m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00431)

Target Name	Metalloproteinase inhibitor 3 (TIMP3)
Synonyms	Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3 Click to Show/Hide
Gene Name	TIMP3
Chromosomal Location	22q12.3
Family	protease inhibitor I35 (TIMP) family
Function	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Click to Show/Hide
Gene ID	7078
Uniprot ID	TIMP3_HUMAN
HGNC ID	HGNC:11822
KEGG ID	hsa:7078

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

TIMP3 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

RNA demethylase ALKBH5 (ALKBH5) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5*
Cell Line	HaCAT cell line	Homo sapiens
Treatment: siALKBH5 HaCAT cells Control: siControl HaCAT cells		GSE211076
Regulation		logFC: -5.86E-01 p-value: 2.60E-20
More Results	Click to View More RNA-seq Results

In total 2 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	ALKBH5 repress Metalloproteinase inhibitor 3 (TIMP3) transcript stability, thereby inhibiting TIMP3 translational production.the present research confirmed the ALKBH5/TIMP3 pathway in the non-small cell lung cancer(NSCLC) oncogenesis progress, providing a novel insight for the epitranscriptome and potential therapeutic target for NSCLC.
Target Regulation	Down regulation
Responsed Disease	Non-small-cell lung carcinoma		ICD-11: 2C25.Y	Disease Info
Cell Process	RNA stability
Cell Process	Cell apoptosis
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	NCI-H460	Lung large cell carcinoma	Homo sapiens	CVCL_0459
	NHBE (Normal bronchial epithelial cells)
	SK-MES-1	Lung squamous cell carcinoma	Homo sapiens	CVCL_0630
In-vivo Model	2 × 10⁶ A549 cells stably transfected with shRNA-ALKBH5 were injected into the flank of male athymic BALB/c nude mice (4-5 weeks old, 10 mice).
Experiment 2 Reporting the m6A Methylation Regulator of This Target Gene				[2]
Response Summary	The expression of CDKN1A (p21) or Metalloproteinase inhibitor 3 (TIMP3) was increased by ALKBH5 knockdown. In conclusions, the ALKBH5-IGF2BPs axis promotes cell proliferation and tumorigenicity, which in turn causes the unfavorable prognosis of NSCLC.
Target Regulation	Down regulation
Responsed Disease	Non-small-cell lung carcinoma		ICD-11: 2C25.Y	Disease Info
Pathway Response	Cell cycle			hsa04110
Cell Process	Arrest cell cycle at G1 phase
In-vitro Model	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	NCI-H460	Lung large cell carcinoma	Homo sapiens	CVCL_0459
	NCI-H2087	Lung adenocarcinoma	Homo sapiens	CVCL_1524
	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	ABC-1	Lung adenocarcinoma	Homo sapiens	CVCL_1066
	NCI-H358	Minimally invasive lung adenocarcinoma	Homo sapiens	CVCL_1559
	BEAS-2B	Normal	Homo sapiens	CVCL_0168
	HEK293	Normal	Homo sapiens	CVCL_0045
	PC-3 [Human lung carcinoma]	Lung adenocarcinoma	Homo sapiens	CVCL_S982
	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
	RERF-LC-MS	Lung adenocarcinoma	Homo sapiens	CVCL_1655
	HLC-1	Lung adenocarcinoma	Homo sapiens	CVCL_5529
	LC-2/ad	Lung adenocarcinoma	Homo sapiens	CVCL_1373

Lung cancer [ICD-11: 2C25]

