m6A Regulator Information

General Information of the m6A Regulator (ID: REG00052)
Regulator Name Thiol S-methyltransferase TMT1B (METTL7B)
Synonyms
TMT1B; UNQ594/PRO1180; Methyltransferase-like protein 7B; Thiol S-methyltransferase METTL7B
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Gene Name METTL7B
Sequence
MDILVPLLQLLVLLLTLPLHLMALLGCWQPLCKSYFPYLMAVLTPKSNRKMESKKRELFS
QIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYE
RFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPY
GSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFSEIQMERQPPPLKWLPVGPHIMG
KAVK
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Family methyltransferase superfamily
Function
Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Selectively methylates S-centered nucleophiles from metabolites such as hydrogen sulfide and dithiothreitol.
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Gene ID 196410
Uniprot ID
TMT1B_HUMAN
Regulator Type WRITER ERASER READER
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Target: Ubiquitin carboxyl-terminal hydrolase 38 (USP38)
 Target Gene 
In total 2 item(s) under this m6A target
Crosstalk ID: M6ACROT03145
 Crosstalk Info 
Epigenetic Regulator Histone deacetylase 3 (HDAC3)
Regulated Target Histone H3 lysine 18 lactylation (H3K18la)
Crosstalk relationship m6A → Histone modification
Crosstalk ID: M6ACROT03146
 Crosstalk Info 
Epigenetic Regulator Histone deacetylase 3 (HDAC3)
Regulated Target Histone H4 lysine 5 lactylation (H4K5la)
Crosstalk relationship m6A → Histone modification