m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00480)

Target Name	Wilms tumor protein (WT1)
Synonyms	WT33 Click to Show/Hide
Gene Name	WT1
Chromosomal Location	11p13
Family	EGR C2H2-type zinc-finger protein family. {ECO:0000305}.
Function	Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. Click to Show/Hide
Gene ID	55083
Uniprot ID	WT1_HUMAN
HGNC ID	HGNC:12796
KEGG ID	hsa:7490

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

WT1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

ETS-related transcription factor Elf-3 (ELF3) [WRITER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Elf3 plays an important role in the process of phenotypic alterations of podocyte induced by the activation of TGF-beta signals. Elf3 protein levels in patients with DN (R2 = 0.7259) were useful as an early non-invasive marker for podocyte injuries in DN. The epithelium-specific transcription factor, Elf3 was induced by AGE stimulation and, subsequently, upregulated RII expression in cultured podocytes. Induction of Elf3 and activation of RII-Smad3 signaling, leading to a decrease in Wilms tumor protein (WT1) expression, were observed in podocytes in diabetic human kidneys.
Responsed Disease	Chronic kidney disease		ICD-11: GB61.Z	Disease Info
Pathway Response	TGF-beta signaling pathway			hsa04350
In-vitro Model	Murine podocytes	Normal	Mus musculus	CVCL_5737

Chronic kidney disease [ICD-11: GB61]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	Elf3 plays an important role in the process of phenotypic alterations of podocyte induced by the activation of TGF-beta signals. Elf3 protein levels in patients with DN (R2 = 0.7259) were useful as an early non-invasive marker for podocyte injuries in DN. The epithelium-specific transcription factor, Elf3 was induced by AGE stimulation and, subsequently, upregulated RII expression in cultured podocytes. Induction of Elf3 and activation of RII-Smad3 signaling, leading to a decrease in Wilms tumor protein (WT1) expression, were observed in podocytes in diabetic human kidneys.
Responsed Disease	Chronic kidney disease [ICD-11: GB61.Z]
Target Regulator	ETS-related transcription factor Elf-3 (ELF3)		WRITER	Regulator Info
Pathway Response	TGF-beta signaling pathway			hsa04350
In-vitro Model	Murine podocytes	Normal	Mus musculus	CVCL_5737

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00480)

Wilms tumor protein (WT1)

N6-methyladenosine (m6A)

