HAVCR1
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Acute kidney failure [ICD-11: GB60]
In total 2 item(s) under this disease |
Experiment 1 Reporting the m6A-centered Disease Response
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[] |
Response Summary |
m6A plays an important role in cisplatin induced acute kidney injury and berberine alleviates this process. Cisplatin induced an increase in Slc12a1 protein levels and a decrease in FGA and Hepatitis A virus cellular receptor 1 (HAVCR1) protein levels. However, berberine pretreatment reversed these effects.
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Responsed Disease |
Acute kidney failure [ICD-11: GB60]
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Responsed Drug |
Cisplatin
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Approved
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Cell Process |
Metabolic processes
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Cell death
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Cell apoptosis
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In-vivo Model |
This study investigated the N6-methyladenosine (m6A) methylome of kidneys from three mouse groups: C57 mice (controls), those with CI-AKI (injury group, IG), and those pretreated with berberine (treatment group, TG).
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Experiment 2 Reporting the m6A-centered Disease Response
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[] |
Response Summary |
m6A plays an important role in cisplatin induced acute kidney injury and berberine alleviates this process. Cisplatin induced an increase in Slc12a1 protein levels and a decrease in FGA and Hepatitis A virus cellular receptor 1 (HAVCR1) protein levels. However, berberine pretreatment reversed these effects.
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Responsed Disease |
Acute kidney failure [ICD-11: GB60]
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Responsed Drug |
Berberine
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Phase 4
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Cell Process |
Metabolic processes
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Cell death
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Cell apoptosis
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In-vivo Model |
This study investigated the N6-methyladenosine (m6A) methylome of kidneys from three mouse groups: C57 mice (controls), those with CI-AKI (injury group, IG), and those pretreated with berberine (treatment group, TG).
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In total 1 item(s) under this drug |
Experiment 1 Reporting the m6A-centered Drug Response
|
[] |
Response Summary |
m6A plays an important role in cisplatin induced acute kidney injury and berberine alleviates this process. Cisplatin induced an increase in Slc12a1 protein levels and a decrease in FGA and Hepatitis A virus cellular receptor 1 (HAVCR1) protein levels. However, berberine pretreatment reversed these effects.
|
Responsed Disease |
Acute kidney failure
|
ICD-11: GB60
|
|
Cell Process |
Metabolic processes
|
Cell death
|
Cell apoptosis
|
In-vivo Model |
This study investigated the N6-methyladenosine (m6A) methylome of kidneys from three mouse groups: C57 mice (controls), those with CI-AKI (injury group, IG), and those pretreated with berberine (treatment group, TG).
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|
|
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In total 1 item(s) under this drug |
Experiment 1 Reporting the m6A-centered Drug Response
|
[] |
Response Summary |
m6A plays an important role in cisplatin induced acute kidney injury and berberine alleviates this process. Cisplatin induced an increase in Slc12a1 protein levels and a decrease in FGA and Hepatitis A virus cellular receptor 1 (HAVCR1) protein levels. However, berberine pretreatment reversed these effects.
|
Responsed Disease |
Acute kidney failure
|
ICD-11: GB60
|
|
Cell Process |
Metabolic processes
|
Cell death
|
Cell apoptosis
|
In-vivo Model |
This study investigated the N6-methyladenosine (m6A) methylome of kidneys from three mouse groups: C57 mice (controls), those with CI-AKI (injury group, IG), and those pretreated with berberine (treatment group, TG).
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