Disease Info

In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	ALKBH5 repress Metalloproteinase inhibitor 3 (TIMP3) transcript stability, thereby inhibiting TIMP3 translational production.the present research confirmed the ALKBH5/TIMP3 pathway in the non-small cell lung cancer(NSCLC) oncogenesis progress, providing a novel insight for the epitranscriptome and potential therapeutic target for NSCLC.
Responsed Disease	Non-small-cell lung carcinoma [ICD-11: 2C25.Y]
Target Regulator	RNA demethylase ALKBH5 (ALKBH5)		ERASER	Regulator Info
Target Regulation	Down regulation
Cell Process	RNA stability
Cell Process	Cell apoptosis
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	NCI-H460	Lung large cell carcinoma	Homo sapiens	CVCL_0459
	NHBE (Normal bronchial epithelial cells)
	SK-MES-1	Lung squamous cell carcinoma	Homo sapiens	CVCL_0630
In-vivo Model	2 × 10⁶ A549 cells stably transfected with shRNA-ALKBH5 were injected into the flank of male athymic BALB/c nude mice (4-5 weeks old, 10 mice).
Experiment 2 Reporting the m6A-centered Disease Response				[2]
Response Summary	The expression of CDKN1A (p21) or Metalloproteinase inhibitor 3 (TIMP3) was increased by ALKBH5 knockdown. In conclusions, the ALKBH5-IGF2BPs axis promotes cell proliferation and tumorigenicity, which in turn causes the unfavorable prognosis of NSCLC.
Responsed Disease	Non-small-cell lung carcinoma [ICD-11: 2C25.Y]
Target Regulator	RNA demethylase ALKBH5 (ALKBH5)		ERASER	Regulator Info
Target Regulation	Down regulation
Pathway Response	Cell cycle			hsa04110
Cell Process	Arrest cell cycle at G1 phase
In-vitro Model	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	NCI-H460	Lung large cell carcinoma	Homo sapiens	CVCL_0459
	NCI-H2087	Lung adenocarcinoma	Homo sapiens	CVCL_1524
	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	ABC-1	Lung adenocarcinoma	Homo sapiens	CVCL_1066
	NCI-H358	Minimally invasive lung adenocarcinoma	Homo sapiens	CVCL_1559
	BEAS-2B	Normal	Homo sapiens	CVCL_0168
	HEK293	Normal	Homo sapiens	CVCL_0045
	PC-3 [Human lung carcinoma]	Lung adenocarcinoma	Homo sapiens	CVCL_S982
	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
	RERF-LC-MS	Lung adenocarcinoma	Homo sapiens	CVCL_1655
	HLC-1	Lung adenocarcinoma	Homo sapiens	CVCL_5529
	LC-2/ad	Lung adenocarcinoma	Homo sapiens	CVCL_1373

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00431)

Metalloproteinase inhibitor 3 (TIMP3)

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002904		Click to Show/Hide the Full List
mod site	chr22:32801903-32801904:+		[4]
Sequence	GGTTGCCCCGCACGGCCCGGCGGGCGAGCGAGCTCGGGCTG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m5C_site_30695
mod ID: M5CSITE002905		Click to Show/Hide the Full List
mod site	chr22:32861745-32861746:+		[5]
Sequence	CGCAAAGCGATGTCAGAGGGCGGTTTTGAGCTTTCTATAAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m5C_site_30696

N6-methyladenosine (m6A)

