m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00506)

Target Name	Tribbles homolog 2 (TRIB2)
Synonyms	TRB-2 Click to Show/Hide
Gene Name	TRIB2
Chromosomal Location	2p24.3
Family	Protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily
Function	Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Click to Show/Hide
Gene ID	28951
Uniprot ID	TRIB2_HUMAN
HGNC ID	HGNC:30809
KEGG ID	hsa:28951

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

TRIB2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 14 (METTL14) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL14*
Cell Line	mouse embryonic stem cells	Mus musculus
Treatment: METTL14-/- ESCs Control: Wild type ESCs		GSE145309
Regulation		logFC: 3.83E+00 p-value: 1.54E-161
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL14, an m6A RNA methyltransferase downregulated in ESCC, suppresses Tribbles homolog 2 (TRIB2) expression via miR-99a-5p-mediated degradation of TRIB2 mRNA by targeting its 3' untranslated region, whereas TRIB2 induces ubiquitin-mediated proteasomal degradation of METTL14 in a COP1-dependent manner.
Target Regulation	Down regulation
Responsed Disease	Esophageal squamous cell carcinoma		ICD-11: 2B70.1	Disease Info
Pathway Response	Ubiquitin mediated proteolysis			hsa04120
Cell Process	Proteasome pathway degradation
In-vitro Model	TE-1	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1759
	KYSE-410	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1352
	KYSE-150	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1348
	HET-1A	Normal	Homo sapiens	CVCL_3702
	HEK293T	Normal	Homo sapiens	CVCL_0063
	Eca-109	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_6898
	CVCL_E307	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_E307
In-vivo Model	Fresh PDX tumor samples collected from two established PDX models (PDX #07 with high TRIB2 expression and PDX #12 with low TRIB2, passages three to four) were minced and subcutaneously implanted into the flanks of 3- to 4-week-old female BALB/c nude mice (Jiesijie Laboratory Animals).

Esophageal cancer [ICD-11: 2B70]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL14, an m6A RNA methyltransferase downregulated in ESCC, suppresses Tribbles homolog 2 (TRIB2) expression via miR-99a-5p-mediated degradation of TRIB2 mRNA by targeting its 3' untranslated region, whereas TRIB2 induces ubiquitin-mediated proteasomal degradation of METTL14 in a COP1-dependent manner.
Responsed Disease	Esophageal squamous cell carcinoma [ICD-11: 2B70.1]
Target Regulator	Methyltransferase-like 14 (METTL14)		WRITER	Regulator Info
Target Regulation	Down regulation
Pathway Response	Ubiquitin mediated proteolysis			hsa04120
Cell Process	Proteasome pathway degradation
In-vitro Model	TE-1	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1759
	KYSE-410	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1352
	KYSE-150	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1348
	HET-1A	Normal	Homo sapiens	CVCL_3702
	HEK293T	Normal	Homo sapiens	CVCL_0063
	Eca-109	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_6898
	CVCL_E307	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_E307
In-vivo Model	Fresh PDX tumor samples collected from two established PDX models (PDX #07 with high TRIB2 expression and PDX #12 with low TRIB2, passages three to four) were minced and subcutaneously implanted into the flanks of 3- to 4-week-old female BALB/c nude mice (Jiesijie Laboratory Animals).

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00506)

Tribbles homolog 2 (TRIB2)

N6-methyladenosine (m6A)

