m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00395)

Target Name	Small kinetochore-associated protein (KNSTRN)
Synonyms	SKAP; Kinetochore-localized astrin-binding protein; Kinastrin; Kinetochore-localized astrin/SPAG5-binding protein; TRAF4-associated factor 1; C15orf23; SKAP; TRAF4AF1; HSD11 Click to Show/Hide
Gene Name	KNSTRN
Chromosomal Location	15q15.1
Function	Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences . Click to Show/Hide
Gene ID	90417
Uniprot ID	SKAP_HUMAN
HGNC ID	HGNC:30767
KEGG ID	hsa:90417

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

KNSTRN can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Disease

Colorectal cancer [ICD-11: 2B91]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response		[]
Response Summary	The study highlights a robust correlation between the level of cancer stemness and traits related to tumor heterogeneity, including the immune microenvironment, TMB, and the expression of m6A RNA methylation regulatory factors in colorectal cancer cells. A three-gene prognostic signature (PARPBP, Small kinetochore-associated protein (KNSTRN), and KIF2C) was explored together with specific clinical features to construct a nomogram, which was successfully validated in an external cohort.
Responsed Disease	Colorectal cancer [ICD-11: 2B91]

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00395)

Small kinetochore-associated protein (KNSTRN)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE006762		Click to Show/Hide the Full List
mod site	chr15:40390330-40390331:+		[1]
Sequence	TTCCTTTCAAGCATACTAGTAATCCCAAATGGGAAGAGAAA
Transcript ID List	ENST00000561169.5; ENST00000448395.6; ENST00000559304.5; ENST00000560321.5; ENST00000559083.1; ENST00000249776.12; ENST00000416151.6; ENST00000608100.5; ENST00000560220.5; ENST00000560981.5; ENST00000561367.1
External Link	RMBase: RNA-editing_site_42388

N6-methyladenosine (m6A)

In total 44 m6A sequence/site(s) in this target gene
mod ID: M6ASITE022396		Click to Show/Hide the Full List
mod site	chr15:40382946-40382947:+		[2]
Sequence	ACCGGAAGTTTCTATTTGAAACCCAGGCGGCCGACTTAGCC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; fibroblasts; A549; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000249776.12; ENST00000559591.5; ENST00000608100.5; ENST00000559604.1; ENST00000560981.5; ENST00000416151.6; ENST00000560321.5; ENST00000448395.6
External Link	RMBase: m6A_site_271186
mod ID: M6ASITE022397		Click to Show/Hide the Full List
mod site	chr15:40383016-40383017:+		[2]
Sequence	TTTAAACGAGAGCGAGAAGGACTGCGGGCAGGACCGGCGGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; fibroblasts; Jurkat; HEK293A-TOA; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000559604.1; ENST00000561196.5; ENST00000560220.5; ENST00000416151.6; ENST00000560321.5; ENST00000608100.5; ENST00000249776.12; ENST00000560673.1; ENST00000559304.5; ENST00000557920.1; ENST00000561169.5; ENST00000559591.5; ENST00000560981.5; ENST00000448395.6
External Link	RMBase: m6A_site_271187
mod ID: M6ASITE022398		Click to Show/Hide the Full List
mod site	chr15:40383028-40383029:+		[2]
Sequence	CGAGAAGGACTGCGGGCAGGACCGGCGGGCTCCTGGGTTCG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; fibroblasts; MT4; Jurkat; HEK293A-TOA; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000561169.5; ENST00000559304.5; ENST00000559604.1; ENST00000557920.1; ENST00000249776.12; ENST00000560220.5; ENST00000448395.6; ENST00000560981.5; ENST00000560673.1; ENST00000416151.6; ENST00000608100.5; ENST00000560321.5; ENST00000561196.5; ENST00000559591.5
External Link	RMBase: m6A_site_271188
mod ID: M6ASITE022399		Click to Show/Hide the Full List
mod site	chr15:40383270-40383271:+		[3]
Sequence	CGATGACCAGTGTGGTTAAGACAGTGTATAGCCTGCAGCCC
