m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00580)

Target Name	Paired mesoderm homeobox protein 1 (PRRX1)
Synonyms	Homeobox protein PHOX1; Paired-related homeobox protein 1; PRX-1 Click to Show/Hide
Gene Name	PRRX1
Chromosomal Location	1q24.2
Family	Paired homeobox family
Function	Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity).. Click to Show/Hide
Gene ID	5396
Uniprot ID	PRRX1_HUMAN
HGNC ID	HGNC:9142
KEGG ID	hsa:5396

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

PRRX1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

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RNA demethylase ALKBH5 (ALKBH5) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5*
Cell Line	143B cell line	Homo sapiens
Treatment: siALKBH5 transfected 143B cells Control: siControl 143B cells		GSE154528
Regulation		logFC: -9.92E-01 p-value: 2.75E-02
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Knockdown of p53 or inhibition of p53's transcriptional activity by addition of its specific inhibitor PFT-Alpha decreased expression of ALKBH5 and Cancer stem cells' malignancies, the pivotal role of ALKBH5 in Cancer stem cells derived from nonsmall-cell lung cancer and highlight the regulatory function of the p53/ALKBH5 axis in modulating CSC progression. p53 transcriptionally regulates Paired mesoderm homeobox protein 1 (PRRX1), which is consistent with our previous report.
Target Regulation	Up regulation
Responsed Disease	Non-small-cell lung carcinoma		ICD-11: 2C25.Y	Disease Info
Pathway Response	p53 signaling pathway			hsa04115
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
In-vivo Model	Cells at 1 × 10⁶ were subcutaneously injected into the mice similarly to nude mice. Twenty-eight days later, grafted tumors were collected and morphologically analyzed.

Lung cancer [ICD-11: 2C25]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	Knockdown of p53 or inhibition of p53's transcriptional activity by addition of its specific inhibitor PFT-Alpha decreased expression of ALKBH5 and Cancer stem cells' malignancies, the pivotal role of ALKBH5 in Cancer stem cells derived from nonsmall-cell lung cancer and highlight the regulatory function of the p53/ALKBH5 axis in modulating CSC progression. p53 transcriptionally regulates Paired mesoderm homeobox protein 1 (PRRX1), which is consistent with our previous report.
Responsed Disease	Non-small-cell lung carcinoma [ICD-11: 2C25.Y]
Target Regulator	RNA demethylase ALKBH5 (ALKBH5)		ERASER	Regulator Info
Target Regulation	Up regulation
Pathway Response	p53 signaling pathway			hsa04115
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
In-vivo Model	Cells at 1 × 10⁶ were subcutaneously injected into the mice similarly to nude mice. Twenty-eight days later, grafted tumors were collected and morphologically analyzed.

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00580)

Paired mesoderm homeobox protein 1 (PRRX1)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000423		Click to Show/Hide the Full List
mod site	chr1:170663439-170663440:+		[2]
Sequence	GGGGAGAGAGAGAAGGGGAAAGGGGGGAACCCACCAGCACC
Transcript ID List	ENST00000553786.1; ENST00000367760.7
External Link	RMBase: RNA-editing_site_10544

N6-methyladenosine (m6A)

In total 53 m6A sequence/site(s) in this target gene
mod ID: M6ASITE066299		Click to Show/Hide the Full List
mod site	chr1:170663163-170663164:+		[3]
Sequence	AAGGGGGTTTTCTTAATCAGACTGTTTTTTGGTCCCAGGGA
Motif Score	3.319380952
Cell/Tissue List	fibroblasts
Seq Type List	m6A-seq
Transcript ID List	ENST00000553786.1; ENST00000367760.7
External Link	RMBase: m6A_site_64249
mod ID: M6ASITE066300		Click to Show/Hide the Full List