In total 53 m6A sequence/site(s) in this target gene
mod ID: M6ASITE043116		Click to Show/Hide the Full List
mod site	chr2:12716938-12716939:+		[2]
Sequence	CGGTGACATTGAATGGGGAGACCGAGCGCGAGCGAGGCGCG
Motif Score	2.876744048
Cell/Tissue List	GSC-11; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000155926.8; ENST00000483034.1; ENST00000381465.2
External Link	RMBase: m6A_site_461395
mod ID: M6ASITE043117		Click to Show/Hide the Full List
mod site	chr2:12717190-12717191:+		[3]
Sequence	GTCAATTTTCTCCAAAACAAACCCCACCGGGCAATTTGGTC
Motif Score	2.185083333
Cell/Tissue List	Jurkat
Seq Type List	m6A-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2; ENST00000483034.1
External Link	RMBase: m6A_site_461396
mod ID: M6ASITE043118		Click to Show/Hide the Full List
mod site	chr2:12717342-12717343:+		[4]
Sequence	CCCCTTGCAGCGCCCGCAGGACCCCCGCAAGCTCGTGCCGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; H1A; H1B; Jurkat; CD4T; GSC-11; HEK293T; HEK293A-TOA; MSC; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000483034.1; ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461397
mod ID: M6ASITE043119		Click to Show/Hide the Full List
mod site	chr2:12717374-12717375:+		[4]
Sequence	TCGTGCCGGCGAAATCGGAGACCGCCGATCTGTCCTCGTTC
Motif Score	2.876744048
Cell/Tissue List	HeLa; H1B; H1A; Jurkat; CD4T; GSC-11; HEK293T; HEK293A-TOA; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000155926.8; ENST00000483034.1; ENST00000381465.2
External Link	RMBase: m6A_site_461398
mod ID: M6ASITE043120		Click to Show/Hide the Full List
mod site	chr2:12717427-12717428:+		[5]
Sequence	CTGGCTGCATTCGGAGGAAGACCTGGGGCGCGAGCGAGCGG
Motif Score	2.876744048
Cell/Tissue List	H1A; Jurkat; CD4T; GSC-11; HEK293T; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2; ENST00000483034.1
External Link	RMBase: m6A_site_461399
mod ID: M6ASITE043121		Click to Show/Hide the Full List
mod site	chr2:12717794-12717795:+		[6]
Sequence	CGTGCGTCGCCAGCCGGTAGACCCGTGCTTGTTTCCTTTCT
Motif Score	2.876744048
Cell/Tissue List	U2OS; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461400
mod ID: M6ASITE043122		Click to Show/Hide the Full List
mod site	chr2:12717843-12717844:+		[6]
Sequence	TTGGCTTCTAACGCGTTGGGACTGAGTCGCCGCCGTGAGCT
Motif Score	4.065041667
Cell/Tissue List	HEK293T; U2OS; H1B; Jurkat; GSC-11; HEK293A-TOA; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461401
mod ID: M6ASITE043123		Click to Show/Hide the Full List
mod site	chr2:12717872-12717873:+		[6]
Sequence	CCGCCGTGAGCTCCCCGAAGACTGCACAAACTACCGCGGGC
Motif Score	3.319380952
Cell/Tissue List	HEK293T; U2OS; H1B; GM12878; Jurkat; CD4T; GSC-11; HEK293A-TOA; MSC; endometrial; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461402
mod ID: M6ASITE043124		Click to Show/Hide the Full List
mod site	chr2:12717877-12717878:+		[7]
Sequence	GTGAGCTCCCCGAAGACTGCACAAACTACCGCGGGCTCCTC
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461403
mod ID: M6ASITE043125		Click to Show/Hide the Full List
mod site	chr2:12717881-12717882:+		[8]
Sequence	GCTCCCCGAAGACTGCACAAACTACCGCGGGCTCCTCCGCC
Motif Score	2.627720238
Cell/Tissue List	HEK293T; U2OS; H1B; GM12878; Jurkat; CD4T; GSC-11; HEK293A-TOA; MSC; TREX; TIME; endometrial; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461404
mod ID: M6ASITE043126		Click to Show/Hide the Full List
mod site	chr2:12718004-12718005:+		[4]
Sequence	CATCCAGATCCACGCCGGGGACACACACACAGAGTAACTAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461405
mod ID: M6ASITE043127		Click to Show/Hide the Full List
mod site	chr2:12718073-12718074:+		[4]
Sequence	TGCTTTGGGGTAACAAAAAGACCCGAGTTGCCTGCCGACCG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461406
mod ID: M6ASITE043128		Click to Show/Hide the Full List
mod site	chr2:12718097-12718098:+		[4]
Sequence	GAGTTGCCTGCCGACCGAGGACCCCCGGGAGCCGGGCTCGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461407
mod ID: M6ASITE043129		Click to Show/Hide the Full List
mod site	chr2:12718311-12718312:+		[4]
