m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00537)
Target Name MAP kinase kinase 4 (MAP2K4)
Synonyms
MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK
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Gene Name MAP2K4
Chromosomal Location 17p12
Family Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
Function
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
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Gene ID 6416
Uniprot ID
MP2K4_HUMAN
HGNC ID
HGNC:6844
KEGG ID
hsa:6416
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MAP2K4 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between MAP2K4 and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 2.75E+00 GSE49339
In total 2 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary YTHDF2 regulates the stability of MAP kinase kinase 4 (MAP2K4) and MAP4K4 mRNAs.This study identified that dasatinib and quercetin alleviate LPS-induced senescence in HUVECs via the TRAF6-MAPK-NF-Kappa-B axis in a YTHDF2-dependent manner, providing novel ideas for clinical treatment of age-related cardiovascular diseases.
Responsed Disease Diseases of the circulatory system ICD-11: BE2Z
 Disease Info 
Experiment 2 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary YTHDF2 knockdown increases mRNA expression levels of MAP kinase kinase 4 (MAP2K4) and MAP4K4 via stabilizing the mRNA transcripts, which activate MAPK and NF-Kappa-B signaling pathways, which promote the expression of proinflammatory cytokines and aggravate the inflammatory response in LPS-stimulated RAW 264.7 cells.
Target Regulation Down regulation
Responsed Disease Inflammatory response ICD-11: MG46
 Disease Info 
Pathway Response MAPK signaling pathway hsa04010
In-vitro Model RAW 264.7 Mouse leukemia Mus musculus CVCL_0493
Diseases of the circulatory system [ICD-11: BE2Z]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary YTHDF2 regulates the stability of MAP kinase kinase 4 (MAP2K4) and MAP4K4 mRNAs.This study identified that dasatinib and quercetin alleviate LPS-induced senescence in HUVECs via the TRAF6-MAPK-NF-Kappa-B axis in a YTHDF2-dependent manner, providing novel ideas for clinical treatment of age-related cardiovascular diseases.
Responsed Disease Diseases of the circulatory system [ICD-11: BE2Z]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Inflammatory response [ICD-11: MG46]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [2]
Response Summary YTHDF2 knockdown increases mRNA expression levels of MAP kinase kinase 4 (MAP2K4) and MAP4K4 via stabilizing the mRNA transcripts, which activate MAPK and NF-Kappa-B signaling pathways, which promote the expression of proinflammatory cytokines and aggravate the inflammatory response in LPS-stimulated RAW 264.7 cells.
Responsed Disease Inflammatory response [ICD-11: MG46]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response MAPK signaling pathway hsa04010
In-vitro Model RAW 264.7 Mouse leukemia Mus musculus CVCL_0493
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00537)
MAP kinase kinase 4 (MAP2K4)
Adenosine-to-Inosine editing (A-to-I)
In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE007749 Click to Show/Hide the Full List
mod site chr17:12093922-12093923:+ [3]
Sequence GAATATTTACAAAAATTATTACATCATGCTTTGAACAAATA
Transcript ID List ENST00000582897.5; ENST00000538465.7; ENST00000582183.5; ENST00000602537.5; ENST00000415385.7; ENST00000602811.5; ENST00000579089.5; ENST00000353533.10; ENST00000602686.5; ENST00000602375.5; ENST00000602305.5; ENST00000581941.5
External Link RMBase: RNA-editing_site_55156
5-methylcytidine (m5C)
In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000988 Click to Show/Hide the Full List
mod site chr17:12125364-12125365:+ [4]
Sequence GATGTCTGGAGTTTGGGGATCACATTGGTATGTTTATGCTG
Seq Type List Bisulfite-seq
