m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00350)

Target Name	RNA-binding protein NOB1 (NOB1)
Synonyms	Phosphorylation regulatory protein HP-10; Protein ART-4; ART4; NOB1P; PSMD8BP1; MSTP158 Click to Show/Hide
Gene Name	NOB1
Chromosomal Location	16q22.1
Family	NOB1 family
Function	May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). Click to Show/Hide
Gene ID	28987
Uniprot ID	NOB1_HUMAN
HGNC ID	HGNC:29540
KEGG ID	hsa:28987

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

NOB1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Disease

Lung cancer [ICD-11: 2C25]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response		[]
Response Summary	ABALON acted as a competing endogenous RNA by sponging miR-139-3p and indirectly regulated the expression of RNA-binding protein NOB1 (NOB1) in the occurrence of lung cancer.
Responsed Disease	Lung cancer [ICD-11: 2C25]
Pathway Response	T cell receptor signaling pathway	hsa04660
	Ribosome biogenesis in eukaryotes	hsa03008
Cell Process	Immune

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00350)

RNA-binding protein NOB1 (NOB1)

N6-methyladenosine (m6A)

In total 36 m6A sequence/site(s) in this target gene
mod ID: M6ASITE028268		Click to Show/Hide the Full List
mod site	chr16:69741876-69741877:-		[1]
Sequence	AGGTTATAATAAAACTAAGAACTACCATTTCTTTCTTTTCT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328582
mod ID: M6ASITE028269		Click to Show/Hide the Full List
mod site	chr16:69741883-69741884:-		[1]
Sequence	AAATACAAGGTTATAATAAAACTAAGAACTACCATTTCTTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; Huh7
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328583
mod ID: M6ASITE028270		Click to Show/Hide the Full List
mod site	chr16:69741899-69741900:-		[2]
Sequence	TTATATTTTTGCCAGAAAATACAAGGTTATAATAAAACTAA
Motif Score	2.110482143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328584
mod ID: M6ASITE028271		Click to Show/Hide the Full List
mod site	chr16:69741955-69741956:-		[2]
Sequence	TAGGTCATCTCAAGGCTGATACTTGAGCTGTGTGCCCAGAG
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328585
mod ID: M6ASITE028272		Click to Show/Hide the Full List
mod site	chr16:69742089-69742090:-		[1]
Sequence	ATTGCATAAAAACAGAAAGAACAACGCCCTGGAGCCAATCT
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328586
mod ID: M6ASITE028273		Click to Show/Hide the Full List
mod site	chr16:69742098-69742099:-		[1]
Sequence	GGAAGTGCAATTGCATAAAAACAGAAAGAACAACGCCCTGG
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328587
mod ID: M6ASITE028274		Click to Show/Hide the Full List
mod site	chr16:69742164-69742165:-		[1]
Sequence	CTGGGTCTGCAGGGAACTGGACTGTCCCATGGCCTGTGAGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328589
mod ID: M6ASITE028275		Click to Show/Hide the Full List
mod site	chr16:69742169-69742170:-		[1]
Sequence	CCCCGCTGGGTCTGCAGGGAACTGGACTGTCCCATGGCCTG
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328590
mod ID: M6ASITE028276		Click to Show/Hide the Full List
mod site	chr16:69742226-69742227:-		[3]
Sequence	AGGACCACCCGATGGAAATAACAGGCGGGCTTCACGGTGCG
Motif Score	2.168095238
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328593
mod ID: M6ASITE028277		Click to Show/Hide the Full List
mod site	chr16:69742243-69742244:-		[1]
Sequence	CCAGCCGTGTCGTCTCCAGGACCACCCGATGGAAATAACAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328594
mod ID: M6ASITE028278		Click to Show/Hide the Full List
mod site	chr16:69742404-69742405:-		[1]
Sequence	AGCTACCCTGCAGGTCCGGGACAGCACCTTGGGAGCTGGGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; H1A; H1B; hNPCs; hESCs; fibroblasts; A549; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; HEK293A-TOA; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328598
mod ID: M6ASITE028279		Click to Show/Hide the Full List
mod site	chr16:69742495-69742496:-		[1]
Sequence	CCCAAAAGGCCAGGCAGAAAACCAACGTGTTCGCCCCTGAC
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; HEK293A-TOA; MSC; TIME; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10
External Link	RMBase: m6A_site_328601
mod ID: M6ASITE028280		Click to Show/Hide the Full List
mod site	chr16:69744888-69744889:-		[1]
Sequence	CCGCAACCCCAAGGTGCTGAACCCCCGCGGCCTCCGGGTGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; MM6; Huh7; peripheral-blood; HEK293T; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000569871.5; ENST00000268802.10
External Link	RMBase: m6A_site_328604
mod ID: M6ASITE028281		Click to Show/Hide the Full List
mod site	chr16:69744967-69744968:-		[1]
