m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00436)

Target Name	Tripartite motif-containing protein 29 (TRIM29)
Synonyms	Ataxia telangiectasia group D-associated protein; ATDC Click to Show/Hide
Gene Name	TRIM29
Chromosomal Location	11q23.3
Function	Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. Click to Show/Hide
Gene ID	23650
Uniprot ID	TRI29_HUMAN
HGNC ID	HGNC:17274
KEGG ID	hsa:23650

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

TRIM29 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

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YTH domain-containing family protein 1 (YTHDF1) [READER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF1*
Cell Line	AGS cell line	Homo sapiens
Treatment: shYTHDF1 AGS Control: shNC AGS		GSE166972
Regulation		logFC: 2.23E+00 p-value: 1.11E-02
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	m6A-YTHDF1-mediated Tripartite motif-containing protein 29 (TRIM29) upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells. TRIM29 acts as an oncogene to promote the CSC-like features of cisplatin-resistant ovarian cancer in an m6A-YTHDF1-dependent manner.
Target Regulation	Up regulation
Responsed Disease	Ovarian cancer		ICD-11: 2C73	Disease Info
Responsed Drug	Cisplatin		Approved	Drug Info
Cell Process	Ectopic expression
In-vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens	CVCL_0134
In-vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens	CVCL_0532
In-vivo Model	The specified number of viable SKOV3/DDP cells and SKOV3/DDP cells with TRIM29 knock down were resuspended in 100 uL PBS, injected subcutaneously under the left and right back of 4-week old nude mice respectively (n = 3 per group).

Ovarian cancer [ICD-11: 2C73]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	m6A-YTHDF1-mediated Tripartite motif-containing protein 29 (TRIM29) upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells. TRIM29 acts as an oncogene to promote the CSC-like features of cisplatin-resistant ovarian cancer in an m6A-YTHDF1-dependent manner.
Responsed Disease	Ovarian cancer [ICD-11: 2C73]
Target Regulator	YTH domain-containing family protein 1 (YTHDF1)		READER	Regulator Info
Target Regulation	Up regulation
Responsed Drug	Cisplatin		Approved	Drug Info
Cell Process	Ectopic expression
In-vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens	CVCL_0134
In-vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens	CVCL_0532
In-vivo Model	The specified number of viable SKOV3/DDP cells and SKOV3/DDP cells with TRIM29 knock down were resuspended in 100 uL PBS, injected subcutaneously under the left and right back of 4-week old nude mice respectively (n = 3 per group).

Cisplatin [Approved]

Drug Info

In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response				[1]
Response Summary	m6A-YTHDF1-mediated Tripartite motif-containing protein 29 (TRIM29) upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells. TRIM29 acts as an oncogene to promote the CSC-like features of cisplatin-resistant ovarian cancer in an m6A-YTHDF1-dependent manner.
Target Regulator	YTH domain-containing family protein 1 (YTHDF1)		READER	Regulator Info
Target Regulation	Up regulation
Responsed Disease	Ovarian cancer		ICD-11: 2C73	Disease Info
Cell Process	Ectopic expression
In-vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens	CVCL_0134
In-vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens	CVCL_0532
In-vivo Model	The specified number of viable SKOV3/DDP cells and SKOV3/DDP cells with TRIM29 knock down were resuspended in 100 uL PBS, injected subcutaneously under the left and right back of 4-week old nude mice respectively (n = 3 per group).

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00436)

Tripartite motif-containing protein 29 (TRIM29)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE005274		Click to Show/Hide the Full List
mod site	chr11:120125400-120125401:-		[2]
Sequence	GGGTTGTCCATCAAACTCAGAGACTGGTTTCGTTCAGATCT
Transcript ID List	ENST00000475051.4; ENST00000528870.5; ENST00000341846.10; ENST00000529044.5; ENST00000530470.1
External Link	RMBase: RNA-editing_site_25697

