m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00275)
Target Name Adenosine 5'-monophosphoramidase HINT2 (HINT2)
Synonyms
HINT-3; HIT-17kDa; Histidine triad nucleotide-binding protein 2, mitochondrial; HINT-2; PKCI-1-related HIT protein
    Click to Show/Hide
Gene Name HINT2
Chromosomal Location 9p13.3
Family HINT family
Function
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro. May be involved in steroid biosynthesis. May play a role in apoptosis.
    Click to Show/Hide
Gene ID 84681
Uniprot ID
HINT2_HUMAN
HGNC ID
HGNC:18344
KEGG ID
hsa:84681
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HINT2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 1 (YTHDF1) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF1
Cell Line AGS cell line Homo sapiens
Treatment: shYTHDF1 AGS
Control: shControl AGS
 GSE159425
Regulation
logFC: 8.82E-01
p-value: 1.64E-04
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary YTHDF1 promoted the translation of methylated Adenosine 5'-monophosphoramidase HINT2 (HINT2) mRNA, a tumor suppressor in ocular melanoma.
Target Regulation Up regulation
Responsed Disease Melanoma ICD-11: 2C30
 Disease Info 
In-vitro Model CM2005.1 Conjunctival melanoma Homo sapiens CVCL_M592
CRMM-1 Conjunctival melanoma Homo sapiens CVCL_M593
HEK293T Normal Homo sapiens CVCL_0063
OCM-1 Amelanotic melanoma Homo sapiens CVCL_6934
OCM-1A Amelanotic melanoma Homo sapiens CVCL_6935
OM431 Uveal melanoma Homo sapiens CVCL_J308
PIG1 Normal Homo sapiens CVCL_S410
In-vivo Model Approximately 1 × 106 melanoma cells from each group were injected subcutaneously into the right side of the abdomen of BALB/c nude mice (male, 6 weeks old).
Melanoma [ICD-11: 2C30]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary YTHDF1 promoted the translation of methylated Adenosine 5'-monophosphoramidase HINT2 (HINT2) mRNA, a tumor suppressor in ocular melanoma.
Responsed Disease Melanoma [ICD-11: 2C30]
Target Regulator YTH domain-containing family protein 1 (YTHDF1) READER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model CM2005.1 Conjunctival melanoma Homo sapiens CVCL_M592
CRMM-1 Conjunctival melanoma Homo sapiens CVCL_M593
HEK293T Normal Homo sapiens CVCL_0063
OCM-1 Amelanotic melanoma Homo sapiens CVCL_6934
OCM-1A Amelanotic melanoma Homo sapiens CVCL_6935
OM431 Uveal melanoma Homo sapiens CVCL_J308
PIG1 Normal Homo sapiens CVCL_S410
In-vivo Model Approximately 1 × 106 melanoma cells from each group were injected subcutaneously into the right side of the abdomen of BALB/c nude mice (male, 6 weeks old).
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00275)
Adenosine 5'-monophosphoramidase HINT2 (HINT2)
5-methylcytidine (m5C)
In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004395 Click to Show/Hide the Full List
mod site chr9:35813073-35813074:- [2]
Sequence ATGTACTTGGGGGCCGGCAGCTCCAGTGGCCTCCAGGTTGA
Cell/Tissue List liver
Seq Type List Bisulfite-seq
Transcript ID List ENST00000472085.5; ENST00000471774.5; ENST00000474908.5; ENST00000474848.6; ENST00000259667.6; ENST00000461169.1; ENST00000490578.1; ENST00000650284.1
External Link RMBase: m5C_site_42506
mod ID: M5CSITE004396 Click to Show/Hide the Full List
mod site chr9:35813713-35813714:- [2]
Sequence GCAGGCAACTCCTGGGGGAGCAGCCCCAACCATCTTCTCCC
Seq Type List Bisulfite-seq
Transcript ID List ENST00000472085.5; ENST00000461169.1; ENST00000474908.5; ENST00000259667.6; ENST00000474848.6; ENST00000490578.1; ENST00000650284.1
External Link RMBase: m5C_site_42507
N6-methyladenosine (m6A)
In total 28 m6A sequence/site(s) in this target gene
mod ID: M6ASITE087976 Click to Show/Hide the Full List
mod site chr9:35812973-35812974:- [3]
Sequence GACCCTGTGATGCTAATAAAACTGTTCTCCCTTAATTATGC
Motif Score 2.627720238
