m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00105)

Target Name	Long intergenic non-protein coding RNA 278 (LINC00278)
Synonyms	LINC00278; NCRNA00278; non-protein coding RNA 278; YY1BM; YY1-blocking micropeptide Click to Show/Hide
Gene Name	LINC00278
Chromosomal Location	Yp11.31
Family	Long intergenic non-protein coding RNAs
Gene ID	100873962
HGNC ID	HGNC:38712

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

LINC00278 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Disease

Esophageal cancer [ICD-11: 2B70]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response		[]
Response Summary	Downregulation of YY1BM significantly upregulated eEF2K expression and inhibited apoptosis, thus conferring esophageal squamous cell carcinoma cells more adaptive to nutrient deprivation. Cigarette smoking decreased m6A modification of Long intergenic non-protein coding RNA 278 (LINC00278) and YY1BM translation.
Responsed Disease	Esophageal squamous cell carcinoma [ICD-11: 2B70.1]
Cell Process	Nutrient deprivation
	Cell apoptosis
In-vitro Model	()
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In-vivo Model	Injected YY1BM intratumorally into ESCC tumors grafted in nude mice and analyzed the survival time.

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00105)

Long intergenic non-protein coding RNA 278 (LINC00278)

Adenosine-to-Inosine editing (A-to-I)

In total 12 m6A sequence/site(s) in this target gene
mod ID: A2ISITE003956		Click to Show/Hide the Full List
mod site	chrY:3040224-3040225:+		[1]
Sequence	ACAAACATGAGCTTGTAATCAGACAATACTTGTGCTGAGAC
Transcript ID List	ENST00000425031.1; ENST00000651090.1; ENST00000444263.5; ENST00000652068.1
External Link	RMBase: RNA-editing_site_143792
mod ID: A2ISITE003957		Click to Show/Hide the Full List
mod site	chrY:3082817-3082818:+		[1]
Sequence	CTTATTCAATAAATGCTACTAGGATAATTTACTAGCCATAG
Transcript ID List	ENST00000444263.5; ENST00000425031.1; rmsk_3181504; ENST00000652068.1; ENST00000651090.1
External Link	RMBase: RNA-editing_site_143793
mod ID: A2ISITE003958		Click to Show/Hide the Full List
mod site	chrY:3091772-3091773:+		[2]
Sequence	GCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGC
Transcript ID List	ENST00000652068.1; ENST00000444263.5; ENST00000425031.1; ENST00000651090.1; rmsk_3181515
External Link	RMBase: RNA-editing_site_143794
mod ID: A2ISITE003959		Click to Show/Hide the Full List
mod site	chrY:3091773-3091774:+		[2]
Sequence	CGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCT
Transcript ID List	ENST00000652068.1; ENST00000425031.1; ENST00000444263.5; rmsk_3181515; ENST00000651090.1
External Link	RMBase: RNA-editing_site_143795
mod ID: A2ISITE003960		Click to Show/Hide the Full List
mod site	chrY:3091808-3091809:+		[2]
Sequence	GAGGCTGAGGTGGGTGGATAAGGAGGTCAGGAGGTCGAGAT
Transcript ID List	ENST00000651090.1; ENST00000444263.5; ENST00000652068.1; rmsk_3181515; ENST00000425031.1
External Link	RMBase: RNA-editing_site_143796
mod ID: A2ISITE003961		Click to Show/Hide the Full List
mod site	chrY:3091816-3091817:+		[2]
Sequence	GGTGGGTGGATAAGGAGGTCAGGAGGTCGAGATCATCCTGG
Transcript ID List	rmsk_3181515; ENST00000652068.1; ENST00000425031.1; ENST00000444263.5; ENST00000651090.1
External Link	RMBase: RNA-editing_site_143797
mod ID: A2ISITE003962		Click to Show/Hide the Full List
mod site	chrY:3091819-3091820:+		[2]
Sequence	GGGTGGATAAGGAGGTCAGGAGGTCGAGATCATCCTGGCCA
Transcript ID List	ENST00000444263.5; ENST00000652068.1; ENST00000425031.1; rmsk_3181515; ENST00000651090.1
External Link	RMBase: RNA-editing_site_143798
mod ID: A2ISITE003963		Click to Show/Hide the Full List
mod site	chrY:3091840-3091841:+		[2]
Sequence	GGTCGAGATCATCCTGGCCAACATGGTGAAACCCCATGGCT
Transcript ID List	ENST00000652068.1; rmsk_3181515; ENST00000444263.5; ENST00000425031.1; ENST00000651090.1
External Link	RMBase: RNA-editing_site_143799
mod ID: A2ISITE003966		Click to Show/Hide the Full List
mod site	chrY:3091879-3091880:+		[2]
Sequence	CTACTAAAAATACAAAAATTAGCCAGTGTAGTGGCGTGCAC
Transcript ID List	rmsk_3181515; ENST00000652068.1; ENST00000651090.1; ENST00000425031.1; ENST00000444263.5
External Link	RMBase: RNA-editing_site_143800
mod ID: A2ISITE003967		Click to Show/Hide the Full List
mod site	chrY:3091904-3091905:+		[2]
Sequence	GTGTAGTGGCGTGCACCCGTAGTCCCAGTTACTCAGGAGGG
Transcript ID List	ENST00000444263.5; ENST00000651090.1; ENST00000652068.1; ENST00000425031.1; rmsk_3181515
External Link	RMBase: RNA-editing_site_143801
mod ID: A2ISITE003968		Click to Show/Hide the Full List
mod site	chrY:3091914-3091915:+		[2]
Sequence	GTGCACCCGTAGTCCCAGTTACTCAGGAGGGTGAGGCAGGA
Transcript ID List	rmsk_3181515; ENST00000651090.1; ENST00000652068.1; ENST00000444263.5; ENST00000425031.1
External Link	RMBase: RNA-editing_site_143802
mod ID: A2ISITE003969		Click to Show/Hide the Full List
mod site	chrY:3091918-3091919:+		[2]
Sequence	ACCCGTAGTCCCAGTTACTCAGGAGGGTGAGGCAGGAGAAT
Transcript ID List	ENST00000652068.1; ENST00000444263.5; rmsk_3181515; ENST00000425031.1; ENST00000651090.1
External Link	RMBase: RNA-editing_site_143803

