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000461023.5
External Link	RMBase: m6A_site_298577
mod ID: M6ASITE025115		Click to Show/Hide the Full List
mod site	chr16:287911-287912:-		[8]
Sequence	CCCCCAAGGAGGCAGCCTGGACCACTCCTCATAGCAATACT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; peripheral-blood; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000461023.5; ENST00000354866.7; ENST00000262320.8
External Link	RMBase: m6A_site_298578
mod ID: M6ASITE025116		Click to Show/Hide the Full List
mod site	chr16:288023-288024:-		[8]
Sequence	ACTCAGGAGCCCGATGGGGAACAGTGTTGGGTGTACCACCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; U2OS; H1A; H1B; LCLs; A549; H1299; MM6; CD4T; peripheral-blood; GSC-11; iSLK; TIME; TREX; MSC; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000461023.5; ENST00000262320.8; ENST00000354866.7
External Link	RMBase: m6A_site_298579
mod ID: M6ASITE025117		Click to Show/Hide the Full List
mod site	chr16:288125-288126:-		[8]
Sequence	CGGCAAAGTGGAGAAGGTGGACTGATAGGCTGGTGGGCTGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; iSLK; TIME; TREX; MSC; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000461023.5
External Link	RMBase: m6A_site_298580
mod ID: M6ASITE025118		Click to Show/Hide the Full List
mod site	chr16:289525-289526:-		[8]
Sequence	GCGTACTACTTCTGCGGGGAACCCATCCCCTACCGCACCCT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; U2OS; MM6; Jurkat; CD4T; peripheral-blood; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000354866.7; ENST00000461023.5; ENST00000457798.1; ENST00000262320.8
External Link	RMBase: m6A_site_298581
mod ID: M6ASITE025119		Click to Show/Hide the Full List
mod site	chr16:289559-289560:-		[9]
Sequence	CGGGAGTGCCCAGCCGTGTGACAGCATCGTTGTGGCGTACT
Motif Score	2.859755952
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000354866.7; ENST00000457798.1; ENST00000461023.5; ENST00000262320.8
External Link	RMBase: m6A_site_298582
mod ID: M6ASITE025120		Click to Show/Hide the Full List
mod site	chr16:289605-289606:-		[8]
Sequence	GCTGCATCTCTTTCCCCAGGACAAGATCGCAGAGGAAGGTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; MT4; MM6; Jurkat; CD4T; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000461023.5; ENST00000457798.1; ENST00000262320.8; ENST00000354866.7
External Link	RMBase: m6A_site_298583
mod ID: M6ASITE025121		Click to Show/Hide the Full List
mod site	chr16:289638-289639:-		[8]
Sequence	CTGTGGGACCTCAGTCCAAAACCAGGTACCACCGCTGCATC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; MT4; MM6; Jurkat; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000457798.1; ENST00000461023.5; ENST00000354866.7; ENST00000262320.8
External Link	RMBase: m6A_site_298584
mod ID: M6ASITE025122		Click to Show/Hide the Full List
mod site	chr16:289651-289652:-		[8]
Sequence	AGCAGGAGGGACCCTGTGGGACCTCAGTCCAAAACCAGGTA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MT4; MM6; Jurkat; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000461023.5; ENST00000354866.7; ENST00000457798.1; ENST00000262320.8
External Link	RMBase: m6A_site_298585
mod ID: M6ASITE025123		Click to Show/Hide the Full List
mod site	chr16:289661-289662:-		[8]
Sequence	GCCTGAGGCCAGCAGGAGGGACCCTGTGGGACCTCAGTCCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MT4; MM6; Jurkat; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000457798.1; ENST00000262320.8; ENST00000354866.7; ENST00000461023.5
External Link	RMBase: m6A_site_298586
mod ID: M6ASITE025124		Click to Show/Hide the Full List
mod site	chr16:290882-290883:-		[8]
Sequence	AGGCTTCCTGTGGGGCAGAGACCTGCCTGCGCCTCCACCCG
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000457798.1; ENST00000262320.8; ENST00000354866.7; ENST00000461023.5
External Link	RMBase: m6A_site_298587
mod ID: M6ASITE025125		Click to Show/Hide the Full List
mod site	chr16:291039-291040:-		[8]
