m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00409)

Target Name	Protein sprouty homolog 2 (SPRY2)
Synonyms	Spry-2 Click to Show/Hide
Gene Name	SPRY2
Chromosomal Location	13q31.1
Family	sprouty family
Function	Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination. Click to Show/Hide
Gene ID	10253
Uniprot ID	SPY2_HUMAN
HGNC ID	HGNC:11270
KEGG ID	hsa:10253

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

SPRY2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

RNA demethylase ALKBH5 (ALKBH5) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5*
Cell Line	NOMO-1 cell line	Homo sapiens
Treatment: shALKBH5 NOMO-1 cells Control: shNS NOMO-1 cells		GSE144968
Regulation		logFC: -2.18E+00 p-value: 1.77E-03
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	ALKBH5 plays an antitumor role in colorectal cancer by modulating the FOXO3/miR-21/Protein sprouty homolog 2 (SPRY2) axis, which not only suggests a regulatory effect between ALKBH5 and FOXO3, but also provides a new therapeutic direction for colorectal cancer.
Target Regulation	Up regulation
Responsed Disease	Colorectal cancer		ICD-11: 2B91	Disease Info
Pathway Response	FoxO signaling pathway			hsa04068
In-vitro Model	Caco-2	Colon adenocarcinoma	Homo sapiens	CVCL_0025
	FHC	Normal	Homo sapiens	CVCL_3688
	HCT 116	Colon carcinoma	Homo sapiens	CVCL_0291
	SW480	Colon adenocarcinoma	Homo sapiens	CVCL_0546
	SW620	Colon adenocarcinoma	Homo sapiens	CVCL_0547

Colorectal cancer [ICD-11: 2B91]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	ALKBH5 plays an antitumor role in colorectal cancer by modulating the FOXO3/miR-21/Protein sprouty homolog 2 (SPRY2) axis, which not only suggests a regulatory effect between ALKBH5 and FOXO3, but also provides a new therapeutic direction for colorectal cancer.
Responsed Disease	Colorectal cancer [ICD-11: 2B91]
Target Regulator	RNA demethylase ALKBH5 (ALKBH5)		ERASER	Regulator Info
Target Regulation	Up regulation
Pathway Response	FoxO signaling pathway			hsa04068
In-vitro Model	Caco-2	Colon adenocarcinoma	Homo sapiens	CVCL_0025
	FHC	Normal	Homo sapiens	CVCL_3688
	HCT 116	Colon carcinoma	Homo sapiens	CVCL_0291
	SW480	Colon adenocarcinoma	Homo sapiens	CVCL_0546
	SW620	Colon adenocarcinoma	Homo sapiens	CVCL_0547

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Histone modification

m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03359		Crosstalk Info
Epigenetic Regulator	Histone deacetylase 2 (HDAC2)
Regulated Target	Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship	Histone modification → m6A
Disease	Colorectal cancer	Disease Info
Crosstalk ID: M6ACROT03455		Crosstalk Info
Epigenetic Regulator	Histone deacetylase 1 (HDAC1)
Regulated Target	Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship	Histone modification → m6A
Disease	Colorectal cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00409)

Protein sprouty homolog 2 (SPRY2)

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000179		Click to Show/Hide the Full List
mod site	chr13:80337750-80337751:-		[2]
Sequence	TCTTGGCTTCCTCAGGAGTTCAGATGTGTTCTAAGCCTGCT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m5C_site_11979

N6-methyladenosine (m6A)

