m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00307)
Target Name Kinesin-like protein KIF2C (KIF2C)
Synonyms
Kinesin-like protein 6; Mitotic centromere-associated kinesin; MCAK; KNSL6
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Gene Name KIF2C
Chromosomal Location 1p34.1
Family TRAFAC class myosin-kinesin ATPase superfamily; Kinesin family; MCAK/KIF2 subfamily
Function
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment.
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Gene ID 11004
Uniprot ID
KIF2C_HUMAN
HGNC ID
HGNC:6393
Ensembl Gene ID
ENSG00000142945
KEGG ID
hsa:11004
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
KIF2C can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Disease
Colorectal cancer [ICD-11: 2B91]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary The study highlights a robust correlation between the level of cancer stemness and traits related to tumor heterogeneity, including the immune microenvironment, TMB, and the expression of m6A RNA methylation regulatory factors in colorectal cancer cells. A three-gene prognostic signature (PARPBP, KNSTRN, and Kinesin-like protein KIF2C (KIF2C)) was explored together with specific clinical features to construct a nomogram, which was successfully validated in an external cohort.
Responsed Disease Colorectal cancer [ICD-11: 2B91]