Transcript ID List ENST00000602686.5; ENST00000415385.7; ENST00000602305.5; ENST00000602537.5; ENST00000538465.7; ENST00000536413.2; ENST00000353533.10; ENST00000602811.5; ENST00000585076.1; ENST00000602375.5
External Link RMBase: m5C_site_18023
mod ID: M5CSITE000989 Click to Show/Hide the Full List
mod site chr17:12142087-12142088:+
Sequence ACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGA
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000415385.7; ENST00000353533.10; ENST00000536413.2
External Link RMBase: m5C_site_18024
N6-methyladenosine (m6A)
In total 70 m6A sequence/site(s) in this target gene
mod ID: M6ASITE030314 Click to Show/Hide the Full List
mod site chr17:12020883-12020884:+ [5]
Sequence CGCTCGGCTCTTCACTCCCAACAATGGCGGCTCCGAGCCCG
Motif Score 2.173910714
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000602811.5; ENST00000415385.7; ENST00000602375.5; ENST00000582183.5; ENST00000602305.5; ENST00000353533.10
External Link RMBase: m6A_site_348699
mod ID: M6ASITE030315 Click to Show/Hide the Full List
mod site chr17:12026901-12026902:+ [6]
Sequence GTGGCATTTTGAATCTGGAGACATTTCGATTGGGAATCTCC
Motif Score 2.897386905
Cell/Tissue List A549; HEK293T; HEK293A-TOA
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000602811.5; ENST00000582897.5; ENST00000582183.5; ENST00000602686.5; ENST00000602537.5; ENST00000538465.7; ENST00000415385.7; ENST00000353533.10; ENST00000602375.5; ENST00000602305.5
External Link RMBase: m6A_site_348700
mod ID: M6ASITE030316 Click to Show/Hide the Full List
mod site chr17:12026935-12026936:+ [6]
Sequence AATCTCCAAGTAAGTAGAAGACTTTAATTAGAGGAAACCAT
Motif Score 3.319380952
Cell/Tissue List A549; HEK293T
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000353533.10; ENST00000602305.5; ENST00000582183.5; ENST00000602686.5; ENST00000602375.5; ENST00000415385.7; ENST00000602811.5; ENST00000602537.5; ENST00000582897.5; ENST00000538465.7
External Link RMBase: m6A_site_348701
mod ID: M6ASITE030317 Click to Show/Hide the Full List
mod site chr17:12081415-12081416:+ [5]
Sequence CTGAAGATCTCCCCTGAACAACACTGGGATTTCACTGCAGA
Motif Score 2.173910714
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000602686.5; ENST00000602811.5; ENST00000602537.5; ENST00000602305.5; ENST00000602375.5; ENST00000353533.10; ENST00000579089.5; ENST00000582183.5; ENST00000415385.7; ENST00000581941.5; ENST00000582897.5; ENST00000538465.7
External Link RMBase: m6A_site_348702
mod ID: M6ASITE030318 Click to Show/Hide the Full List
mod site chr17:12081486-12081487:+ [5]
Sequence AGGAGCTTATGGTTCTGTCAACAAAATGGTCCACAAACCAA
Motif Score 2.173910714
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000602375.5; ENST00000415385.7; ENST00000602811.5; ENST00000602305.5; ENST00000582183.5; ENST00000538465.7; ENST00000602686.5; ENST00000602537.5; ENST00000581941.5; ENST00000353533.10; ENST00000582897.5; ENST00000579089.5
External Link RMBase: m6A_site_348703
mod ID: M6ASITE030319 Click to Show/Hide the Full List
mod site chr17:12081498-12081499:+ [5]
Sequence TTCTGTCAACAAAATGGTCCACAAACCAAGTGGGCAAATAA
Motif Score 2.053113095
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000602305.5; ENST00000602686.5; ENST00000538465.7; ENST00000579089.5; ENST00000602375.5; ENST00000602811.5; ENST00000582183.5; ENST00000353533.10; ENST00000602537.5; ENST00000415385.7; ENST00000582897.5; ENST00000581941.5
External Link RMBase: m6A_site_348704
mod ID: M6ASITE030320 Click to Show/Hide the Full List
mod site chr17:12095609-12095610:+ [5]
Sequence GTGGATGAAAAAGAACAAAAACAACTTCTTATGGATTTGGA
Motif Score 2.20572619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000602811.5; ENST00000602375.5; ENST00000602537.5; ENST00000582897.5; ENST00000581941.5; ENST00000415385.7; ENST00000582377.1; ENST00000602686.5; ENST00000602305.5; ENST00000353533.10; ENST00000538465.7; ENST00000582183.5; ENST00000579089.5
External Link RMBase: m6A_site_348705
mod ID: M6ASITE030321 Click to Show/Hide the Full List
mod site chr17:12095659-12095660:+ [5]
Sequence GCGGAGTAGTGATTGCCCATACATTGTTCAGTTTTATGGTG