Sequence	AGAGGGTCCCGTGGCATCAGACTCGAAGCTGCCCGAGAGCC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000457798.1; ENST00000461023.5; ENST00000354866.7; ENST00000262320.8
External Link	RMBase: m6A_site_298588
mod ID: M6ASITE025126		Click to Show/Hide the Full List
mod site	chr16:291431-291432:-		[8]
Sequence	GTGTCTTGTCTACCCTGCAAACTGGAGCCTGCGCAGGGTGG
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000262320.8; ENST00000461023.5; ENST00000354866.7; ENST00000457798.1
External Link	RMBase: m6A_site_298589
mod ID: M6ASITE025127		Click to Show/Hide the Full List
mod site	chr16:291456-291457:-		[8]
Sequence	CAAGGCAGGCCTAGGAGGGGACTCGGTGTCTTGTCTACCCT
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000461023.5; ENST00000262320.8; ENST00000457798.1; ENST00000354866.7
External Link	RMBase: m6A_site_298590
mod ID: M6ASITE025128		Click to Show/Hide the Full List
mod site	chr16:291535-291536:-		[10]
Sequence	CCCAAAGTGCGGTCCAGGGAACTCAGGGGGTTGGTGCCGGG
Motif Score	3.373380952
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000457798.1; ENST00000354866.7; ENST00000262320.8; ENST00000461023.5
External Link	RMBase: m6A_site_298591
mod ID: M6ASITE025129		Click to Show/Hide the Full List
mod site	chr16:291632-291633:-		[8]
Sequence	TCATGCCAAGAGACTGAAGGACAGACTCTCGGGACGAGATG
Motif Score	3.643047619
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000354866.7; ENST00000457798.1; ENST00000262320.8; ENST00000461023.5
External Link	RMBase: m6A_site_298592
mod ID: M6ASITE025130		Click to Show/Hide the Full List
mod site	chr16:291640-291641:-		[8]
Sequence	TGGGGAATTCATGCCAAGAGACTGAAGGACAGACTCTCGGG
Motif Score	3.319380952
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000457798.1; ENST00000354866.7; ENST00000461023.5; ENST00000262320.8
External Link	RMBase: m6A_site_298593
mod ID: M6ASITE025131		Click to Show/Hide the Full List
mod site	chr16:291705-291706:-		[8]
Sequence	TCAGCCTCCCTGAGGTGCAGACCGAGTTGCCACGCACGCCC
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000457798.1; ENST00000461023.5
External Link	RMBase: m6A_site_298594
mod ID: M6ASITE025132		Click to Show/Hide the Full List
mod site	chr16:293598-293599:-		[8]
Sequence	CTCCCACCTCTTCATCCAAGACCCCACCATGCCACCCCACC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MT4; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000354866.7; ENST00000461023.5; ENST00000262320.8
External Link	RMBase: m6A_site_298595
mod ID: M6ASITE025133		Click to Show/Hide the Full List
mod site	chr16:293632-293633:-		[8]
Sequence	GGGCCGGCCCTCAGCTCCGGACCTCCGTGCAGCCCTCCCAC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MT4; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262320.8; ENST00000461023.5; ENST00000354866.7
External Link	RMBase: m6A_site_298596
mod ID: M6ASITE025134		Click to Show/Hide the Full List
mod site	chr16:293675-293676:-		[8]
Sequence	CAGCCCCATGAGAACTCCAGACCCTTGTCCCTTGAGCACCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; U2OS; MT4; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000461023.5; ENST00000354866.7; ENST00000262320.8
External Link	RMBase: m6A_site_298597
mod ID: M6ASITE025135		Click to Show/Hide the Full List
mod site	chr16:293682-293683:-		[8]
Sequence	GAAGCCACAGCCCCATGAGAACTCCAGACCCTTGTCCCTTG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; U2OS; MT4; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262320.8; ENST00000461023.5; ENST00000354866.7
External Link	RMBase: m6A_site_298598
mod ID: M6ASITE025136		Click to Show/Hide the Full List
mod site	chr16:297065-297066:-		[8]
Sequence	AGATCAGCAGGCACCGCAGGACCGGCCACGGGTGAGCACCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; U2OS; LCLs; MT4; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000354866.7; ENST00000461023.5; ENST00000262320.8
External Link	RMBase: m6A_site_298599
mod ID: M6ASITE025137		Click to Show/Hide the Full List
mod site	chr16:297124-297125:-		[8]