Sequence	TGCGATCCTCACACTCATGAACATACACAGGTCTACCCCCA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; hNPCs; fibroblasts; GM12878; CD8T; HEK293A-TOA; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000381465.2; ENST00000405331.3; ENST00000155926.8
External Link	RMBase: m6A_site_461408
mod ID: M6ASITE043130		Click to Show/Hide the Full List
mod site	chr2:12718362-12718363:+		[4]
Sequence	GAGATATGGGAGATCGCGGAACAAAACCCAGGATTTCGAAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; U2OS; hNPCs; hESCs; fibroblasts; GM12878; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000405331.3; ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461409
mod ID: M6ASITE043131		Click to Show/Hide the Full List
mod site	chr2:12718367-12718368:+		[4]
Sequence	ATGGGAGATCGCGGAACAAAACCCAGGATTTCGAAGAGTTG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; U2OS; hNPCs; hESCs; fibroblasts; GM12878; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000155926.8; ENST00000405331.3; ENST00000381465.2
External Link	RMBase: m6A_site_461410
mod ID: M6ASITE043132		Click to Show/Hide the Full List
mod site	chr2:12718431-12718432:+		[8]
Sequence	CAGCCAGAGTTTCAGCCCGAACCTCGGCTCCCCGAGCCCGC
Motif Score	2.930744048
Cell/Tissue List	HEK293T; U2OS; hNPCs; hESCs; GM12878; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2; ENST00000405331.3
External Link	RMBase: m6A_site_461411
mod ID: M6ASITE043133		Click to Show/Hide the Full List
mod site	chr2:12718457-12718458:+		[6]
Sequence	GCTCCCCGAGCCCGCCCGAGACTCCGAACTTGTCGCATTGC
Motif Score	3.319380952
Cell/Tissue List	HEK293T; U2OS; GM12878; HEK293A-TOA; MSC; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000405331.3; ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461412
mod ID: M6ASITE043134		Click to Show/Hide the Full List
mod site	chr2:12718464-12718465:+		[6]
Sequence	GAGCCCGCCCGAGACTCCGAACTTGTCGCATTGCGTTTCTT
Motif Score	3.373380952
Cell/Tissue List	HEK293T; U2OS; GM12878; HEK293A-TOA; MSC; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000381465.2; ENST00000405331.3; ENST00000155926.8
External Link	RMBase: m6A_site_461413
mod ID: M6ASITE043135		Click to Show/Hide the Full List
mod site	chr2:12718510-12718511:+		[9]
Sequence	GGGAAATACTTATTGTTGGAACCTCTGGAGGGAGACCACGT
Motif Score	2.930744048
Cell/Tissue List	HepG2; U2OS; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381465.2; ENST00000405331.3; ENST00000155926.8
External Link	RMBase: m6A_site_461414
mod ID: M6ASITE043136		Click to Show/Hide the Full List
mod site	chr2:12718524-12718525:+		[9]
Sequence	GTTGGAACCTCTGGAGGGAGACCACGTTTTTCGTGCCGTGC
Motif Score	2.876744048
Cell/Tissue List	HepG2; U2OS; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381465.2; ENST00000405331.3; ENST00000155926.8
External Link	RMBase: m6A_site_461415
mod ID: M6ASITE043137		Click to Show/Hide the Full List
mod site	chr2:12723358-12723359:+		[4]
Sequence	CTGAAATTATCCTGGGTGAGACCAAAGCCTATGTGTTCTTT
Motif Score	2.876744048
Cell/Tissue List	HeLa; hESCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8; ENST00000405331.3
External Link	RMBase: m6A_site_461416
mod ID: M6ASITE043138		Click to Show/Hide the Full List
mod site	chr2:12723395-12723396:+		[4]
Sequence	CTTTGAGCGAAGCTATGGGGACATGCATTCCTTCGTCCGCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; hNPCs; hESCs; HEK293T; Jurkat; HEK293A-TOA; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000381465.2; ENST00000405331.3; ENST00000155926.8
External Link	RMBase: m6A_site_461417
mod ID: M6ASITE043139		Click to Show/Hide the Full List
mod site	chr2:12723450-12723451:+		[4]
Sequence	AGAGAGGAGGAGGCAGCCAGACTGTTCTACCAGATTGCCTC
Motif Score	3.319380952
Cell/Tissue List	HeLa; H1A; H1B; hNPCs; hESCs; HEK293T; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8; ENST00000405331.3
External Link	RMBase: m6A_site_461418
mod ID: M6ASITE043140		Click to Show/Hide the Full List
mod site	chr2:12723512-12723513:+		[4]