Motif Score 2.110482143
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000602811.5; ENST00000353533.10; ENST00000581941.5; ENST00000602375.5; ENST00000602537.5; ENST00000582897.5; ENST00000582183.5; ENST00000602305.5; ENST00000415385.7; ENST00000538465.7; ENST00000582377.1; ENST00000579089.5; ENST00000602686.5
External Link RMBase: m6A_site_348706
mod ID: M6ASITE030322 Click to Show/Hide the Full List
mod site chr17:12107841-12107842:+ [5]
Sequence TACCTCGTTTGATAAGTTTTACAAATATGTATATAGTGTAT
Motif Score 2.07285119
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000582377.1; ENST00000602375.5; ENST00000415385.7; ENST00000602686.5; ENST00000602537.5; ENST00000582183.5; ENST00000602305.5; ENST00000602811.5; ENST00000538465.7; ENST00000581941.5; ENST00000579089.5; ENST00000353533.10
External Link RMBase: m6A_site_348707
mod ID: M6ASITE030323 Click to Show/Hide the Full List
mod site chr17:12110390-12110391:+ [7]
Sequence CTAGACTGTGAAAGCACTAAACCACTTAAAAGAAAACTTGA
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000582183.5; ENST00000581941.5; ENST00000579089.5; ENST00000602537.5; ENST00000602686.5; ENST00000353533.10; ENST00000415385.7; ENST00000538465.7; ENST00000582377.1; ENST00000602811.5; ENST00000602375.5; ENST00000602305.5
External Link RMBase: m6A_site_348708
mod ID: M6ASITE030324 Click to Show/Hide the Full List
mod site chr17:12110405-12110406:+ [7]
Sequence ACTAAACCACTTAAAAGAAAACTTGAAAATTATTCACAGAG
Motif Score 2.627720238
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000353533.10; ENST00000602537.5; ENST00000602811.5; ENST00000582183.5; ENST00000582377.1; ENST00000579089.5; ENST00000581941.5; ENST00000538465.7; ENST00000415385.7; ENST00000602686.5; ENST00000602375.5; ENST00000602305.5
External Link RMBase: m6A_site_348709
mod ID: M6ASITE030325 Click to Show/Hide the Full List
mod site chr17:12113259-12113260:+ [7]
Sequence ACCTTCCAATATTCTTCTGGACAGAAGTGGAAATATTAAGC
Motif Score 3.643047619
Cell/Tissue List HeLa; HEK293T
Seq Type List m6A-seq; DART-seq
Transcript ID List ENST00000602375.5; ENST00000602686.5; ENST00000582183.5; ENST00000353533.10; ENST00000585076.1; ENST00000538465.7; ENST00000602537.5; ENST00000415385.7; ENST00000581941.5; ENST00000579089.5; ENST00000602811.5; ENST00000602305.5
External Link RMBase: m6A_site_348710
mod ID: M6ASITE030326 Click to Show/Hide the Full List
mod site chr17:12113327-12113328:+ [8]
Sequence TTGTGGACTCTATTGCCAAGACAAGAGATGCTGGCTGTAGG
Motif Score 2.897386905
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000602305.5; ENST00000602537.5; ENST00000353533.10; ENST00000538465.7; ENST00000602375.5; ENST00000415385.7; ENST00000602686.5; ENST00000579089.5; ENST00000585076.1; ENST00000602811.5; ENST00000581941.5
External Link RMBase: m6A_site_348711
mod ID: M6ASITE030327 Click to Show/Hide the Full List
mod site chr17:12125319-12125320:+ [8]
Sequence AGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCG
Motif Score 2.021232143
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000579089.5; ENST00000602375.5; ENST00000602305.5; ENST00000353533.10; ENST00000585076.1; ENST00000602686.5; ENST00000602811.5; ENST00000415385.7; ENST00000536413.2; ENST00000538465.7; ENST00000602537.5
External Link RMBase: m6A_site_348712
mod ID: M6ASITE030328 Click to Show/Hide the Full List
mod site chr17:12125322-12125323:+ [8]
Sequence ATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTC
Motif Score 2.865571429
Cell/Tissue List HEK293T; hESC-HEK293T
Seq Type List DART-seq; MAZTER-seq
Transcript ID List ENST00000536413.2; ENST00000602375.5; ENST00000579089.5; ENST00000585076.1; ENST00000538465.7; ENST00000602686.5; ENST00000602537.5; ENST00000415385.7; ENST00000602811.5; ENST00000353533.10; ENST00000602305.5
External Link RMBase: m6A_site_348713
mod ID: M6ASITE030329 Click to Show/Hide the Full List
mod site chr17:12125365-12125366:+ [5]
Sequence ATGTCTGGAGTTTGGGGATCACATTGGTATGTTTATGCTGA