Sequence	CTCGGAGGATGCGGAGAAGAACCAGAAAATCATGCAGTGGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; U2OS; LCLs; MT4; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262320.8; ENST00000354866.7; ENST00000461023.5
External Link	RMBase: m6A_site_298600
mod ID: M6ASITE025138		Click to Show/Hide the Full List
mod site	chr16:297804-297805:-		[8]
Sequence	AGCTTCGCCTGGGGCCTGGAACCACACAGCCATGGGGCAAG
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; A549; U2OS; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; TREX; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262320.8; ENST00000354866.7; ENST00000461023.5
External Link	RMBase: m6A_site_298601
mod ID: M6ASITE025139		Click to Show/Hide the Full List
mod site	chr16:297906-297907:-		[7]
Sequence	GCCGGCCTGCACCACCACCGACACGTCCACCACCACGTCCA
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000354866.7; ENST00000481769.1; ENST00000461023.5; ENST00000262320.8
External Link	RMBase: m6A_site_298602
mod ID: M6ASITE025140		Click to Show/Hide the Full List
mod site	chr16:298021-298022:-		[8]
Sequence	GCCTGGCCATCGCTCCCCGGACAGTGGGCACGTGGCCAAGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; hESC-HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000461023.5; ENST00000262320.8; ENST00000354866.7; ENST00000481769.1
External Link	RMBase: m6A_site_298603
mod ID: M6ASITE025141		Click to Show/Hide the Full List
mod site	chr16:298064-298065:-		[8]
Sequence	ACGTACAGCGTGTGCTGAGGACACCTGGCCGCCAGTCGCCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000354866.7; ENST00000461023.5; ENST00000262320.8; ENST00000481769.1
External Link	RMBase: m6A_site_298604
mod ID: M6ASITE025142		Click to Show/Hide the Full List
mod site	chr16:298108-298109:-		[8]
Sequence	CCGGGATGCACACGAGGAGAACCCTGAGAGCATCCTGGACG
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; MT4; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000354866.7; ENST00000481769.1; ENST00000262320.8; ENST00000461023.5
External Link	RMBase: m6A_site_298605
mod ID: M6ASITE025143		Click to Show/Hide the Full List
mod site	chr16:298119-298120:-		[9]
Sequence	TGTGCCGGGCTCCGGGATGCACACGAGGAGAACCCTGAGAG
Motif Score	2.830589286
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000481769.1; ENST00000354866.7; ENST00000461023.5; ENST00000262320.8
External Link	RMBase: m6A_site_298606
mod ID: M6ASITE025144		Click to Show/Hide the Full List
mod site	chr16:298147-298148:-		[8]
Sequence	CTTCCCGCCCCGCTGTGTGGACATGGGCTGTGCCGGGCTCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; GM12878; MT4; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000461023.5; ENST00000354866.7; ENST00000481769.1; ENST00000262320.8
External Link	RMBase: m6A_site_298607
mod ID: M6ASITE025145		Click to Show/Hide the Full List
mod site	chr16:298198-298199:-		[7]
Sequence	AGGGCCCCCAGGGCCGTGTCACAAGCTGCCTCCCGCCCCCG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000354866.7; ENST00000461023.5; ENST00000481769.1; ENST00000262320.8
External Link	RMBase: m6A_site_298608
mod ID: M6ASITE025146		Click to Show/Hide the Full List
mod site	chr16:308353-308354:-		[11]
Sequence	CCTCAGAAGGGTCAGGAAGGACAGAAGCTGTGGAGTGCGTT
Motif Score	3.643047619
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000262320.8; ENST00000354866.7; ENST00000481769.1; ENST00000461023.5
External Link	RMBase: m6A_site_298609
mod ID: M6ASITE025147		Click to Show/Hide the Full List
mod site	chr16:308408-308409:-		[11]
Sequence	GTAGAAAGTGCATGCCACAGACTCTGGATGAGGGGGCATCA
Motif Score	3.319380952
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000262320.8; ENST00000461023.5; ENST00000481769.1; ENST00000354866.7
External Link	RMBase: m6A_site_298610
mod ID: M6ASITE025148		Click to Show/Hide the Full List
mod site	chr16:314551-314552:-		[8]