mod site	chr1:170663447-170663448:+		[4]
Sequence	AGAGAAGGGGAAAGGGGGGAACCCACCAGCACCCTCCGTCG
Motif Score	2.930744048
Cell/Tissue List	GSC-11; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367760.7; ENST00000553786.1
External Link	RMBase: m6A_site_64250
mod ID: M6ASITE066301		Click to Show/Hide the Full List
mod site	chr1:170663469-170663470:+		[4]
Sequence	CCACCAGCACCCTCCGTCGGACTCTTGAAGCCTTTTTTTTT
Motif Score	4.065041667
Cell/Tissue List	GSC-11; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000553786.1; ENST00000367760.7
External Link	RMBase: m6A_site_64251
mod ID: M6ASITE066302		Click to Show/Hide the Full List
mod site	chr1:170663562-170663563:+		[3]
Sequence	CTCTCTAATACATCTGCAAGACATCACCCTCTCCTCCTGAA
Motif Score	2.897386905
Cell/Tissue List	fibroblasts; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367760.7; ENST00000553786.1
External Link	RMBase: m6A_site_64252
mod ID: M6ASITE066303		Click to Show/Hide the Full List
mod site	chr1:170663583-170663584:+		[3]
Sequence	CATCACCCTCTCCTCCTGAAACTTTAGTCACTCCTGAGAAT
Motif Score	2.627720238
Cell/Tissue List	fibroblasts; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367760.7; ENST00000553786.1
External Link	RMBase: m6A_site_64253
mod ID: M6ASITE066304		Click to Show/Hide the Full List
mod site	chr1:170663628-170663629:+		[3]
Sequence	AGGAGTGCAGAGAGGGGGGAACACGTTTTCTTGAAGATGTT
Motif Score	2.951386905
Cell/Tissue List	fibroblasts; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000553786.1; ENST00000367760.7
External Link	RMBase: m6A_site_64254
mod ID: M6ASITE066305		Click to Show/Hide the Full List
mod site	chr1:170663660-170663661:+		[5]
Sequence	GAAGATGTTTTAAAGCTGGAACAAGCCTTCTTCTGTTGGTG
Motif Score	2.951386905
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000367760.7; ENST00000553786.1
External Link	RMBase: m6A_site_64255
mod ID: M6ASITE066306		Click to Show/Hide the Full List
mod site	chr1:170663686-170663687:+		[5]
Sequence	CTTCTTCTGTTGGTGCTTGAACTCTTGCCTGGGAATAACTT
Motif Score	3.373380952
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000553786.1; ENST00000367760.7
External Link	RMBase: m6A_site_64256
mod ID: M6ASITE066307		Click to Show/Hide the Full List
mod site	chr1:170663724-170663725:+		[5]
Sequence	CTTTTTTAACCTTTAAAAAAACCATTCACTTTGATTCTTCT
Motif Score	2.185083333
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000553786.1; ENST00000367760.7
External Link	RMBase: m6A_site_64257
mod ID: M6ASITE066308		Click to Show/Hide the Full List
mod site	chr1:170663850-170663851:+		[3]
Sequence	TTTTTAGTCTGTGCGTGTGGACACTTTTGGAGAGTTGGAAG
Motif Score	3.643047619
Cell/Tissue List	fibroblasts; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000553786.1; ENST00000367760.7
External Link	RMBase: m6A_site_64258
mod ID: M6ASITE066309		Click to Show/Hide the Full List
mod site	chr1:170663893-170663894:+		[3]
Sequence	ATTTTTTTCTCCTGACTTGAACATAGGGTGACTTTTTAATA
Motif Score	2.951386905
Cell/Tissue List	fibroblasts; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367760.7; ENST00000553786.1
External Link	RMBase: m6A_site_64259
mod ID: M6ASITE066310		Click to Show/Hide the Full List
mod site	chr1:170663943-170663944:+		[3]
Sequence	ACTGTGGATTATCTCTTTGGACCGCGCCGGACTTGGCCTCA
Motif Score	3.622404762
Cell/Tissue List	fibroblasts; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000553786.1; ENST00000497230.2; ENST00000367760.7
External Link	RMBase: m6A_site_64260
mod ID: M6ASITE066311		Click to Show/Hide the Full List
mod site	chr1:170663953-170663954:+		[3]
Sequence	ATCTCTTTGGACCGCGCCGGACTTGGCCTCAGGAAATCAAC
Motif Score	4.065041667
Cell/Tissue List	fibroblasts; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367760.7; ENST00000553786.1; ENST00000497230.2