In total 65 m6A sequence/site(s) in this target gene
mod ID: M6ASITE057825		Click to Show/Hide the Full List
mod site	chr22:32802053-32802054:+		[6]
Sequence	GGGCAGCTGGAGCCTGGGGGACTGGGGCGCCGAGGCGTGCA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; GSC-11; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563368
mod ID: M6ASITE057826		Click to Show/Hide the Full List
mod site	chr22:32802116-32802117:+		[7]
Sequence	GGACGCCTTCTGCAACTCCGACATCGGTAAGCGCTCCTGGT
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563369
mod ID: M6ASITE057827		Click to Show/Hide the Full List
mod site	chr22:32849514-32849515:+		[7]
Sequence	GCCCTTCGGCACGCTGGTCTACACCATCAAGCAGATGAAGG
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563370
mod ID: M6ASITE057828		Click to Show/Hide the Full List
mod site	chr22:32857285-32857286:+		[7]
Sequence	CAAGATGCCCCATGTGCAGTACATCCATACGGAAGCTTCCG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563371
mod ID: M6ASITE057829		Click to Show/Hide the Full List
mod site	chr22:32857336-32857337:+		[7]
Sequence	TGGCCTTAAGCTGGAGGTCAACAAGTACCAGTACCTGCTGA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563372
mod ID: M6ASITE057830		Click to Show/Hide the Full List
mod site	chr22:32858040-32858041:+		[7]
Sequence	CGTCTATGATGGCAAGATGTACACGGGGCTGTGCAACTTCG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563373
mod ID: M6ASITE057831		Click to Show/Hide the Full List
mod site	chr22:32858073-32858074:+		[8]
Sequence	CAACTTCGTGGAGAGGTGGGACCAGCTCACCCTCTCCCAGC
Motif Score	3.622404762
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563374
mod ID: M6ASITE057832		Click to Show/Hide the Full List
mod site	chr22:32858106-32858107:+		[8]
Sequence	CTCCCAGCGCAAGGGGCTGAACTATCGGTATCACCTGGGTT
Motif Score	3.373380952
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563375
mod ID: M6ASITE057833		Click to Show/Hide the Full List
mod site	chr22:32859236-32859237:+		[9]
Sequence	CCAAGAACGAGTGTCTCTGGACCGACATGCTCTCCAATTTC
Motif Score	3.622404762
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563376
mod ID: M6ASITE057834		Click to Show/Hide the Full List
mod site	chr22:32859240-32859241:+		[7]
Sequence	GAACGAGTGTCTCTGGACCGACATGCTCTCCAATTTCGGTT
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563377
mod ID: M6ASITE057835		Click to Show/Hide the Full List
mod site	chr22:32859280-32859281:+		[6]
Sequence	TACCCTGGCTACCAGTCCAAACACTACGCCTGCATCCGGCA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563378
mod ID: M6ASITE057836		Click to Show/Hide the Full List
mod site	chr22:32859369-32859370:+		[6]
Sequence	AAGCATCATCAATGCCACAGACCCCTGAGCGCCAGACCCTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563379
mod ID: M6ASITE057837		Click to Show/Hide the Full List
mod site	chr22:32859384-32859385:+		[6]
Sequence	CACAGACCCCTGAGCGCCAGACCCTGCCCCACCTCACTTCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563380
mod ID: M6ASITE057838		Click to Show/Hide the Full List
mod site	chr22:32859431-32859432:+		[6]
Sequence	TCCCGCTGAGCTTCCCTTGGACACTAACTCTTCCCAGATGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; brain; kidney; liver; hESC-HEK293T; U2OS; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563381
mod ID: M6ASITE057839		Click to Show/Hide the Full List
mod site	chr22:32859437-32859438:+		[10]
Sequence	TGAGCTTCCCTTGGACACTAACTCTTCCCAGATGATGACAA
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563382
mod ID: M6ASITE057840		Click to Show/Hide the Full List
mod site	chr22:32859454-32859455:+		[10]
Sequence	CTAACTCTTCCCAGATGATGACAATGAAATTAGTGCCTGTT
Motif Score	2.859755952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563383
mod ID: M6ASITE057841		Click to Show/Hide the Full List
mod site	chr22:32859498-32859499:+		[6]
Sequence	TTGCAAATTTAGCACTTGGAACATTTAAAGAAAGGTCTATG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; kidney; U2OS; H1B; hNPCs; fibroblasts; Huh7; HEK293A-TOA; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563384
mod ID: M6ASITE057842		Click to Show/Hide the Full List
mod site	chr22:32859542-32859543:+		[6]