Sequence	AGACACCCTGTCCCTCACGGACAGCAGCGTGTAAGTCCCGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; peripheral-blood; TREX; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000461023.5; ENST00000262320.8; ENST00000354866.7; ENST00000481769.1
External Link	RMBase: m6A_site_298611
mod ID: M6ASITE025149		Click to Show/Hide the Full List
mod site	chr16:314569-314570:-		[8]
Sequence	GAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACGGACA
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; MM6; peripheral-blood; TREX; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000461023.5; ENST00000481769.1; ENST00000354866.7; ENST00000262320.8
External Link	RMBase: m6A_site_298612
mod ID: M6ASITE025150		Click to Show/Hide the Full List
mod site	chr16:346202-346203:-		[8]
Sequence	CTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTCTCC
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1B; H1A; GM12878; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262320.8; ENST00000461023.5; ENST00000354866.7; ENST00000481769.1
External Link	RMBase: m6A_site_298613
mod ID: M6ASITE025151		Click to Show/Hide the Full List
mod site	chr16:346227-346228:-		[8]
Sequence	GACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCT
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; GM12878; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000481769.1; ENST00000354866.7; ENST00000461023.5; ENST00000262320.8
External Link	RMBase: m6A_site_298614
mod ID: M6ASITE025152		Click to Show/Hide the Full List
mod site	chr16:346270-346271:-		[8]
Sequence	GGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000354866.7; ENST00000481769.1; ENST00000262320.8; ENST00000461023.5
External Link	RMBase: m6A_site_298615
mod ID: M6ASITE025153		Click to Show/Hide the Full List
mod site	chr16:346337-346338:-		[8]
Sequence	ACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; CD8T; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000481769.1; ENST00000262320.8; ENST00000354866.7
External Link	RMBase: m6A_site_298616
mod ID: M6ASITE025154		Click to Show/Hide the Full List
mod site	chr16:346388-346389:-		[8]
Sequence	TTTATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; CD8T; MT4; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000481769.1; ENST00000262320.8; ENST00000354866.7
External Link	RMBase: m6A_site_298617
mod ID: M6ASITE025155		Click to Show/Hide the Full List
mod site	chr16:346438-346439:-		[8]
Sequence	CCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTA
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; hNPCs; hESCs; fibroblasts; GM12878; MT4; H1299; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000481769.1
External Link	RMBase: m6A_site_298618
mod ID: M6ASITE025156		Click to Show/Hide the Full List
mod site	chr16:346466-346467:-		[8]
Sequence	CCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATG
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; hNPCs; hESCs; fibroblasts; GM12878; MT4; H1299; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000262320.8; ENST00000481769.1; ENST00000354866.7
External Link	RMBase: m6A_site_298619
mod ID: M6ASITE025157		Click to Show/Hide the Full List
mod site	chr16:346547-346548:-		[8]
Sequence	ATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262320.8; ENST00000481769.1; ENST00000354866.7
External Link	RMBase: m6A_site_298620
mod ID: M6ASITE025158		Click to Show/Hide the Full List
mod site	chr16:346570-346571:-		[7]
Sequence	CCGAAAGTACATTCTTGATAACAATGGCATCGTGTCCCGGC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000354866.7; ENST00000481769.1; ENST00000262320.8
External Link	RMBase: m6A_site_298621
mod ID: M6ASITE025159		Click to Show/Hide the Full List
mod site	chr16:346582-346583:-		[7]
Sequence	GAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000481769.1
External Link	RMBase: m6A_site_298622
mod ID: M6ASITE025160		Click to Show/Hide the Full List
mod site	chr16:346678-346679:-		[8]