External Link	RMBase: m6A_site_64261
mod ID: M6ASITE066312		Click to Show/Hide the Full List
mod site	chr1:170664215-170664216:+		[5]
Sequence	GGGTGGGATCGGTGGGGGAGACCATGACCTCCAGCTACGGG
Motif Score	2.876744048
Cell/Tissue List	MSC; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000497230.2; ENST00000239461.11; ENST00000367760.7; ENST00000553786.1
External Link	RMBase: m6A_site_64262
mod ID: M6ASITE066313		Click to Show/Hide the Full List
mod site	chr1:170664276-170664277:+		[3]
Sequence	GGCGCTGGGCGGCCGCTTGGACAGCCCGGGCAACCTCGACA
Motif Score	3.643047619
Cell/Tissue List	fibroblasts; GSC-11; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000239461.11; ENST00000367760.7; ENST00000497230.2; ENST00000553786.1
External Link	RMBase: m6A_site_64263
mod ID: M6ASITE066314		Click to Show/Hide the Full List
mod site	chr1:170664315-170664316:+		[3]
Sequence	CACCCTGCAGGCGAAAAAGAACTTCTCCGTCAGTCACCTGC
Motif Score	3.373380952
Cell/Tissue List	fibroblasts; GSC-11; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367760.7; ENST00000239461.11; ENST00000553786.1; ENST00000497230.2
External Link	RMBase: m6A_site_64264
mod ID: M6ASITE066315		Click to Show/Hide the Full List
mod site	chr1:170664339-170664340:+		[3]
Sequence	CTCCGTCAGTCACCTGCTAGACCTGGAGGAAGCCGGGGACA
Motif Score	2.876744048
Cell/Tissue List	fibroblasts; GSC-11; MSC; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000239461.11; ENST00000497230.2; ENST00000553786.1; ENST00000367760.7
External Link	RMBase: m6A_site_64265
mod ID: M6ASITE066316		Click to Show/Hide the Full List
mod site	chr1:170664357-170664358:+		[3]
Sequence	AGACCTGGAGGAAGCCGGGGACATGGTGGCGGCACAGGCGG
Motif Score	3.643047619
Cell/Tissue List	fibroblasts; GSC-11; MSC; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000239461.11; ENST00000553786.1; ENST00000367760.7; ENST00000497230.2
External Link	RMBase: m6A_site_64266
mod ID: M6ASITE066317		Click to Show/Hide the Full List
mod site	chr1:170664424-170664425:+		[3]
Sequence	AGCCTGCTGGAGTCGCCGGGACTCACCAGCGGCAGCGACAC
Motif Score	4.065041667
Cell/Tissue List	fibroblasts; GSC-11; MSC; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000497230.2; ENST00000239461.11; ENST00000553786.1; ENST00000367760.7
External Link	RMBase: m6A_site_64267
mod ID: M6ASITE066318		Click to Show/Hide the Full List
mod site	chr1:170664456-170664457:+		[3]
Sequence	CAGCGACACCCCGCAGCAGGACAGTGAGTGAGGGGCGCATG
Motif Score	3.643047619
Cell/Tissue List	fibroblasts; GSC-11; MSC; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000553786.1; ENST00000239461.11; ENST00000497230.2; ENST00000367760.7
External Link	RMBase: m6A_site_64268
mod ID: M6ASITE066319		Click to Show/Hide the Full List
mod site	chr1:170719737-170719738:+		[3]
Sequence	TATTCCAGATGACCAGCTGAACTCAGAAGAAAAAAAGAAGA
Motif Score	3.373380952
Cell/Tissue List	fibroblasts; GSC-11; MSC; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000553786.1; ENST00000367760.7; ENST00000239461.11; ENST00000497230.2
External Link	RMBase: m6A_site_64269
mod ID: M6ASITE066320		Click to Show/Hide the Full List
mod site	chr1:170719778-170719779:+		[3]
Sequence	GAAAGCAGCGAAGGAATAGGACAACCTTCAATAGCAGCCAG
Motif Score	3.643047619
Cell/Tissue List	fibroblasts; GSC-11; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000497230.2; ENST00000553786.1; ENST00000367760.7; ENST00000239461.11
External Link	RMBase: m6A_site_64270
mod ID: M6ASITE066321		Click to Show/Hide the Full List
mod site	chr1:170719829-170719830:+		[5]
Sequence	TGGAGCGTGTCTTTGAGCGGACACACTATCCTGATGCTTTT
Motif Score	3.643047619
Cell/Tissue List	MSC; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000497230.2; ENST00000553786.1; ENST00000239461.11; ENST00000367760.7
