m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00160)

Target Name	6-phosphogluconate dehydrogenase, decarboxylating (6PGD/PGD)
Synonyms	PGDH Click to Show/Hide
Gene Name	PGD
Chromosomal Location	1p36.22
Family	6-phosphogluconate dehydrogenase family
Function	Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Click to Show/Hide
Gene ID	5226
Uniprot ID	6PGD_HUMAN
HGNC ID	HGNC:8891
KEGG ID	hsa:5226

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

PGD can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

YTH domain-containing family protein 2 (YTHDF2) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	YTHDF2 directly binds to the m6A modification site of 6-phosphogluconate dehydrogenase, decarboxylating (6PGD/PGD) three prime untranslated region (3'-UTR) to promote 6PGD mRNA translation in lung cancer cells.
Target Regulation	Up regulation
Responsed Disease	Lung cancer		ICD-11: 2C25	Disease Info
Pathway Response	Pentose phosphate pathway			hsa00030
Cell Process	Cell growth
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	HEK293T	Normal	Homo sapiens	CVCL_0063

Lung cancer [ICD-11: 2C25]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	YTHDF2 directly binds to the m6A modification site of 6-phosphogluconate dehydrogenase, decarboxylating (6PGD/PGD) three prime untranslated region (3'-UTR) to promote 6PGD mRNA translation in lung cancer cells.
Responsed Disease	Lung cancer [ICD-11: 2C25]
Target Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Pentose phosphate pathway			hsa00030
Cell Process	Cell growth
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	HEK293T	Normal	Homo sapiens	CVCL_0063

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

DNA modification

m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02136		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target	RNA demethylase ALKBH5 (ALKBH5)
Crosstalk relationship	DNA modification → m6A
Disease	Lung cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00160)

6-phosphogluconate dehydrogenase, decarboxylating (6PGD/PGD)

N4-acetylcytidine (ac4C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000106		Click to Show/Hide the Full List
mod site	chr1:10413179-10413180:+		[2]
Sequence	GCCAAAGATCAGGGACAGCGCGGGGCAGAAGGGCACAGGGA
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000270776.13; ENST00000483936.5; ENST00000460189.1; ENST00000493288.1
External Link	RMBase: ac4C_site_16
mod ID: AC4SITE000125		Click to Show/Hide the Full List
mod site	chr1:10420017-10420018:+		[3]
Sequence	GCAGTGGCTTCCGCGTGCCCCGTGTGCTGGTGCGGTTCCCA
Cell/Tissue List	HEK293T
Seq Type List	ac4C-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: ac4C_site_17

Adenosine-to-Inosine editing (A-to-I)

In total 3 m6A sequence/site(s) in this target gene
mod ID: A2ISITE001949		Click to Show/Hide the Full List
mod site	chr1:10402843-10402844:+		[4]
Sequence	ACAAAAAAAATTTTAAAACTAGCTGGGCATTGTGGTTCAAG
Transcript ID List	ENST00000465632.5; ENST00000483936.5; rmsk_19690; ENST00000270776.13; ENST00000477958.5; ENST00000460189.1; ENST00000491493.5
External Link	RMBase: RNA-editing_site_1214
mod ID: A2ISITE001988		Click to Show/Hide the Full List
mod site	chr1:10404704-10404705:+		[4]
Sequence	AGACAGGGTTTCACCATGTTACCTTGGGTGGTCTCGAACTC
Transcript ID List	ENST00000465632.5; ENST00000460189.1; ENST00000483936.5; ENST00000491493.5; ENST00000270776.13
External Link	RMBase: RNA-editing_site_1215
mod ID: A2ISITE001989		Click to Show/Hide the Full List
mod site	chr1:10418627-10418628:+		[4]
Sequence	CTACTAAAAATACAAAAATTAGCCGGTTGTAGTGGTGCGTG
Transcript ID List	ENST00000498356.1; ENST00000270776.13; rmsk_19725
External Link	RMBase: RNA-editing_site_1216

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005219		Click to Show/Hide the Full List
mod site	chr1:10416978-10416979:+		[5]
Sequence	GTTTCCTCTTCCCGATCTCCCCATGTAGGAGAAGCTGTCTT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000493288.1; ENST00000270776.13; ENST00000483936.5; ENST00000498356.1
External Link	RMBase: m5C_site_790