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005396		Click to Show/Hide the Full List
mod site	chr11:120120609-120120610:-		[3]
Sequence	GGCCGCTTCACCAAGGAGACCACCCAGAAGAATTTCAACAA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000528870.5; ENST00000524816.7; ENST00000529044.5; ENST00000531555.5; ENST00000524956.4; ENST00000526881.1; ENST00000533302.5; ENST00000525887.5; ENST00000341846.10; ENST00000525327.5; ENST00000475051.4
External Link	RMBase: m5C_site_9127
mod ID: M5CSITE005397		Click to Show/Hide the Full List
mod site	chr11:120137568-120137569:-		[4]
Sequence	CCCGGCGGAACAGCTACCCCCGGGCCGACACGGGCCTTTTT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000475051.4; ENST00000627238.1; ENST00000341846.10
External Link	RMBase: m5C_site_9128

N6-methyladenosine (m6A)

In total 46 m6A sequence/site(s) in this target gene
mod ID: M6ASITE009404		Click to Show/Hide the Full List
mod site	chr11:120111299-120111300:-		[5]
Sequence	GGCTTTCCCCTTTGGAATAAACCATTGGTCTGTCACTTCTC
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000524816.7; ENST00000341846.10
External Link	RMBase: m6A_site_167475
mod ID: M6ASITE009405		Click to Show/Hide the Full List
mod site	chr11:120111331-120111332:-		[5]
Sequence	TGCAGGGGTTGGGGAGGGAGACATCCAGCTTGGGCTTTCCC
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000524816.7; ENST00000341846.10
External Link	RMBase: m6A_site_167476
mod ID: M6ASITE009406		Click to Show/Hide the Full List
mod site	chr11:120111408-120111409:-		[6]
Sequence	CCAGGAGCAGCACAGTGGGGACATCTCCCGTCTCAACAGCC
Motif Score	3.643047619
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000524816.7; ENST00000341846.10
External Link	RMBase: m6A_site_167477
mod ID: M6ASITE009407		Click to Show/Hide the Full List
mod site	chr11:120111429-120111430:-		[6]
Sequence	AGGATTGGAGAGGAGACAAAACCAGGAGCAGCACAGTGGGG
Motif Score	2.185083333
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000524816.7; ENST00000341846.10
External Link	RMBase: m6A_site_167478
mod ID: M6ASITE009408		Click to Show/Hide the Full List
mod site	chr11:120111831-120111832:-		[5]
Sequence	CTTGGCCACTGCAGATGGAAACCTCTCAGTGTCTTGACATC
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000524816.7; ENST00000341846.10
External Link	RMBase: m6A_site_167479
mod ID: M6ASITE009409		Click to Show/Hide the Full List
mod site	chr11:120111861-120111862:-		[5]
Sequence	TCAATGCCCAGCATGGCAGAACCTGCAGCCCTTGGCCACTG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000341846.10; ENST00000524816.7
External Link	RMBase: m6A_site_167480
mod ID: M6ASITE009410		Click to Show/Hide the Full List
mod site	chr11:120111914-120111915:-		[5]
Sequence	CACCTCCTGCTTCCCAGAGGACTGGCCCTACGTGCTCTCTC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000341846.10; ENST00000524816.7
External Link	RMBase: m6A_site_167481
mod ID: M6ASITE009411		Click to Show/Hide the Full List
mod site	chr11:120111968-120111969:-		[5]
Sequence	TGTTGTCAGCAGATGCCTGGACAGCACAGCCACCCATCTCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000524816.7; ENST00000341846.10
External Link	RMBase: m6A_site_167482
mod ID: M6ASITE009412		Click to Show/Hide the Full List
mod site	chr11:120112220-120112221:-		[5]
Sequence	ACTGGCCACACTCCATTCAGACTCCTTTCCTGCCTTGTGAC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000524816.7; ENST00000341846.10
External Link	RMBase: m6A_site_167483
mod ID: M6ASITE009413		Click to Show/Hide the Full List
mod site	chr11:120113563-120113564:-		[7]