Motif Score	2.897386905
Cell/Tissue List	HepG2; HeLa; A549; fibroblasts; MT4; Jurkat; peripheral-blood; HEK293A-TOA; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000559604.1; ENST00000608100.5; ENST00000560220.5; ENST00000560321.5; ENST00000560981.5; ENST00000559591.5; ENST00000416151.6; ENST00000561196.5; ENST00000249776.12; ENST00000557920.1; ENST00000559304.5; ENST00000559083.1; ENST00000448395.6; ENST00000561169.5; ENST00000560673.1
External Link	RMBase: m6A_site_271189
mod ID: M6ASITE022400		Click to Show/Hide the Full List
mod site	chr15:40384761-40384762:+		[2]
Sequence	GAAAAAAAAAAAGGTGGAAAACCATATACAATGATAAACAA
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000416151.6; ENST00000559591.5; ENST00000559304.5; ENST00000560673.1; ENST00000559083.1; ENST00000448395.6; ENST00000560981.5; ENST00000560220.5; ENST00000249776.12; ENST00000557920.1; ENST00000560321.5; ENST00000561169.5; ENST00000608100.5
External Link	RMBase: m6A_site_271190
mod ID: M6ASITE022401		Click to Show/Hide the Full List
mod site	chr15:40384778-40384779:+		[2]
Sequence	AAAACCATATACAATGATAAACAAGTTTCCTTCCCTTCCTT
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000561169.5; ENST00000249776.12; ENST00000557920.1; ENST00000608100.5; ENST00000560220.5; ENST00000560321.5; ENST00000559304.5; ENST00000559591.5; ENST00000559083.1; ENST00000416151.6; ENST00000448395.6; ENST00000560981.5; ENST00000560673.1
External Link	RMBase: m6A_site_271191
mod ID: M6ASITE022402		Click to Show/Hide the Full List
mod site	chr15:40386361-40386362:+		[4]
Sequence	CCTCTCATTTTCCTTTGCAGACACACAAACTCGGGCCACTT
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000560673.1; ENST00000560981.5; ENST00000560321.5; ENST00000608100.5; ENST00000557920.1; ENST00000448395.6; ENST00000416151.6; ENST00000559304.5; ENST00000560220.5; ENST00000561169.5; ENST00000559083.1; ENST00000249776.12
External Link	RMBase: m6A_site_271192
mod ID: M6ASITE022403		Click to Show/Hide the Full List
mod site	chr15:40386365-40386366:+		[4]
Sequence	TCATTTTCCTTTGCAGACACACAAACTCGGGCCACTTCTAA
Motif Score	2.084928571
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000249776.12; ENST00000559304.5; ENST00000561169.5; ENST00000416151.6; ENST00000560673.1; ENST00000560981.5; ENST00000557920.1; ENST00000560321.5; ENST00000560220.5; ENST00000559083.1; ENST00000448395.6; ENST00000608100.5
External Link	RMBase: m6A_site_271193
mod ID: M6ASITE022404		Click to Show/Hide the Full List
mod site	chr15:40386462-40386463:+		[4]
Sequence	GAGGTCCAGAGAATGATGTTACAAAAATCACCAAACTGAGA
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000560220.5; ENST00000608100.5; ENST00000560981.5; ENST00000559083.1; ENST00000561169.5; ENST00000249776.12; ENST00000560321.5; ENST00000559304.5; ENST00000448395.6; ENST00000560673.1; ENST00000416151.6; ENST00000557920.1
External Link	RMBase: m6A_site_271194
mod ID: M6ASITE022405		Click to Show/Hide the Full List
mod site	chr15:40387175-40387176:+		[4]
Sequence	TAGGCAAATGAAAGCTACTGACACTGCCACCAGAAGGAATG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000557920.1; ENST00000559304.5; ENST00000561169.5; ENST00000448395.6; ENST00000416151.6; ENST00000249776.12; ENST00000559083.1; ENST00000560220.5; ENST00000560321.5; ENST00000560981.5; ENST00000608100.5
External Link	RMBase: m6A_site_271195
mod ID: M6ASITE022406		Click to Show/Hide the Full List
mod site	chr15:40389507-40389508:+		[4]
Sequence	GTACAACTATTATTACAGCTACAAACCACTGAGTAAGCAAA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000557920.1; ENST00000448395.6; ENST00000560220.5; ENST00000561169.5; ENST00000559083.1; ENST00000249776.12; ENST00000559304.5; ENST00000416151.6; ENST00000608100.5; ENST00000560981.5; ENST00000560321.5
External Link	RMBase: m6A_site_271196