N6-methyladenosine (m6A)

In total 57 m6A sequence/site(s) in this target gene
mod ID: M6ASITE067169		Click to Show/Hide the Full List
mod site	chr1:10398731-10398732:+		[6]
Sequence	GGCGTCCGAGTGCCTGGTAAACTGTAAAGCGCGGTCCTGCG
Motif Score	2.627720238
Cell/Tissue List	HeLa; A549; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000491493.5
External Link	RMBase: m6A_site_6485
mod ID: M6ASITE067205		Click to Show/Hide the Full List
mod site	chr1:10399530-10399531:+		[6]
Sequence	AGGCGCGGAGGAAAGTGCAGACTCCCAGTCACGGCCAAATG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; A549; MSC; TIME; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000491493.5; ENST00000477958.5; ENST00000465632.5; ENST00000487775.1; ENST00000483936.5; ENST00000270776.13
External Link	RMBase: m6A_site_6486
mod ID: M6ASITE067257		Click to Show/Hide the Full List
mod site	chr1:10399558-10399559:+		[6]
Sequence	TCACGGCCAAATGTGGAAGGACCGGACCCCTGGGTTGCAGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000491493.5; ENST00000483936.5; ENST00000465632.5; ENST00000270776.13; ENST00000477958.5; ENST00000487775.1
External Link	RMBase: m6A_site_6487
mod ID: M6ASITE067258		Click to Show/Hide the Full List
mod site	chr1:10399563-10399564:+		[6]
Sequence	GCCAAATGTGGAAGGACCGGACCCCTGGGTTGCAGCGCGTC
Motif Score	3.622404762
Cell/Tissue List	HeLa; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000477958.5; ENST00000491493.5; ENST00000270776.13; ENST00000487775.1; ENST00000465632.5; ENST00000483936.5
External Link	RMBase: m6A_site_6488
mod ID: M6ASITE067259		Click to Show/Hide the Full List
mod site	chr1:10399633-10399634:+		[7]
Sequence	TTTCTGCCTCTCTAGAGCTGACATCGCGCTGATCGGATTGG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000460189.1; ENST00000487775.1; ENST00000491493.5; ENST00000270776.13; ENST00000483936.5; ENST00000477958.5; ENST00000465632.5
External Link	RMBase: m6A_site_6489
mod ID: M6ASITE067260		Click to Show/Hide the Full List
mod site	chr1:10399669-10399670:+		[8]
Sequence	ATTGGCCGTCATGGGCCAGAACTTAATTCTGAACATGAATG
Motif Score	3.373380952
Cell/Tissue List	A549; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000270776.13; ENST00000483936.5; ENST00000491493.5; ENST00000465632.5; ENST00000460189.1; ENST00000477958.5; ENST00000487775.1
External Link	RMBase: m6A_site_6490
mod ID: M6ASITE067307		Click to Show/Hide the Full List
mod site	chr1:10399681-10399682:+		[7]
Sequence	GGGCCAGAACTTAATTCTGAACATGAATGACCACGGCTTTG
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T; A549; TIME
Seq Type List	MAZTER-seq; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000483936.5; ENST00000487775.1; ENST00000477958.5; ENST00000491493.5; ENST00000270776.13; ENST00000465632.5; ENST00000460189.1
External Link	RMBase: m6A_site_6491
mod ID: M6ASITE067310		Click to Show/Hide the Full List
mod site	chr1:10400410-10400411:+		[9]
Sequence	AGGTCTGTGCTTTTAATAGGACTGTCTCCAAAGTTGATGAT
Motif Score	4.065041667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000465632.5; ENST00000491493.5; ENST00000483936.5; ENST00000270776.13; ENST00000477958.5; ENST00000460189.1
External Link	RMBase: m6A_site_6492
mod ID: M6ASITE067346		Click to Show/Hide the Full List
mod site	chr1:10403092-10403093:+		[7]
Sequence	ACCATTGTTGGATACTGGTGACATCATCATTGACGGAGGAA
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000477958.5; ENST00000460189.1; ENST00000465632.5; ENST00000483936.5; ENST00000270776.13; ENST00000491493.5
External Link	RMBase: m6A_site_6493