Sequence	AGGTGTCAGTTCCCTGAGAGACAGGGCCAAAGGCAGTGTAC
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000524816.7; ENST00000525327.5; ENST00000531555.5; ENST00000524664.5; ENST00000530919.5; ENST00000341846.10; ENST00000525887.5; ENST00000529044.5; ENST00000475051.4; ENST00000533302.5; ENST00000528870.5; ENST00000526161.5
External Link	RMBase: m6A_site_167484
mod ID: M6ASITE009414		Click to Show/Hide the Full List
mod site	chr11:120115345-120115346:-		[5]
Sequence	CTTGGAAATCTGGCAAGCAGACTATGCTGGTAAGGGAAGTG
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000529044.5; ENST00000533302.5; ENST00000526161.5; ENST00000531555.5; ENST00000525887.5; ENST00000525327.5; ENST00000341846.10; ENST00000524816.7; ENST00000524664.5; ENST00000528870.5; ENST00000524956.4; ENST00000530919.5; ENST00000475051.4
External Link	RMBase: m6A_site_167485
mod ID: M6ASITE009415		Click to Show/Hide the Full List
mod site	chr11:120115366-120115367:-		[5]
Sequence	GCCCCAAGGCCCAGCCCCAGACTTGGAAATCTGGCAAGCAG
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000525887.5; ENST00000531555.5; ENST00000524956.4; ENST00000528870.5; ENST00000533302.5; ENST00000341846.10; ENST00000529044.5; ENST00000526881.1; ENST00000526161.5; ENST00000524816.7; ENST00000524664.5; ENST00000525327.5; ENST00000475051.4; ENST00000530919.5
External Link	RMBase: m6A_site_167486
mod ID: M6ASITE009416		Click to Show/Hide the Full List
mod site	chr11:120118275-120118276:-		[5]
Sequence	GTACTCCTCCAGCATTCAGAACTCTGACAATGACCTGCCCG
Motif Score	3.373380952
Cell/Tissue List	HeLa; A549
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000525327.5; ENST00000531555.5; ENST00000528870.5; ENST00000524664.5; ENST00000529044.5; ENST00000475051.4; ENST00000341846.10; ENST00000524816.7; ENST00000526881.1; ENST00000525887.5; ENST00000533302.5; ENST00000524956.4
External Link	RMBase: m6A_site_167487
mod ID: M6ASITE009417		Click to Show/Hide the Full List
mod site	chr11:120120611-120120612:-		[8]
Sequence	CTGGCCGCTTCACCAAGGAGACCACCCAGAAGAATTTCAAC
Motif Score	2.876744048
Cell/Tissue List	A549; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000524816.7; ENST00000524956.4; ENST00000533302.5; ENST00000531555.5; ENST00000475051.4; ENST00000525327.5; ENST00000341846.10; ENST00000529044.5; ENST00000528870.5; ENST00000525887.5; ENST00000526881.1
External Link	RMBase: m6A_site_167488
mod ID: M6ASITE009418		Click to Show/Hide the Full List
mod site	chr11:120120653-120120654:-		[8]
Sequence	GCTTCACAGGTGGGGTCCGGACATCATACCAGCCCTCGTCT
Motif Score	3.643047619
Cell/Tissue List	A549; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000531555.5; ENST00000524816.7; ENST00000525327.5; ENST00000528870.5; ENST00000529044.5; ENST00000475051.4; ENST00000533302.5; ENST00000526881.1; ENST00000525887.5; ENST00000341846.10; ENST00000524956.4
External Link	RMBase: m6A_site_167489
mod ID: M6ASITE009419		Click to Show/Hide the Full List
mod site	chr11:120120781-120120782:-		[8]
Sequence	ACTTATGTCAGACCCAAAGGACTTCTCTCAGTGGTGGAATC
Motif Score	4.065041667
Cell/Tissue List	A549; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000526881.1; ENST00000531555.5; ENST00000475051.4; ENST00000524956.4; ENST00000341846.10; ENST00000533302.5; ENST00000528870.5; ENST00000525327.5; ENST00000525887.5; ENST00000529044.5; ENST00000524816.7
External Link	RMBase: m6A_site_167490
mod ID: M6ASITE009420		Click to Show/Hide the Full List
mod site	chr11:120120790-120120791:-		[8]
Sequence	AGTTGATTGACTTATGTCAGACCCAAAGGACTTCTCTCAGT