In total 37 m6A sequence/site(s) in this target gene
mod ID: M6ASITE017933		Click to Show/Hide the Full List
mod site	chr13:80336080-80336081:-		[3]
Sequence	TTTATTTTAAGAGGCATCTTACAAATTTTGCCCCTTTTATG
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232616
mod ID: M6ASITE017934		Click to Show/Hide the Full List
mod site	chr13:80336202-80336203:-		[4]
Sequence	TTGGACTTCATGTATATTGTACAGTTACAGTAAAATTCAAC
Motif Score	2.856142857
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232617
mod ID: M6ASITE017935		Click to Show/Hide the Full List
mod site	chr13:80336236-80336237:-		[5]
Sequence	CAGAAAGCCTTTATTGTAAGACTCTGATTTCCCTTTGGACT
Motif Score	3.319380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232618
mod ID: M6ASITE017936		Click to Show/Hide the Full List
mod site	chr13:80336310-80336311:-		[3]
Sequence	ATATTATACTAATATGTTGTACATTCGGAAGAATGTGAATC
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232619
mod ID: M6ASITE017937		Click to Show/Hide the Full List
mod site	chr13:80336390-80336391:-		[3]
Sequence	TGTGCTATATTTTTGTATATACAATAATATTTGCAACTGTG
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232620
mod ID: M6ASITE017938		Click to Show/Hide the Full List
mod site	chr13:80336440-80336441:-		[5]
Sequence	AACTTGTAAATTAGCAGATGACTTTTTTCCATTGTTTTCTC
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232621
mod ID: M6ASITE017939		Click to Show/Hide the Full List
mod site	chr13:80336502-80336503:-		[3]
Sequence	CATAAGCTAAAGCAACACAGACACTCCTAGGCAAAGTTTTT
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232622
mod ID: M6ASITE017940		Click to Show/Hide the Full List
mod site	chr13:80336766-80336767:-		[6]
Sequence	CCCCCTAGGAACTTTGAAAAACCAACATAGCATCATTAATC
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232623
mod ID: M6ASITE017941		Click to Show/Hide the Full List
mod site	chr13:80336776-80336777:-		[6]
Sequence	TCCCACTGTCCCCCCTAGGAACTTTGAAAAACCAACATAGC
Motif Score	3.373380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232624
mod ID: M6ASITE017942		Click to Show/Hide the Full List
mod site	chr13:80336815-80336816:-		[6]
Sequence	TTGCCGCTGTAAAAACTCAAACACAGTTTGCTGCAAAGTTC
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232625
mod ID: M6ASITE017943		Click to Show/Hide the Full List
mod site	chr13:80336821-80336822:-		[6]
Sequence	GCCTGGTTGCCGCTGTAAAAACTCAAACACAGTTTGCTGCA
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232626
mod ID: M6ASITE017944		Click to Show/Hide the Full List
mod site	chr13:80336954-80336955:-		[3]
Sequence	GCAGCCAGTCTCACTGTTGTACACGATGGTCAGCCATGGGT
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232627
mod ID: M6ASITE017945		Click to Show/Hide the Full List
mod site	chr13:80337001-80337002:-		[7]
Sequence	CTGTTCTAATGATGATGAGGACAACTGTGCTGACAACCCAT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232628
mod ID: M6ASITE017946		Click to Show/Hide the Full List
mod site	chr13:80337056-80337057:-		[7]
Sequence	AGAACGTGATTGACTATGGGACTTGTGTATGCTGTGTGAAA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; Brain; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232629
mod ID: M6ASITE017947		Click to Show/Hide the Full List
mod site	chr13:80337064-80337065:-		[8]
Sequence	CTCGGCCCAGAACGTGATTGACTATGGGACTTGTGTATGCT
Motif Score	3.28175
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232630
mod ID: M6ASITE017948		Click to Show/Hide the Full List
mod site	chr13:80337073-80337074:-		[9]
Sequence	GTGCCTTTGCTCGGCCCAGAACGTGATTGACTATGGGACTT
Motif Score	2.925321429
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232631
mod ID: M6ASITE017949		Click to Show/Hide the Full List
mod site	chr13:80337100-80337101:-		[5]
Sequence	GCCATCAGACTGGATCTGCGACAAGCAGTGCCTTTGCTCGG
Motif Score	2.865571429
Cell/Tissue List	HEK293T; hESC-HEK293T; A549
Seq Type List	DART-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232632
mod ID: M6ASITE017950		Click to Show/Hide the Full List
mod site	chr13:80337112-80337113:-		[7]
Sequence	CCCAAGGCCTCTGCCATCAGACTGGATCTGCGACAAGCAGT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; Brain; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232633
mod ID: M6ASITE017951		Click to Show/Hide the Full List
mod site	chr13:80337166-80337167:-		[7]
Sequence	GCACGCCTACAGGTGTGAGGACTGTGGCAAGTGCAAATGTA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; Brain; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232634
mod ID: M6ASITE017952		Click to Show/Hide the Full List
mod site	chr13:80337303-80337304:-		[7]
Sequence	AGCAGCTCCTCTGAACAGAGACTGCTAGGATCATCCTTCTC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232635
mod ID: M6ASITE017953		Click to Show/Hide the Full List
mod site	chr13:80337309-80337310:-		[7]
Sequence	ACCAGCAGCAGCTCCTCTGAACAGAGACTGCTAGGATCATC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232636
mod ID: M6ASITE017954		Click to Show/Hide the Full List
mod site	chr13:80337335-80337336:-		[7]