Sequence	CGGGGGGCTGGTGCTGCGGGACCTCAAGCTGCGGAAATTCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; H1A; H1B; hESCs; GM12878; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381465.2; ENST00000405331.3; ENST00000155926.8
External Link	RMBase: m6A_site_461419
mod ID: M6ASITE043141		Click to Show/Hide the Full List
mod site	chr2:12740435-12740436:+		[4]
Sequence	CGTAAGCCCAGAGATCTTGAACACCAGTGGCAGCTACTCGG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461420
mod ID: M6ASITE043142		Click to Show/Hide the Full List
mod site	chr2:12740535-12740536:+		[4]
Sequence	TACCCTTTCCATGACATTGAACCCAGCTCCCTCTTCAGCAA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461421
mod ID: M6ASITE043143		Click to Show/Hide the Full List
mod site	chr2:12740576-12740577:+		[7]
Sequence	GATCCGGCGTGGCCAGTTCAACATTCCAGAGACTCTGTCGC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461422
mod ID: M6ASITE043144		Click to Show/Hide the Full List
mod site	chr2:12740587-12740588:+		[4]
Sequence	GCCAGTTCAACATTCCAGAGACTCTGTCGCCCAAGGCCAAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461423
mod ID: M6ASITE043145		Click to Show/Hide the Full List
mod site	chr2:12740672-12740673:+		[4]
Sequence	GACCTCGCAGGAAATTCTGGACCATCCTTGGTTTTCTACAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461424
mod ID: M6ASITE043146		Click to Show/Hide the Full List
mod site	chr2:12740738-12740739:+		[10]
Sequence	TGGTGCTAAGGAAGTGTCTGACCAGCTGGTGCCGGACGTCA
Motif Score	2.839113095
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461425
mod ID: M6ASITE043147		Click to Show/Hide the Full List
mod site	chr2:12740753-12740754:+		[10]
Sequence	GTCTGACCAGCTGGTGCCGGACGTCAACATGGAAGAGAACT
Motif Score	3.616982143
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461426
mod ID: M6ASITE043148		Click to Show/Hide the Full List
mod site	chr2:12740759-12740760:+		[7]
Sequence	CCAGCTGGTGCCGGACGTCAACATGGAAGAGAACTTGGACC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T; CD8T
Seq Type List	MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461427
mod ID: M6ASITE043149		Click to Show/Hide the Full List
mod site	chr2:12740771-12740772:+		[4]
Sequence	GGACGTCAACATGGAAGAGAACTTGGACCCTTTCTTTAACT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; CD8T; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461428
mod ID: M6ASITE043150		Click to Show/Hide the Full List
mod site	chr2:12740777-12740778:+		[4]
Sequence	CAACATGGAAGAGAACTTGGACCCTTTCTTTAACTGAGCTC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; CD8T; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461429
mod ID: M6ASITE043151		Click to Show/Hide the Full List
mod site	chr2:12740789-12740790:+		[10]
Sequence	GAACTTGGACCCTTTCTTTAACTGAGCTCATGCCCCACGGA
Motif Score	2.590089286
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461430
mod ID: M6ASITE043152		Click to Show/Hide the Full List
mod site	chr2:12740811-12740812:+		[4]
Sequence	TGAGCTCATGCCCCACGGAGACTTAGCAGGTTCCAGGAGTG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; CD8T; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461431
mod ID: M6ASITE043153		Click to Show/Hide the Full List
mod site	chr2:12740865-12740866:+		[4]
Sequence	GAAAGGAGTTCTTCCGGGGGACACGAATTGCCTGGCTGAGT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461432
mod ID: M6ASITE043154		Click to Show/Hide the Full List
mod site	chr2:12740896-12740897:+		[4]
Sequence	CTGGCTGAGTAGCAAGAAAGACACACTCTTAAGTTTCTTGG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461433
mod ID: M6ASITE043155		Click to Show/Hide the Full List
mod site	chr2:12740931-12740932:+		[4]
Sequence	TCTTGGTTCAGAGCAGGAAAACCTTCAAGGAGCTGACTGAC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461434
mod ID: M6ASITE043156		Click to Show/Hide the Full List
mod site	chr2:12741031-12741032:+		[11]
Sequence	GCTGGAGCTTGTCTTCCCTAACATAGCCTGGGAGACCACCC
Motif Score	2.168095238
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461435
mod ID: M6ASITE043157		Click to Show/Hide the Full List
mod site	chr2:12741045-12741046:+		[4]