Cell/Tissue List HeLa; HEK293T; A549; hESCs; Jurkat; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000490578.1; ENST00000471774.5; ENST00000474908.5; ENST00000650284.1; ENST00000461169.1; ENST00000259667.6; ENST00000474848.6; ENST00000472085.5
External Link RMBase: m6A_site_821345
mod ID: M6ASITE087977 Click to Show/Hide the Full List
mod site chr9:35812992-35812993:- [3]
Sequence GGATGGAAAGGGAAAAATGGACCCTGTGATGCTAATAAAAC
Motif Score 3.622404762
Cell/Tissue List HeLa; HEK293T; A549; hESCs; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000461169.1; ENST00000471774.5; ENST00000474848.6; ENST00000259667.6; ENST00000490578.1; ENST00000472085.5; ENST00000474908.5; ENST00000650284.1
External Link RMBase: m6A_site_821346
mod ID: M6ASITE087978 Click to Show/Hide the Full List
mod site chr9:35813025-35813026:- [3]
Sequence AACTGATTAAAGGACACCAGACTCTGGATGCTTGGATGGAA
Motif Score 3.319380952
Cell/Tissue List HeLa; HEK293T; hESCs; A549; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000472085.5; ENST00000474848.6; ENST00000461169.1; ENST00000259667.6; ENST00000474908.5; ENST00000471774.5; ENST00000490578.1; ENST00000650284.1
External Link RMBase: m6A_site_821347
mod ID: M6ASITE087979 Click to Show/Hide the Full List
mod site chr9:35813032-35813033:- [3]
Sequence ACCTGCCAACTGATTAAAGGACACCAGACTCTGGATGCTTG
Motif Score 3.643047619
Cell/Tissue List HeLa; HEK293T; hESC-HEK293T; hESCs; A549; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List ENST00000461169.1; ENST00000490578.1; ENST00000259667.6; ENST00000474848.6; ENST00000474908.5; ENST00000471774.5; ENST00000472085.5; ENST00000650284.1
External Link RMBase: m6A_site_821348
mod ID: M6ASITE087980 Click to Show/Hide the Full List
mod site chr9:35813052-35813053:- [3]
Sequence TCCAGTGGCCTCCAGGTTGAACCTGCCAACTGATTAAAGGA
Motif Score 2.930744048
Cell/Tissue List HeLa; HEK293T; hESCs; A549; HEK293A-TOA; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000490578.1; ENST00000461169.1; ENST00000474908.5; ENST00000471774.5; ENST00000472085.5; ENST00000259667.6; ENST00000650284.1; ENST00000474848.6
External Link RMBase: m6A_site_821349
mod ID: M6ASITE087982 Click to Show/Hide the Full List
mod site chr9:35813099-35813100:- [4]
Sequence ACAATCTGTGTATCATCTGCACATTCATGTACTTGGGGGCC
Motif Score 2.830589286
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000490578.1; ENST00000474848.6; ENST00000461169.1; ENST00000259667.6; ENST00000471774.5; ENST00000650284.1; ENST00000474908.5; ENST00000472085.5
External Link RMBase: m6A_site_821350
mod ID: M6ASITE087983 Click to Show/Hide the Full List
mod site chr9:35813119-35813120:- [4]
Sequence AACGATGGGAAGCTGGGTGCACAATCTGTGTATCATCTGCA
Motif Score 2.830589286
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000472085.5; ENST00000650284.1; ENST00000471774.5; ENST00000474848.6; ENST00000461169.1; ENST00000259667.6; ENST00000474908.5; ENST00000490578.1
External Link RMBase: m6A_site_821351
mod ID: M6ASITE087984 Click to Show/Hide the Full List
mod site chr9:35813189-35813190:- [5]
Sequence AATATGATCTTCATTCTTCGACCTCTGCCATGATCCTGACT
Motif Score 2.844928571
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000472085.5; ENST00000650284.1; ENST00000474848.6; ENST00000471774.5; ENST00000474908.5; ENST00000490578.1; ENST00000461169.1; ENST00000259667.6
External Link RMBase: m6A_site_821352
mod ID: M6ASITE087985 Click to Show/Hide the Full List
mod site chr9:35813304-35813305:- [6]
Sequence TACTCCTTGTGGCCAAGCAGACAGCAAAGGCTGAGGGCCTG
Motif Score 2.897386905
Cell/Tissue List peripheral-blood; endometrial; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000461169.1; ENST00000472085.5; ENST00000471774.5; ENST00000474848.6; ENST00000650284.1; ENST00000259667.6; ENST00000490578.1; ENST00000474908.5
External Link RMBase: m6A_site_821353
mod ID: M6ASITE087986 Click to Show/Hide the Full List
mod site chr9:35813329-35813330:- [3]