Motif Score	2.876744048
Cell/Tissue List	A549; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000525327.5; ENST00000524816.7; ENST00000531555.5; ENST00000524956.4; ENST00000528870.5; ENST00000529044.5; ENST00000533302.5; ENST00000525887.5; ENST00000475051.4; ENST00000526881.1; ENST00000341846.10
External Link	RMBase: m6A_site_167491
mod ID: M6ASITE009421		Click to Show/Hide the Full List
mod site	chr11:120121408-120121409:-		[5]
Sequence	TCACCAAGGAGATGAAAGAAACAAGGCCCCTAAAGGGACTG
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000524956.4; ENST00000525887.5; ENST00000533302.5; ENST00000529044.5; ENST00000341846.10; ENST00000525327.5; ENST00000528870.5; ENST00000531555.5; ENST00000524816.7; ENST00000475051.4
External Link	RMBase: m6A_site_167492
mod ID: M6ASITE009422		Click to Show/Hide the Full List
mod site	chr11:120121439-120121440:-		[5]
Sequence	AGGGTGGAGTTGGGGGGAGAACAGGAAGCAATCACCAAGGA
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000525887.5; ENST00000341846.10; ENST00000524956.4; ENST00000533302.5; ENST00000531555.5; ENST00000475051.4; ENST00000528870.5; ENST00000524816.7; ENST00000529044.5; ENST00000525327.5
External Link	RMBase: m6A_site_167493
mod ID: M6ASITE009423		Click to Show/Hide the Full List
mod site	chr11:120121493-120121494:-		[5]
Sequence	CTGTGCCGAGGACAGGAGGGACAGGAAATCTGCCCTCTGGG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000475051.4; ENST00000533302.5; ENST00000525327.5; ENST00000525887.5; ENST00000524956.4; ENST00000341846.10; ENST00000529044.5; ENST00000524816.7; ENST00000531555.5; ENST00000528870.5
External Link	RMBase: m6A_site_167494
mod ID: M6ASITE009424		Click to Show/Hide the Full List
mod site	chr11:120121502-120121503:-		[5]
Sequence	GTGGGTAGCCTGTGCCGAGGACAGGAGGGACAGGAAATCTG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000341846.10; ENST00000533302.5; ENST00000525327.5; ENST00000525887.5; ENST00000524816.7; ENST00000529044.5; ENST00000531555.5; ENST00000528870.5; ENST00000475051.4; ENST00000524956.4
External Link	RMBase: m6A_site_167495
mod ID: M6ASITE009425		Click to Show/Hide the Full List
mod site	chr11:120126335-120126336:-		[5]
Sequence	GAGGCAGGAGAATTGCTTGAACCCAAAAGACGGAGGTTGCA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000475051.4; rmsk_3674963; ENST00000341846.10; ENST00000530470.1; ENST00000529044.5
External Link	RMBase: m6A_site_167496
mod ID: M6ASITE009426		Click to Show/Hide the Full List
mod site	chr11:120127382-120127383:-		[5]
Sequence	TGCTGCATGAGGACAAGCAGACCCGGGAGCAGCTGCATAGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000475051.4; ENST00000529044.5; ENST00000341846.10
External Link	RMBase: m6A_site_167497
mod ID: M6ASITE009427		Click to Show/Hide the Full List
mod site	chr11:120127390-120127391:-		[5]
Sequence	AGCCAAGGTGCTGCATGAGGACAAGCAGACCCGGGAGCAGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000529044.5; ENST00000341846.10; ENST00000475051.4
External Link	RMBase: m6A_site_167498
mod ID: M6ASITE009428		Click to Show/Hide the Full List
mod site	chr11:120127447-120127448:-		[5]
Sequence	GCGGGAGCAGGATGCTGTGGACCAAGTGAAGGTGATCATGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000475051.4; ENST00000532195.1; ENST00000341846.10; ENST00000529044.5
External Link	RMBase: m6A_site_167499
mod ID: M6ASITE009429		Click to Show/Hide the Full List
mod site	chr11:120127510-120127511:-		[5]
Sequence	CTTCCGGGACCTGGTGCGGGACCTGGAGAAGCAAAAGGAGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000532195.1; ENST00000341846.10; ENST00000529044.5; ENST00000475051.4