Sequence	GCTCACACTGTGGGAACAAGACCCTGAAGAAAGTGTCCGTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MM6; Huh7; peripheral-blood; HEK293T; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10; ENST00000564620.5; ENST00000569871.5
External Link	RMBase: m6A_site_328605
mod ID: M6ASITE028282		Click to Show/Hide the Full List
mod site	chr16:69744972-69744973:-		[1]
Sequence	GTTCTGCTCACACTGTGGGAACAAGACCCTGAAGAAAGTGT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; Huh7; peripheral-blood; HEK293T; endometrial; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10; ENST00000569871.5; ENST00000564620.5
External Link	RMBase: m6A_site_328606
mod ID: M6ASITE028283		Click to Show/Hide the Full List
mod site	chr16:69748755-69748756:-		[1]
Sequence	TAATTTTGCTTAGAGGCTAGACAATCGTCATATAATGACAA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000268802.10; ENST00000564620.5; ENST00000561677.6; ENST00000569871.5
External Link	RMBase: m6A_site_328607
mod ID: M6ASITE028284		Click to Show/Hide the Full List
mod site	chr16:69748800-69748801:-		[1]
Sequence	TTCTTTTCCTGGTTCTGGAAACCACCTGTGCCATTTGGTGA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; peripheral-blood; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000569871.5; ENST00000561677.6; ENST00000268802.10; ENST00000564620.5
External Link	RMBase: m6A_site_328608
mod ID: M6ASITE028285		Click to Show/Hide the Full List
mod site	chr16:69748838-69748839:-		[1]
Sequence	GGTGTACAGATGTACACGGAACTGGTGCTGTGCAGCGCTTC
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000569871.5; ENST00000268802.10; ENST00000564620.5; ENST00000561677.6
External Link	RMBase: m6A_site_328609
mod ID: M6ASITE028286		Click to Show/Hide the Full List
mod site	chr16:69748930-69748931:-		[1]
Sequence	GGTTGGCTGCCTGACCACAGACTTCGCCATGCAGGTGGGTA
Motif Score	3.319380952
Cell/Tissue List	HeLa; MM6; Huh7; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10; ENST00000561677.6; ENST00000564620.5; ENST00000569871.5
External Link	RMBase: m6A_site_328610
mod ID: M6ASITE028287		Click to Show/Hide the Full List
mod site	chr16:69749056-69749057:-		[1]
Sequence	GGAAGAAAACGGGTTTGAAGACAGAAAAGATGACAGCGATG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; hNPCs; fibroblasts; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000569871.5; ENST00000563055.1; ENST00000561677.6; ENST00000268802.10; ENST00000564620.5
External Link	RMBase: m6A_site_328611
mod ID: M6ASITE028288		Click to Show/Hide the Full List
mod site	chr16:69749113-69749114:-		[4]
Sequence	TCTGTTGATGTTTCAGATTGACAGAGGTGAGGACGTTCCAA
Motif Score	2.859755952
Cell/Tissue List	kidney; liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000561677.6; ENST00000268802.10; ENST00000564620.5; ENST00000569871.5; ENST00000563055.1
External Link	RMBase: m6A_site_328612
mod ID: M6ASITE028289		Click to Show/Hide the Full List
mod site	chr16:69749227-69749228:-		[1]
Sequence	TTGCCCAACATCGATCATGAACTGCAGGAGCTGCTGGTGAG
Motif Score	3.373380952
Cell/Tissue List	HeLa; Huh7; endometrial; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10; ENST00000561677.6; ENST00000564620.5; ENST00000569871.5; ENST00000563055.1
External Link	RMBase: m6A_site_328613
mod ID: M6ASITE028290		Click to Show/Hide the Full List
mod site	chr16:69749252-69749253:-		[1]
Sequence	TTCCTTCATGTTCTGGAGAAACCCTTTGCCCAACATCGATC
Motif Score	2.185083333
Cell/Tissue List	HeLa; Huh7; endometrial; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10; ENST00000561677.6; ENST00000564620.5; ENST00000569871.5; ENST00000563055.1
External Link	RMBase: m6A_site_328614
mod ID: M6ASITE028291		Click to Show/Hide the Full List
mod site	chr16:69749285-69749286:-		[1]
Sequence	CTCAGCTTGTGAGCCTGAGAACCTGGAATTTAGTTCCTTCA
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; Huh7; endometrial; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000569871.5; ENST00000561677.6; ENST00000564620.5; ENST00000563055.1; ENST00000268802.10
External Link	RMBase: m6A_site_328615
mod ID: M6ASITE028292		Click to Show/Hide the Full List
mod site	chr16:69749308-69749309:-		[1]
Sequence	CCACAAGAAACAGAAAAAGGACACTCAGCTTGTGAGCCTGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; Huh7; endometrial; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000563055.1; ENST00000268802.10; ENST00000564620.5; ENST00000569871.5; ENST00000561677.6
External Link	RMBase: m6A_site_328616
mod ID: M6ASITE028293		Click to Show/Hide the Full List
mod site	chr16:69749319-69749320:-		[1]