External Link	RMBase: m6A_site_64271
mod ID: M6ASITE066322		Click to Show/Hide the Full List
mod site	chr1:170719860-170719861:+		[6]
Sequence	TGATGCTTTTGTGCGAGAAGACCTTGCCCGCCGGGTGAACC
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000497230.2; ENST00000367760.7; ENST00000553786.1; ENST00000239461.11
External Link	RMBase: m6A_site_64272
mod ID: M6ASITE066323		Click to Show/Hide the Full List
mod site	chr1:170719878-170719879:+		[6]
Sequence	AGACCTTGCCCGCCGGGTGAACCTCACCGAGGCGAGAGTGC
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000497230.2; ENST00000239461.11; ENST00000553786.1; ENST00000367760.7
External Link	RMBase: m6A_site_64273
mod ID: M6ASITE066324		Click to Show/Hide the Full List
mod site	chr1:170722660-170722661:+		[6]
Sequence	ATTCTGGGCCAATTCTCAAAACTATCCTGTAAGTAGATATT
Motif Score	2.627720238
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000495280.5; ENST00000497230.2; ENST00000239461.11; ENST00000367760.7; ENST00000476867.6
External Link	RMBase: m6A_site_64274
mod ID: M6ASITE066325		Click to Show/Hide the Full List
mod site	chr1:170726232-170726233:+		[6]
Sequence	CCTCCAGGTGTGGTTTCAGAACCGAAGAGCCAAGTTCCGCA
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000476867.6; ENST00000495280.5; ENST00000367760.7; ENST00000497230.2; ENST00000239461.11
External Link	RMBase: m6A_site_64275
mod ID: M6ASITE066329		Click to Show/Hide the Full List
mod site	chr1:170726359-170726360:+
Sequence	GTACCTCGTCCTGCTCCGAGACCCACCGATTATCTCTCCTG
Motif Score	2.876744048
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000367760.7; ENST00000497230.2; ENST00000495280.5; ENST00000476867.6; ENST00000239461.11
External Link	RMBase: m6A_site_64276
mod ID: M6ASITE066331		Click to Show/Hide the Full List
mod site	chr1:170726384-170726385:+
Sequence	CCGATTATCTCTCCTGGGGGACAGCGTCTCCGTACAGGTGA
Motif Score	3.643047619
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000239461.11; ENST00000476867.6; ENST00000367760.7; ENST00000495280.5; ENST00000497230.2
External Link	RMBase: m6A_site_64277
mod ID: M6ASITE066332		Click to Show/Hide the Full List
mod site	chr1:170726518-170726519:+		[3]
Sequence	CTGGGTTAATCTCTTCAGAGACATTCAACTTGCTGACATCC
Motif Score	2.897386905
Cell/Tissue List	HEK293T; fibroblasts; HEK293A-TOA; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000476867.6; ENST00000495280.5; ENST00000239461.11; ENST00000497230.2; ENST00000367760.7
External Link	RMBase: m6A_site_64278
mod ID: M6ASITE066336		Click to Show/Hide the Full List
mod site	chr1:170726630-170726631:+		[3]
Sequence	TCTCACCAATCTCCTCTTGGACTCAGGAACTCTTGCAAAGG
Motif Score	4.065041667
Cell/Tissue List	HEK293T; fibroblasts; HEK293A-TOA; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000367760.7; ENST00000239461.11; ENST00000476867.6; ENST00000497230.2; ENST00000495280.5
External Link	RMBase: m6A_site_64279
mod ID: M6ASITE066345		Click to Show/Hide the Full List
mod site	chr1:170726638-170726639:+		[3]
Sequence	ATCTCCTCTTGGACTCAGGAACTCTTGCAAAGGTTTCAAAG
Motif Score	3.373380952
Cell/Tissue List	HEK293T; fibroblasts; HEK293A-TOA; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000239461.11; ENST00000476867.6; ENST00000367760.7; ENST00000495280.5; ENST00000497230.2
External Link	RMBase: m6A_site_64280
mod ID: M6ASITE066346		Click to Show/Hide the Full List
mod site	chr1:170726726-170726727:+		[3]
Sequence	CCTCTTGCAACAATTCTGGAACAAAACTTTACCCTGTTTCC
Motif Score	2.951386905
Cell/Tissue List	HEK293T; fibroblasts; HEK293A-TOA; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000367760.7; ENST00000497230.2; ENST00000495280.5; ENST00000476867.6; ENST00000239461.11
External Link	RMBase: m6A_site_64281
mod ID: M6ASITE066347		Click to Show/Hide the Full List