mod ID: M6ASITE067373		Click to Show/Hide the Full List
mod site	chr1:10403128-10403129:+		[10]
Sequence	AGGAAATTCTGAATATAGGGACACCACAGTAAGTGTTCTTC
Motif Score	3.643047619
Cell/Tissue List	MT4; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000491493.5; ENST00000477958.5; ENST00000460189.1; ENST00000483936.5; ENST00000270776.13; ENST00000465632.5
External Link	RMBase: m6A_site_6494
mod ID: M6ASITE067374		Click to Show/Hide the Full List
mod site	chr1:10403133-10403134:+		[7]
Sequence	ATTCTGAATATAGGGACACCACAGTAAGTGTTCTTCAGTCC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000483936.5; ENST00000270776.13; ENST00000465632.5; ENST00000477958.5; ENST00000491493.5; ENST00000460189.1
External Link	RMBase: m6A_site_6495
mod ID: M6ASITE067375		Click to Show/Hide the Full List
mod site	chr1:10404173-10404174:+		[10]
Sequence	CCTTCAGAGACGGTGCCGAGACCTCAAGGCCAAGGGAATTT
Motif Score	2.876744048
Cell/Tissue List	MT4; A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000270776.13; ENST00000477958.5; ENST00000483936.5; ENST00000465632.5; ENST00000491493.5; ENST00000460189.1
External Link	RMBase: m6A_site_6496
mod ID: M6ASITE067376		Click to Show/Hide the Full List
mod site	chr1:10404266-10404267:+		[7]
Sequence	ATCGCTCATGCCAGGAGGGAACAAAGAAGCGTGGTGAGTGC
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T; HepG2; MT4; A549; Huh7; endometrial
Seq Type List	MAZTER-seq; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000491493.5; ENST00000477958.5; ENST00000465632.5; ENST00000483936.5; ENST00000460189.1; ENST00000270776.13
External Link	RMBase: m6A_site_6497
mod ID: M6ASITE067417		Click to Show/Hide the Full List
mod site	chr1:10408075-10408076:+		[7]
Sequence	TGTTTCTTTACACAGGCCCCACATCAAGACCATCTTCCAAG
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000491493.5; ENST00000460189.1; ENST00000270776.13; ENST00000465632.5; ENST00000483936.5
External Link	RMBase: m6A_site_6498
mod ID: M6ASITE067457		Click to Show/Hide the Full List
mod site	chr1:10408083-10408084:+		[11]
Sequence	TACACAGGCCCCACATCAAGACCATCTTCCAAGGCATTGCT
Motif Score	2.876744048
Cell/Tissue List	HepG2; MT4; A549; Huh7; peripheral-blood; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000483936.5; ENST00000491493.5; ENST00000465632.5; ENST00000460189.1; ENST00000270776.13
External Link	RMBase: m6A_site_6499
mod ID: M6ASITE067480		Click to Show/Hide the Full List
mod site	chr1:10408116-10408117:+		[11]
Sequence	GCATTGCTGCAAAAGTGGGAACTGGAGAACCCTGCTGTGAC
Motif Score	3.373380952
Cell/Tissue List	HepG2; MT4; A549; Huh7; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000465632.5; ENST00000483936.5; ENST00000491493.5; ENST00000270776.13; ENST00000460189.1
External Link	RMBase: m6A_site_6500
mod ID: M6ASITE067581		Click to Show/Hide the Full List
mod site	chr1:10408124-10408125:+		[11]
Sequence	GCAAAAGTGGGAACTGGAGAACCCTGCTGTGACTGGGCAAG
Motif Score	2.930744048
Cell/Tissue List	HepG2; MT4; A549; Huh7; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000483936.5; ENST00000270776.13; ENST00000460189.1; ENST00000491493.5; ENST00000465632.5
External Link	RMBase: m6A_site_6501
mod ID: M6ASITE067658		Click to Show/Hide the Full List
mod site	chr1:10411457-10411458:+		[7]
Sequence	CCACTTCGTGAAGATGGTGCACAACGGGATAGAGTATGGGG
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000270776.13; ENST00000491493.5; ENST00000460189.1; ENST00000483936.5
External Link	RMBase: m6A_site_6502
mod ID: M6ASITE067659		Click to Show/Hide the Full List