Motif Score 2.047297619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000353533.10; ENST00000585076.1; ENST00000415385.7; ENST00000538465.7; ENST00000602811.5; ENST00000602305.5; ENST00000602537.5; ENST00000602375.5; ENST00000536413.2; ENST00000602686.5
External Link RMBase: m6A_site_348714
mod ID: M6ASITE030330 Click to Show/Hide the Full List
mod site chr17:12129198-12129199:+ [5]
Sequence ATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGAT
Motif Score 2.168095238
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000602375.5; ENST00000415385.7; ENST00000602811.5; ENST00000353533.10; ENST00000536413.2; ENST00000602537.5; ENST00000585076.1; ENST00000602686.5; ENST00000538465.7; ENST00000602305.5
External Link RMBase: m6A_site_348715
mod ID: M6ASITE030331 Click to Show/Hide the Full List
mod site chr17:12141148-12141149:+ [7]
Sequence TTTTCAATTTTCTTGCAGAAACATCCCTTTATTTTGATGTA
Motif Score 2.20572619
Cell/Tissue List HeLa; hESC-HEK293T
Seq Type List m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List ENST00000536413.2; ENST00000353533.10; ENST00000538465.7; ENST00000602537.5; ENST00000602375.5; ENST00000602686.5; ENST00000602305.5; ENST00000415385.7; ENST00000602811.5
External Link RMBase: m6A_site_348716
mod ID: M6ASITE030332 Click to Show/Hide the Full List
mod site chr17:12141175-12141176:+ [8]
Sequence TTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATG
Motif Score 2.925321429
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000602811.5; ENST00000536413.2; ENST00000602686.5; ENST00000415385.7; ENST00000353533.10; ENST00000602375.5; ENST00000602305.5; ENST00000602537.5; ENST00000538465.7
External Link RMBase: m6A_site_348717
mod ID: M6ASITE030333 Click to Show/Hide the Full List
mod site chr17:12141270-12141271:+ [5]
Sequence TGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAG
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000602305.5; ENST00000538465.7; ENST00000353533.10; ENST00000536413.2; ENST00000602375.5; ENST00000415385.7; ENST00000602811.5
External Link RMBase: m6A_site_348718
mod ID: M6ASITE030334 Click to Show/Hide the Full List
mod site chr17:12141277-12141278:+ [7]
Sequence TGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAG
Motif Score 3.319380952
Cell/Tissue List HeLa; HEK293T; A549; HepG2; U2OS; hNPCs; hESCs; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List ENST00000353533.10; ENST00000538465.7; ENST00000602305.5; ENST00000415385.7; ENST00000602375.5; ENST00000602811.5; ENST00000536413.2
External Link RMBase: m6A_site_348719
mod ID: M6ASITE030335 Click to Show/Hide the Full List
mod site chr17:12141308-12141309:+ [8]
Sequence AAGGGCTGAGAGGAAGCAAGACGTAAAGAATTTTCATCCCG
Motif Score 2.871321429
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000538465.7; ENST00000415385.7; ENST00000353533.10; ENST00000536413.2
External Link RMBase: m6A_site_348720
mod ID: M6ASITE030336 Click to Show/Hide the Full List
mod site chr17:12141333-12141334:+ [8]
Sequence AAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCC
Motif Score 2.047297619
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000353533.10; ENST00000536413.2; ENST00000538465.7; ENST00000415385.7
External Link RMBase: m6A_site_348721
mod ID: M6ASITE030337 Click to Show/Hide the Full List
mod site chr17:12141357-12141358:+ [7]
Sequence TGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTG
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List ENST00000353533.10; ENST00000538465.7; ENST00000415385.7; ENST00000536413.2
External Link RMBase: m6A_site_348722
mod ID: M6ASITE030338 Click to Show/Hide the Full List
mod site chr17:12141448-12141449:+ [5]
Sequence CTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCA
Motif Score 2.047297619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000415385.7; ENST00000353533.10; ENST00000538465.7; ENST00000536413.2
External Link RMBase: m6A_site_348723
mod ID: M6ASITE030339 Click to Show/Hide the Full List