In total 31 m6A sequence/site(s) in this target gene
mod ID: M6ASITE004700		Click to Show/Hide the Full List
mod site	chr11:32388074-32388075:-
Sequence	GTATATGTGAAAAAAATGAGACTTACTGGGTGAGGAAATCC
Motif Score	3.319380952
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000332351.8; ENST00000530998.5; ENST00000379079.7; ENST00000379077.8; ENST00000452863.8; ENST00000652724.1; ENST00000651819.1
External Link	RMBase: m6A_site_135749
mod ID: M6ASITE004702		Click to Show/Hide the Full List
mod site	chr11:32388110-32388111:-
Sequence	TGTTTTTAAGTAACTTAAGGACCTTTGGGTCTACAAGTATA
Motif Score	3.622404762
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000379077.8; ENST00000452863.8; ENST00000530998.5; ENST00000379079.7; ENST00000651819.1; ENST00000652724.1; ENST00000332351.8
External Link	RMBase: m6A_site_135750
mod ID: M6ASITE004703		Click to Show/Hide the Full List
mod site	chr11:32388132-32388133:-
Sequence	CCAGGATCTCCACTGATAAGACTGTTTTTAAGTAACTTAAG
Motif Score	3.319380952
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000651819.1; ENST00000332351.8; ENST00000452863.8; ENST00000640146.2; ENST00000379079.7; ENST00000379077.8; ENST00000652724.1; ENST00000650861.1; ENST00000650745.1; ENST00000639907.2; ENST00000652579.1; ENST00000651668.1; ENST00000651533.1; ENST00000530998.5
External Link	RMBase: m6A_site_135751
mod ID: M6ASITE004704		Click to Show/Hide the Full List
mod site	chr11:32388385-32388386:-		[2]
Sequence	ATTCAGTTAATTCAATGTGAACACTGGCACACTGCTCTTAA
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T; AML
Seq Type List	MAZTER-seq; miCLIP
Transcript ID List	ENST00000379079.7; ENST00000652724.1; ENST00000452863.8; ENST00000651794.1; ENST00000651819.1; ENST00000650745.1; ENST00000530998.5; ENST00000651459.1; ENST00000651533.1; ENST00000640146.2; ENST00000652579.1; ENST00000650861.1; ENST00000332351.8; ENST00000651668.1; ENST00000639907.2; ENST00000379077.8
External Link	RMBase: m6A_site_135752
mod ID: M6ASITE004705		Click to Show/Hide the Full List
mod site	chr11:32388906-32388907:-		[3]
Sequence	AGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; A549; HEK293A-TOA; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000650745.1; ENST00000639907.2; ENST00000651794.1; ENST00000332351.8; ENST00000651533.1; ENST00000651459.1; ENST00000651668.1; ENST00000448076.8; ENST00000530998.5; ENST00000650861.1; ENST00000652724.1; ENST00000640146.2; ENST00000379079.7; ENST00000452863.8; ENST00000651819.1; ENST00000652579.1; ENST00000379077.8
External Link	RMBase: m6A_site_135753
mod ID: M6ASITE004706		Click to Show/Hide the Full List
mod site	chr11:32388929-32388930:-		[3]
Sequence	TTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGG
Motif Score	2.897386905
Cell/Tissue List	HEK293T; A549; MM6; peripheral-blood; HEK293A-TOA; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000652579.1; ENST00000650745.1; ENST00000652724.1; ENST00000651533.1; ENST00000452863.8; ENST00000448076.8; ENST00000332351.8; ENST00000379079.7; ENST00000530998.5; ENST00000651794.1; ENST00000639907.2; ENST00000651459.1; ENST00000379077.8; ENST00000650861.1; ENST00000651668.1; ENST00000640146.2; ENST00000651819.1
External Link	RMBase: m6A_site_135754
mod ID: M6ASITE004707		Click to Show/Hide the Full List
mod site	chr11:32388962-32388963:-		[3]
Sequence	TCCTCCTCACTAAAAAGGAAACTTCAGTTGATCTTCTTCAT
Motif Score	2.627720238
Cell/Tissue List	HEK293T; U2OS; A549; peripheral-blood; HEK293A-TOA; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000651668.1; ENST00000651794.1; ENST00000652724.1; ENST00000651533.1; ENST00000530998.5; ENST00000448076.8; ENST00000379079.7; ENST00000650861.1; ENST00000651459.1; ENST00000379077.8; ENST00000650745.1; ENST00000640146.2; ENST00000651819.1; ENST00000452863.8; ENST00000332351.8; ENST00000652579.1; ENST00000639907.2
External Link	RMBase: m6A_site_135755
mod ID: M6ASITE004708		Click to Show/Hide the Full List
mod site	chr11:32389007-32389008:-		[3]
Sequence	CCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCT
Motif Score	3.373380952