mod site	chr1:10411478-10411479:+		[7]
Sequence	CAACGGGATAGAGTATGGGGACATGCAGCTGATCTGTGAGG
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; HepG2; MT4; A549; Huh7; peripheral-blood; endometrial; NB4
Seq Type List	MAZTER-seq; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000483936.5; ENST00000491493.5; ENST00000270776.13; ENST00000460189.1
External Link	RMBase: m6A_site_6503
mod ID: M6ASITE067660		Click to Show/Hide the Full List
mod site	chr1:10411538-10411539:+		[9]
Sequence	CGTGCTGGGCATGGCGCAGGACGAGATGGCCCAGGTGAGGC
Motif Score	3.616982143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000491493.5; ENST00000483936.5; ENST00000460189.1; ENST00000270776.13
External Link	RMBase: m6A_site_6504
mod ID: M6ASITE067661		Click to Show/Hide the Full List
mod site	chr1:10412836-10412837:+		[10]
Sequence	GAGCCCTTGCCTCTGAGGAGACAACACTTCTGGTGGCCAGA
Motif Score	2.897386905
Cell/Tissue List	MT4; A549; Huh7; peripheral-blood; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000270776.13; ENST00000483936.5; ENST00000493288.1; ENST00000460189.1
External Link	RMBase: m6A_site_6505
mod ID: M6ASITE067662		Click to Show/Hide the Full List
mod site	chr1:10412880-10412881:+		[10]
Sequence	TCAGTATAACCAGGTTCAGAACAAACACAACTGACTCTGGG
Motif Score	2.951386905
Cell/Tissue List	MT4; A549; Huh7; peripheral-blood; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000493288.1; ENST00000483936.5; ENST00000270776.13; ENST00000460189.1
External Link	RMBase: m6A_site_6506
mod ID: M6ASITE067663		Click to Show/Hide the Full List
mod site	chr1:10412911-10412912:+		[10]
Sequence	TGACTCTGGGTTAGCATAAAACTCAACCAGCAGGAGCAGAA
Motif Score	2.627720238
Cell/Tissue List	MT4; A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000493288.1; ENST00000270776.13; ENST00000460189.1; ENST00000483936.5
External Link	RMBase: m6A_site_6507
mod ID: M6ASITE067664		Click to Show/Hide the Full List
mod site	chr1:10413082-10413083:+		[12]
Sequence	CCTTTGAGGATTGGAATAAGACAGAGCTAGACTCATTCCTG
Motif Score	2.897386905
Cell/Tissue List	CD34; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000460189.1; ENST00000493288.1; ENST00000483936.5; ENST00000270776.13
External Link	RMBase: m6A_site_6508
mod ID: M6ASITE067665		Click to Show/Hide the Full List
mod site	chr1:10413092-10413093:+		[12]
Sequence	TTGGAATAAGACAGAGCTAGACTCATTCCTGATTGAAATCA
Motif Score	3.319380952
Cell/Tissue List	CD34; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000483936.5; ENST00000493288.1; ENST00000460189.1; ENST00000270776.13
External Link	RMBase: m6A_site_6509
mod ID: M6ASITE067666		Click to Show/Hide the Full List
mod site	chr1:10413112-10413113:+		[13]
Sequence	ACTCATTCCTGATTGAAATCACAGCCAATATTCTCAAGTTC
Motif Score	2.047297619
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000270776.13; ENST00000460189.1; ENST00000483936.5; ENST00000493288.1
External Link	RMBase: m6A_site_6510
mod ID: M6ASITE067667		Click to Show/Hide the Full List
mod site	chr1:10413137-10413138:+		[12]
Sequence	CAATATTCTCAAGTTCCAAGACACCGATGGCAAACACCTGC
Motif Score	2.897386905
Cell/Tissue List	CD34; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000483936.5; ENST00000270776.13; ENST00000460189.1; ENST00000493288.1
External Link	RMBase: m6A_site_6511
mod ID: M6ASITE067751		Click to Show/Hide the Full List
mod site	chr1:10413150-10413151:+		[12]
Sequence	TTCCAAGACACCGATGGCAAACACCTGCTGCCAAAGATCAG
Motif Score	2.20572619