2'-O-Methylation (2'-O-Me)

In total 4 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000566		Click to Show/Hide the Full List
mod site	chrY:3137024-3137025:+		[3]
Sequence	CAATAGTTGTTGCCTTGGTAATCCTGCTCAGTATGAGAGGA
Cell/Tissue List	HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	ENST00000651090.1; rmsk_3181610
External Link	RMBase: Nm_site_7069
mod ID: 2OMSITE000568		Click to Show/Hide the Full List
mod site	chrY:3137057-3137058:+		[3]
Sequence	TGAGAGGAACCACAGATTCAGACATTTGGTGTATGTGCTTG
Cell/Tissue List	HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	rmsk_3181610; ENST00000651090.1
External Link	RMBase: Nm_site_7071
mod ID: 2OMSITE000569		Click to Show/Hide the Full List
mod site	chrY:3137071-3137072:+		[3]
Sequence	GATTCAGACATTTGGTGTATGTGCTTGGCTGAGGAACCAAT
Cell/Tissue List	HEK293; cytosolic
Seq Type List	RiboMeth-seq
Transcript ID List	ENST00000651090.1; rmsk_3181610
External Link	RMBase: Nm_site_7072
mod ID: 2OMSITE000567		Click to Show/Hide the Full List
mod site	chrY:3137054-3137055:+		[4]
Sequence	GTATGAGAGGAACCACAGATTCAGACATTTGGTGTATGTGC
Transcript ID List	ENST00000651090.1; rmsk_3181610
External Link	RMBase: Nm_site_7070

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000288		Click to Show/Hide the Full List
mod site	chrY:3137070-3137071:+		[5]
Sequence	AGATTCAGACATTTGGTGTATGTGCTTGGCTGAGGAACCAA
Cell/Tissue List	cytosolic
Transcript ID List	rmsk_3181610; ENST00000651090.1
External Link	RMBase: Pseudo_site_5025

Ref 1	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 2	Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res. 2004 Sep;14(9):1719-25. doi: 10.1101/gr.2855504.
Ref 3	High-throughput identification of C/D box snoRNA targets with CLIP and RiboMeth-seq. Nucleic Acids Res. 2017 Mar 17;45(5):2341-2353. doi: 10.1093/nar/gkw1321.
Ref 4	snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D158-62. doi: 10.1093/nar/gkj002.
Ref 5	MODOMICS: a database of RNA modification pathways. 2017 update. Nucleic Acids Res. 2018 Jan 4;46(D1):D303-D307. doi: 10.1093/nar/gkx1030.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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