mod site chr17:12141474-12141475:+ [7]
Sequence TGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTTGTG
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000415385.7; ENST00000536413.2; ENST00000538465.7; ENST00000353533.10
External Link RMBase: m6A_site_348724
mod ID: M6ASITE030340 Click to Show/Hide the Full List
mod site chr17:12141499-12141500:+ [7]
Sequence ATCCTGCTCTTTTGTGATGAACATATTCATGAAATGTGGAA
Motif Score 2.951386905
Cell/Tissue List HeLa; HepG2; HEK293T; brain; A549; hESC-HEK293T; U2OS; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq
Transcript ID List ENST00000415385.7; ENST00000536413.2; ENST00000353533.10; ENST00000538465.7
External Link RMBase: m6A_site_348725
mod ID: M6ASITE030341 Click to Show/Hide the Full List
mod site chr17:12141555-12141556:+ [5]
Sequence TTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAG
Motif Score 2.047297619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000536413.2; ENST00000415385.7; ENST00000538465.7; ENST00000353533.10
External Link RMBase: m6A_site_348726
mod ID: M6ASITE030342 Click to Show/Hide the Full List
mod site chr17:12141576-12141577:+ [7]
Sequence CATCTTAAATTCATTTCTAGACTCAAAACCTGGAGATGCAG
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000415385.7; ENST00000538465.7; ENST00000536413.2; ENST00000353533.10
External Link RMBase: m6A_site_348727
mod ID: M6ASITE030343 Click to Show/Hide the Full List
mod site chr17:12141583-12141584:+ [7]
Sequence AATTCATTTCTAGACTCAAAACCTGGAGATGCAGCTACTGG
Motif Score 2.185083333
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000353533.10; ENST00000415385.7; ENST00000538465.7; ENST00000536413.2
External Link RMBase: m6A_site_348728
mod ID: M6ASITE030344 Click to Show/Hide the Full List
mod site chr17:12141620-12141621:+ [7]
Sequence CTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGAC
Motif Score 3.319380952
Cell/Tissue List HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List ENST00000538465.7; ENST00000353533.10; ENST00000536413.2; ENST00000415385.7
External Link RMBase: m6A_site_348729
mod ID: M6ASITE030345 Click to Show/Hide the Full List
mod site chr17:12141639-12141640:+ [7]
Sequence GACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTAT
Motif Score 3.643047619
Cell/Tissue List HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List ENST00000353533.10; ENST00000536413.2; ENST00000415385.7
External Link RMBase: m6A_site_348730
mod ID: M6ASITE030346 Click to Show/Hide the Full List
mod site chr17:12141666-12141667:+ [7]
Sequence GATGAATGTACTATGTCTGAACATAGAAACTCGGGCTTGAG
Motif Score 2.951386905
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List ENST00000353533.10; ENST00000536413.2; ENST00000415385.7
External Link RMBase: m6A_site_348731
mod ID: M6ASITE030347 Click to Show/Hide the Full List
mod site chr17:12141674-12141675:+ [7]
Sequence TACTATGTCTGAACATAGAAACTCGGGCTTGAGTGAGAAGA
Motif Score 2.627720238
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000353533.10; ENST00000536413.2; ENST00000415385.7
External Link RMBase: m6A_site_348732
mod ID: M6ASITE030348 Click to Show/Hide the Full List
mod site chr17:12141713-12141714:+ [7]
Sequence GAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTG
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000415385.7; ENST00000536413.2; ENST00000353533.10
External Link RMBase: m6A_site_348733
mod ID: M6ASITE030349 Click to Show/Hide the Full List
mod site chr17:12141738-12141739:+ [7]
Sequence TTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTC
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List ENST00000353533.10; ENST00000415385.7; ENST00000536413.2
External Link RMBase: m6A_site_348734
mod ID: M6ASITE030350 Click to Show/Hide the Full List
mod site chr17:12141803-12141804:+ [8]
Sequence ATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGG
Motif Score 2.07285119
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000415385.7; ENST00000353533.10; ENST00000536413.2