mod site	chr1:170726731-170726732:+		[3]
Sequence	TGCAACAATTCTGGAACAAAACTTTACCCTGTTTCCAAATT
Motif Score	2.627720238
Cell/Tissue List	HEK293T; fibroblasts; HEK293A-TOA; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000497230.2; ENST00000495280.5; ENST00000239461.11; ENST00000476867.6; ENST00000367760.7
External Link	RMBase: m6A_site_64282
mod ID: M6ASITE066348		Click to Show/Hide the Full List
mod site	chr1:170726800-170726801:+		[7]
Sequence	GTAGGGACGTAACTTGTAAAACTCCAAGTATAGGGCCAAAG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000476867.6; ENST00000239461.11; ENST00000367760.7; ENST00000497230.2; ENST00000495280.5
External Link	RMBase: m6A_site_64283
mod ID: M6ASITE066349		Click to Show/Hide the Full List
mod site	chr1:170726825-170726826:+		[7]
Sequence	AAGTATAGGGCCAAAGGCAAACTTTGCAGTAAAACTGGCTT
Motif Score	2.627720238
Cell/Tissue List	HEK293T; fibroblasts; MSC; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000239461.11; ENST00000497230.2; ENST00000495280.5; ENST00000367760.7; ENST00000476867.6
External Link	RMBase: m6A_site_64284
mod ID: M6ASITE066350		Click to Show/Hide the Full List
mod site	chr1:170726838-170726839:+		[7]
Sequence	AAGGCAAACTTTGCAGTAAAACTGGCTTTGAATTAAAAAAA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; fibroblasts; MSC; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000476867.6; ENST00000495280.5; ENST00000497230.2; ENST00000239461.11; ENST00000367760.7
External Link	RMBase: m6A_site_64285
mod ID: M6ASITE066351		Click to Show/Hide the Full List
mod site	chr1:170726919-170726920:+		[3]
Sequence	GAAGGAGAGAGACGAGAGGGACTATGACAGAGAGAGGAGGA
Motif Score	4.065041667
Cell/Tissue List	HEK293T; fibroblasts; GSC-11; MSC; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000367760.7; ENST00000239461.11; rmsk_301217; ENST00000497230.2; ENST00000476867.6; ENST00000495280.5
External Link	RMBase: m6A_site_64286
mod ID: M6ASITE066352		Click to Show/Hide the Full List
mod site	chr1:170736131-170736132:+		[3]
Sequence	AACAGCATTGCCAACCTGAGACTGAAGGCCAAGGAATATAG
Motif Score	3.319380952
Cell/Tissue List	fibroblasts; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000496573.1; ENST00000476867.6; ENST00000367760.7; ENST00000485529.5; ENST00000495280.5; ENST00000239461.11
External Link	RMBase: m6A_site_64287
mod ID: M6ASITE066353		Click to Show/Hide the Full List
mod site	chr1:170736163-170736164:+		[3]
Sequence	GGAATATAGTTTACAGAGGAACCAGGTGCCAACAGTCAACT
Motif Score	2.930744048
Cell/Tissue List	fibroblasts; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000496573.1; ENST00000367760.7; ENST00000485529.5; ENST00000239461.11; ENST00000495280.5; ENST00000476867.6
External Link	RMBase: m6A_site_64288
mod ID: M6ASITE066354		Click to Show/Hide the Full List
mod site	chr1:170736203-170736204:+		[3]
Sequence	TGAGGAAAAAAAATAATTAAACAGGCCTAAGAAGAAATCAA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000495280.5; ENST00000239461.11; ENST00000485529.5; ENST00000496573.1; ENST00000367760.7; ENST00000476867.6
External Link	RMBase: m6A_site_64289
mod ID: M6ASITE066355		Click to Show/Hide the Full List
mod site	chr1:170736226-170736227:+		[3]
Sequence	GGCCTAAGAAGAAATCAAAAACCATAAGACACCTATCCTGC
Motif Score	2.185083333
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000495280.5; ENST00000239461.11; ENST00000367760.7; ENST00000496573.1; ENST00000476867.6; ENST00000485529.5
External Link	RMBase: m6A_site_64290
mod ID: M6ASITE066356		Click to Show/Hide the Full List
mod site	chr1:170736234-170736235:+		[3]
Sequence	AAGAAATCAAAAACCATAAGACACCTATCCTGCTCTGTTAT
Motif Score	2.897386905
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000476867.6; ENST00000239461.11; ENST00000367760.7