Sequence	AGCCTAAACCCCCACAAGAAACAGAAAAAGGACACTCAGCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; Huh7; endometrial; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10; ENST00000569871.5; ENST00000563055.1; ENST00000561677.6; ENST00000564620.5; ENST00000562416.1
External Link	RMBase: m6A_site_328617
mod ID: M6ASITE028294		Click to Show/Hide the Full List
mod site	chr16:69749332-69749333:-		[1]
Sequence	TTCTTTTAATTTCAGCCTAAACCCCCACAAGAAACAGAAAA
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; Huh7; endometrial; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000268802.10; ENST00000569871.5; ENST00000561677.6; ENST00000563055.1; ENST00000564620.5; ENST00000562416.1
External Link	RMBase: m6A_site_328618
mod ID: M6ASITE028295		Click to Show/Hide the Full List
mod site	chr16:69749596-69749597:-		[1]
Sequence	CATCGATTCAGCACCCAGAAACACCTCTGCACATTTCTGGT
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000563055.1; ENST00000562416.1; ENST00000561677.6; ENST00000569871.5; ENST00000268802.10; ENST00000564620.5
External Link	RMBase: m6A_site_328619
mod ID: M6ASITE028296		Click to Show/Hide the Full List
mod site	chr16:69752249-69752250:-		[1]
Sequence	GTGTCTCACCTAAAACAAGAACCACAGAAGGTAAATCAAGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; Huh7; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000569871.5; ENST00000563055.1; ENST00000564620.5; ENST00000561677.6; ENST00000562416.1; ENST00000268802.10
External Link	RMBase: m6A_site_328620
mod ID: M6ASITE028297		Click to Show/Hide the Full List
mod site	chr16:69752255-69752256:-		[1]
Sequence	GTTGGGGTGTCTCACCTAAAACAAGAACCACAGAAGGTAAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; Huh7; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000569871.5; ENST00000563055.1; ENST00000562416.1; ENST00000268802.10; ENST00000564620.5
External Link	RMBase: m6A_site_328621
mod ID: M6ASITE028298		Click to Show/Hide the Full List
mod site	chr16:69752319-69752320:-		[1]
Sequence	CCCCAGCCTCTCTGCCACGGACATCCAAGTGCTTGCACTCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; Huh7; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000569871.5; ENST00000562416.1; ENST00000564620.5; ENST00000563055.1; ENST00000268802.10
External Link	RMBase: m6A_site_328622
mod ID: M6ASITE028299		Click to Show/Hide the Full List
mod site	chr16:69752343-69752344:-		[1]
Sequence	GTTTTCAAAGAAAACAGGAGACTACCCCAGCCTCTCTGCCA
Motif Score	3.319380952
Cell/Tissue List	HeLa; Huh7; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000564620.5; ENST00000563055.1; ENST00000268802.10; ENST00000562416.1; ENST00000569871.5
External Link	RMBase: m6A_site_328623
mod ID: M6ASITE028300		Click to Show/Hide the Full List
mod site	chr16:69752350-69752351:-		[1]
Sequence	TGACTGAGTTTTCAAAGAAAACAGGAGACTACCCCAGCCTC
Motif Score	2.20572619
Cell/Tissue List	HeLa; Huh7; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000563055.1; ENST00000564620.5; ENST00000562416.1; ENST00000268802.10; ENST00000569871.5
External Link	RMBase: m6A_site_328624
mod ID: M6ASITE028301		Click to Show/Hide the Full List
mod site	chr16:69754673-69754674:-		[1]
Sequence	GGTGGTCACTGAGATTCGGGACAAGGCCACACGCAGGCGGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; MT4; A549; Huh7; peripheral-blood; MSC; TIME; TREX; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000563055.1; ENST00000564620.5; ENST00000569871.5; ENST00000268802.10; ENST00000562416.1
External Link	RMBase: m6A_site_328625
mod ID: M6ASITE028302		Click to Show/Hide the Full List
mod site	chr16:69754712-69754713:-		[1]
Sequence	TCCGCAGGACATCGGGAAGAACATTTACACCATCCGGGAGG
Motif Score	2.951386905
Cell/Tissue List	HeLa; MT4; A549; Huh7; peripheral-blood; MSC; TIME; TREX; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000563055.1; ENST00000569871.5; ENST00000268802.10; ENST00000562416.1; ENST00000564620.5
External Link	RMBase: m6A_site_328626
mod ID: M6ASITE028303		Click to Show/Hide the Full List
mod site	chr16:69754724-69754725:-		[1]
Sequence	TGGGGCGTTCTGTCCGCAGGACATCGGGAAGAACATTTACA
Motif Score	3.643047619
Cell/Tissue List	HeLa; MT4; A549; Huh7; peripheral-blood; MSC; TIME; TREX; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000563055.1; ENST00000562416.1; ENST00000564620.5; ENST00000569871.5; ENST00000268802.10
External Link	RMBase: m6A_site_328627

Ref 1	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 2	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 3	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
Ref 4	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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