External Link RMBase: m6A_site_348735
mod ID: M6ASITE030351 Click to Show/Hide the Full List
mod site chr17:12141809-12141810:+ [8]
Sequence TATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCG
Motif Score 2.07285119
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000536413.2; ENST00000353533.10; ENST00000415385.7
External Link RMBase: m6A_site_348736
mod ID: M6ASITE030352 Click to Show/Hide the Full List
mod site chr17:12141897-12141898:+ [9]
Sequence TGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGG
Motif Score 2.185083333
Cell/Tissue List HEK293T; HeLa; hNPCs; fibroblasts; A549; GM12878; Huh7; iSLK
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000353533.10; ENST00000536413.2; ENST00000415385.7
External Link RMBase: m6A_site_348737
mod ID: M6ASITE030353 Click to Show/Hide the Full List
mod site chr17:12141921-12141922:+ [5]
Sequence TGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGG
Motif Score 2.951386905
Cell/Tissue List HEK293T; hESC-HEK293T; HeLa; hNPCs; fibroblasts; A549; GM12878; Huh7; iSLK
Seq Type List MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List ENST00000353533.10; ENST00000536413.2; ENST00000415385.7
External Link RMBase: m6A_site_348738
mod ID: M6ASITE030354 Click to Show/Hide the Full List
mod site chr17:12141937-12141938:+ [8]
Sequence GTGAACATTAAAATATAGAGACAGGACAGAATGTGTTCTTT
Motif Score 2.897386905
Cell/Tissue List HEK293T; HeLa; hNPCs; fibroblasts; A549; GM12878; Huh7; iSLK
Seq Type List MeRIP-seq; DART-seq; m6A-seq
Transcript ID List ENST00000415385.7; ENST00000536413.2; ENST00000353533.10
External Link RMBase: m6A_site_348739
mod ID: M6ASITE030355 Click to Show/Hide the Full List
mod site chr17:12141942-12141943:+ [8]
Sequence CATTAAAATATAGAGACAGGACAGAATGTGTTCTTTTCTCC
Motif Score 3.643047619
Cell/Tissue List HEK293T; HeLa; hNPCs; fibroblasts; A549; GM12878; Huh7; iSLK
Seq Type List MeRIP-seq; DART-seq; m6A-seq
Transcript ID List ENST00000415385.7; ENST00000536413.2; ENST00000353533.10
External Link RMBase: m6A_site_348740
mod ID: M6ASITE030356 Click to Show/Hide the Full List
mod site chr17:12141991-12141992:+ [9]
Sequence TCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGT
Motif Score 3.319380952
Cell/Tissue List HEK293T; HeLa; hNPCs; A549; GM12878; Huh7
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000536413.2; ENST00000353533.10; ENST00000415385.7
External Link RMBase: m6A_site_348741
mod ID: M6ASITE030357 Click to Show/Hide the Full List
mod site chr17:12142086-12142087:+ [5]
Sequence AACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAG
Motif Score 2.053113095
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000353533.10; ENST00000415385.7; ENST00000536413.2
External Link RMBase: m6A_site_348742
mod ID: M6ASITE030358 Click to Show/Hide the Full List
mod site chr17:12142090-12142091:+
Sequence TGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGA
Motif Score 2.185083333
Cell/Tissue List HEK293T
Seq Type List MeRIP-seq
Transcript ID List ENST00000536413.2; ENST00000353533.10; ENST00000415385.7
External Link RMBase: m6A_site_348743
mod ID: M6ASITE030359 Click to Show/Hide the Full List
mod site chr17:12142099-12142100:+
Sequence ACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTAC
Motif Score 4.065041667
Cell/Tissue List HEK293T
Seq Type List MeRIP-seq
Transcript ID List ENST00000415385.7; ENST00000536413.2; ENST00000353533.10
External Link RMBase: m6A_site_348744
mod ID: M6ASITE030360 Click to Show/Hide the Full List
mod site chr17:12142113-12142114:+
Sequence ACCAGGACTGAAAGAAGAAAACAGTACAGAAGGCAAAGTTT
Motif Score 2.20572619
Cell/Tissue List HEK293T
Seq Type List MeRIP-seq
Transcript ID List ENST00000353533.10; ENST00000415385.7; ENST00000536413.2
External Link RMBase: m6A_site_348745
mod ID: M6ASITE030361 Click to Show/Hide the Full List
mod site chr17:12142167-12142168:+ [5]