mod ID: M6ASITE022407		Click to Show/Hide the Full List
mod site	chr15:40389511-40389512:+		[5]
Sequence	AACTATTATTACAGCTACAAACCACTGAGTAAGCAAAAATC
Motif Score	2.185083333
Cell/Tissue List	H1299; Jurkat; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000560321.5; ENST00000249776.12; ENST00000448395.6; ENST00000416151.6; ENST00000560220.5; ENST00000557920.1; ENST00000561169.5; ENST00000560981.5; ENST00000559083.1; ENST00000608100.5; ENST00000559304.5
External Link	RMBase: m6A_site_271197
mod ID: M6ASITE022408		Click to Show/Hide the Full List
mod site	chr15:40389549-40389550:+		[4]
Sequence	ATCAGAGGAAGAGCTCAAGGACAAGAACCAGCTGTTAGAAG
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; H1299; Jurkat; peripheral-blood; endometrial; NB4; MM6
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000559083.1; ENST00000560981.5; ENST00000249776.12; ENST00000559304.5; ENST00000416151.6; ENST00000557920.1; ENST00000560220.5; ENST00000608100.5; ENST00000448395.6; ENST00000561169.5; ENST00000560321.5
External Link	RMBase: m6A_site_271198
mod ID: M6ASITE022409		Click to Show/Hide the Full List
mod site	chr15:40389555-40389556:+		[5]
Sequence	GGAAGAGCTCAAGGACAAGAACCAGCTGTTAGAAGCCGTCA
Motif Score	2.930744048
Cell/Tissue List	H1299; Jurkat; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000559304.5; ENST00000559083.1; ENST00000560321.5; ENST00000416151.6; ENST00000249776.12; ENST00000560220.5; ENST00000561169.5; ENST00000448395.6; ENST00000560981.5; ENST00000608100.5; ENST00000557920.1
External Link	RMBase: m6A_site_271199
mod ID: M6ASITE022410		Click to Show/Hide the Full List
mod site	chr15:40389576-40389577:+		[4]
Sequence	CCAGCTGTTAGAAGCCGTCAACAAGCAGTTGCACCAGAAGT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000561169.5; ENST00000559083.1; ENST00000249776.12; ENST00000608100.5; ENST00000559304.5; ENST00000560981.5; ENST00000416151.6; ENST00000448395.6; ENST00000557920.1; ENST00000560220.5; ENST00000560321.5
External Link	RMBase: m6A_site_271200
mod ID: M6ASITE022411		Click to Show/Hide the Full List
mod site	chr15:40389605-40389606:+		[5]
Sequence	TGCACCAGAAGTTGACTGAAACTCAGGTAAGAGACCCACCA
Motif Score	2.627720238
Cell/Tissue List	H1299; Jurkat; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000249776.12; ENST00000416151.6; ENST00000448395.6; ENST00000557920.1; ENST00000561169.5; ENST00000559304.5; ENST00000608100.5; ENST00000560981.5; ENST00000560220.5; ENST00000560321.5; ENST00000559083.1
External Link	RMBase: m6A_site_271201
mod ID: M6ASITE022412		Click to Show/Hide the Full List
mod site	chr15:40389848-40389849:+		[6]
Sequence	CCAATAGGGAGAGCTGAAGGACCTGACCCAGAAGGTAGAGC
Motif Score	3.622404762
Cell/Tissue List	BGC823; Jurkat; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000608100.5; ENST00000557920.1; ENST00000560981.5; ENST00000559304.5; ENST00000249776.12; ENST00000416151.6; ENST00000559083.1; ENST00000448395.6; ENST00000561367.1; ENST00000561169.5; ENST00000560220.5; ENST00000560321.5
External Link	RMBase: m6A_site_271202
mod ID: M6ASITE022413		Click to Show/Hide the Full List
mod site	chr15:40389887-40389888:+		[4]
Sequence	GCTGCTGGAGAAGTTTCGGGACAACTGTTTGGCAATTTTGG
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; BGC823; Jurkat; peripheral-blood; endometrial; NB4; MM6
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000448395.6; ENST00000557920.1; ENST00000560981.5; ENST00000561367.1; ENST00000249776.12; ENST00000559083.1; ENST00000608100.5; ENST00000560220.5; ENST00000560321.5; ENST00000559304.5; ENST00000416151.6; ENST00000561169.5
External Link	RMBase: m6A_site_271203
mod ID: M6ASITE022414		Click to Show/Hide the Full List
mod site	chr15:40391506-40391507:+		[6]
Sequence	CATCAGCTTTAGGCAGTGAGACCCTGGCATCACGACAAGAA
Motif Score	2.876744048
