m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00281)
Target Name Putative heat shock 70 kDa protein 7 (HSPA7)
Synonyms
Heat shock 70 kDa protein B; HSP70B
    Click to Show/Hide
Gene Name HSPA7
Chromosomal Location 1q23.3
Family heat shock protein 70 family
Uniprot ID
HSP77_HUMAN
HGNC ID
HGNC:5240
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HSPA7 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Browse Drug
Brain cancer [ICD-11: 2A00]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary Putative heat shock 70 kDa protein 7 (HSPA7) promoted macrophage infiltration and SPP1 expression via upregulating the YAP1 and LOX expression of glioblastoma stem cells in vitro and in clinical glioblastoma tumor samples. HSPA7 is expected to predict the ability of PD-1 inhibitors to respond to treatment in glioblastoma.
Responsed Disease Glioblastoma [ICD-11: 2A00.00]
Responsed Drug Pembrolizumab Approved
 Drug Info 
Pathway Response PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235
In-vitro Model ()
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Pembrolizumab [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response []
Response Summary Putative heat shock 70 kDa protein 7 (HSPA7) promoted macrophage infiltration and SPP1 expression via upregulating the YAP1 and LOX expression of glioblastoma stem cells in vitro and in clinical glioblastoma tumor samples. HSPA7 is expected to predict the ability of PD-1 inhibitors to respond to treatment in glioblastoma.
Responsed Disease Glioblastoma ICD-11: 2A00.00
 Disease Info 
Pathway Response PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235
In-vitro Model ()
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Nivolumab [Phase 2]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response []
Response Summary Putative heat shock 70 kDa protein 7 (HSPA7) promoted macrophage infiltration and SPP1 expression via upregulating the YAP1 and LOX expression of glioblastoma stem cells in vitro and in clinical glioblastoma tumor samples. HSPA7 is expected to predict the ability of PD-1 inhibitors to respond to treatment in glioblastoma.
Responsed Disease Glioblastoma ICD-11: 2A00.00
 Disease Info 
Pathway Response PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235
In-vitro Model ()
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RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00281)
Putative heat shock 70 kDa protein 7 (HSPA7)
N6-methyladenosine (m6A)
In total 26 m6A sequence/site(s) in this target gene
mod ID: M6ASITE062740 Click to Show/Hide the Full List
mod site chr1:161606480-161606481:+ [1]
Sequence CAAGAGCCAGGCGGCCCTGAACCCCCACAACACCGTGTTCG
Motif Score 2.930744048
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61495
mod ID: M6ASITE062741 Click to Show/Hide the Full List
mod site chr1:161606534-161606535:+ [1]
Sequence GATCGGGCGCAAGTTCGCGGACACCACGGTGCAGTCGGACA
Motif Score 3.643047619
Cell/Tissue List endometrial; GSCs
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61496
mod ID: M6ASITE062742 Click to Show/Hide the Full List
mod site chr1:161606552-161606553:+ [1]
Sequence GGACACCACGGTGCAGTCGGACATGAAGCACTGGCCCTTCC
Motif Score 3.643047619
Cell/Tissue List endometrial; GSCs
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61497
mod ID: M6ASITE062743 Click to Show/Hide the Full List
mod site chr1:161606627-161606628:+ [1]
Sequence CGTATGCTACCGCGGGGAGGACAAGACGTTCTACCCCGAGG
Motif Score 3.643047619
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61498
mod ID: M6ASITE062744 Click to Show/Hide the Full List
mod site chr1:161606852-161606853:+ [2]
Sequence AGCCATCGCCTATGGGCTGGACCGGCGGGGCGCGGGAAAGC
Motif Score 3.622404762
Cell/Tissue List GM12878; LCLs; peripheral-blood; GSC-11; endometrial; GSCs
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61499
mod ID: M6ASITE062745 Click to Show/Hide the Full List
mod site chr1:161606990-161606991:+ [2]
Sequence TACCCACCTGGGAGGAGAGGACTTCGACAACCGGCTCGTGA
Motif Score 4.065041667
Cell/Tissue List GM12878; endometrial; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61500
mod ID: M6ASITE062746 Click to Show/Hide the Full List
mod site chr1:161607011-161607012:+ [2]
Sequence CTTCGACAACCGGCTCGTGAACCACTTCATGGAAGAATTCC
Motif Score 2.930744048
Cell/Tissue List GM12878; endometrial; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61501
mod ID: M6ASITE062747 Click to Show/Hide the Full List
mod site chr1:161607050-161607051:+ [2]
Sequence CCGGCGGAAGCATGGGAAGGACCTGAGCGGGAACAAGCGTG
Motif Score 3.622404762
Cell/Tissue List GM12878; LCLs; GSC-11; endometrial; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61502
mod ID: M6ASITE062748 Click to Show/Hide the Full List
mod site chr1:161607062-161607063:+ [2]
Sequence TGGGAAGGACCTGAGCGGGAACAAGCGTGCCCTGCGCAGGC
Motif Score 2.951386905
Cell/Tissue List GM12878; LCLs; GSC-11; endometrial; GSCs; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61503
mod ID: M6ASITE062749 Click to Show/Hide the Full List