Sequence ATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATA
Motif Score 2.951386905
Cell/Tissue List hESC-HEK293T; Huh7
Seq Type List MAZTER-seq; MeRIP-seq
Transcript ID List ENST00000415385.7; ENST00000353533.10; ENST00000536413.2
External Link RMBase: m6A_site_348746
mod ID: M6ASITE030362 Click to Show/Hide the Full List
mod site chr17:12142235-12142236:+ [10]
Sequence TTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAG
Motif Score 2.168095238
Cell/Tissue List brain
Seq Type List m6A-REF-seq
Transcript ID List ENST00000415385.7; ENST00000353533.10; ENST00000536413.2
External Link RMBase: m6A_site_348747
mod ID: M6ASITE030363 Click to Show/Hide the Full List
mod site chr17:12142304-12142305:+ [8]
Sequence TTTCTAGTAGGCAGCAAAAGACCAAATCTCAGTTGTTTGCT
Motif Score 2.876744048
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000353533.10; ENST00000415385.7; ENST00000536413.2
External Link RMBase: m6A_site_348748
mod ID: M6ASITE030364 Click to Show/Hide the Full List
mod site chr17:12142399-12142400:+ [8]
Sequence TGGTCTATTGTCGCTATGTGACTTGCGCTTAATCCAATATT
Motif Score 3.28175
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000353533.10; ENST00000415385.7; ENST00000536413.2
External Link RMBase: m6A_site_348749
mod ID: M6ASITE030365 Click to Show/Hide the Full List
mod site chr17:12142579-12142580:+ [5]
Sequence AAGAGGCATCTTTTCTAGAGACACATTGGACCAGATGAGGA
Motif Score 2.897386905
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000415385.7; ENST00000536413.2; ENST00000353533.10
External Link RMBase: m6A_site_348750
mod ID: M6ASITE030366 Click to Show/Hide the Full List
mod site chr17:12142691-12142692:+ [5]
Sequence GAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCC
Motif Score 2.110482143
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000415385.7; ENST00000536413.2; ENST00000353533.10
External Link RMBase: m6A_site_348751
mod ID: M6ASITE030367 Click to Show/Hide the Full List
mod site chr17:12142723-12142724:+ [5]
Sequence ACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATC
Motif Score 2.07285119
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000536413.2; ENST00000353533.10; ENST00000415385.7
External Link RMBase: m6A_site_348752
mod ID: M6ASITE030368 Click to Show/Hide the Full List
mod site chr17:12142973-12142974:+ [11]
Sequence ACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGC
Motif Score 2.20572619
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000415385.7; ENST00000353533.10; ENST00000536413.2
External Link RMBase: m6A_site_348753
mod ID: M6ASITE030369 Click to Show/Hide the Full List
mod site chr17:12143005-12143006:+ [5]
Sequence GAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGCAGAA
Motif Score 2.047297619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000353533.10; ENST00000536413.2; ENST00000415385.7
External Link RMBase: m6A_site_348754
mod ID: M6ASITE030370 Click to Show/Hide the Full List
mod site chr17:12143093-12143094:+ [9]
Sequence TCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGTTC
Motif Score 2.627720238
Cell/Tissue List HEK293T; HeLa; Huh7
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000353533.10; ENST00000415385.7; ENST00000536413.2
External Link RMBase: m6A_site_348755
mod ID: M6ASITE030371 Click to Show/Hide the Full List
mod site chr17:12143100-12143101:+ [9]
Sequence CACGGTATCCTAAACTTTAGACTTCCCACTGTTCTGAAAGG
Motif Score 3.319380952
Cell/Tissue List HEK293T; HeLa; Huh7
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000353533.10; ENST00000536413.2; ENST00000415385.7
External Link RMBase: m6A_site_348756
mod ID: M6ASITE030372 Click to Show/Hide the Full List
mod site chr17:12143123-12143124:+ [5]
Sequence TCCCACTGTTCTGAAAGGAGACATTGCTCTATGTCTGCCTT
Motif Score 2.897386905
Cell/Tissue List HEK293T; hESC-HEK293T; HeLa; Huh7
Seq Type List MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List ENST00000536413.2; ENST00000353533.10; ENST00000415385.7
External Link RMBase: m6A_site_348757