External Link	RMBase: m6A_site_167500
mod ID: M6ASITE009430		Click to Show/Hide the Full List
mod site	chr11:120127522-120127523:-		[5]
Sequence	CCTGGAGCAGAACTTCCGGGACCTGGTGCGGGACCTGGAGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000529044.5; ENST00000475051.4; ENST00000341846.10; ENST00000532195.1
External Link	RMBase: m6A_site_167501
mod ID: M6ASITE009431		Click to Show/Hide the Full List
mod site	chr11:120127531-120127532:-		[5]
Sequence	GAAGGCCATCCTGGAGCAGAACTTCCGGGACCTGGTGCGGG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000475051.4; ENST00000341846.10; ENST00000532195.1; ENST00000529044.5
External Link	RMBase: m6A_site_167502
mod ID: M6ASITE009432		Click to Show/Hide the Full List
mod site	chr11:120128409-120128410:-		[5]
Sequence	GAAGTGGCAGAAGGAGAAGGACCGCATCAAGGTGAGCAGCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000475051.4; ENST00000341846.10; ENST00000532195.1; ENST00000529044.5
External Link	RMBase: m6A_site_167503
mod ID: M6ASITE009433		Click to Show/Hide the Full List
mod site	chr11:120128750-120128751:-		[5]
Sequence	GAGGTTTAGCCCTTAAAAAGACATGGCTAGGATATCCAGCC
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000341846.10; ENST00000529044.5; ENST00000532195.1; ENST00000475051.4
External Link	RMBase: m6A_site_167504
mod ID: M6ASITE009434		Click to Show/Hide the Full List
mod site	chr11:120128909-120128910:-		[5]
Sequence	CACACTGTTACTGCCACGAGACACTCCCTGGGCTGGGCTGG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000341846.10; ENST00000475051.4; ENST00000529044.5; ENST00000532195.1
External Link	RMBase: m6A_site_167505
mod ID: M6ASITE009435		Click to Show/Hide the Full List
mod site	chr11:120137310-120137311:-		[6]
Sequence	TCTTCTGCCAGACCGACCAGACCTGCATCTGCTACCTTTGC
Motif Score	2.876744048
Cell/Tissue List	HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000341846.10; ENST00000475051.4
External Link	RMBase: m6A_site_167506
mod ID: M6ASITE009436		Click to Show/Hide the Full List
mod site	chr11:120137319-120137320:-		[6]
Sequence	CGATGGAGCTCTTCTGCCAGACCGACCAGACCTGCATCTGC
Motif Score	2.876744048
Cell/Tissue List	HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000341846.10; ENST00000475051.4
External Link	RMBase: m6A_site_167507
mod ID: M6ASITE009437		Click to Show/Hide the Full List
mod site	chr11:120137375-120137376:-		[5]
Sequence	GCTGCTCGAGCCCATCCGGGACTTTGAGGCCCGCAAGTGTC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000341846.10; ENST00000475051.4; ENST00000627238.1
External Link	RMBase: m6A_site_167508
mod ID: M6ASITE009438		Click to Show/Hide the Full List
mod site	chr11:120137402-120137403:-		[5]
Sequence	GGAGGGCGCCGCCTTCCGAGACCACCAGCTGCTCGAGCCCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000627238.1; ENST00000341846.10; ENST00000475051.4
External Link	RMBase: m6A_site_167509
mod ID: M6ASITE009439		Click to Show/Hide the Full List
mod site	chr11:120137579-120137580:-		[5]
Sequence	GCCCGGGGAGACCCGGCGGAACAGCTACCCCCGGGCCGACA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000341846.10; ENST00000627238.1; ENST00000475051.4
External Link	RMBase: m6A_site_167510
mod ID: M6ASITE009440		Click to Show/Hide the Full List
mod site	chr11:120137589-120137590:-		[5]
Sequence	CCATCATGGAGCCCGGGGAGACCCGGCGGAACAGCTACCCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000341846.10; ENST00000475051.4; ENST00000627238.1
External Link	RMBase: m6A_site_167511
mod ID: M6ASITE009441		Click to Show/Hide the Full List