mod site chr1:161607149-161607150:+ [2]
Sequence CCAGGCCACCCTGGAGATAGACTCCCTGTTCGAGGGCGTGG
Motif Score 3.319380952
Cell/Tissue List GM12878; LCLs; CD4T; GSC-11; endometrial; GSCs; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61504
mod ID: M6ASITE062750 Click to Show/Hide the Full List
mod site chr1:161607170-161607171:+ [2]
Sequence CTCCCTGTTCGAGGGCGTGGACTTCTACAAGTCCATCACTC
Motif Score 4.065041667
Cell/Tissue List GM12878; LCLs; CD4T; GSC-11; endometrial; GSCs; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61505
mod ID: M6ASITE062751 Click to Show/Hide the Full List
mod site chr1:161607207-161607208:+ [2]
Sequence ACTCGTGCCCGCTTTGAGGAACTGTGCTCAGACCTCTTCCG
Motif Score 3.373380952
Cell/Tissue List GM12878; LCLs; CD4T; GSC-11; endometrial; GSCs; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61506
mod ID: M6ASITE062752 Click to Show/Hide the Full List
mod site chr1:161607218-161607219:+ [2]
Sequence CTTTGAGGAACTGTGCTCAGACCTCTTCCGCAGCACCCTGG
Motif Score 2.876744048
Cell/Tissue List GM12878; LCLs; CD4T; peripheral-blood; endometrial; GSCs; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61507
mod ID: M6ASITE062753 Click to Show/Hide the Full List
mod site chr1:161607275-161607276:+ [2]
Sequence CCTGCGGGATGCCAAGCTGGACAAGGCCCAGATTCATGACT
Motif Score 3.643047619
Cell/Tissue List GM12878; LCLs; Jurkat; peripheral-blood; endometrial; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61508
mod ID: M6ASITE062754 Click to Show/Hide the Full List
mod site chr1:161607351-161607352:+ [2]
Sequence GGTGCAGAAGTTGCTGCAGGACTTCTTCAACGGCAAGGAGC
Motif Score 4.065041667
Cell/Tissue List GM12878; LCLs; Jurkat; peripheral-blood; endometrial; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61509
mod ID: M6ASITE062755 Click to Show/Hide the Full List
mod site chr1:161607375-161607376:+ [3]
Sequence CTTCAACGGCAAGGAGCTGAACAAGAGCATCAACCCTGATG
Motif Score 2.951386905
Cell/Tissue List LCLs; Jurkat; peripheral-blood; endometrial; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61510
mod ID: M6ASITE062756 Click to Show/Hide the Full List
mod site chr1:161607569-161607570:+ [2]
Sequence CCACTATCCCCACCAAGCAGACCCAGACTTTCACCACCTAC
Motif Score 2.876744048
Cell/Tissue List GM12878; LCLs; MT4; peripheral-blood; endometrial; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61511
mod ID: M6ASITE062757 Click to Show/Hide the Full List
mod site chr1:161607575-161607576:+ [2]
Sequence TCCCCACCAAGCAGACCCAGACTTTCACCACCTACTCGGAC
Motif Score 3.319380952
Cell/Tissue List GM12878; LCLs; MT4; peripheral-blood; endometrial; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61512
mod ID: M6ASITE062758 Click to Show/Hide the Full List
mod site chr1:161607594-161607595:+ [2]
Sequence GACTTTCACCACCTACTCGGACAACCAGCCTGGGGTCTTCA
Motif Score 3.643047619
Cell/Tissue List GM12878; LCLs; MT4; peripheral-blood; endometrial; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61513
mod ID: M6ASITE062759 Click to Show/Hide the Full List
mod site chr1:161607651-161607652:+ [2]
Sequence TGAGAGGGCCATGACCAAGGACAACAACCTGCTGGGGCGTT
Motif Score 3.643047619
Cell/Tissue List GM12878; LCLs; MT4; CD4T; peripheral-blood; GSC-11; endometrial; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61514
mod ID: M6ASITE062760 Click to Show/Hide the Full List
mod site chr1:161607676-161607677:+ [2]
Sequence AACCTGCTGGGGCGTTTTGAACTCATTGGCATCCCTCCTGC
Motif Score 3.373380952
Cell/Tissue List GM12878; LCLs; MT4; MM6; CD4T; peripheral-blood; GSC-11; endometrial; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61515
mod ID: M6ASITE062761 Click to Show/Hide the Full List
mod site chr1:161607891-161607892:+ [3]
Sequence TGAGGATGAGGCCCAGAGGGACAGAGTGGCTGCCAAAAACT
Motif Score 3.643047619
Cell/Tissue List LCLs; peripheral-blood; endometrial; GSCs; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61516
mod ID: M6ASITE062762 Click to Show/Hide the Full List
mod site chr1:161607909-161607910:+ [3]
Sequence GGACAGAGTGGCTGCCAAAAACTCGCTGGAGGCCCATGTCT
Motif Score 2.627720238
Cell/Tissue List LCLs; peripheral-blood; endometrial; GSCs; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61517
mod ID: M6ASITE062763 Click to Show/Hide the Full List
mod site chr1:161607969-161607970:+ [3]
Sequence GCAAGAGGAAAGCCTTAGGGACAAGATTCCCGAAGAGGACA
Motif Score 3.643047619
Cell/Tissue List LCLs; peripheral-blood; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61518
mod ID: M6ASITE062764 Click to Show/Hide the Full List
mod site chr1:161607987-161607988:+ [3]
Sequence GGACAAGATTCCCGAAGAGGACAGGCGCAAAGTGCAAGACA
Motif Score 3.643047619
Cell/Tissue List LCLs; peripheral-blood; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61519
mod ID: M6ASITE062765 Click to Show/Hide the Full List
mod site chr1:161608005-161608006:+ [3]
Sequence GGACAGGCGCAAAGTGCAAGACAAGTGTCAGGAAGTCCTTG
Motif Score 2.897386905
Cell/Tissue List LCLs; peripheral-blood; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000445535.1
External Link RMBase: m6A_site_61520