Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00553)
Target Name Krueppel-like factor 1 (KLF1)
Synonyms
EKLF: Erythroid krueppel-like transcription factor; EKLF
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Gene Name KLF1
Sequence
MATAETALPSISTLTALGPFPDTQDDFLKWWRSEEAQDMGPGPPDPTEPPLHVKSEDQPGEEEDDERGADATWDLDLLLTNFSGPEPGGAPQTCALAPSEASGAQYPPPPETLGAYAGGPGLVAGLLGSEDHSGWVRPALRARAPDAFVGPALAPAPAPEPKALALQPVYPGPGAGSSGGYFPRTGLSVPAASGAPYGLLSGYPAMYPAPQYQGHFQLFRGLQGPAPGPATSPSFLSCLGPGTVGTGLGGTAEDPGVIAETAPSKRGRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYACTWEGCGWRFARSDELTRHYRKHTGQRPFRCQLCPRAFSRSDHLALHMKRHL
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Family Krueppel C2H2-type zinc-finger protein family
Function
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters (PubMed:21055716). When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation. {ECO:0000250|UniProtKB:P46099, ECO:0000269|PubMed:21055716, ECO:0000269|PubMed:25585695}.
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Gene ID 10661
HGNC ID HGNC:6345
Ensembl Gene ID ENSG00000105610
KEGG ID hsa:10661
Chromosomal Location 19p13.13
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00553)
Krueppel-like factor 1 (KLF1)
N6-methyladenosine (m6A)
In total 17 m6A sequence/site(s) in this target gene
mod ID: M6ASITE040101 Click to Show/Hide the Full List
mod site chr19:12884518-12884519:- [1]
Sequence TGGGATGAGGCTTCCCAGAGACCCTGGGTCTAGAAAGCGGC
Motif Score 2.876744048
Cell/Tissue List HeLa; H1A; H1B; MM6; peripheral-blood; TREX; NB4
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423111
mod ID: M6ASITE040102 Click to Show/Hide the Full List
mod site chr19:12884554-12884555:- [2]
Sequence CAGCTCCCAGATGGCCCTGGACAGCAGGAGAGGGTGTGGGA
Motif Score 3.643047619
Cell/Tissue List CD34; HEK293T; HeLa; H1A; H1B; hESCs; MM6; peripheral-blood; TREX; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423112
mod ID: M6ASITE040103 Click to Show/Hide the Full List
mod site chr19:12884576-12884577:- [2]
Sequence CGGACTCAGTGGACACTCAGACCAGCTCCCAGATGGCCCTG
Motif Score 2.876744048
Cell/Tissue List CD34; HEK293T; HeLa; H1A; H1B; hESCs; MM6; peripheral-blood; TREX; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423113
mod ID: M6ASITE040104 Click to Show/Hide the Full List
mod site chr19:12884584-12884585:- [2]
Sequence CAAATAAACGGACTCAGTGGACACTCAGACCAGCTCCCAGA
Motif Score 3.643047619
Cell/Tissue List CD34; HEK293T; HeLa; H1A; H1B; hESCs; MM6; peripheral-blood; TREX; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423114
mod ID: M6ASITE040105 Click to Show/Hide the Full List
mod site chr19:12884593-12884594:- [2]
Sequence ACAGACCGCCAAATAAACGGACTCAGTGGACACTCAGACCA
Motif Score 4.065041667
Cell/Tissue List CD34; HEK293T; HeLa; H1A; H1B; hESCs; MM6; peripheral-blood; TREX; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423115
mod ID: M6ASITE040106 Click to Show/Hide the Full List
mod site chr19:12884613-12884614:- [1]
Sequence TGTCGTGCAAACCCAGTGAGACAGACCGCCAAATAAACGGA
Motif Score 2.897386905
Cell/Tissue List HEK293T; HeLa; H1A; H1B; hESCs; GM12878; MM6; peripheral-blood; TREX
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423116
mod ID: M6ASITE040107 Click to Show/Hide the Full List
mod site chr19:12884623-12884624:- [1]
Sequence ATGTCCAAACTGTCGTGCAAACCCAGTGAGACAGACCGCCA