External Link	RMBase: m6A_site_64291
mod ID: M6ASITE066357		Click to Show/Hide the Full List
mod site	chr1:170736290-170736291:+		[3]
Sequence	GGGGAAAAAGTAAATTACAAACAAACAAACAAAGCAGAACT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_301229; ENST00000239461.11; ENST00000367760.7; ENST00000476867.6
External Link	RMBase: m6A_site_64292
mod ID: M6ASITE066358		Click to Show/Hide the Full List
mod site	chr1:170736298-170736299:+		[3]
Sequence	AGTAAATTACAAACAAACAAACAAAGCAGAACTAAAATATT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000239461.11; ENST00000367760.7; rmsk_301229; ENST00000476867.6
External Link	RMBase: m6A_site_64293
mod ID: M6ASITE066359		Click to Show/Hide the Full List
mod site	chr1:170736308-170736309:+		[3]
Sequence	AAACAAACAAACAAAGCAGAACTAAAATATTGGGACCATGG
Motif Score	3.373380952
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_301229; ENST00000239461.11; ENST00000476867.6; ENST00000367760.7
External Link	RMBase: m6A_site_64294
mod ID: M6ASITE066360		Click to Show/Hide the Full List
mod site	chr1:170736322-170736323:+		[3]
Sequence	AGCAGAACTAAAATATTGGGACCATGGCAGAGAAAAGCAGG
Motif Score	3.622404762
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000476867.6; ENST00000239461.11; ENST00000367760.7
External Link	RMBase: m6A_site_64295
mod ID: M6ASITE066361		Click to Show/Hide the Full List
mod site	chr1:170738555-170738556:+		[3]
Sequence	GATTATCAAGTTTTGAAGGAACTGTACATCCCAACAGACTG
Motif Score	3.373380952
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000239461.11
External Link	RMBase: m6A_site_64296
mod ID: M6ASITE066362		Click to Show/Hide the Full List
mod site	chr1:170738572-170738573:+		[3]
Sequence	GGAACTGTACATCCCAACAGACTGAAACATTCTAAGTGAAA
Motif Score	3.319380952
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000239461.11
External Link	RMBase: m6A_site_64297
mod ID: M6ASITE066363		Click to Show/Hide the Full List
mod site	chr1:170738578-170738579:+		[3]
Sequence	GTACATCCCAACAGACTGAAACATTCTAAGTGAAATGAGTA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000239461.11
External Link	RMBase: m6A_site_64298
mod ID: M6ASITE066364		Click to Show/Hide the Full List
mod site	chr1:170738618-170738619:+		[3]
Sequence	ATAATCCAAGTAACTGGTGAACTTTGGAGGTTTGGAGCTTG
Motif Score	3.373380952
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000239461.11
External Link	RMBase: m6A_site_64299
mod ID: M6ASITE066365		Click to Show/Hide the Full List
mod site	chr1:170738677-170738678:+		[3]
Sequence	ATTTGAATTATAGGGAGGGAACAGAAATCATACATGAAAAG
Motif Score	2.951386905
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000239461.11
External Link	RMBase: m6A_site_64300
mod ID: M6ASITE066366		Click to Show/Hide the Full List
mod site	chr1:170738718-170738719:+		[3]
Sequence	GTTTTACTGAGAAGGGGAAAACCTTAGATAGAGGGACATGT
Motif Score	2.185083333
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000239461.11
External Link	RMBase: m6A_site_64301

Ref 1	RNA Demethylase ALKBH5 Prevents Lung Cancer Progression by Regulating EMT and Stemness via Regulating p53. Front Oncol. 2022 Apr 22;12:858694. doi: 10.3389/fonc.2022.858694. eCollection 2022.
Ref 2	Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2012 Jan;22(1):142-50. doi: 10.1101/gr.124107.111. Epub 2011 Sep 29.
Ref 3	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 4	m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell. 2017 Apr 10;31(4):591-606.e6. doi: 10.1016/j.ccell.2017.02.013. Epub 2017 Mar 23.
Ref 5	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 6	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 7	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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