Sequence	GGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTG
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000262320.8; ENST00000354866.7; ENST00000481769.1
External Link	RMBase: m6A_site_298623
mod ID: M6ASITE025161		Click to Show/Hide the Full List
mod site	chr16:346715-346716:-		[8]
Sequence	ATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000481769.1
External Link	RMBase: m6A_site_298624
mod ID: M6ASITE025162		Click to Show/Hide the Full List
mod site	chr16:346741-346742:-		[11]
Sequence	ACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGT
Motif Score	2.839113095
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000262320.8; ENST00000481769.1; ENST00000354866.7
External Link	RMBase: m6A_site_298625
mod ID: M6ASITE025163		Click to Show/Hide the Full List
mod site	chr16:346780-346781:-		[6]
Sequence	TGCCTCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCAC
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000481769.1; ENST00000354866.7; ENST00000262320.8
External Link	RMBase: m6A_site_298626
mod ID: M6ASITE025164		Click to Show/Hide the Full List
mod site	chr16:346825-346826:-		[8]
Sequence	TCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000481769.1; ENST00000262320.8; ENST00000354866.7
External Link	RMBase: m6A_site_298627
mod ID: M6ASITE025165		Click to Show/Hide the Full List
mod site	chr16:346859-346860:-		[8]
Sequence	GTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGG
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000481769.1; ENST00000262320.8; ENST00000354866.7
External Link	RMBase: m6A_site_298628
mod ID: M6ASITE025166		Click to Show/Hide the Full List
mod site	chr16:346918-346919:-		[8]
Sequence	GGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACA
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000481769.1
External Link	RMBase: m6A_site_298629
mod ID: M6ASITE025167		Click to Show/Hide the Full List
mod site	chr16:346932-346933:-		[8]
Sequence	GTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAG
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262320.8; ENST00000354866.7; ENST00000481769.1
External Link	RMBase: m6A_site_298630
mod ID: M6ASITE025168		Click to Show/Hide the Full List
mod site	chr16:346993-346994:-		[8]
Sequence	AGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; MM6; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000481769.1
External Link	RMBase: m6A_site_298631
mod ID: M6ASITE025169		Click to Show/Hide the Full List
mod site	chr16:347039-347040:-		[6]
Sequence	GCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAAT
Motif Score	2.833690476
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000481769.1
External Link	RMBase: m6A_site_298632
mod ID: M6ASITE025170		Click to Show/Hide the Full List
mod site	chr16:352423-352424:-		[8]
Sequence	CGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGG
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000354866.7; ENST00000262320.8; ENST00000481769.1
External Link	RMBase: m6A_site_298633

Ref 1	Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture. J Biochem Mol Toxicol. 2007;21(3):101-9. doi: 10.1002/jbt.20168.
Ref 2	P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood-brain barrier in?vivo. Neuropharmacology. 2016 Apr;103:104-11. doi: 10.1016/j.neuropharm.2015.12.009. Epub 2015 Dec 15.
Ref 3	YTHDF2 interference suppresses the EMT of cervical cancer cells and enhances cisplatin chemosensitivity by regulating AXIN1. Drug Dev Res. 2022 Apr 30. doi: 10.1002/ddr.21942. Online ahead of print.
Ref 4	Clinical pipeline report, company report or official report of Zydus Cadila.
Ref 5	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 6	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 10	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 11	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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