Cell/Tissue List	CD34; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000460189.1; ENST00000493288.1; ENST00000270776.13; ENST00000483936.5
External Link	RMBase: m6A_site_6512
mod ID: M6ASITE067782		Click to Show/Hide the Full List
mod site	chr1:10413173-10413174:+		[12]
Sequence	CCTGCTGCCAAAGATCAGGGACAGCGCGGGGCAGAAGGGCA
Motif Score	3.643047619
Cell/Tissue List	CD34; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000483936.5; ENST00000493288.1; ENST00000460189.1; ENST00000270776.13
External Link	RMBase: m6A_site_6513
mod ID: M6ASITE067783		Click to Show/Hide the Full List
mod site	chr1:10413205-10413206:+		[12]
Sequence	AGAAGGGCACAGGGAAGTGGACCGCCATCTCCGCCCTGGAA
Motif Score	3.622404762
Cell/Tissue List	CD34; HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000460189.1; ENST00000483936.5; ENST00000270776.13; ENST00000493288.1
External Link	RMBase: m6A_site_6514
mod ID: M6ASITE067784		Click to Show/Hide the Full List
mod site	chr1:10415378-10415379:+		[12]
Sequence	GAGCAATTTATTCATCACGGACTCAAGTATATGTGTAAGTA
Motif Score	4.065041667
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000493288.1; ENST00000270776.13; ENST00000498356.1; ENST00000483936.5
External Link	RMBase: m6A_site_6515
mod ID: M6ASITE067785		Click to Show/Hide the Full List
mod site	chr1:10417106-10417107:+		[7]
Sequence	TAAGAAATCATTCCTGGAGGACATTCGGAAGGTGGGACACA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000270776.13; ENST00000498356.1; ENST00000483936.5
External Link	RMBase: m6A_site_6516
mod ID: M6ASITE067864		Click to Show/Hide the Full List
mod site	chr1:10418917-10418918:+		[12]
Sequence	CTTTAAGTCAGCTGTTGAAAACTGCCAGGTATGTAGCCTAG
Motif Score	2.627720238
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000496718.1; ENST00000498356.1; ENST00000270776.13
External Link	RMBase: m6A_site_6517
mod ID: M6ASITE067958		Click to Show/Hide the Full List
mod site	chr1:10419508-10419509:+		[12]
Sequence	TCCTTCTATGACGGGTACAGACATGAGATGCTTCCAGCCAG
Motif Score	2.897386905
Cell/Tissue List	CD34; hESC-HEK293T; HepG2; HeLa
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000498356.1; ENST00000496718.1; ENST00000270776.13
External Link	RMBase: m6A_site_6518
mod ID: M6ASITE067970		Click to Show/Hide the Full List
mod site	chr1:10419595-10419596:+		[12]
Sequence	CTCGGGGGCGTGCGCCATGGACTGTCCTGACCAACCTACTC
Motif Score	4.065041667
Cell/Tissue List	CD34; HepG2; HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000270776.13; ENST00000496718.1; ENST00000498356.1
External Link	RMBase: m6A_site_6519
mod ID: M6ASITE067971		Click to Show/Hide the Full List
mod site	chr1:10419654-10419655:+		[7]
Sequence	GCGGGATTACTTCGGGGCTCACACCTATGAACTCTTGGCCA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000270776.13; ENST00000498356.1; ENST00000496718.1
External Link	RMBase: m6A_site_6520
mod ID: M6ASITE067972		Click to Show/Hide the Full List
mod site	chr1:10419664-10419665:+		[12]
Sequence	TTCGGGGCTCACACCTATGAACTCTTGGCCAAACCAGGGCA
Motif Score	3.373380952
Cell/Tissue List	CD34; HEK293T; HepG2; HeLa; A549; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000270776.13; ENST00000498356.1; ENST00000496718.1
External Link	RMBase: m6A_site_6521
mod ID: M6ASITE067973		Click to Show/Hide the Full List
mod site	chr1:10419676-10419677:+		[12]
Sequence	ACCTATGAACTCTTGGCCAAACCAGGGCAGTTTATCCACAC
Motif Score	2.185083333
Cell/Tissue List	CD34; HEK293T; HepG2; HeLa; A549; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000270776.13; ENST00000498356.1; ENST00000496718.1