Sequence	TCCCTAACATAGCCTGGGAGACCACCCCTTGCCACTTGGGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; MT4; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461436
mod ID: M6ASITE043158		Click to Show/Hide the Full List
mod site	chr2:12741129-12741130:+		[12]
Sequence	CAGATCCTGACAGAATCAAAACTCTCTGCCTCAAACACACA
Motif Score	2.627720238
Cell/Tissue List	GM12878; HEC-1-A; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461437
mod ID: M6ASITE043159		Click to Show/Hide the Full List
mod site	chr2:12741143-12741144:+		[13]
Sequence	ATCAAAACTCTCTGCCTCAAACACACATCCTGGCATCGCAC
Motif Score	2.20572619
Cell/Tissue List	NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461438
mod ID: M6ASITE043160		Click to Show/Hide the Full List
mod site	chr2:12741147-12741148:+		[7]
Sequence	AAACTCTCTGCCTCAAACACACATCCTGGCATCGCACTGTT
Motif Score	2.084928571
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461439
mod ID: M6ASITE043161		Click to Show/Hide the Full List
mod site	chr2:12741202-12741203:+		[13]
Sequence	TGTTAGGATTCAGGGAAGGAACAGTTGGCCAAGAATTTTTT
Motif Score	2.951386905
Cell/Tissue List	NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461440
mod ID: M6ASITE043162		Click to Show/Hide the Full List
mod site	chr2:12741331-12741332:+		[7]
Sequence	GGGTGCTACAGTAAAAGAAAACAAAAGTCCAGTTTGTGTCT
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461441
mod ID: M6ASITE043163		Click to Show/Hide the Full List
mod site	chr2:12741415-12741416:+		[7]
Sequence	AATATCCTGGTCAGGAAATGACATGTTAATGCTTTGCTCCC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461442
mod ID: M6ASITE043164		Click to Show/Hide the Full List
mod site	chr2:12741732-12741733:+		[7]
Sequence	AGTACTCTGATCGCAACTAAACATTTGTCTTTGTTTTATTA
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461443
mod ID: M6ASITE043165		Click to Show/Hide the Full List
mod site	chr2:12741931-12741932:+		[11]
Sequence	CTATGATGATATAAATAAAAACAGCTCTCTATCCCAATACG
Motif Score	2.20572619
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461444
mod ID: M6ASITE043166		Click to Show/Hide the Full List
mod site	chr2:12741998-12741999:+		[7]
Sequence	TATTTATTAAGGAAAATGTCACATTGTGATGTATTAAGCCA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461445
mod ID: M6ASITE043167		Click to Show/Hide the Full List
mod site	chr2:12742048-12742049:+		[7]
Sequence	TTACGGGTTGACTTGGGATGACATATTACATGCTGTAGTTA
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000381465.2; ENST00000155926.8
External Link	RMBase: m6A_site_461446
mod ID: M6ASITE043168		Click to Show/Hide the Full List
mod site	chr2:12742306-12742307:+		[7]
Sequence	GTCCTGTTTTTGGGTAGGTGACACGTGGACTCTAGTATGTA
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000155926.8; ENST00000381465.2
External Link	RMBase: m6A_site_461447

Ref 1	A methyltransferase-like 14/miR-99a-5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2-mediated epigenetic modulation in esophageal squamous cell carcinoma. Clin Transl Med. 2021 Sep;11(9):e545. doi: 10.1002/ctm2.545.
Ref 2	m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell. 2017 Apr 10;31(4):591-606.e6. doi: 10.1016/j.ccell.2017.02.013. Epub 2017 Mar 23.
Ref 3	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife. 2016 Jul 2;5:e15528. doi: 10.7554/eLife.15528.
Ref 4	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 5	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 6	RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 9	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 10	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 11	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 12	Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. J Am Chem Soc. 2015 Feb 11;137(5):2107-15. doi: 10.1021/ja513080v. Epub 2015 Feb 2.
Ref 13	METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification. Cell Stem Cell. 2018 Feb 1;22(2):191-205.e9. doi: 10.1016/j.stem.2017.11.016. Epub 2017 Dec 28.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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