mod site	chr11:120137741-120137742:-		[5]
Sequence	CTCCAACTACTTCAGCATGGACTCTATGGAAGGCAAGAGGT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000627238.1; ENST00000341846.10; ENST00000529011.1; ENST00000475051.4
External Link	RMBase: m6A_site_167512
mod ID: M6ASITE009442		Click to Show/Hide the Full List
mod site	chr11:120137762-120137763:-		[5]
Sequence	CGAGTCCGGGGACGACAAGAACTCCAACTACTTCAGCATGG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000475051.4; ENST00000529495.1; ENST00000341846.10; ENST00000627238.1; ENST00000529011.1
External Link	RMBase: m6A_site_167513
mod ID: M6ASITE009443		Click to Show/Hide the Full List
mod site	chr11:120137768-120137769:-		[9]
Sequence	GTTTGTCGAGTCCGGGGACGACAAGAACTCCAACTACTTCA
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000532833.1; ENST00000529495.1; ENST00000341846.10; ENST00000529011.1; ENST00000475051.4; ENST00000627238.1
External Link	RMBase: m6A_site_167514
mod ID: M6ASITE009444		Click to Show/Hide the Full List
mod site	chr11:120137907-120137908:-		[5]
Sequence	CTGACGGCAAGGATGCCAAGACCACCAACGGGCACGGCGGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000341846.10; ENST00000532833.1; ENST00000627238.1; ENST00000529495.1; ENST00000475051.4; ENST00000529011.1
External Link	RMBase: m6A_site_167515
mod ID: M6ASITE009445		Click to Show/Hide the Full List
mod site	chr11:120138053-120138054:-		[10]
Sequence	TGAACCCCAGCAAGCCTGAAACAGCTCAGCCAAGCACCCTG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000475051.4; ENST00000529495.1; ENST00000341846.10; ENST00000529011.1; ENST00000529040.1; ENST00000532833.1
External Link	RMBase: m6A_site_167516
mod ID: M6ASITE009446		Click to Show/Hide the Full List
mod site	chr11:120138070-120138071:-		[10]
Sequence	AGAAAGGTCACCTATCCTGAACCCCAGCAAGCCTGAAACAG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000529040.1; ENST00000529011.1; ENST00000532833.1; ENST00000529495.1; ENST00000475051.4; ENST00000341846.10
External Link	RMBase: m6A_site_167517
mod ID: M6ASITE009447		Click to Show/Hide the Full List
mod site	chr11:120185342-120185343:-		[11]
Sequence	ACTCCTTCTGGAACTTCAGGACCTTGGATGCTCCCCTCCTC
Motif Score	3.622404762
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000532833.1; ENST00000529040.1
External Link	RMBase: m6A_site_167518
mod ID: M6ASITE009448		Click to Show/Hide the Full List
mod site	chr11:120185350-120185351:-		[11]
Sequence	AAGGCTGGACTCCTTCTGGAACTTCAGGACCTTGGATGCTC
Motif Score	3.373380952
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000529040.1; ENST00000532833.1
External Link	RMBase: m6A_site_167519
mod ID: M6ASITE009449		Click to Show/Hide the Full List
mod site	chr11:120185362-120185363:-		[11]
Sequence	AGGCTCTGTGAGAAGGCTGGACTCCTTCTGGAACTTCAGGA
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000532833.1; ENST00000529040.1
External Link	RMBase: m6A_site_167520

Ref 1	m6A-YTHDF1-mediated TRIM29 upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118878. doi: 10.1016/j.bbamcr.2020.118878. Epub 2020 Oct 1.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 7	N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27.
Ref 8	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 9	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 10	RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat Commun. 2019 May 6;10(1):2065. doi: 10.1038/s41467-019-09865-9.
Ref 11	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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