Motif Score 2.185083333
Cell/Tissue List HEK293T; HeLa; H1A; H1B; hESCs; GM12878; MM6; peripheral-blood; TREX
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423117
mod ID: M6ASITE040108 Click to Show/Hide the Full List
mod site chr19:12884635-12884636:- [1]
Sequence AGCCACACAGAGATGTCCAAACTGTCGTGCAAACCCAGTGA
Motif Score 2.627720238
Cell/Tissue List HEK293T; HeLa; H1A; H1B; hESCs; GM12878; MM6; peripheral-blood; TREX
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423118
mod ID: M6ASITE040109 Click to Show/Hide the Full List
mod site chr19:12884708-12884709:- [2]
Sequence TATCAAACACGGACCCATAGACAGCCCTGGGGGAGCCTCTT
Motif Score 2.897386905
Cell/Tissue List CD34; HEK293T; HeLa; H1A; H1B; hESCs; GM12878; MM6; peripheral-blood; MSC; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423119
mod ID: M6ASITE040110 Click to Show/Hide the Full List
mod site chr19:12884716-12884717:- [2]
Sequence CACCCAAATATCAAACACGGACCCATAGACAGCCCTGGGGG
Motif Score 3.622404762
Cell/Tissue List CD34; HEK293T; HeLa; H1A; H1B; hESCs; GM12878; MM6; peripheral-blood; MSC; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423120
mod ID: M6ASITE040111 Click to Show/Hide the Full List
mod site chr19:12884722-12884723:- [2]
Sequence AAGATCCACCCAAATATCAAACACGGACCCATAGACAGCCC
Motif Score 2.20572619
Cell/Tissue List CD34; HEK293T; HeLa; H1A; H1B; hESCs; GM12878; MM6; peripheral-blood; MSC; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423121
mod ID: M6ASITE040112 Click to Show/Hide the Full List
mod site chr19:12884755-12884756:- [2]
Sequence ACGAATGGACCCTCTCCTGGACTCGCGTTCCCAAAGATCCA
Motif Score 4.065041667
Cell/Tissue List CD34; HEK293T; HeLa; H1A; H1B; hESCs; GM12878; MM6; peripheral-blood; MSC; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423122
mod ID: M6ASITE040113 Click to Show/Hide the Full List
mod site chr19:12884767-12884768:- [2]
Sequence GGTGGTTTTCCCACGAATGGACCCTCTCCTGGACTCGCGTT
Motif Score 3.622404762
Cell/Tissue List CD34; HEK293T; HeLa; H1A; H1B; hESCs; GM12878; MM6; peripheral-blood; MSC; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423123
mod ID: M6ASITE040114 Click to Show/Hide the Full List
mod site chr19:12884840-12884841:- [3]
Sequence TCCTAGTGACTGGGGATGGGACAAGAAGCCTGTTTGGTGGT
Motif Score 3.643047619
Cell/Tissue List HEK293T; H1A; H1B; GM12878; MM6; peripheral-blood; TREX
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List rmsk_4943158; ENST00000264834.5
External Link RMBase: m6A_site_423124
mod ID: M6ASITE040115 Click to Show/Hide the Full List
mod site chr19:12884864-12884865:- [3]
Sequence AGCCCTGCCCTGGCACTTGGACTCTCCTAGTGACTGGGGAT
Motif Score 4.065041667
Cell/Tissue List HEK293T; H1A; H1B; GM12878; MM6; peripheral-blood; TREX
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423125
mod ID: M6ASITE040116 Click to Show/Hide the Full List
mod site chr19:12884977-12884978:- [4]
Sequence CTGACCCGCCACTACCGGAAACACACGGGGCAGCGCCCCTT
Motif Score 2.20572619
Cell/Tissue List GM12878
Seq Type List m6A-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423126
mod ID: M6ASITE040117 Click to Show/Hide the Full List
mod site chr19:12886008-12886009:- [3]
Sequence GGGCGCGGACGCCACCTGGGACCTGGATCTCCTCCTCACCA
Motif Score 3.622404762
Cell/Tissue List H1B
Seq Type List m6A-seq
Transcript ID List ENST00000264834.5
External Link RMBase: m6A_site_423127