Cell/Tissue List	HEK293T; U2OS; A549; HEK293A-TOA; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000651819.1; ENST00000448076.8; ENST00000651533.1; ENST00000332351.8; ENST00000379079.7; ENST00000650861.1; ENST00000651459.1; ENST00000530998.5; ENST00000652579.1; ENST00000651794.1; ENST00000639907.2; ENST00000651668.1; ENST00000452863.8; ENST00000650745.1; ENST00000652724.1; ENST00000379077.8; ENST00000640146.2
External Link	RMBase: m6A_site_135756
mod ID: M6ASITE004709		Click to Show/Hide the Full List
mod site	chr11:32389040-32389041:-		[4]
Sequence	TTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAG
Motif Score	3.622404762
Cell/Tissue List	HEK293T; U2OS; A549; HEK293A-TOA; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000379077.8; ENST00000452863.8; ENST00000379079.7; ENST00000650745.1; ENST00000651533.1; ENST00000651794.1; ENST00000650861.1; ENST00000639907.2; ENST00000651668.1; ENST00000530998.5; ENST00000652579.1; ENST00000651459.1; ENST00000448076.8; ENST00000651819.1; ENST00000640146.2; ENST00000332351.8; ENST00000652724.1
External Link	RMBase: m6A_site_135757
mod ID: M6ASITE004710		Click to Show/Hide the Full List
mod site	chr11:32389075-32389076:-		[4]
Sequence	CATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAGG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; U2OS; A549; HEK293A-TOA; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000640146.2; ENST00000452863.8; ENST00000651533.1; ENST00000332351.8; ENST00000639563.2; ENST00000639907.2; ENST00000651459.1; ENST00000651668.1; ENST00000651819.1; ENST00000652579.1; ENST00000650986.1; ENST00000527882.5; ENST00000379077.8; ENST00000448076.8; ENST00000379079.7; ENST00000652724.1; ENST00000530998.5; ENST00000651794.1; ENST00000650861.1; ENST00000650745.1
External Link	RMBase: m6A_site_135758
mod ID: M6ASITE004711		Click to Show/Hide the Full List
mod site	chr11:32389085-32389086:-		[4]
Sequence	TCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; U2OS; A549; HEK293A-TOA; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000640146.2; ENST00000652724.1; ENST00000452863.8; ENST00000650986.1; ENST00000639907.2; ENST00000379079.7; ENST00000527882.5; ENST00000448076.8; ENST00000379077.8; ENST00000639563.2; ENST00000651819.1; ENST00000332351.8; ENST00000652579.1; ENST00000651794.1; ENST00000530998.5; ENST00000650745.1; ENST00000651668.1; ENST00000650861.1; ENST00000651459.1; ENST00000651533.1
External Link	RMBase: m6A_site_135759
mod ID: M6ASITE004713		Click to Show/Hide the Full List
mod site	chr11:32391974-32391975:-		[5]
Sequence	CCAGGACTCATACAGGTAAAACAAGTGCGTAAACTTTTCTT
Motif Score	2.20572619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000530998.5; ENST00000379079.7; ENST00000651794.1; ENST00000651459.1; ENST00000651819.1; ENST00000526685.2; ENST00000651533.1; ENST00000650986.1; ENST00000639563.2; ENST00000448076.8; ENST00000650745.1; ENST00000650861.1; ENST00000379077.8; ENST00000651668.1; ENST00000527882.5; ENST00000332351.8; ENST00000652724.1; ENST00000452863.8; ENST00000639907.2; ENST00000652579.1; ENST00000640146.2
External Link	RMBase: m6A_site_135760
mod ID: M6ASITE004714		Click to Show/Hide the Full List
mod site	chr11:32391989-32391990:-		[5]
Sequence	ACCTGAAGACCCACACCAGGACTCATACAGGTAAAACAAGT
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000651533.1; ENST00000650745.1; ENST00000652579.1; ENST00000651819.1; ENST00000652724.1; ENST00000379079.7; ENST00000448076.8; ENST00000526685.2; ENST00000640146.2; ENST00000332351.8; ENST00000650861.1; ENST00000651459.1; ENST00000639907.2; ENST00000530998.5; ENST00000639563.2; ENST00000527882.5; ENST00000651668.1; ENST00000452863.8; ENST00000651794.1; ENST00000379077.8; ENST00000650986.1
External Link	RMBase: m6A_site_135761
mod ID: M6ASITE004715		Click to Show/Hide the Full List
mod site	chr11:32392001-32392002:-		[5]
Sequence	CCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACA
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000452863.8; ENST00000379079.7; ENST00000651794.1; ENST00000640146.2; ENST00000639907.2; ENST00000530998.5; ENST00000379077.8; ENST00000639563.2; ENST00000650986.1; ENST00000527882.5; ENST00000651668.1; ENST00000651819.1; ENST00000652724.1; ENST00000448076.8; ENST00000650861.1; ENST00000651533.1; ENST00000651459.1; ENST00000332351.8; ENST00000526685.2; ENST00000652579.1; ENST00000650745.1
External Link	RMBase: m6A_site_135762
mod ID: M6ASITE004716		Click to Show/Hide the Full List