External Link	RMBase: m6A_site_6522
mod ID: M6ASITE067981		Click to Show/Hide the Full List
mod site	chr1:10419693-10419694:+		[13]
Sequence	CAAACCAGGGCAGTTTATCCACACCAACTGGACAGGCCATG
Motif Score	2.053113095
Cell/Tissue List	HEK293; kidney; liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000270776.13; ENST00000496718.1; ENST00000498356.1
External Link	RMBase: m6A_site_6523
mod ID: M6ASITE067992		Click to Show/Hide the Full List
mod site	chr1:10419704-10419705:+		[12]
Sequence	AGTTTATCCACACCAACTGGACAGGCCATGGTGGCACCGTG
Motif Score	3.643047619
Cell/Tissue List	CD34; HEK293T; hESC-HEK293T; HepG2; HeLa; hESCs; A549; Huh7; HEK293A-TOA; MSC; TIME; iSLK
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000270776.13; ENST00000498356.1; ENST00000496718.1
External Link	RMBase: m6A_site_6524
mod ID: M6ASITE068037		Click to Show/Hide the Full List
mod site	chr1:10419738-10419739:+		[7]
Sequence	CACCGTGTCATCCTCGTCATACAATGCCTGATCATGCTGCT
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000270776.13; ENST00000498356.1; ENST00000496718.1
External Link	RMBase: m6A_site_6525
mod ID: M6ASITE068122		Click to Show/Hide the Full List
mod site	chr1:10419784-10419785:+		[12]
Sequence	CACCCTCCACGATTCCACAGACCAGGACATTCCATGTGCCT
Motif Score	2.876744048
Cell/Tissue List	CD34; HEK293T; HepG2; HeLa; hESCs; A549; Huh7; HEK293A-TOA; MSC; TIME; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000496718.1; ENST00000498356.1; ENST00000270776.13
External Link	RMBase: m6A_site_6526
mod ID: M6ASITE068177		Click to Show/Hide the Full List
mod site	chr1:10419790-10419791:+		[12]
Sequence	CCACGATTCCACAGACCAGGACATTCCATGTGCCTCATGGC
Motif Score	3.643047619
Cell/Tissue List	CD34; HEK293T; hESC-HEK293T; HepG2; HeLa; hESCs; A549; Huh7; HEK293A-TOA; MSC; TIME; iSLK
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000270776.13; ENST00000498356.1; ENST00000496718.1
External Link	RMBase: m6A_site_6527
mod ID: M6ASITE068266		Click to Show/Hide the Full List
mod site	chr1:10419869-10419870:+		[12]
Sequence	TTTTAAAAGTGTTGTAAGAGACTCCTGAGGAAGACACACAG
Motif Score	3.319380952
Cell/Tissue List	CD34; HEK293T; HepG2; HeLa; hESCs; A549; MSC; TIME; iSLK
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6528
mod ID: M6ASITE068283		Click to Show/Hide the Full List
mod site	chr1:10419882-10419883:+		[12]
Sequence	GTAAGAGACTCCTGAGGAAGACACACAGTTTATTTGTAAAG
Motif Score	2.897386905
Cell/Tissue List	CD34; HEK293T; hESC-HEK293T; HepG2; HeLa; hESCs; A549; MSC; TIME; iSLK
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6529
mod ID: M6ASITE068284		Click to Show/Hide the Full List
mod site	chr1:10419947-10419948:+		[9]
Sequence	CTCTGCCCTTGCCTCTTGGGACTGACCAGGAGCTGCTCATG
Motif Score	4.065041667
Cell/Tissue List	HEK293T; HepG2; HeLa; A549; TIME
Seq Type List	DART-seq; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6530
mod ID: M6ASITE068285		Click to Show/Hide the Full List
mod site	chr1:10419983-10419984:+		[11]
Sequence	TCATGTGCGTGAGAGTGGGAACCATCTCCTTGCGGCAGTGG
Motif Score	2.930744048
Cell/Tissue List	HepG2; HeLa; A549; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6531
mod ID: M6ASITE068286		Click to Show/Hide the Full List
mod site	chr1:10420046-10420047:+		[13]
Sequence	GTGCGGTTCCCATCACGCAGACAGGAAGGGTGTTTGCGCAC
Motif Score	2.897386905
Cell/Tissue List	HEK293; HeLa; A549
Seq Type List	m6A-REF-seq; m6A-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6532
mod ID: M6ASITE068287		Click to Show/Hide the Full List