Cell/Tissue List	BGC823; Jurkat; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000561169.5; ENST00000448395.6; ENST00000560220.5; ENST00000608100.5; ENST00000561367.1; ENST00000560981.5; ENST00000249776.12; ENST00000559083.1; ENST00000559304.5; ENST00000416151.6; ENST00000560321.5
External Link	RMBase: m6A_site_271204
mod ID: M6ASITE022415		Click to Show/Hide the Full List
mod site	chr15:40391520-40391521:+		[4]
Sequence	AGTGAGACCCTGGCATCACGACAAGAATCCACTACTGATCA
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000608100.5; ENST00000561169.5; ENST00000560321.5; ENST00000559083.1; ENST00000416151.6; ENST00000561367.1; ENST00000560220.5; ENST00000560981.5; ENST00000448395.6; ENST00000249776.12; ENST00000559304.5
External Link	RMBase: m6A_site_271205
mod ID: M6ASITE022416		Click to Show/Hide the Full List
mod site	chr15:40391540-40391541:+		[4]
Sequence	ACAAGAATCCACTACTGATCACATGGACTCTATGGTGAGGG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000608100.5; ENST00000448395.6; ENST00000559304.5; ENST00000249776.12; ENST00000560220.5; ENST00000561169.5; ENST00000560321.5; ENST00000561367.1; ENST00000416151.6; ENST00000560981.5; ENST00000559083.1
External Link	RMBase: m6A_site_271206
mod ID: M6ASITE022417		Click to Show/Hide the Full List
mod site	chr15:40391546-40391547:+		[6]
Sequence	ATCCACTACTGATCACATGGACTCTATGGTGAGGGCATGGG
Motif Score	4.065041667
Cell/Tissue List	BGC823; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000560981.5; ENST00000416151.6; ENST00000560321.5; ENST00000560220.5; ENST00000559304.5; ENST00000561169.5; ENST00000561367.1; ENST00000448395.6; ENST00000559083.1; ENST00000608100.5; ENST00000249776.12
External Link	RMBase: m6A_site_271207
mod ID: M6ASITE022418		Click to Show/Hide the Full List
mod site	chr15:40391641-40391642:+		[6]
Sequence	CTCTGCTATATATTCCATAAACTCCAAGAAACAGCCTTTGA
Motif Score	2.627720238
Cell/Tissue List	BGC823
Seq Type List	m6A-seq
Transcript ID List	ENST00000559083.1; ENST00000561367.1; ENST00000560981.5; ENST00000416151.6; ENST00000448395.6; ENST00000608100.5; ENST00000560220.5; ENST00000560321.5; ENST00000249776.12; ENST00000559304.5; ENST00000561169.5
External Link	RMBase: m6A_site_271208
mod ID: M6ASITE022419		Click to Show/Hide the Full List
mod site	chr15:40391651-40391652:+		[6]
Sequence	TATTCCATAAACTCCAAGAAACAGCCTTTGATTATCTGTGA
Motif Score	2.20572619
Cell/Tissue List	BGC823
Seq Type List	m6A-seq
Transcript ID List	ENST00000560981.5; ENST00000448395.6; ENST00000561367.1; ENST00000560220.5; ENST00000249776.12; ENST00000561169.5; ENST00000560321.5; ENST00000559304.5; ENST00000416151.6; ENST00000608100.5; ENST00000559083.1
External Link	RMBase: m6A_site_271209
mod ID: M6ASITE022420		Click to Show/Hide the Full List
mod site	chr15:40391960-40391961:+		[6]
Sequence	CCTCTTAGTTGCTGTTAGAAACTTTGCAAGAGGAGCTGAAG
Motif Score	2.627720238
Cell/Tissue List	BGC823
Seq Type List	m6A-seq
Transcript ID List	ENST00000559304.5; ENST00000561169.5; ENST00000448395.6; ENST00000559083.1; ENST00000608100.5; ENST00000416151.6; ENST00000561367.1; ENST00000560220.5; ENST00000560321.5; ENST00000560981.5; ENST00000249776.12
External Link	RMBase: m6A_site_271210
mod ID: M6ASITE022421		Click to Show/Hide the Full List
mod site	chr15:40391993-40391994:+		[7]
Sequence	AGCTGAAGCTTTTTAACGAAACAGCCAAAAAGCAGATGGAG
Motif Score	2.20572619
Cell/Tissue List	HEK293; BGC823
Seq Type List	m6A-REF-seq; m6A-seq
Transcript ID List	ENST00000561367.1; ENST00000560981.5; ENST00000448395.6; ENST00000560321.5; ENST00000416151.6; ENST00000608100.5; ENST00000560220.5; ENST00000559304.5; ENST00000559083.1; ENST00000249776.12; ENST00000561169.5
External Link	RMBase: m6A_site_271211
mod ID: M6ASITE022422		Click to Show/Hide the Full List
mod site	chr15:40393518-40393519:+		[2]