Sequence	GGTCGCGGAGCAGTACGAGGACAAGTACCAGCAGCAGCTCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232637
mod ID: M6ASITE017955		Click to Show/Hide the Full List
mod site	chr13:80337462-80337463:-		[7]
Sequence	ACTCAGCACAAACACGAGAGACTCCACGGTCTGCCTGAGCA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232638
mod ID: M6ASITE017956		Click to Show/Hide the Full List
mod site	chr13:80337471-80337472:-		[7]
Sequence	CGCCCCTCCACTCAGCACAAACACGAGAGACTCCACGGTCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232639
mod ID: M6ASITE017957		Click to Show/Hide the Full List
mod site	chr13:80337513-80337514:-		[7]
Sequence	GGGCCTACTGTCGTCCCAAGACCTGGGCTCAAGCCTGCTCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232640
mod ID: M6ASITE017958		Click to Show/Hide the Full List
mod site	chr13:80337553-80337554:-		[7]
Sequence	TCAGATCAGAGCCATCCGAAACACCAATGAGTACACAGAGG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232641
mod ID: M6ASITE017959		Click to Show/Hide the Full List
mod site	chr13:80337591-80337592:-		[3]
Sequence	GACGCCCTCACCCAGCAGGTACATGTCTTGTCTCTGGATCA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232642
mod ID: M6ASITE017960		Click to Show/Hide the Full List
mod site	chr13:80337636-80337637:-		[7]
Sequence	ACGCCCCGTGACGGTGGCAGACAGCGTGGGGAGCCCGACCC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MT4; H1299; MM6; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232643
mod ID: M6ASITE017961		Click to Show/Hide the Full List
mod site	chr13:80337709-80337710:-		[7]
Sequence	GGAGTGACCACACTTCCAAGACCTGATGGAGGCCAGAGCTC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; HepG2; H1A; H1B; H1299; MM6; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; TIME; MSC; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232644
mod ID: M6ASITE017962		Click to Show/Hide the Full List
mod site	chr13:80337720-80337721:-		[3]
Sequence	CTAAGCCTGCTGGAGTGACCACACTTCCAAGACCTGATGGA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232645
mod ID: M6ASITE017963		Click to Show/Hide the Full List
mod site	chr13:80338885-80338886:-		[10]
Sequence	GGGGCACAGAGAGGCGATAAACTAAGTGAAAGCAAAGAGCA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; GSC-11
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232646
mod ID: M6ASITE017964		Click to Show/Hide the Full List
mod site	chr13:80338950-80338951:-		[10]
Sequence	GCGTCAGTCCGCCTGGAGAAACTCCCCTGGGGATCGGCTGT
Motif Score	2.627720238
Cell/Tissue List	GSC-11
Seq Type List	m6A-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232647
mod ID: M6ASITE017965		Click to Show/Hide the Full List
mod site	chr13:80338973-80338974:-		[10]
Sequence	GGGGGCAGCCTGGCCCATGGACAGCGTCAGTCCGCCTGGAG
Motif Score	3.643047619
Cell/Tissue List	GSC-11
Seq Type List	m6A-seq
Transcript ID List	ENST00000377104.4; ENST00000377102.5
External Link	RMBase: m6A_site_232648
mod ID: M6ASITE017966		Click to Show/Hide the Full List
mod site	chr13:80339652-80339653:-		[7]
Sequence	ACTTTCAAAGGGGAGGGGGGACTGGGAAAGAGAAGAGGGGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; H1B; MM6; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000377102.5; ENST00000377104.4
External Link	RMBase: m6A_site_232649
mod ID: M6ASITE017967		Click to Show/Hide the Full List
mod site	chr13:80340677-80340678:-		[3]
Sequence	TCGAGACTGGATTTATTTGCACATCGCAGAAAGAAGAGAAT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377104.4
External Link	RMBase: m6A_site_232650
mod ID: M6ASITE017968		Click to Show/Hide the Full List
mod site	chr13:80340692-80340693:-		[7]
Sequence	GGAAAAAAGTTTGCATCGAGACTGGATTTATTTGCACATCG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; H1B; MM6; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000377104.4
External Link	RMBase: m6A_site_232651
mod ID: M6ASITE017969		Click to Show/Hide the Full List
mod site	chr13:80340811-80340812:-		[7]
Sequence	GGAGTCGTCTCCAGCTCCGAACCCCGGAGTGTTCATCAGCG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000377104.4
External Link	RMBase: m6A_site_232652

Ref 1	m(6)A demethylase ALKBH5 inhibits cell proliferation and the metastasis of colorectal cancer by regulating the FOXO3/miR-21/SPRY2 axis. Am J Transl Res. 2021 Oct 15;13(10):11209-11222. eCollection 2021.
Ref 2	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 3	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 4	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 5	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 6	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 7	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 8	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
Ref 9	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 10	m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell. 2017 Apr 10;31(4):591-606.e6. doi: 10.1016/j.ccell.2017.02.013. Epub 2017 Mar 23.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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