mod site	chr1:10420081-10420082:+		[8]
Sequence	GCGCACTCTGATCAACTGGAACCTCTGTATCATGCGGCTGA
Motif Score	2.930744048
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6533
mod ID: M6ASITE068288		Click to Show/Hide the Full List
mod site	chr1:10420118-10420119:+		[9]
Sequence	CTGAATTCCCTTTTTCCTTTACTCAATAAAAGCTACATCAG
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6534
mod ID: M6ASITE068289		Click to Show/Hide the Full List
mod site	chr1:10420132-10420133:+		[9]
Sequence	TCCTTTACTCAATAAAAGCTACATCAGACTGATGCTCTTTC
Motif Score	2.078666667
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6535
mod ID: M6ASITE068290		Click to Show/Hide the Full List
mod site	chr1:10420139-10420140:+		[9]
Sequence	CTCAATAAAAGCTACATCAGACTGATGCTCTTTCTCCAGAT
Motif Score	3.319380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6536
mod ID: M6ASITE068291		Click to Show/Hide the Full List
mod site	chr1:10420230-10420231:+		[6]
Sequence	ATTTTTCTTTAAAAAAAAAGACTAGAATAACACAAGAAACC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6537
mod ID: M6ASITE068292		Click to Show/Hide the Full List
mod site	chr1:10420239-10420240:+		[9]
Sequence	TAAAAAAAAAGACTAGAATAACACAAGAAACCACATTTAGG
Motif Score	2.168095238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6538
mod ID: M6ASITE068293		Click to Show/Hide the Full List
mod site	chr1:10420248-10420249:+		[6]
Sequence	AGACTAGAATAACACAAGAAACCACATTTAGGATTATGCTT
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: m6A_site_6539
mod ID: M6ASITE068294		Click to Show/Hide the Full List
mod site	chr1:10420294-10420295:+		[6]
Sequence	AGAGGAGGCAGGCAGGGAGGACACACCAGGGGCTTTAATAC
Motif Score	3.643047619
Cell/Tissue List	HeLa; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000270776.13; rmsk_19727
External Link	RMBase: m6A_site_6540
mod ID: M6ASITE068310		Click to Show/Hide the Full List
mod site	chr1:10420364-10420365:+		[9]
Sequence	CAATGGGTACATGGACGTTCACTGTAACGTGCTTTTTCTTT
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000270776.13; rmsk_19727
External Link	RMBase: m6A_site_6541

2'-O-Methylation (2'-O-Me)

In total 2 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000153		Click to Show/Hide the Full List
mod site	chr1:10419960-10419961:+		[14]
Sequence	TCTTGGGACTGACCAGGAGCTGCTCATGTGCGTGAGAGTGG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: Nm_site_24
mod ID: 2OMSITE000160		Click to Show/Hide the Full List
mod site	chr1:10420077-10420078:+		[14]
Sequence	GTTTGCGCACTCTGATCAACTGGAACCTCTGTATCATGCGG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000270776.13
External Link	RMBase: Nm_site_25

Ref 1	YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation. Carcinogenesis. 2020 Jul 10;41(5):541-550. doi: 10.1093/carcin/bgz152.
Ref 2	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 3	Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature. 2020 Jul;583(7817):638-643. doi: 10.1038/s41586-020-2418-2. Epub 2020 Jun 17.
Ref 4	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 5	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 May 5;62(3):335-345. doi: 10.1016/j.molcel.2016.03.021. Epub 2016 Apr 21.
Ref 9	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 10	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 11	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 12	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 13	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 14	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

Visitor Map