mod site	chr11:32392040-32392041:-		[5]
Sequence	TGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTCTCC
Motif Score	2.627720238
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000639907.2; ENST00000448076.8; ENST00000379077.8; ENST00000650861.1; ENST00000652724.1; ENST00000651668.1; ENST00000639563.2; ENST00000652579.1; ENST00000651794.1; ENST00000526685.2; ENST00000651819.1; ENST00000452863.8; ENST00000530998.5; ENST00000651459.1; ENST00000527882.5; ENST00000332351.8; ENST00000650986.1; ENST00000650745.1; ENST00000651533.1; ENST00000640146.2; ENST00000379079.7
External Link	RMBase: m6A_site_135763
mod ID: M6ASITE004717		Click to Show/Hide the Full List
mod site	chr11:32392056-32392057:-		[5]
Sequence	TCTGTCCATTTAGGTGTGAAACCATTCCAGTGTAAAACTTG
Motif Score	2.185083333
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000651819.1; ENST00000640146.2; ENST00000526685.2; ENST00000650861.1; ENST00000639907.2; ENST00000448076.8; ENST00000652724.1; ENST00000332351.8; ENST00000650745.1; ENST00000379079.7; ENST00000651459.1; ENST00000650986.1; ENST00000652579.1; ENST00000651668.1; ENST00000379077.8; ENST00000639563.2; ENST00000530998.5; ENST00000452863.8; ENST00000651533.1; ENST00000527882.5; ENST00000651794.1
External Link	RMBase: m6A_site_135764
mod ID: M6ASITE004718		Click to Show/Hide the Full List
mod site	chr11:32392082-32392083:-		[5]
Sequence	ATTGTTAGGGCCGAGGCTAGACCTTCTCTGTCCATTTAGGT
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000639563.2; ENST00000448076.8; ENST00000379079.7; ENST00000651819.1; ENST00000652724.1; ENST00000651459.1; ENST00000332351.8; ENST00000527882.5; ENST00000651794.1; ENST00000639907.2; ENST00000651533.1; ENST00000526685.2; ENST00000452863.8; ENST00000640146.2; ENST00000651668.1; ENST00000530998.5; ENST00000652579.1; ENST00000650745.1; ENST00000650861.1; ENST00000379077.8
External Link	RMBase: m6A_site_135765
mod ID: M6ASITE004719		Click to Show/Hide the Full List
mod site	chr11:32396352-32396353:-		[5]
Sequence	TTGTACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTC
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000452863.8; ENST00000379079.7; ENST00000652724.1; ENST00000651819.1; ENST00000379077.8; ENST00000639907.2; ENST00000651668.1; ENST00000651459.1; ENST00000332351.8; ENST00000650861.1; ENST00000527882.5; ENST00000526685.2; ENST00000448076.8; ENST00000530998.5; ENST00000640146.2; ENST00000652579.1; ENST00000639563.2; ENST00000651794.1
External Link	RMBase: m6A_site_135766
mod ID: M6ASITE004720		Click to Show/Hide the Full List
mod site	chr11:32400511-32400512:-		[5]
Sequence	TGTAATCCCCACTTCTGAGGACATGACATCTCTTCTTGCGT
Motif Score	3.643047619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000379077.8; ENST00000530998.5; ENST00000379079.7; ENST00000651794.1; ENST00000652579.1; ENST00000448076.8; ENST00000527775.1; ENST00000640146.2; ENST00000526685.2; ENST00000527882.5; ENST00000639563.2; ENST00000332351.8; ENST00000452863.8
External Link	RMBase: m6A_site_135767
mod ID: M6ASITE004721		Click to Show/Hide the Full List
mod site	chr11:32400568-32400569:-		[5]
Sequence	GAGTTAAGCTGATCTGGAAAACTGACCTGTCATTTAAGCAG
Motif Score	2.627720238
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000530998.5; ENST00000379077.8; ENST00000452863.8; ENST00000379079.7; ENST00000640146.2; ENST00000448076.8; ENST00000639563.2; ENST00000527882.5; ENST00000526685.2; ENST00000652579.1; ENST00000651794.1; ENST00000527775.1; ENST00000332351.8
External Link	RMBase: m6A_site_135768
mod ID: M6ASITE004722		Click to Show/Hide the Full List
mod site	chr11:32412094-32412095:-		[5]
Sequence	CTTCCCTCGCGGGCTCGTGAACATAAGGTATCCGTCCAAGA
Motif Score	2.951386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000452863.8; ENST00000379077.8; ENST00000530998.5; ENST00000639563.2; ENST00000448076.8; ENST00000652579.1; ENST00000332351.8; ENST00000379079.7; ENST00000640146.2; ENST00000527775.1; ENST00000527882.5; ENST00000651794.1
External Link	RMBase: m6A_site_135769
mod ID: M6ASITE004724		Click to Show/Hide the Full List
mod site	chr11:32434146-32434147:-		[6]
Sequence	CACATTAAGTATCGTAGAGAACTAGAATGAGCACATGCACC
Motif Score	3.373380952