Sequence CTCTCTCTATAGCTTCTAGGACACCTACTCCTTGTGGCCAA
Motif Score 3.643047619
Cell/Tissue List HeLa; hESC-HEK293T; peripheral-blood; endometrial
Seq Type List m6A-seq; MAZTER-seq
Transcript ID List ENST00000474908.5; ENST00000650284.1; ENST00000474848.6; ENST00000471774.5; ENST00000490578.1; ENST00000472085.5; ENST00000461169.1; ENST00000259667.6
External Link RMBase: m6A_site_821354
mod ID: M6ASITE087987 Click to Show/Hide the Full List
mod site chr9:35813400-35813401:- [3]
Sequence TGGCTGGGAGGAGCCCCTGGACCCAGCTAGAGGTCTTGCTC
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000461169.1; ENST00000471774.5; ENST00000474848.6; ENST00000472085.5; ENST00000259667.6; ENST00000490578.1; ENST00000650284.1; ENST00000474908.5
External Link RMBase: m6A_site_821355
mod ID: M6ASITE087988 Click to Show/Hide the Full List
mod site chr9:35813434-35813435:- [3]
Sequence AAGACCAGCAGGTGGGAAGAACAGGGCCAGGGTTTGGCTGG
Motif Score 2.951386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000259667.6; ENST00000461169.1; ENST00000490578.1; ENST00000472085.5; ENST00000471774.5; ENST00000474848.6; ENST00000474908.5; ENST00000650284.1
External Link RMBase: m6A_site_821356
mod ID: M6ASITE087989 Click to Show/Hide the Full List
mod site chr9:35813451-35813452:- [3]
Sequence TAGCCAGGCTGAAGAAGAAGACCAGCAGGTGGGAAGAACAG
Motif Score 2.876744048
Cell/Tissue List HeLa; peripheral-blood; HEK293T; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000259667.6; ENST00000461169.1; ENST00000472085.5; ENST00000471774.5; ENST00000474908.5; ENST00000474848.6; ENST00000490578.1; ENST00000650284.1
External Link RMBase: m6A_site_821357
mod ID: M6ASITE087990 Click to Show/Hide the Full List
mod site chr9:35813626-35813627:- [3]
Sequence GCAGGTGGGGTGCTCTTAGGACCTATCCCCTTAGGAATGTT
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; A549; Jurkat; GSC-11; HEK293T; endometrial; HEC-1-A; GSCs; MM6
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000650284.1; ENST00000259667.6; ENST00000474908.5; ENST00000490578.1; ENST00000461169.1; ENST00000471774.5; ENST00000472085.5; ENST00000474848.6
External Link RMBase: m6A_site_821358
mod ID: M6ASITE087991 Click to Show/Hide the Full List
mod site chr9:35813650-35813651:- [3]
Sequence AGCTGACATTCTCTATGAGGACCAGCAGGTGGGGTGCTCTT
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; A549; Jurkat; peripheral-blood; GSC-11; HEK293T; iSLK; endometrial; HEC-1-A; GSCs; MM6
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000259667.6; ENST00000650284.1; ENST00000472085.5; ENST00000474908.5; ENST00000474848.6; ENST00000471774.5; ENST00000461169.1; ENST00000490578.1
External Link RMBase: m6A_site_821359
mod ID: M6ASITE087993 Click to Show/Hide the Full List
mod site chr9:35813665-35813666:- [4]
Sequence GGACAAGAGCCTCCCAGCTGACATTCTCTATGAGGACCAGC
Motif Score 2.859755952
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000474848.6; ENST00000259667.6; ENST00000474908.5; ENST00000650284.1; ENST00000471774.5; ENST00000490578.1; ENST00000461169.1; ENST00000472085.5
External Link RMBase: m6A_site_821360
mod ID: M6ASITE087994 Click to Show/Hide the Full List
mod site chr9:35813683-35813684:- [3]
Sequence CATCTTCTCCCGGATCCTGGACAAGAGCCTCCCAGCTGACA
Motif Score 3.643047619
Cell/Tissue List HeLa; HepG2; A549; U2OS; MM6; Jurkat; peripheral-blood; GSC-11; HEK293T; iSLK; endometrial; HEC-1-A; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000474848.6; ENST00000471774.5; ENST00000650284.1; ENST00000472085.5; ENST00000461169.1; ENST00000474908.5; ENST00000490578.1; ENST00000259667.6
External Link RMBase: m6A_site_821361
mod ID: M6ASITE087995 Click to Show/Hide the Full List
mod site chr9:35813896-35813897:- [3]
Sequence TGGTGCTCTGAAATTCAGGAACTTTCCTCCTGGGTGGGAAC
Motif Score 3.373380952
Cell/Tissue List HeLa; H1A
Seq Type List m6A-seq