Sequence	GAAAGAGTCCGATTCCTAGAACAGCAAACCTTATGTAACAA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; U2OS; fibroblasts; LCLs; H1299; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000560981.5; ENST00000249776.12; ENST00000560321.5; ENST00000561169.5; ENST00000416151.6; ENST00000560220.5; ENST00000448395.6; ENST00000559304.5; ENST00000608100.5
External Link	RMBase: m6A_site_271212
mod ID: M6ASITE022423		Click to Show/Hide the Full List
mod site	chr15:40393525-40393526:+		[2]
Sequence	TCCGATTCCTAGAACAGCAAACCTTATGTAACAATCAAGTA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; U2OS; fibroblasts; LCLs; H1299; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000249776.12; ENST00000560981.5; ENST00000561169.5; ENST00000608100.5; ENST00000559304.5; ENST00000416151.6; ENST00000448395.6; ENST00000560220.5; ENST00000560321.5
External Link	RMBase: m6A_site_271213
mod ID: M6ASITE022424		Click to Show/Hide the Full List
mod site	chr15:40393659-40393660:+		[2]
Sequence	CTCAGAGGAAGCTACTTAGGACATCATCTTGGCCATGATCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000416151.6; ENST00000608100.5; ENST00000560321.5; ENST00000249776.12; ENST00000448395.6; ENST00000560981.5; ENST00000561169.5
External Link	RMBase: m6A_site_271214
mod ID: M6ASITE022425		Click to Show/Hide the Full List
mod site	chr15:40393686-40393687:+		[2]
Sequence	CTTGGCCATGATCTTCTGGGACTCACCATCTCCAGAATGAA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000560981.5; ENST00000448395.6; ENST00000416151.6; ENST00000249776.12; ENST00000608100.5; ENST00000561169.5
External Link	RMBase: m6A_site_271215
mod ID: M6ASITE022426		Click to Show/Hide the Full List
mod site	chr15:40393708-40393709:+		[2]
Sequence	TCACCATCTCCAGAATGAAAACAATTTCTACAGTAGACTTA
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000560981.5; ENST00000608100.5; ENST00000416151.6; ENST00000249776.12; ENST00000448395.6; ENST00000561169.5
External Link	RMBase: m6A_site_271216
mod ID: M6ASITE022427		Click to Show/Hide the Full List
mod site	chr15:40393724-40393725:+		[2]
Sequence	GAAAACAATTTCTACAGTAGACTTAAGGACAGTTTATGCTG
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000416151.6; ENST00000560981.5; ENST00000448395.6; ENST00000249776.12; ENST00000608100.5; ENST00000561169.5
External Link	RMBase: m6A_site_271217
mod ID: M6ASITE022428		Click to Show/Hide the Full List
mod site	chr15:40393732-40393733:+		[2]
Sequence	TTTCTACAGTAGACTTAAGGACAGTTTATGCTGAAATGGCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000249776.12; ENST00000416151.6; ENST00000608100.5; ENST00000448395.6; ENST00000560981.5; ENST00000561169.5
External Link	RMBase: m6A_site_271218
mod ID: M6ASITE022429		Click to Show/Hide the Full List
mod site	chr15:40393831-40393832:+		[4]
Sequence	CAGGTGGATAATTGAGGCCTACAAGAGAGGGGAGCCTAGGA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000560981.5; ENST00000608100.5; ENST00000448395.6; ENST00000416151.6; ENST00000561169.5; ENST00000249776.12
External Link	RMBase: m6A_site_271219
mod ID: M6ASITE022430		Click to Show/Hide the Full List
mod site	chr15:40393882-40393883:+		[8]
Sequence	ACCTTCTAGTCAACCACCTGACTTCAGCACACCATTACAAT
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000560981.5; ENST00000249776.12; ENST00000561169.5; ENST00000416151.6; ENST00000608100.5; ENST00000448395.6
External Link	RMBase: m6A_site_271220
mod ID: M6ASITE022431		Click to Show/Hide the Full List
mod site	chr15:40393890-40393891:+		[4]
Sequence	GTCAACCACCTGACTTCAGCACACCATTACAATCGGGAGAC
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000249776.12; ENST00000608100.5; ENST00000416151.6; ENST00000561169.5; ENST00000448395.6; ENST00000560981.5
External Link	RMBase: m6A_site_271221
mod ID: M6ASITE022432		Click to Show/Hide the Full List
mod site	chr15:40393909-40393910:+		[2]