Sequence	TCATATGGGGTTTATTGGGAACTATCCTCCTGGCCCCACCC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; U2OS; Huh7; HEK293A-TOA; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563385
mod ID: M6ASITE057843		Click to Show/Hide the Full List
mod site	chr22:32859584-32859585:+		[7]
Sequence	GCCCCTTCTTTTTGGTTTTGACATCATTCATTTCCACCTGG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563386
mod ID: M6ASITE057844		Click to Show/Hide the Full List
mod site	chr22:32859638-32859639:+		[11]
Sequence	CATGCCAGAAAGAATGAGGAACCTGTATTCCTCTTCTTCGT
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563387
mod ID: M6ASITE057845		Click to Show/Hide the Full List
mod site	chr22:32859688-32859689:+		[7]
Sequence	ATCTCTATTTTTTTAGGAAAACAAAAATGAAAAACTACTCC
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T; Huh7
Seq Type List	MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563388
mod ID: M6ASITE057846		Click to Show/Hide the Full List
mod site	chr22:32859701-32859702:+		[6]
Sequence	TAGGAAAACAAAAATGAAAAACTACTCCATTTGAGGATTGT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563389
mod ID: M6ASITE057847		Click to Show/Hide the Full List
mod site	chr22:32859704-32859705:+		[10]
Sequence	GAAAACAAAAATGAAAAACTACTCCATTTGAGGATTGTAAT
Motif Score	2.500660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563390
mod ID: M6ASITE057848		Click to Show/Hide the Full List
mod site	chr22:32859766-32859767:+		[6]
Sequence	CCCACCTCACCATCTCCCAGACCCTCTTCCCTTTGCCCTTC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; Huh7; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000266085.6; rmsk_5277560
External Link	RMBase: m6A_site_563391
mod ID: M6ASITE057849		Click to Show/Hide the Full List
mod site	chr22:32859805-32859806:+		[6]
Sequence	TCTCCTCCAATACATAAAGGACACAGACAAGGAACTTGCTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; fibroblasts; Huh7; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563392
mod ID: M6ASITE057850		Click to Show/Hide the Full List
mod site	chr22:32859811-32859812:+		[6]
Sequence	CCAATACATAAAGGACACAGACAAGGAACTTGCTGAAAGGC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; fibroblasts; Huh7; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563393
mod ID: M6ASITE057851		Click to Show/Hide the Full List
mod site	chr22:32859818-32859819:+		[6]
Sequence	ATAAAGGACACAGACAAGGAACTTGCTGAAAGGCCAACCAT
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; fibroblasts; Huh7; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563394
mod ID: M6ASITE057852		Click to Show/Hide the Full List
mod site	chr22:32859871-32859872:+		[6]
Sequence	CAAAGGCAGCAAGCAGATAGACTCAAGGTGTGTGAAAGATG
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; fibroblasts; Huh7; GSC-11; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563395
mod ID: M6ASITE057853		Click to Show/Hide the Full List
mod site	chr22:32859929-32859930:+		[6]
Sequence	CCACTGCATGTCCCAACCAGACTGTGTCTGTCTGTGTCTGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; Huh7; GSC-11; HEK293A-TOA; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563396
mod ID: M6ASITE057854		Click to Show/Hide the Full List
mod site	chr22:32859978-32859979:+		[8]
Sequence	GTGAGGGAGGGAAGGAAGGAACTACAAGAGAGTCGGAGATG
Motif Score	3.373380952
Cell/Tissue List	HepG2; HeLa; HEK293T; Huh7; GSC-11; HEK293A-TOA; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563397
mod ID: M6ASITE057855		Click to Show/Hide the Full List
mod site	chr22:32859981-32859982:+		[12]
Sequence	AGGGAGGGAAGGAAGGAACTACAAGAGAGTCGGAGATGATG
Motif Score	2.078666667
Cell/Tissue List	kidney; liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563398
mod ID: M6ASITE057856		Click to Show/Hide the Full List
mod site	chr22:32860008-32860009:+		[10]
Sequence	AGTCGGAGATGATGCAGCACACACACAATTCCCCAGCCCAG
Motif Score	2.084928571
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563399
mod ID: M6ASITE057857		Click to Show/Hide the Full List
mod site	chr22:32860110-32860111:+		[11]
Sequence	AGCTTTCTTAGTTGGTGAAGACTTAAACATCTGCCTGAGGT
Motif Score	3.319380952