Transcript ID List ENST00000259667.6; ENST00000474848.6; ENST00000472085.5; ENST00000650284.1; ENST00000461169.1; ENST00000474908.5
External Link RMBase: m6A_site_821362
mod ID: M6ASITE087996 Click to Show/Hide the Full List
mod site chr9:35814013-35814014:-
Sequence AACAGTGCTATATTTCGTGGACACATGAGCAGGAATCAATT
Motif Score 3.643047619
Cell/Tissue List HEK293T
Seq Type List MeRIP-seq
Transcript ID List ENST00000474848.6; ENST00000474908.5; ENST00000472085.5; ENST00000650284.1; ENST00000461169.1; ENST00000259667.6
External Link RMBase: m6A_site_821363
mod ID: M6ASITE087997 Click to Show/Hide the Full List
mod site chr9:35814032-35814033:-
Sequence ATTCTAGATCCTTTCCCTAAACAGTGCTATATTTCGTGGAC
Motif Score 2.20572619
Cell/Tissue List HEK293T
Seq Type List MeRIP-seq
Transcript ID List ENST00000474908.5; ENST00000461169.1; ENST00000474848.6; ENST00000650284.1; ENST00000259667.6; ENST00000472085.5
External Link RMBase: m6A_site_821364
mod ID: M6ASITE087998 Click to Show/Hide the Full List
mod site chr9:35814234-35814235:- [7]
Sequence CAAGGCTTAAAGATCAGAAAACAAGTAACGGAAATAAGTGG
Motif Score 2.20572619
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000650284.1; ENST00000474908.5; ENST00000259667.6; ENST00000461169.1; ENST00000474848.6; ENST00000472085.5
External Link RMBase: m6A_site_821365
mod ID: M6ASITE087999 Click to Show/Hide the Full List
mod site chr9:35814262-35814263:- [7]
Sequence TGCATTAAAACTTAAATAAAACAGGCGACAAGGCTTAAAGA
Motif Score 2.20572619
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000474848.6; ENST00000650284.1; ENST00000472085.5; ENST00000259667.6; ENST00000474908.5; ENST00000461169.1
External Link RMBase: m6A_site_821366
mod ID: M6ASITE088000 Click to Show/Hide the Full List
mod site chr9:35814273-35814274:- [7]
Sequence AACAGGGCGATTGCATTAAAACTTAAATAAAACAGGCGACA
Motif Score 2.627720238
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000650284.1; ENST00000472085.5; ENST00000474908.5; ENST00000461169.1; ENST00000474848.6; ENST00000259667.6
External Link RMBase: m6A_site_821367
mod ID: M6ASITE088001 Click to Show/Hide the Full List
mod site chr9:35814675-35814676:- [3]
Sequence GCCGGGGCGCCGAGGTCGGGACAGGGTCAGTGCAGCGGCTG
Motif Score 3.643047619
Cell/Tissue List HeLa; HEK293T
Seq Type List m6A-seq
Transcript ID List ENST00000474848.6; ENST00000472085.5; ENST00000650284.1; ENST00000461169.1; ENST00000474908.5; ENST00000259667.6
External Link RMBase: m6A_site_821368
mod ID: M6ASITE088002 Click to Show/Hide the Full List
mod site chr9:35814743-35814744:- [3]
Sequence GGGCTGTGTGGTGAGGTCGAACTGGTGGCTCCGGAGAACGA
Motif Score 3.373380952
Cell/Tissue List HeLa; HEK293T
Seq Type List m6A-seq
Transcript ID List ENST00000650284.1; ENST00000472085.5; ENST00000474848.6; ENST00000474908.5; ENST00000461169.1; ENST00000259667.6
External Link RMBase: m6A_site_821369
mod ID: M6ASITE088004 Click to Show/Hide the Full List
mod site chr9:35815218-35815219:- [3]
Sequence CACACGGACTAGAAGACGAAACCAATGGAATGGAAAATTGT
Motif Score 2.185083333
Cell/Tissue List HeLa; HEK293T; H1B; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000474908.5; ENST00000650284.1; ENST00000474848.6
External Link RMBase: m6A_site_821375
mod ID: M6ASITE088005 Click to Show/Hide the Full List
mod site chr9:35815231-35815232:- [3]
Sequence GGAAAAGAACGTTCACACGGACTAGAAGACGAAACCAATGG
Motif Score 4.065041667
Cell/Tissue List HeLa; HEK293T; H1B; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000474848.6; ENST00000650284.1; ENST00000474908.5
External Link RMBase: m6A_site_821376
mod ID: M6ASITE088006 Click to Show/Hide the Full List
mod site chr9:35815271-35815272:- [7]
Sequence GAAGTTTCTCTCACAGAGAAACTAGTAAGGGGATCCAATGG
Motif Score 2.627720238
Cell/Tissue List HEK293T; Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000650284.1; ENST00000474908.5; ENST00000474848.6
External Link RMBase: m6A_site_821377