Sequence	CACACCATTACAATCGGGAGACTAAACCAACAACCAGAGGA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000249776.12; ENST00000608100.5; ENST00000560981.5; ENST00000448395.6; ENST00000416151.6; ENST00000561169.5
External Link	RMBase: m6A_site_271222
mod ID: M6ASITE022433		Click to Show/Hide the Full List
mod site	chr15:40393914-40393915:+		[2]
Sequence	CATTACAATCGGGAGACTAAACCAACAACCAGAGGATCTAA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000608100.5; ENST00000416151.6; ENST00000561169.5; ENST00000560981.5; ENST00000249776.12; ENST00000448395.6
External Link	RMBase: m6A_site_271223
mod ID: M6ASITE022434		Click to Show/Hide the Full List
mod site	chr15:40394001-40394002:+		[2]
Sequence	GCACAAATGTTCCATACAAGACATCATTGAGGAGCCATGCT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000608100.5; ENST00000560981.5; ENST00000416151.6; ENST00000249776.12; ENST00000561169.5; ENST00000448395.6
External Link	RMBase: m6A_site_271224
mod ID: M6ASITE022435		Click to Show/Hide the Full List
mod site	chr15:40394040-40394041:+		[2]
Sequence	CTGTCCCCTTCTAACCTGAAACACATTCTTTCCCATCCTGG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; hESCs; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000608100.5; ENST00000416151.6; ENST00000560981.5; ENST00000561169.5; ENST00000448395.6; ENST00000249776.12
External Link	RMBase: m6A_site_271225
mod ID: M6ASITE022436		Click to Show/Hide the Full List
mod site	chr15:40394093-40394094:+		[2]
Sequence	ACCTCCTTATTAATTTATGAACCTGAAGTTGCTTGAAGTGT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000608100.5; ENST00000448395.6; ENST00000560981.5; ENST00000416151.6; ENST00000249776.12; ENST00000561169.5
External Link	RMBase: m6A_site_271226
mod ID: M6ASITE022437		Click to Show/Hide the Full List
mod site	chr15:40394154-40394155:+		[4]
Sequence	TGAAAGTATAGGTAGCAGTAACACCTACATGAAACAATACA
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000448395.6; ENST00000249776.12; ENST00000608100.5; ENST00000560981.5; ENST00000561169.5
External Link	RMBase: m6A_site_271227
mod ID: M6ASITE022438		Click to Show/Hide the Full List
mod site	chr15:40394167-40394168:+		[2]
Sequence	AGCAGTAACACCTACATGAAACAATACACCTTGGATCTTTT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; GM12878; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000448395.6; ENST00000560981.5; ENST00000608100.5; ENST00000249776.12
External Link	RMBase: m6A_site_271228
mod ID: M6ASITE022439		Click to Show/Hide the Full List
mod site	chr15:40394172-40394173:+		[4]
Sequence	TAACACCTACATGAAACAATACACCTTGGATCTTTTAATCT
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000608100.5; ENST00000249776.12
External Link	RMBase: m6A_site_271229

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000056		Click to Show/Hide the Full List
mod site	chr15:40393633-40393634:+		[9]
Sequence	AGATGGCTCCCTCTTGGGCATAAAATCTCAGAGGAAGCTAC
Transcript ID List	ENST00000416151.6; ENST00000561169.5; ENST00000608100.5; ENST00000249776.12; ENST00000560981.5; ENST00000560321.5; ENST00000448395.6
External Link	RMBase: Pseudo_site_1585

Ref 1	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 4	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 5	The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 May 5;62(3):335-345. doi: 10.1016/j.molcel.2016.03.021. Epub 2016 Apr 21.
Ref 6	METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer. Mol Cancer. 2019 Oct 13;18(1):142. doi: 10.1186/s12943-019-1065-4.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 8	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 9	Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11(8):592-7. doi: 10.1038/nchembio.1836. Epub 2015 Jun 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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