Cell/Tissue List	Huh7; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563400
mod ID: M6ASITE057858		Click to Show/Hide the Full List
mod site	chr22:32860116-32860117:+		[9]
Sequence	CTTAGTTGGTGAAGACTTAAACATCTGCCTGAGGTCAGGAG
Motif Score	2.20572619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563401
mod ID: M6ASITE057859		Click to Show/Hide the Full List
mod site	chr22:32860155-32860156:+		[12]
Sequence	AGGCAATTTGCCTGCCTTGTACAAAAGCTCAGGTGAAAGAC
Motif Score	2.856142857
Cell/Tissue List	brain; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563402
mod ID: M6ASITE057860		Click to Show/Hide the Full List
mod site	chr22:32860213-32860214:+		[11]
Sequence	CTCTCCCTGCCTCCCACCAGACTTCCTCCTGGAAAACGCTT
Motif Score	3.319380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563403
mod ID: M6ASITE057861		Click to Show/Hide the Full List
mod site	chr22:32860228-32860229:+		[10]
Sequence	ACCAGACTTCCTCCTGGAAAACGCTTTGGTAGATTTGGCCA
Motif Score	2.179660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563404
mod ID: M6ASITE057862		Click to Show/Hide the Full List
mod site	chr22:32860279-32860280:+		[7]
Sequence	TTTATGTAAATTGGATAAATACACACACCATACACTATCCA
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563405
mod ID: M6ASITE057863		Click to Show/Hide the Full List
mod site	chr22:32860380-32860381:+		[7]
Sequence	CTAGGGGGATATGTTTGTATACACATTTGCATATACCCACA
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563406
mod ID: M6ASITE057864		Click to Show/Hide the Full List
mod site	chr22:32860406-32860407:+		[6]
Sequence	TTGCATATACCCACATGGGGACATAAGCTAATTTTTTTACA
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563407
mod ID: M6ASITE057865		Click to Show/Hide the Full List
mod site	chr22:32860429-32860430:+		[6]
Sequence	TAAGCTAATTTTTTTACAGGACACAGAATTCTGTTCAATGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563408
mod ID: M6ASITE057866		Click to Show/Hide the Full List
mod site	chr22:32860516-32860517:+		[10]
Sequence	CTTGTTTGAAGAAAATCATGACATTCCAAGTTGACATTTTT
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563409
mod ID: M6ASITE057867		Click to Show/Hide the Full List
mod site	chr22:32860760-32860761:+		[6]
Sequence	TGCCTGCCTTGGCTGGAGGGACACCTCTCCTGGGTGTGGAG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563410
mod ID: M6ASITE057868		Click to Show/Hide the Full List
mod site	chr22:32860781-32860782:+		[6]
Sequence	CACCTCTCCTGGGTGTGGAGACAGCTTGGTTCCCTTTCCCT
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563411
mod ID: M6ASITE057869		Click to Show/Hide the Full List
mod site	chr22:32861028-32861029:+		[12]
Sequence	TAGGTGATAATGTATATTTTACAGAGTGGGGGTTGGCAGGA
Motif Score	2.07285119
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563412
mod ID: M6ASITE057870		Click to Show/Hide the Full List
mod site	chr22:32861166-32861167:+		[9]
Sequence	AAACAGAGCTGCCAATTGAAACAGAAGAAGAAAAAAAAAAA
Motif Score	2.20572619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563413
mod ID: M6ASITE057871		Click to Show/Hide the Full List
mod site	chr22:32861196-32861197:+		[9]
Sequence	AAAAAAAAAAAAAGCAGCAGACAACACACTGTAGAGTCTTG
Motif Score	2.897386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563414
mod ID: M6ASITE057872		Click to Show/Hide the Full List
mod site	chr22:32861218-32861219:+		[10]
Sequence	AACACACTGTAGAGTCTTGCACACACACAAGTGCCCAGGCA
Motif Score	2.830589286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563415
mod ID: M6ASITE057873		Click to Show/Hide the Full List
mod site	chr22:32861253-32861254:+		[9]
Sequence	CAGGCAAGGTGCTTGGCAGAACCGCAGAGTGGGAAGAGAGT
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563416
mod ID: M6ASITE057874		Click to Show/Hide the Full List
mod site	chr22:32861437-32861438:+		[9]
Sequence	TTTTGAAGGGATGAGCCCAGACTTGATGTTTTGGGATTGTC
Motif Score	3.319380952
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563417
mod ID: M6ASITE057875		Click to Show/Hide the Full List
mod site	chr22:32861529-32861530:+		[9]
Sequence	AAGTTCCCTCCCACAAGTGGACATCAGTGTCTTCTCTGTGA
Motif Score	3.643047619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563418