mod ID: M6ASITE030373 Click to Show/Hide the Full List
mod site chr17:12143182-12143183:+ [9]
Sequence ATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTCT
Motif Score 4.065041667
Cell/Tissue List HEK293T; HeLa; A549; Huh7; HEK293A-TOA
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000536413.2; ENST00000353533.10; ENST00000415385.7
External Link RMBase: m6A_site_348758
mod ID: M6ASITE030374 Click to Show/Hide the Full List
mod site chr17:12143297-12143298:+ [8]
Sequence ACTGTCCAGGAGCTAATCTGACCGTTCTATTGTGTGGATGA
Motif Score 2.839113095
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000415385.7; ENST00000353533.10; ENST00000536413.2
External Link RMBase: m6A_site_348759
mod ID: M6ASITE030375 Click to Show/Hide the Full List
mod site chr17:12143364-12143365:+ [8]
Sequence TTAATCATAGATTATTATAAACTATAAACTTAAGGGCAAGG
Motif Score 2.627720238
Cell/Tissue List HEK293T; HeLa; A549; hNPCs; hESCs; HEK293A-TOA
Seq Type List MeRIP-seq; DART-seq; m6A-seq
Transcript ID List ENST00000415385.7; ENST00000536413.2; ENST00000353533.10
External Link RMBase: m6A_site_348760
mod ID: M6ASITE030376 Click to Show/Hide the Full List
mod site chr17:12143371-12143372:+ [8]
Sequence TAGATTATTATAAACTATAAACTTAAGGGCAAGGAGTTTAT
Motif Score 2.627720238
Cell/Tissue List HEK293T; HeLa; A549; hNPCs; hESCs; HEK293A-TOA
Seq Type List MeRIP-seq; DART-seq; m6A-seq
Transcript ID List ENST00000536413.2; ENST00000415385.7; ENST00000353533.10
External Link RMBase: m6A_site_348761
mod ID: M6ASITE030377 Click to Show/Hide the Full List
mod site chr17:12143393-12143394:+ [8]
Sequence TTAAGGGCAAGGAGTTTATTACAATGTATCTTTATTAAAAC
Motif Score 2.07285119
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000353533.10; ENST00000536413.2; ENST00000415385.7
External Link RMBase: m6A_site_348762
mod ID: M6ASITE030378 Click to Show/Hide the Full List
mod site chr17:12143412-12143413:+ [6]
Sequence TACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTC
Motif Score 2.20572619
Cell/Tissue List HEK293T; HeLa; hNPCs; hESCs
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000353533.10; ENST00000415385.7; ENST00000536413.2
External Link RMBase: m6A_site_348763
mod ID: M6ASITE030379 Click to Show/Hide the Full List
mod site chr17:12143437-12143438:+ [8]
Sequence AGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAA
Motif Score 2.627720238
Cell/Tissue List HEK293T; HeLa; hNPCs; hESCs
Seq Type List MeRIP-seq; DART-seq; m6A-seq
Transcript ID List ENST00000353533.10; ENST00000415385.7; ENST00000536413.2
External Link RMBase: m6A_site_348764
mod ID: M6ASITE030380 Click to Show/Hide the Full List
mod site chr17:12143457-12143458:+ [8]
Sequence ACTGTGAAAATAGTGTAAGAACTGTACATTGTGAGCTCTGG
Motif Score 3.373380952
Cell/Tissue List HEK293T; hNPCs; hESCs
Seq Type List MeRIP-seq; DART-seq; m6A-seq
Transcript ID List ENST00000415385.7; ENST00000536413.2; ENST00000353533.10
External Link RMBase: m6A_site_348765
mod ID: M6ASITE030381 Click to Show/Hide the Full List
mod site chr17:12143462-12143463:+ [8]
Sequence GAAAATAGTGTAAGAACTGTACATTGTGAGCTCTGGTTATT
Motif Score 2.856142857
Cell/Tissue List HEK293T; hESC-HEK293T
Seq Type List DART-seq; MAZTER-seq
Transcript ID List ENST00000415385.7; ENST00000353533.10; ENST00000536413.2
External Link RMBase: m6A_site_348766
mod ID: M6ASITE030382 Click to Show/Hide the Full List
mod site chr17:12143577-12143578:+ [5]
Sequence GTAAAAAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCT
Motif Score 2.168095238
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000353533.10; ENST00000415385.7; ENST00000536413.2
External Link RMBase: m6A_site_348767
mod ID: M6ASITE030383 Click to Show/Hide the Full List
mod site chr17:12143653-12143654:+ [5]
Sequence CTCCTCTATTTAAGATATATACATGGAATCGAAGTGTTTAT
Motif Score 2.110482143
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000353533.10; ENST00000536413.2; ENST00000415385.7
External Link RMBase: m6A_site_348768