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000639563.2; ENST00000452863.8; ENST00000640146.2; ENST00000448076.8; ENST00000332351.8; ENST00000379077.8
External Link	RMBase: m6A_site_135770
mod ID: M6ASITE004725		Click to Show/Hide the Full List
mod site	chr11:32434922-32434923:-		[7]
Sequence	CCGCCTCACTCCTTCATCAAACAGGAGCCGAGCTGGGGCGG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000448076.8; ENST00000452863.8; ENST00000379077.8; ENST00000332351.8; ENST00000639563.2
External Link	RMBase: m6A_site_135771
mod ID: M6ASITE004726		Click to Show/Hide the Full List
mod site	chr11:32435025-32435026:-		[7]
Sequence	GCAGTGGGCGCCGGTGCTGGACTTTGCGCCCCCGGGCGCTT
Motif Score	4.065041667
Cell/Tissue List	HEK293T; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000379077.8; ENST00000452863.8; ENST00000639563.2; ENST00000448076.8; ENST00000332351.8
External Link	RMBase: m6A_site_135772
mod ID: M6ASITE004727		Click to Show/Hide the Full List
mod site	chr11:32435121-32435122:-		[8]
Sequence	AATGGGCTCCGACGTGCGGGACCTGAACGCGCTGCTGCCCG
Motif Score	3.622404762
Cell/Tissue List	peripheral-blood; HEK293T; HEK293A-TOA; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000452863.8; ENST00000379077.8; ENST00000639563.2; ENST00000332351.8; ENST00000448076.8
External Link	RMBase: m6A_site_135773
mod ID: M6ASITE004728		Click to Show/Hide the Full List
mod site	chr11:32435241-32435242:-		[9]
Sequence	AGAGCAGCAGGGAGTCCGGGACCCGGGCGGCATCTGGGCCA
Motif Score	3.622404762
Cell/Tissue List	MM6; peripheral-blood; HEK293T; HEK293A-TOA; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000639563.2; ENST00000452863.8; ENST00000379077.8; ENST00000448076.8; ENST00000332351.8
External Link	RMBase: m6A_site_135774
mod ID: M6ASITE004729		Click to Show/Hide the Full List
mod site	chr11:32435337-32435338:-		[8]
Sequence	GGACTTCCTCTTGCTGCAGGACCCGGCTTCCACGTGTGTCC
Motif Score	3.622404762
Cell/Tissue List	peripheral-blood; HEK293A-TOA; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000379077.8; ENST00000639563.2; ENST00000332351.8; ENST00000448076.8; ENST00000452863.8
External Link	RMBase: m6A_site_135776
mod ID: M6ASITE004730		Click to Show/Hide the Full List
mod site	chr11:32435355-32435356:-		[10]
Sequence	TCTCCTCGCCGCGATCCTGGACTTCCTCTTGCTGCAGGACC
Motif Score	4.065041667
Cell/Tissue List	A549; peripheral-blood; HEK293A-TOA; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000379077.8; ENST00000332351.8; ENST00000452863.8; ENST00000639563.2; ENST00000448076.8
External Link	RMBase: m6A_site_135777
mod ID: M6ASITE004731		Click to Show/Hide the Full List
mod site	chr11:32435700-32435701:-		[7]
Sequence	CGAGAGGGACGCTCCCTCGGACCCGCCCTCACCCCAGCTGC
Motif Score	3.622404762
Cell/Tissue List	HEK293T; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000452863.8
External Link	RMBase: m6A_site_135779
mod ID: M6ASITE004733		Click to Show/Hide the Full List
mod site	chr11:32435837-32435838:-		[5]
Sequence	CTCACTGCTTACCTGAACGGACTCTCCAGTGAGACGAGGCT
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000452863.8
External Link	RMBase: m6A_site_135781
mod ID: M6ASITE004734		Click to Show/Hide the Full List
mod site	chr11:32435858-32435859:-		[5]
Sequence	CCGCATTCGACCCTGCCCGGACTCACTGCTTACCTGAACGG
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000452863.8
External Link	RMBase: m6A_site_135782

Ref 1	Involvement of Elf3 on Smad3 activation-dependent injuries in podocytes and excretion of urinary exosome in diabetic nephropathy. PLoS One. 2019 May 31;14(5):e0216788. doi: 10.1371/journal.pone.0216788. eCollection 2019.
Ref 2	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 3	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 4	RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.
Ref 5	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 6	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
Ref 7	Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016 Nov 9;20(5):666-673. doi: 10.1016/j.chom.2016.10.002. Epub 2016 Oct 20.
Ref 8	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.
Ref 9	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell. 2017 Jan 9;31(1):127-141. doi: 10.1016/j.ccell.2016.11.017. Epub 2016 Dec 22.
Ref 10	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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