mod ID: M6ASITE057876		Click to Show/Hide the Full List
mod site	chr22:32861605-32861606:+		[9]
Sequence	CCTCTCTCACACAAGGAGGAACTTGGGTGAAGGCTGAGTGT
Motif Score	3.373380952
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563419
mod ID: M6ASITE057877		Click to Show/Hide the Full List
mod site	chr22:32861668-32861669:+		[9]
Sequence	GGAGTCGATAAATTAGCAGAACCACATCCCCATCTGTTAGG
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563420
mod ID: M6ASITE057878		Click to Show/Hide the Full List
mod site	chr22:32861671-32861672:+		[12]
Sequence	GTCGATAAATTAGCAGAACCACATCCCCATCTGTTAGGCCT
Motif Score	2.053113095
Cell/Tissue List	liver; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563421
mod ID: M6ASITE057879		Click to Show/Hide the Full List
mod site	chr22:32861830-32861831:+		[7]
Sequence	AAATCATTTATGTAGCTGAGACACTTCTGTATTTCAATCAT
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563422
mod ID: M6ASITE057880		Click to Show/Hide the Full List
mod site	chr22:32862511-32862512:+		[9]
Sequence	ACTACCCTTCCATGCCCCAGACCTCTGTCTTGCATGTGACA
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563423
mod ID: M6ASITE057881		Click to Show/Hide the Full List
mod site	chr22:32862545-32862546:+		[9]
Sequence	TGTGACAATTGACAATCTGGACTACCCCAAGATGGCACCCA
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563424
mod ID: M6ASITE057882		Click to Show/Hide the Full List
mod site	chr22:32862623-32862624:+		[9]
Sequence	CTAGAGTATTTTTATGAGAGACAAACATTATAAAAATCTGA
Motif Score	2.897386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563425
mod ID: M6ASITE057883		Click to Show/Hide the Full List
mod site	chr22:32862657-32862658:+		[9]
Sequence	AATCTGATGGCAAAAGCAAAACAAAATGGAAAGTAGGGGAG
Motif Score	2.20572619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563426
mod ID: M6ASITE057884		Click to Show/Hide the Full List
mod site	chr22:32862690-32862691:+		[7]
Sequence	TAGGGGAGGTGGATGTGACAACAACTTCCAAATTGGCTCTT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563427
mod ID: M6ASITE057885		Click to Show/Hide the Full List
mod site	chr22:32862733-32862734:+		[8]
Sequence	GAGGCGAGAGGAAGGGGAGAACTTGGAGAATAGTTTTTGCT
Motif Score	3.373380952
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563428
mod ID: M6ASITE057886		Click to Show/Hide the Full List
mod site	chr22:32862822-32862823:+		[8]
Sequence	AGCCAGTCTGCTGTCCTGAAACCCAGAAGTGATGGAGAGAA
Motif Score	2.185083333
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563429
mod ID: M6ASITE057887		Click to Show/Hide the Full List
mod site	chr22:32862843-32862844:+		[8]
Sequence	CCCAGAAGTGATGGAGAGAAACCAACAAGAGATCTCGAACC
Motif Score	2.185083333
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563430
mod ID: M6ASITE057888		Click to Show/Hide the Full List
mod site	chr22:32862861-32862862:+		[8]
Sequence	AAACCAACAAGAGATCTCGAACCCTGTCTAGAAGGAATGTA
Motif Score	2.930744048
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563431
mod ID: M6ASITE057889		Click to Show/Hide the Full List
mod site	chr22:32862985-32862986:+		[10]
Sequence	TGTAATGTTGCATAATGTTCACTTTTTATAGTGTGTCCTTT
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000266085.6
External Link	RMBase: m6A_site_563432

Ref 1	N(6)-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability. Gene. 2020 Mar 20;731:144348. doi: 10.1016/j.gene.2020.144348. Epub 2020 Jan 9.
Ref 2	m(6)A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer. Cancer Gene Ther. 2022 Mar 22. doi: 10.1038/s41417-022-00451-8. Online ahead of print.
Ref 3	The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate. J Biol Chem. 2017 Aug 25;292(34):14240-14249. doi: 10.1074/jbc.M117.798405. Epub 2017 Jun 19.
Ref 4	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 5	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 9	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 10	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 11	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 12	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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